LOCUS       NM_139272               4131 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 2
            (Galnt2), mRNA.
ACCESSION   NM_139272
VERSION     NM_139272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   Mercanoglu,B., Waschkowski,S.A., Neuburg,E., Schraps,N.,
            Giannou,A.D., Dreyer,B., Harder,S., Heine,M., Krebs,C.F.,
            Gungor,C., Schluter,H., Melling,N., Hackert,T., Bockhorn,M.,
            Wagener,C. and Wolters-Eisfeld,G.
  TITLE     GalNT2-mediated O-glycosylation affects pancreas development and
            function in mice
  JOURNAL   Sci Rep 14 (1), 29760 (2024)
   PUBMED   39613794
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Ma,W., Li,H., Hu,J., Gao,Y., Lv,H., Zhang,X., Zhang,Q., Xu,M. and
            Cheng,Y.
  TITLE     Role of a novel mouse mutant of the Galnt2tm1Lat/tm1Lat gene in
            otitis media
  JOURNAL   Front Neurol 13, 1054704 (2023)
   PUBMED   36874359
  REMARK    Erratum:[Front Neurol. 2023 Oct 09;14:1287032. doi:
            10.3389/fneur.2023.1287032. PMID: 37885477]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Hu,Q., Tian,T., Leng,Y., Tang,Y., Chen,S., Lv,Y., Liang,J., Liu,Y.,
            Liu,T., Shen,L. and Dong,X.
  TITLE     The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in
            non-small cell lung cancer
  JOURNAL   Cell Mol Biol Lett 27 (1), 71 (2022)
   PUBMED   36058918
  REMARK    GeneRIF: The O-glycosylating enzyme GALNT2 acts as an oncogenic
            driver in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Verzijl,C.R.C., Oldoni,F., Loaiza,N., Wolters,J.C., Rimbert,A.,
            Tian,E., Yang,W., Struik,D., Smit,M., Kloosterhuis,N.J.,
            Fernandez,A.J., Samara,N.L., Ten Hagen,K.G., Dalal,K., Chernish,A.,
            McCluggage,P., Tabak,L.A., Jonker,J.W. and Kuivenhoven,J.A.
  TITLE     A novel role for GalNAc-T2 dependent glycosylation in energy
            homeostasis
  JOURNAL   Mol Metab 60, 101472 (2022)
   PUBMED   35304331
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Johnsen,J.M., Levy,G.G., Westrick,R.J., Tucker,P.K. and Ginsburg,D.
  TITLE     The endothelial-specific regulatory mutation, Mvwf1, is a common
            mouse founder allele
  JOURNAL   Mamm Genome 19 (1), 32-40 (2008)
   PUBMED   18188647
  REMARK    GeneRIF: These data suggest that the region responsible for the
            Mvwf1 regulatory switch lies within an approximately 30-kb genomic
            interval upstream of the B4galnt2 gene.
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   Young,W.W. Jr., Holcomb,D.R., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Expression of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase isoforms in murine tissues
            determined by real-time PCR: a new view of a large family
  JOURNAL   Glycobiology 13 (7), 549-557 (2003)
   PUBMED   12651884
REFERENCE   8  (bases 1 to 4131)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4131)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   10 (bases 1 to 4131)
  AUTHORS   Hagen,F.K., Ten Hagen,K.G., Beres,T.M., Balys,M.M.,
            VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     cDNA cloning and expression of a novel
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 272 (21), 13843-13848 (1997)
   PUBMED   9153242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ770019.1, BC059818.1 and BC053063.1.
