LOCUS       NM_172855               3247 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 5
            (Galnt5), mRNA.
ACCESSION   NM_172855
VERSION     NM_172855.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Yoshida,C.A., Kawane,T., Moriishi,T., Purushothaman,A.,
            Miyazaki,T., Komori,H., Mori,M., Qin,X., Hashimoto,A., Sugahara,K.,
            Yamana,K., Takada,K. and Komori,T.
  TITLE     Overexpression of Galnt3 in chondrocytes resulted in dwarfism due
            to the increase of mucin-type O-glycans and reduction of
            glycosaminoglycans
  JOURNAL   J Biol Chem 289 (38), 26584-26596 (2014)
   PUBMED   25107907
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC116331.1 and BC116332.1.
            
            On Oct 27, 2007 this sequence version replaced NM_172855.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116332.1, AK029323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1221              BC116331.1         1-1221
            1222-3247           BC116332.1         1222-3247
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 32.93 cM"
     gene            1..3247
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /note="polypeptide N-acetylgalactosaminyltransferase 5"
                     /db_xref="GeneID:241391"
                     /db_xref="MGI:MGI:2179403"
     exon            1..1659
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..3028
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T5; pp-GaNTase 5; polypeptide GalNAc
                     transferase 5; protein-UDP acetylgalactosaminyltransferase
                     5; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 5; ppGaNTase-T5;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 5"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 5"
                     /protein_id="NP_766443.2"
                     /db_xref="CCDS:CCDS38125.1"
                     /db_xref="GeneID:241391"
                     /db_xref="MGI:MGI:2179403"
                     /translation="MNKIRKFFRGSGRVLAFIFAASVIWLLFDMAALRLSFSEINAGL
                     LKEDIIRREHTGFRVEPDQVKVLYTSIRGMGLPRNGAWGKENFRKAENHELKVEENMD
                     QVQRKGKMQNLLGRRKAVPLWHLAHLQTLPVTIPMQKTQGRDSKPEVSSQYMMSKWMT
                     VLESEKTPFTASRGVPLTKIAGRTETFDKKQEAPQNYNVSSDTSKQASERTLNMTISV
                     KTDRSKQKSQTVTKLRMHFASPPILKSEEVTVIKKAEAQSKDLKHEALKALPLLKFIA
                     DMGHLKNQSTNETQLGRLPEDDAAKVAPGKKLNFSESHVVIITKEEELKTDTKEVPNS
                     KTQTVFPKLLGGSPHKQIPRNQSKTSSSPPALKKAVSQSKPTISGGLHTARSNLTAKA
                     PTVGYQQSHANIPENPGMHHVFRIDVTLSPRDLNAPGQFGRPVVVPPEKKKEAEQRWK
                     EGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIMCFVDEVWSALLRSVHS
                     VLNRSPPHLIKEILLVDDFSTKEYLKADLDKYMSQFPKVRILRLKERHGLIRARLAGA
                     QNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQ
                     RGVFTWPMNFGWKTIPPDVVAKNGIKETDIIRCPVMAGGLFSIDKSYFYELGTYDPGL
                     DVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAE
                     VWLDDYRELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLDNVFPDLKAPVV
                     RASGVLINMALGKCVSIENITVTLEDCDGSSQLQQFNYTWVRLIKHGEWCVAPIPEKG
                     SLTLYHCDNRNNRLKWLHKSASAFHPELVDHIVFENYQQLLCMEGNFSQKTLKLAACN
                     PMELQQKWKFEKYYEV"
     exon            1660..1826
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1946
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2082
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2202
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2320
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2644
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2725
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2887
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3247
                     /gene="Galnt5"
                     /gene_synonym="4832424J23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggagcgg gcacaaatac tttgctgtga aatgccacgc aggcagagag tgacaggcag
