LOCUS       NM_015737               5136 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 4
            (Galnt4), mRNA.
ACCESSION   NM_015737
VERSION     NM_015737.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5136)
  AUTHORS   Zhou,J., Guo,L., Ma,T., Qiu,T., Wang,S., Tian,S., Zhang,L., Hu,F.,
            Li,W., Liu,Z., Hu,Y., Wang,T., Kong,C., Yang,J., Zhou,J. and Li,H.
  TITLE     N-acetylgalactosaminyltransferase-4 protects against hepatic
            ischemia/reperfusion injury by blocking apoptosis signal-regulating
            kinase 1 N-terminal dimerization
  JOURNAL   Hepatology 75 (6), 1446-1460 (2022)
   PUBMED   34662438
  REMARK    GeneRIF: N-acetylgalactosaminyltransferase-4 protects against
            hepatic ischemia/reperfusion injury by blocking apoptosis
            signal-regulating kinase 1 N-terminal dimerization.
REFERENCE   2  (bases 1 to 5136)
  AUTHORS   Ye,Z., Guo,H., Wang,L., Li,Y., Xu,M., Zhao,X., Song,X., Chen,Z. and
            Huang,R.
  TITLE     GALNT4 primes monocytes adhesion and transmigration by regulating
            O-Glycosylation of PSGL-1 in atherosclerosis
  JOURNAL   J Mol Cell Cardiol 165, 54-63 (2022)
   PUBMED   34974060
  REMARK    GeneRIF: GALNT4 primes monocytes adhesion and transmigration by
            regulating O-Glycosylation of PSGL-1 in atherosclerosis.
REFERENCE   3  (bases 1 to 5136)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (bases 1 to 5136)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (bases 1 to 5136)
  AUTHORS   Tang,J., Zheng,H., Chen,L., Gao,S., Shi,X., Liu,J. and Xu,L.
  TITLE     Isoform-specific regulation of osteogenic factors by polypeptide
            N-Acetylgalactosaminyltransferases 1 and 4
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1449-1454 (2017)
   PUBMED   27965094
  REMARK    GeneRIF: the ppGalNAc-T4 was highly expressed in MC3T3-E1 cells
            during osteogenesis for the first time; ppGalNAc-T1 and -T4
            affected the expression of different osteogenic factors, suggesting
            distinct roles ppGalNAc-T isoforms play in regulating osteogenesis
            in vitro
REFERENCE   6  (bases 1 to 5136)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5136)
  AUTHORS   Sommer,P., Napier,H.R., Hogan,B.L. and Kidson,S.H.
  TITLE     Identification of Tgf beta1i4 as a downstream target of Foxc1
  JOURNAL   Dev Growth Differ 48 (5), 297-308 (2006)
   PUBMED   16759280
REFERENCE   8  (bases 1 to 5136)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 5136)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   10 (bases 1 to 5136)
  AUTHORS   Hagen,F.K., Ten Hagen,K.G., Beres,T.M., Balys,M.M.,
            VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     cDNA cloning and expression of a novel
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 272 (21), 13843-13848 (1997)
   PUBMED   9153242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093518.1, AK148036.1, BQ179479.1, AV080565.2 and BP761617.1.
            
            On Apr 21, 2009 this sequence version replaced NM_015737.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CJ093518.1         1-33
            34-2895             AK148036.1         2-2863
            2896-3446           BQ179479.1         142-692
            3447-4448           AK148036.1         3415-4416
            4449-4948           AV080565.2         519-1018
            4949-5136           BP761617.1         24-211              c
FEATURES             Location/Qualifiers
     source          1..5136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.06 cM"
     gene            1..5136
                     /gene="Galnt4"
                     /note="polypeptide N-acetylgalactosaminyltransferase 4"
                     /db_xref="GeneID:14426"
                     /db_xref="MGI:MGI:894692"
     exon            1..5113
                     /gene="Galnt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..2017
                     /gene="Galnt4"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T4; pp-GaNTase 4; polypeptide GalNAc