            
            On Apr 29, 2004 this sequence version replaced NM_139272.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059818.1, AK145122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BQ770019.1         1-55
            56-2325             BC059818.1         1-2270
            2326-4131           BC053063.1         2170-3975
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.52 cM"
     gene            1..4131
                     /gene="Galnt2"
                     /note="polypeptide N-acetylgalactosaminyltransferase 2"
                     /db_xref="GeneID:108148"
                     /db_xref="MGI:MGI:894694"
     exon            1..256
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..350
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..504
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..603
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..671
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..737
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..859
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..947
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1035
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1139
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1266
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1359
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1443
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1570
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1690
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..4110
                     /gene="Galnt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt2"
                     /note="hexamer: AATAAA"
     polyA_site      4110
                     /gene="Galnt2"
                     /note="major polyA site"
ORIGIN      
        1 cgggcgccga gcgccgagcg ccgagcgccg cccgccgagc gccgcgtctt cccgcgccgc
       61 cgccccgagc tccgcccgcc gcgcgctccg cccgccgcgc cgccaggctg cccggcggcc
      121 gcccagagcg aggatgcggc ggcgctcgcg gatgctgctg tgcttcgcgc tgctctgggt
      181 cctgggcatc gcctactaca tgtactcggg gggcggctcc gcgctggccg cgggcggggg
      241 cggcgccggc aggaagggtg actggaatga catcgactcc attaagaaga aagaccttca
      301 ccacagcaga ggagatgaga aagcacaggg tgtggagacc ctccctccag gcaaagtccg
      361 gtggccagac tttaaccagg aggcatacgt tggcggtaca atggttcgct ctgggcagga
      421 cccgtacgca cgcaacaagt tcaaccaggt ggagagtgac aagctgcaca tggacagagg
      481 catccccgac acccggcatg accagtgtca gcgcaagcag tggcgagtgg acctgccagc
      541 caccagcgtg gtgatcacat tccacaatga agccaggtcg gccctgctgc ggacggtggt
      601 cagtgtcctc aagaggagtc cacctcacct catcaaggag ataatcctgg tggatgacta
      661 cagcaacgac cctgaggacg gggccctctt ggggaaaatc gagaaggtgc gggtcctcag
      721 aaatgaccgg agagaaggtc taatgcgctc tcgggtccgg ggtgccgacg ccgcccaggc
      781 caaggtcctg accttcctag acagtcactg cgagtgtaac gagcgatggc tggagccact
      841 cttggagcgg gttgctgagg acaggacccg agttgtatcc cccattatcg atgtcattaa
      901 catggataat ttccagtatg tgggcgcctc tgctgacctc aagggtggtt ttgactggaa
      961 cttggtgttc aagtgggatt acatgacacc agagcagagg cgatcccggc aggggaaccc
     1021 agttgcccct ataaaaactc cgatgatcgc tggcggcctc ttcgtgatgg acaagctcta
     1081 ttttgaagag ctggggaagt acgacatgat gatggacgtg tggggaggag agaacttgga
     1141 gatctcattc cgagtgtggc agtgtggtgg cagcctggag atcatcccgt gcagccgcgt
     1201 gggccacgtg ttccggaagc agcatcccta cacgttcccc ggtggcagcg gcactgtctt
     1261 tgcccggaac acacgccggg cagctgaagt ctggatggat gagtacaaac atttctacta
     1321 cgcagcggtg ccttctgcac gaaacgtgcc ctatgggaat attcagagca ggctggagct
