LOCUS       NM_015736               3684 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 3
            (Galnt3), mRNA.
ACCESSION   NM_015736 XM_885274 XM_980400
VERSION     NM_015736.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Dalal,K., Yang,W., Tian,E., Chernish,A., McCluggage,P., Lara,A.J.,
            Ten Hagen,K.G. and Tabak,L.A.
  TITLE     In vivo mapping of the mouse Galnt3-specific O-glycoproteome
  JOURNAL   J Biol Chem 300 (9), 107628 (2024)
   PUBMED   39098533
  REMARK    GeneRIF: In vivo mapping of the mouse Galnt3-specific
            O-glycoproteome.
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Wang,Y.K., Li,S.J., Zhou,L.L., Li,D. and Guo,L.W.
  TITLE     GALNT3 protects against vascular calcification by reducing
            oxidative stress and apoptosis of smooth muscle cells
  JOURNAL   Eur J Pharmacol 939, 175447 (2023)
   PUBMED   36473594
  REMARK    GeneRIF: GALNT3 protects against vascular calcification by reducing
            oxidative stress and apoptosis of smooth muscle cells.
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Guo,L., Wang,Y., Li,S., Zhou,L. and Li,D.
  TITLE     GALNT3 protects against phosphate-induced calcification in vascular
            smooth muscle cells by enhancing active FGF23 and inhibiting the
            wnt/beta-catenin signaling pathway
  JOURNAL   Cell Signal 100, 110477 (2022)
   PUBMED   36162588
  REMARK    GeneRIF: GALNT3 protects against phosphate-induced calcification in
            vascular smooth muscle cells by enhancing active FGF23 and
            inhibiting the wnt/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Clerin,V., Saito,H., Filipski,K.J., Nguyen,A.H., Garren,J.,
            Kisucka,J., Reyes,M. and Juppner,H.
  TITLE     Selective pharmacological inhibition of the sodium-dependent
            phosphate cotransporter NPT2a promotes phosphate excretion
  JOURNAL   J Clin Invest 130 (12), 6510-6522 (2020)
   PUBMED   32853180
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
  REMARK    GeneRIF: Loss of the disease-associated glycosyltransferase Galnt3
            alters Muc10 glycosylation and the composition of the oral
            microbiome.
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Ichikawa,S., Sorenson,A.H., Austin,A.M., Mackenzie,D.S.,
            Fritz,T.A., Moh,A., Hui,S.L. and Econs,M.J.
  TITLE     Ablation of the Galnt3 gene leads to low-circulating intact
            fibroblast growth factor 23 (Fgf23) concentrations and
            hyperphosphatemia despite increased Fgf23 expression
  JOURNAL   Endocrinology 150 (6), 2543-2550 (2009)
   PUBMED   19213845
  REMARK    GeneRIF: Galnt3-deficient mice have a biochemical phenotype of
            tumoral calcinosis and provide in vivo evidence that Galnt3 plays
            an essential role in proper secretion of Fgf23 in mice.
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Hagen,F.K., Ten Hagen,K.G., Beres,T.M., Balys,M.M.,
            VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     cDNA cloning and expression of a novel
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 272 (21), 13843-13848 (1997)
   PUBMED   9153242
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Zara,J., Hagen,F.K., Ten Hagen,K.G., Van Wuyckhuyse,B.C. and
            Tabak,L.A.
  TITLE     Cloning and expression of mouse UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase-T3
  JOURNAL   Biochem Biophys Res Commun 228 (1), 38-44 (1996)
   PUBMED   8912633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019995.1, AK135489.1, AL929230.6 and AV274239.2.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_015736.3.