                     transferase 4; protein-UDP acetylgalactosaminyltransferase
                     4; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 4; ppGaNTase-T4;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 4"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 4"
                     /protein_id="NP_056552.1"
                     /db_xref="CCDS:CCDS48679.1"
                     /db_xref="GeneID:14426"
                     /db_xref="MGI:MGI:894692"
                     /translation="MAVRWTWAGKSCLLLALLTLAYILVEFSVSTLYASPGAGGAREL
                     GPRRLPDLDTREEDLSQPLYIKPPADSHALGEWGRASKLQLNEGELKQQEELIERYAI
                     NIYLSDRISLHRHIEDKRMYECKAKKFHYRSLPTTSVIIAFYNEAWSTLLRTIHSVLE
                     TSPAVLLKEIILVDDLSDRIYLKAQLETYISNLERVRLIRTNKREGLVRARLIGATFA
                     TGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCPVIDTIDWNTFEFYMQTGEPMIG
                     GFDWRLTFQWHSVPKHERDRRTSRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVW
                     GGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKE
                     HFYNRNPPARKEAYGDLSERKLLRERLKCKSFDWYLKNVFSNLHVPEDRPGWHGAIRS
                     MGISSECLDYNAPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPQ
                     QKDYVGMQNCPKDGLPVPVNIIWHFKEDGTIFHPHTRLCLSAYRTAEGRPSVHMKTCD
                     ALDKNQLWRFEK"
     regulatory      5079..5084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt4"
                     /note="hexamer: AATAAA"
     polyA_site      5113
                     /gene="Galnt4"
                     /note="major polyA site"
ORIGIN      
        1 ggtggagtat tggctggaga gtttgtgaaa agttctgaga cgagcaggag gaagtgggga
       61 ccgaccagtt gagcaccacc agaggccggg gagcgagggg gtctcaagtg acccctggga
      121 aactccggtg tcggaaagga gccgagcgcc tacatgaaag gaggaacctt ctcggaagtt
      181 cgcccctacc tgagccggga actccagctt caggatccgc ggcgctttcc ccgcgtgctg
      241 gctcggtggc cgcgtctaca cacgacccgt gaggatccgg atggccgtga ggtggacctg
      301 ggcaggcaag agctgcctgc tgctggccct tttaacactg gcttatattc tggtggagtt
      361 ctcagtctcc actttgtatg cctctccagg agccggcggt gccagggagc tggggccaag
      421 gcggctcccg gaccttgata caagggaaga ggatttgtct cagcctcttt atataaagcc
      481 ccctgcagat tcccatgctc ttggggaatg ggggagagca agcaaactcc agctcaacga
      541 gggggaactg aagcagcaag aagaacttat tgagagatat gccatcaaca tttacctcag
      601 tgacaggatc tccctgcacc gccacataga ggataaaaga atgtatgagt gtaaagccaa
      661 gaagttccac tacaggtcgc tccccaccac ctccgttatc atcgccttct ataacgaagc
      721 ctggtccact ctgcttcgga ccattcacag tgttttagaa acttctccag ctgtgctttt
      781 aaaggagatc atcttggtgg atgacttgag tgatagaatt tatttgaagg cgcaacttga
      841 aacttacatc agcaacctgg agagagttcg cttgattaga accaataaga gagaggggct
      901 ggtccgggcc cgtctaattg gggccacttt tgccaccggg gatgtcctca ctttcctgga
      961 ttgtcactgt gagtgtaaca ctggttggtt ggaaccactt ttggagagga tcagtagaga
     1021 cgaaaccgca atcgtatgtc ctgtcatcga cactattgac tggaacactt tcgaattcta
     1081 catgcagacc ggggagccca tgattggtgg gtttgactgg cgtttgacct tccagtggca
     1141 ttctgtcccc aaacatgaaa gggacaggcg aacgtcaaga attgacccca tcaggtcccc
     1201 caccatggca ggaggactgt ttgctgtcag caagaagtat tttcagtacc tgggcaccta
     1261 tgacactggc atggaagtct ggggaggcga aaaccttgag ttgtctttca gggtttggca
     1321 gtgtggcggc aagctggaga tccacccatg ctcgcacgtg ggccacgtgt ttcccaagcg
     1381 cgcgccctat gctcgcccca acttcctaca gaataccgcg cgggcggccg aagtgtggat
     1441 ggatgaatac aaagagcatt tctataaccg aaacccccca gctcggaaag aggcctatgg
     1501 cgatctttct gaaaggaagt tactaaggga acggctgaaa tgtaagagct tcgactggta
     1561 tctgaaaaat gtgttctcta acttacacgt ccccgaggat agacctggct ggcacggagc
     1621 catccgcagc atgggcatct cttccgagtg cttagattat aacgctcccg acaacaaccc
     1681 tacgggggct aatctttcgt tgtttggatg ccacggtcaa ggaggcaatc agttctttga
     1741 atatacttca aacaaagaaa tcagattcaa ttccgtgact gaattatgtg cagaggtccc
     1801 ccaacaaaag gattatgtag ggatgcaaaa ctgccccaaa gacgggctcc cagttccagt
     1861 gaacatcatt tggcatttta aagaagacgg aacgattttt caccctcaca caagactgtg