       61 tcagtaagag ctgagctttt cccccttgga cagctatttc ctgcttggtt ccgacgagag
      121 gggccttgct cctactgctg ctgctgttgc tgctactact actgctgttg ctacctcaac
      181 tctctctctc cactccaggt aagcagagcg caagctgcaa gtcagccttt gtacgatgaa
      241 caagatccga aagtttttcc gaggaagtgg gcgagtcttg gcatttatat ttgcagcgtc
      301 tgtcatctgg ttgctctttg acatggcagc tctccgcctc tcattcagtg agatcaacgc
      361 agggctactc aaagaagata tcataaggag ggaacatacg ggattcagag ttgagccaga
      421 ccaagtgaag gtcctttaca ccagcatcag agggatgggg ctgcctcgga atggagcgtg
      481 gggtaaggag aactttagaa aagctgagaa ccatgaactc aaggttgagg agaatatgga
      541 ccaagtccag aggaaaggga aaatgcagaa cctcctggga aggagaaagg ctgtgccttt
      601 gtggcatctt gcacatctgc aaaccctccc agtgacaatt cccatgcaga agacccaggg
      661 gagagatagc aagcctgaag tctcctccca atacatgatg tccaagtgga tgacagtgtt
      721 agagtctgag aagaccccat tcacagcttc aagaggagtt ccattgacca aaatagcagg
      781 acgtacagaa accttcgata aaaaacaaga ggccccccaa aattataatg tcagcagcga
      841 tacatcaaag caagcatctg aaaggaccct gaatatgacc atcagtgtca agactgatag
      901 atcaaagcaa aaatcacaga cagtaacaaa attgaggatg cactttgcca gcccaccaat
      961 cctgaaatct gaggaagtca cagtcataaa gaaagctgag gctcagagca aagacctaaa
     1021 acatgaagcc cttaaagcgc taccacttct taagttcatt gcagatatgg gtcatttaaa
     1081 gaaccaatct acaaatgaga cacagttggg aagattgcca gaagatgatg cagccaaagt
     1141 ggcgccaggg aagaaactta atttctctga aagtcatgtt gtgattataa ctaaagagga
     1201 agaactgaag acagacacca aagaggtacc taattctaaa acccaaactg tgtttcctaa
     1261 attactgggt ggaagtccac ataaacaaat ccccagaaat caaagcaaga cgtcatcctc
     1321 tcccccagct ctgaagaaag cagtgtctca gtccaagccc accatatctg ggggactcca
     1381 tacagcaaga agcaacttga ctgccaaggc tccaactgtg ggataccagc aaagccatgc
     1441 aaatatccct gaaaaccctg gaatgcacca cgtgttcaga attgatgtga ccctttctcc
     1501 aagggatctc aatgctccgg gtcagtttgg gcgccctgtg gttgttcccc ctgagaagaa
     1561 gaaggaggcc gagcagagat ggaaagaagg aaacttcaat gtctacctta gtgatttgat
     1621 tccagtggac agagccattg aagacacaag gcctgctggg tgtgcagagc aactagttca
     1681 caatgacctc ccaaccacca gcatcatcat gtgctttgta gatgaggtgt ggtccgctct
     1741 actgaggtct gtgcacagcg tcctcaaccg ctcccctcca cacctcatca aggagattct
     1801 gctggtggat gacttcagca ccaaagaata cctcaaagct gatttggata aatacatgtc
     1861 tcaatttcca aaagttcgga ttcttcgcct gaaggagaga catggcttga tcagagcgag
     1921 gctggctggg gcacagaacg caacaggtga tgtgctgaca ttcctagact ctcatgtgga
     1981 gtgtaatgtg ggctggctgg aacctctact ggaaagagtt tatttaaata gaaagaaagt
     2041 ggcctgtcca gtaattgaag tcataaatga caaggacatg agttacatga cagtggacaa
     2101 cttccaaaga ggtgtcttca cctggcccat gaactttggc tggaaaacaa tccctccaga
     2161 tgttgttgca aaaaatggaa ttaaagaaac agatataata aggtgcccag tcatggcagg
     2221 tggattattt tccattgaca aaagttactt ttatgaactt ggaacatatg accctggtct
     2281 tgatgtttgg ggaggagaaa atatggagct atcattcaag gtctggatgt gtggtggtga
     2341 aattgagatc atcccctgtt ccagagtggg ccacatattc agaaacgaca atccatattc
     2401 cttccccaaa gaccgtatga agacagtgga acggaacctg gtgcgggttg ctgaggtttg
     2461 gcttgatgac tacagggaac tcttctatgg ccatggggat cacctcatag accaagggct
     2521 ggatgtgggc aaccttaccc agcaaaggga gttgcggaag aagctgaaat gcaaaagttt
     2581 caagtggtac ttggacaatg tctttcctga cttgaaggcg cccgttgtga gagctagtgg
     2641 tgtgcttatt aatatggcct tgggcaagtg cgtttccatt gaaaatatca cagtcaccct
     2701 cgaggactgc gatgggagca gccagcttca acaatttaat tatacctggg taagacttat
     2761 taagcacgga gagtggtgtg tggcacccat ccctgaaaaa ggatccctga cactgtacca
     2821 ttgtgacaac agaaacaaca ggcttaaatg gctgcacaaa tcagcatctg ccttccatcc
     2881 agaactggtg gatcacattg tttttgaaaa ctatcagcag ttattatgta tggaagggaa
     2941 tttctctcag aagaccctga aactggctgc ttgtaaccca atggaactgc aacaaaagtg
     3001 gaaatttgaa aaatactacg aagtctaaag aaaaataatt tatcaattta agccactagg
     3061 ttctgtgaaa ataacaccaa atttgctgac tgaatttctc tccatagtag cttaaatttt
     3121 ccattttaat agcatttgaa tggaaggctt ttgaaaatga ctacatttga atcaccagac
     3181 aataactcag ggaaccaagc tgccattggg ctgctgctct tcagctttgg gtggcctttg
     3241 gaagtgt
//