            
            On or before Dec 20, 2007 this sequence version replaced
            XM_980400.1, XM_885274.2, NM_015736.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019995.1, AK135489.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK019995.1         1-40
            41-3014             AK135489.1         2-2975
            3015-3329           AK019995.1         3014-3328
            3330-3330           AL929230.6         120077-120077       c
            3331-3682           AK019995.1         3330-3681
            3683-3684           AV274239.2         648-649
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 38.99 cM"
     gene            1..3684
                     /gene="Galnt3"
                     /note="polypeptide N-acetylgalactosaminyltransferase 3"
                     /db_xref="GeneID:14425"
                     /db_xref="MGI:MGI:894695"
     exon            1..270
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..893
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..2280
                     /gene="Galnt3"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T3; pp-GaNTase 3; polypeptide GalNAc
                     transferase 3; protein-UDP acetylgalactosaminyltransferase
                     3; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 3; ppGaNTase-T3;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 3"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 3"
                     /protein_id="NP_056551.2"
                     /db_xref="CCDS:CCDS16075.1"
                     /db_xref="GeneID:14425"
                     /db_xref="MGI:MGI:894695"
                     /translation="MAHLKRLVKLHIKRHYHRKFWKLGAVIFFFLVVLILMQREVSVQ
                     YSKEESKMERNLKNKNKMLDFMLEAVNNIKDAMPKMQIGAPIKENIDVRERPCLQGYY
                     TAAELKPVFDRPPQDSNAPGASGKPFKITHLSPEEQKEKERGETKHCFNAFASDRISL
                     HRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLK
                     EIILVDDASVDDYLHEKLEEYIKQFSIVKIVRQQERKGLITARLLGAAVATAETLTFL
                     DAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWS
                     LSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENI
                     EMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKGTQVIARNQVRLAEVWMDEYKEI
                     FYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYVPDLNPVISGY
                     IKSVGQPLCLDVGENNQGGKPLILYTCHGLGGNQYFEYSAQREIRHNIQKELCLHATQ
                     GVVQLKACVYKGHRTIAPGEQIWEIRKDQLLYNPLFKMCLSSNGEHPNLVPCDATDLL
                     QKWIFSQND"
     exon            894..1066
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1216
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1451
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1569
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1770
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1902
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2004
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2157
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..3684
                     /gene="Galnt3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2989..2994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt3"
                     /note="hexamer: AATAAA"
     regulatory      2998..3003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt3"
                     /note="hexamer: TATAAA"
     polyA_site      3006
                     /gene="Galnt3"
                     /note="major polyA site"
     polyA_site      3017
                     /gene="Galnt3"
ORIGIN      
        1 gatccggcct cgcccctgcc gacgtcgccg gcgggagctc acctgggaga ctcgcagagg
       61 aagaggagcc tcggcgtggc ctcgcttggc aacgcgggag gcccggcggg aaggcaggaa
      121 gcggcggcgg aggaggagtt gagccgagcg gccacgagag ccacggccac ccgagtcgcc
      181 ggcgtcgcca cctgcacttg gctctggacc cccgcggaca gagccccggc cggccgccgc
      241 ttcccgccgc ctgccctgcc cacctgccag gtattaccac ttaaagaaac ccttttaccg
      301 gcaaacctat gctaaagagt ataagtaaca aaggaaacca aacagttatc tgtcaagtaa
      361 caagcattta atgacagaat ggctcacctt aagcgactag taaaattgca cattaaaaga