     1921 tcttagtgct taccggacag ccgagggccg acctagtgtc catatgaaaa cgtgtgatgc
     1981 ccttgataaa aaccagctct ggaggtttga gaaataggct agcagcagag cgccttctct
     2041 tcgggagctg acagtagcct ccggaaagtc accgtgcccc aagatgactg tattttacca
     2101 gaagtcacct ggcagctgtc tgtaagaaca ctggaaagcc gtggttcatc tggggatatc
     2161 actctgaagc tgggtacaca gagcaccgct gctcaatatc tcaaagtgcc ttctttgctc
     2221 tcgggttgtt ttatttaaaa gctttgtcaa tatggtctcc tgcaactcct taaagaaagc
     2281 tgctgtgaac tgagatacac aaaacactga agtatgggtg tagcttagca gtagaatgct
     2341 tagctagcat gtgcaagacc ctgagtctga cccacagcac cacaaactac atgcaagact
     2401 taatatttag aacataaaag tccagacaaa atggggtatg attcattctg atttgtaaat
     2461 tcattgcatg tacttttctt tcttcttttc ttttctcttc ttttctttat caaaacatgt
     2521 gaatgtgtaa ttagaactat tactttctga ttacattctt tcagccagca cattacattt
     2581 taggttttta aaaaccaact tgtctttggt aaaataaaag ttgaagaaat ttgatcttga
     2641 ggaaaaggcc tggggttgat atatgtttca ttggaagagg gtcctggtct tgaatgcaag
     2701 tttggaggtc ttattttatt ttattttatt ttgagataga tcttaggcat cccaggctga
     2761 ccttgaactc ctgagtcttg cttccacctc tcaagtactg ggattacagg cgtgtgccac
     2821 cacaggtggt ttggaggtct ttcttggcag acaggtatct cagaaagata gtgggacatt
     2881 caccttcagt tctctgtaac cgggagccgt tggagtgaac tggcccatat ctcaacacct
     2941 cacatcaccc cgctctgtaa gctgcattct ctgtgaactt gtttgtgagt aatggggcat
     3001 tttctgattg cacctcctta gttatggatg tcctagaatg aagctcattc agaaggctgg
     3061 gcctcccgtc cttaatgtct aatggtttga agtcaacaca agtgagactt ccccaaagcc
     3121 aaccccaaat gcctttaccg aaatgtgtga aactgaagtg ggccagccca gttctgcaga
     3181 gagtgttcaa ctcccctcag agtgggcgct gacctggaaa tggagaggct tcctctttat
     3241 tgcagtgggg gaaaggctgt cttggtcatt gttgattggt gccttggagc tcctggaaag
     3301 cacaaggcag ccgggcacct gggcagctct taccttgtgt gagcagatgt ctcagcggaa
     3361 ggggttgttt ctcttgtttg ggcctcagtt tcctcttctg tctcgctgag ttggtcggtg
     3421 aggatcccta aaggtcgatt gcacctccct ctggggccct cacctctatg caacttggag
     3481 agaagcactt ctgtgtcttt ccttttaacg tgggtggtgc tgagtagctg gtcagtttca
     3541 gtttggaaga tggaaaggca atttttatat ttacatgagc tgagctcccc tgaagtggtg
     3601 agtttctccc aggatatcat gagagctagt tttctactca ttttattttg acaacggtta
     3661 gactgattgt gcttttttaa aaaaaagttt tcaactttca aagcaattct tttgactaag
     3721 agtataaata tttcccaaac taaattattt cagaagtaca cgttttgcca tattttgact
     3781 agttccctac taacgtttta tccagacagc acagcccaaa ttttgggagt gagtctcagg
     3841 tttttgactt tgatttgaaa atgcatgttc catagagaac cagcccacag gacttcatag
     3901 gaaagttgtt ttcagggttc acttgtcagg atggagaggg ggaagactct gagtttcagt
     3961 agcttgttta gggtgaccat tgaaaacatg aaggtttgtg tgtacttgtg gctgttttgt
     4021 ttctcactga ttcttagaat gaaaatctct tactactttt ttgtaagtta cctagcatcc
     4081 ttacagttta tggaccaccc acctggctag agattccatg agcaatggtt ggccctgggt
     4141 tttatttaag ggaaatatac ataaatgctc attcaggagg aaattctcca acatgcattc
     4201 tcacctcgcc ccatcctttt gctgttctgg ctaagccccg tgtctgtcgc atgagagaat
     4261 taaatggatg caattgagaa gggaccattg aaaatacttt tacttagtat ctctgtgccc
     4321 ctagccaaag agagacgagg cttttaagac tagagtattc cctcctgtgt tacctgtctc
     4381 tctataggtg cttatggccc ctcggtcctt tttaggctgg tagattattt ctgtctgtaa
     4441 ttcagaagaa tataactcag aatactatac ataatgaagt aaactggagt tgtgttttta
     4501 tatgcagaca tggtccaatt tcattccaaa agcacaccat agtgaaacat gcaagagacg
     4561 ctttcactta tttccagttt ttggccaacc acccaagttc tccattttgc tgtagaattt
     4621 acatgtttaa atgttaggaa aatatttgat gagcaaggag tttcccattc tattgtttac
     4681 ttaatcagtc ctgtgaatag attggctcta tgagcatctt agcacttgtt ttatttttaa
     4741 aatggtaaca gagtcatcag aagggtctct ctaaccgtaa acaccttgtt tgtaagggaa
     4801 agtgtgttta ttcagccagt aaatagtagg ctcttgcatg tgcattgatg ttagcagatt
     4861 gaaatattcc aggcaaagga tttgttttta agttgtatac tctcagttat tttattgtct
     4921 cagttttaat gaataaaatt tagatttgac ttgtcttttg gaattgctgt tttaacaaga
     4981 tttctgaatg ggcacaaagc tgaggtctag atttctgtct tttgagcggt gactgtttct
     5041 ttttgttaat ggtgtctgta atattggcga agacatgcaa taaaatgtat gcctaattat
     5101 ttttgcaaac caaaaaaaaa aaaaaaaaaa aaaaaa
//
