LOCUS       NP_644678                570 aa            linear   ROD 10-FEB-2025
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 2 [Mus musculus].
ACCESSION   NP_644678
VERSION     NP_644678.2
DBSOURCE    REFSEQ: accession NM_139272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 570)
  AUTHORS   Mercanoglu,B., Waschkowski,S.A., Neuburg,E., Schraps,N.,
            Giannou,A.D., Dreyer,B., Harder,S., Heine,M., Krebs,C.F.,
            Gungor,C., Schluter,H., Melling,N., Hackert,T., Bockhorn,M.,
            Wagener,C. and Wolters-Eisfeld,G.
  TITLE     GalNT2-mediated O-glycosylation affects pancreas development and
            function in mice
  JOURNAL   Sci Rep 14 (1), 29760 (2024)
   PUBMED   39613794
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 570)
  AUTHORS   Ma,W., Li,H., Hu,J., Gao,Y., Lv,H., Zhang,X., Zhang,Q., Xu,M. and
            Cheng,Y.
  TITLE     Role of a novel mouse mutant of the Galnt2tm1Lat/tm1Lat gene in
            otitis media
  JOURNAL   Front Neurol 13, 1054704 (2023)
   PUBMED   36874359
  REMARK    Erratum:[Front Neurol. 2023 Oct 09;14:1287032. doi:
            10.3389/fneur.2023.1287032.. PMID: 37885477]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 570)
  AUTHORS   Hu,Q., Tian,T., Leng,Y., Tang,Y., Chen,S., Lv,Y., Liang,J., Liu,Y.,
            Liu,T., Shen,L. and Dong,X.
  TITLE     The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in
            non-small cell lung cancer
  JOURNAL   Cell Mol Biol Lett 27 (1), 71 (2022)
   PUBMED   36058918
  REMARK    GeneRIF: The O-glycosylating enzyme GALNT2 acts as an oncogenic
            driver in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 570)
  AUTHORS   Verzijl,C.R.C., Oldoni,F., Loaiza,N., Wolters,J.C., Rimbert,A.,
            Tian,E., Yang,W., Struik,D., Smit,M., Kloosterhuis,N.J.,
            Fernandez,A.J., Samara,N.L., Ten Hagen,K.G., Dalal,K., Chernish,A.,
            McCluggage,P., Tabak,L.A., Jonker,J.W. and Kuivenhoven,J.A.
  TITLE     A novel role for GalNAc-T2 dependent glycosylation in energy
            homeostasis
  JOURNAL   Mol Metab 60, 101472 (2022)
   PUBMED   35304331
REFERENCE   6  (residues 1 to 570)
  AUTHORS   Johnsen,J.M., Levy,G.G., Westrick,R.J., Tucker,P.K. and Ginsburg,D.
  TITLE     The endothelial-specific regulatory mutation, Mvwf1, is a common
            mouse founder allele
  JOURNAL   Mamm Genome 19 (1), 32-40 (2008)
   PUBMED   18188647
  REMARK    GeneRIF: These data suggest that the region responsible for the
            Mvwf1 regulatory switch lies within an approximately 30-kb genomic
            interval upstream of the B4galnt2 gene.
REFERENCE   7  (residues 1 to 570)
  AUTHORS   Young,W.W. Jr., Holcomb,D.R., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Expression of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase isoforms in murine tissues
            determined by real-time PCR: a new view of a large family
  JOURNAL   Glycobiology 13 (7), 549-557 (2003)
   PUBMED   12651884
REFERENCE   8  (residues 1 to 570)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 570)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   10 (residues 1 to 570)
  AUTHORS   Hagen,F.K., Ten Hagen,K.G., Beres,T.M., Balys,M.M.,
            VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     cDNA cloning and expression of a novel
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 272 (21), 13843-13848 (1997)
   PUBMED   9153242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ770019.1, BC059818.1 and BC053063.1.
            
            On Apr 29, 2004 this sequence version replaced NP_644678.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059818.1, AK145122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.52 cM"
     Protein         1..570
                     /product="polypeptide N-acetylgalactosaminyltransferase 2"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T2; pp-GaNTase 2; polypeptide GalNAc
                     transferase 2; protein-UDP acetylgalactosaminyltransferase
                     2; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 2; ppGaNTase-T2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 2"
                     /calculated_mol_wt=64384
     Site            7..24
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB93.1)"
     Site            29
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:Q10471; propagated from
                     UniProtKB/Swiss-Prot (Q6PB93.1)"
     Region          134..239
                     /region_name="Catalytic subdomain A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB93.1)"
     Region          138..433
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(142..144,146,175,200,203,207,223..225,307..308,
                     330..331,333,358,361,366)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(223,225,358)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          299..361
                     /region_name="Catalytic subdomain B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB93.1)"
     Region          445..564
                     /region_name="beta-trefoil_Ricin_GALNT2"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide N-acetylgalactosaminyltransferase 2
                     (GALNT2) and similar proteins; cd23434"
                     /db_xref="CDD:467312"
     Site            order(457..460,468,470,473,478..479)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467312"
     Site            order(497..500,508,510,513,518..519)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467312"
     Site            515
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6PB93.1)"
     Site            535
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q10471; propagated from
                     UniProtKB/Swiss-Prot (Q6PB93.1)"
     Site            order(540..543,550,552,555,559..560)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467312"
     CDS             1..570
                     /gene="Galnt2"
                     /coded_by="NM_139272.2:134..1846"
                     /db_xref="CCDS:CCDS22769.1"
                     /db_xref="GeneID:108148"
                     /db_xref="MGI:MGI:894694"
ORIGIN      
        1 mrrrsrmllc fallwvlgia yymysgggsa laaggggagr kgdwndidsi kkkdlhhsrg
       61 dekaqgvetl ppgkvrwpdf nqeayvggtm vrsgqdpyar nkfnqvesdk lhmdrgipdt
      121 rhdqcqrkqw rvdlpatsvv itfhnearsa llrtvvsvlk rspphlikei ilvddysndp
      181 edgallgkie kvrvlrndrr eglmrsrvrg adaaqakvlt fldshcecne rwlepllerv
      241 aedrtrvvsp iidvinmdnf qyvgasadlk ggfdwnlvfk wdymtpeqrr srqgnpvapi
      301 ktpmiagglf vmdklyfeel gkydmmmdvw ggenleisfr vwqcggslei ipcsrvghvf
      361 rkqhpytfpg gsgtvfarnt rraaevwmde ykhfyyaavp sarnvpygni qsrlelrkkl
      421 gckpfkwyld nvypelrvpd hqdiafgalq qgtncldtlg hfadgvvgiy echnaggnqe
      481 waltkeksvk hmdlcltvvd rspgslirlq gcrendsrqk weqiegnskl rhvgsnlcld
      541 srtaksggls vevcgpalsq qwkfslnlqq
//