      421 cattaccaca gaaagttctg gaagctgggt gcagtcatct ttttcttttt agtagttctg
      481 attttaatgc aaagagaagt aagtgttcag tattccaagg aggaatcaaa gatggagagg
      541 aacttgaaaa acaaaaacaa aatgttggat tttatgctcg aagctgtaaa taatattaaa
      601 gatgcaatgc caaagatgca aataggagcg cccattaagg agaatatcga cgtccgcgag
      661 agaccctgtc tgcaagggta ctacacagcc gcggagttga agccggtttt tgatcgccca
      721 cctcaggatt ctaacgcacc tggtgcttct ggcaagccgt ttaagatcac ccacctcagc
      781 ccggaggagc agaaggagaa agagcgaggg gaaacgaagc actgcttcaa cgcctttgca
      841 agtgacagaa tttctctgca ccgggacctt gggcctgaca cccgaccacc tgaatgtatt
      901 gaacaaaaat ttaagcgctg cccgcccctg cctaccacca gtgtcataat agtctttcac
      961 aatgaagcat ggtccacgct gcttaggacc gtccacagtg tgctctattc ttcacctgcc
     1021 atactgctga aggagatcat tttggtggat gatgctagtg tagacgacta cctgcatgaa
     1081 aagctggagg aatacataaa acagttttct attgtgaaaa tagtcaggca gcaagaaagg
     1141 aaaggcctga tcaccgcgcg gttgctaggg gcagctgtag caactgccga gacgctcacg
     1201 ttcttagatg ctcactgtga gtgcttctat ggctggctgg aacctctgct ggccaggata
     1261 gctgagaact acactgccgt ggtgagtcca gacatcgcat ccatagatct aaacacattt
     1321 gaattcaaca agccttctcc gtacggaagc aaccataacc gtggaaattt tgactggagc
     1381 ctttcctttg gctgggagtc acttcctgat catgagaagc aaagaaggaa agatgaaacc
     1441 tacccaatta agacccccac ctttgcagga ggcctttttt ctatatctaa aaaatatttt
     1501 gagcacattg gaagttacga tgaagaaatg gaaatctggg gaggtgaaaa tatagaaatg
     1561 tcattccgag tgtggcaatg tggtgggcag ttggagatta tgccttgctc tgttgttgga
     1621 catgtttttc gcagcaaaag ccctcatacc ttcccaaaag gcacgcaggt gattgctcgt
     1681 aaccaagttc gccttgcaga ggtctggatg gacgaataca aggaaatatt ttataggaga
     1741 aacacagatg cagcaaaaat cgttaagcaa aaatcatttg gtgatctttc caaaagattt
     1801 gaaataaaga aacgccttca gtgtaaaaat tttacctggt acctgaacac tatttacccg
     1861 gaagcgtatg tgccagacct taatcctgtt atatctggat atattaagag tgtgggtcaa
     1921 cctttatgtc tggatgttgg tgagaataac cagggaggca aaccattgat tctgtacacg
     1981 tgccacggcc tcgggggaaa tcagtacttc gagtattctg ctcagcgtga aatccggcac
     2041 aacatccaga aggagctgtg tcttcatgct actcagggtg tcgtccagct gaaggcatgt
     2101 gtctataaag gtcacaggac catcgcccct ggagaacaga tatgggagat tcggaaggac
     2161 caacttctat ataatccatt atttaaaatg tgcctttcat caaatggaga gcatccaaac
     2221 ttagtgccat gtgacgcaac agatctactc caaaaatgga tttttagcca aaatgattaa
     2281 gtgttcctta aaattaagga gttgaaaagg acatactctt cctcataaaa ctgtgactag
     2341 gcatacactg tagttgttga aaattatgca aaagcagcta attgtaactt attccaagtg
     2401 catttcctta tttatatctt aagatgtcta tgtagaaccg ctgcagaaac cctggggttt
     2461 ctgtctgaaa gcacagcaac tagaatacca aagacgattc tgaaatgtcc agatgtagaa
     2521 gagagatgtt tacagtgtga agaaaataat ttccttagta aagtgaggtg tggttgtaca
     2581 cttggggatc tacacacctg catccacaca ctcacagctg aaaatgtttc ccctaatttt
     2641 aggggcaata gaaaaagatt tgatactgta tttttataac tatatagaaa tggatcaatg
     2701 aaggccaatc atttggcctt tcggtacaaa ccaggaactt tttatcaatc tagaattcat
     2761 tgttttaaaa tccaggtaaa cttttgttgt ctcttgttga cttgtctgtc aaatatttcc
     2821 ttaaacatga agttgataag gagaggacta tttttaacat ttaaattttt ggaaaattta
     2881 caaatatttt ttagaagccc actccacttg atgcacatga gtcttcccca aatagctttt
     2941 ctgaagtgac tatactgtgt gttttctcag agtacttttt aaaaaataaa taaactttat
     3001 aaattattag ctgttaataa tggttctttt tttctttcta gtagtcttgt tttcttagca
     3061 aaattcacta atcttgaata tttatgacac tgaattttaa atgcagaaaa ttgactcaac
     3121 cctaaatttc gttgaatcat tacataaact atcttttcaa taggtttatc tcatcaaatt
     3181 aaaaaagagc cttgatttta tctacataga aaatgtaaat taaaaaagaa gaaccctaaa
     3241 cacaattaca aatctttgtt tcagttttgt ccagttggag caagatttgt aattgatggc
     3301 ggcgggcgga gagcatccat tttttcactc tagattttag tcatctgctg tttgtggagc
     3361 cccaggttcc tttaaggaaa atgtaaaccg tgacaccagt gtgacaacag aagcgaagat
     3421 aagatactgg tggaaatgtg aacctttgat aacatccttt aatgacctct taaaattatc
     3481 ttttgaagtc accattttct ctttggccat tttacagaga aaggtcttgt attattccag
     3541 aagcaaaata gaatttgtgt gaacctttga aactagtggg tctcagttaa caaaagaaaa
     3601 catttcctag aattatagtt ttaattaaaa aaaataaagc atccattaaa ttttaaatat
     3661 cgaattaaaa attccatatt ctct
//