     1381 caggaaaaag ctgggctgca agcccttcaa gtggtacctg gacaacgtct acccggagct
     1441 gagggttcca gaccaccagg acatagcttt cggggcctta cagcagggaa ccaactgcct
     1501 ggacaccttg ggacacttcg cggatggagt tgttggaatt tatgagtgtc acaacgctgg
     1561 aggaaaccag gaatgggcct tgacaaagga gaagtcggtg aagcacatgg acctgtgcct
     1621 tactgtggtg gaccgttcgc ctgggtcact catcaggctg cagggctgcc gggagaacga
     1681 cagcagacag aagtgggagc agatcgaagg caactccaaa ctgcgacacg tgggcagcaa
     1741 cctgtgcctg gatagccgca ctgccaagag cggaggcctg agtgtggagg tgtgtggccc
     1801 ggccctgtca caacagtgga agttctcact caacctgcag caataagagg cccccggggc
     1861 ccaacgtcca cccgcacacc ggcccagttt gttgatcacg taattacgtt tctgaaactt
     1921 tccgcaaaac tatatacctc agtgttccat cacggtctga cagtcttaag tctcaagtct
     1981 tcatcgaggc atgagcgggg cagacagcag tgcagaagag gaaaggagcc cctggggctc
     2041 aggacagagg gtccctccca aggctggcgc cctctgcctc cctctttctg cttcctgctc
     2101 acaccccagc actggccgga acaagtgggc aagcagcaat catgtttata tctcagacag
     2161 aggaagcagg ggcaggcgcc cccacagtga gagctcgcca atctccactc tgttttacct
     2221 attcaaaatc gtgtgtgtgt gtgtgaacca ggcatggtgg ccagtgcctg taatcccatc
     2281 actcaggagg ctgaggcagg caaggccctg tctaaggaaa aaaaaaaaaa tgatttccac
     2341 aaagctggcc tttccttgtc tgtccctgca cccgggctca gctggcctcc cagccacgtc
     2401 ccctcttcca ttgacatact tgctgtattt gaacgtgaac tttcctctgg tggacactaa
     2461 atagagataa agagaatcat ggtccgttcc ctacgcttcc ccgacatcat cttgtgaacc
     2521 ctgcaacgca gcgcagccca gagcaaaggt gcatctctgg ggcctcacca gccggcccac
     2581 gctgctcctc cagtaggggc atccccaaac cactggcccc acccacaagc gtcaatgttt
     2641 aacttcagcg aggggatcgc agctgggtta gaaagtctgc tttgtgccca ttgtcatctg
     2701 taaaactaaa taggtcacct cttttggcaa gtattgcttt gggttttctt ttaaaattag
     2761 atttcttttc tttaggaaaa ctcaacccca cagcttctaa ctaatgtgag ccagcaggac
     2821 cctactgcct tgtgacagac cagggacact ggacagctgt cacccactat ccctaggctc
     2881 acagtggttt gagaccctgt atgttgggtc tttggtacta agctgccggc agagcacaga
     2941 agagcagctc ttcagcctgt gggtggaccc cacgtgcccg tagccctggt gtgggtaata
     3001 cccccggtac atccacaggc aactgcagga attatgggta gagttcagat cacaaggcct
     3061 gcgcactccc actgaggacc taggcatgtg ttagccacag aggtgacctg gatgtgggga
     3121 agtgacacct ggtgggctgc aggcatcata cgtgctcatc tcgggtatcc cagagatctc
     3181 gggaatcaga gttccaggtg gtcagagggc ctgtaggtga gtgctgtgcc tcccgcctgc
     3241 tccagaaggg gggtagctgg tttcttctac ctgaggggct ccatgtgtgt actcaccatg
     3301 tgtgtattcg ccatgaccat ggaccctctg cgaaggcctg gccaggtgct gaccctctgt
     3361 ctttctaccc ctgccaagca accaacagaa gagacattgt aacagacagg gtgcccacat
     3421 gtctaattaa gttcatacaa tgtccacctt ccaatgtagg ctctgggaac tgtcactccc
     3481 aggtacaggt gcaaagctgt caaggacaag gcaggagttt gctggagtcc ggtcaccacg
     3541 acctttgcta accctgacac tcctgcactg cttctatcag agtgactcca cagatgtgag
     3601 acaacatggg gcgtcccaac cacacgtgta ccccacccca ccctgtggcc tcttaacctt
     3661 tgtaccatct gattgtctgg ccaccagggt gccaactcaa cccagctccg agcagagggg
     3721 ggtgtgggca gggcccgtcg gtgagccatg tttacatgac agtgtgccaa agtgactcgc
     3781 cgagcttgta ttgctttgta gtcatctggg ctatcccacc ctcccaactc ctgtttttaa
     3841 aactaaaaac tcccaggagc cctgggcgca cacaggcaaa ggtggctgtc ttctgtggtg
     3901 gtccttgagt ctccgtgaag ctgaaaatga tggtgtctgt gagtatgttt tgcaaattca
     3961 aaatatagtt tggtaatttt ttttccagtt gatttttaaa aaaacaaaac aaaaaactgc
     4021 tgtacagagc ttgtactttg tccattttat agatggaaac catccttgaa attgtttaac
     4081 ttaaataaag agaagatact ttatagataa aaaaaaaaaa aaaaaaaaaa a
//
