LOCUS       NM_001360903            2545 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 18
            (Galnt18), transcript variant 2, mRNA.
ACCESSION   NM_001360903 XM_006507658
VERSION     NM_001360903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003.. PMID: 25715345]
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Tabak,L.A.
  TITLE     The role of mucin-type O-glycans in eukaryotic development
  JOURNAL   Semin Cell Dev Biol 21 (6), 616-621 (2010)
   PUBMED   20144722
  REMARK    Review article
REFERENCE   9  (bases 1 to 2545)
  AUTHORS   Tian,E. and Ten Hagen,K.G.
  TITLE     Recent insights into the biological roles of mucin-type
            O-glycosylation
  JOURNAL   Glycoconj J 26 (3), 325-334 (2009)
   PUBMED   18695988
  REMARK    Review article
REFERENCE   10 (bases 1 to 2545)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138151.3, AB175685.1, AC139943.3 and AW124105.1.
            
            On Feb 17, 2018 this sequence version replaced XM_006507658.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB175685.1, SRR7652917.723857.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC138151.3         12426-12855
            431-2254            AB175685.1         1-1824
            2255-2529           AC139943.3         48099-48373
            2530-2545           AW124105.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.19 cM"
     gene            1..2545
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /note="polypeptide N-acetylgalactosaminyltransferase 18"
                     /db_xref="GeneID:233733"
                     /db_xref="MGI:MGI:2446239"
     exon            1..665
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2254
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /EC_number="2.4.1.41"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 18; galNAc-T-like
                     protein 4; pp-GaNTase-like protein 4; polypeptide GalNAc
                     transferase-like protein 4; protein-UDP
                     acetylgalactosaminyltransferase-like protein 4;
                     UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 4;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 4; polypeptide
                     GalNAc transferase 18"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 18
                     isoform 2"
                     /protein_id="NP_001347832.1"
                     /db_xref="CCDS:CCDS90311.1"
                     /db_xref="GeneID:233733"
                     /db_xref="MGI:MGI:2446239"
                     /translation="MVCTRKTKTLVSTCVILSGMTNIICLLYVGWVTNYIASVYVRGQ
                     EPVPDKKLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPFTDSSLFAHWG
                     QELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSFPDSLPEVSIVF
                     IFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDKVNGQKPG
                     FIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRII
                     SPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKLENSTAPIRSPALIGCF
                     IVDRQYFEEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTE
                     DLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTF
                     RWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTENVPIVYICHGMTPQNVYY
                     TSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGSIQNR
                     KSKRCLELQENSDMEFGFQLVLQKCSGQHWTITNVLRSLVS"
     exon            666..858
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1025
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1209
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1407
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1522
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1708
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1846
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1942
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2107
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2535
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /note="hexamer: AATAAA"
     polyA_site      2535
                     /gene="Galnt18"
                     /gene_synonym="2900011G21Rik; galNAc-T18; Galntl4;
                     mpp-GalNAc-T18(O18)"
                     /note="major polyA site"
ORIGIN      
        1 gttctcctga gcggcgagcg gagggctggt ggcatctccc aggcagccag cactggagat
       61 ggaaagcaac gcggctgggc cctggcagtg acaaagtttc ccagccctgc aggtctcgtc
      121 tcgccactgc cggccacccg tgaccgccta gggaaaagct cggggatttt gaatttgcgg
      181 gggaaaagcc caaaacaaaa atctagaccc acctcgtttt ctttgtggag ctctttctca
      241 gggtggccag cggccggagc tgcaaagttg tgcgccgcag ctcacactgc caggagaccc
      301 gcctttggag agacttaggt gctggcgcac ccagagaccc cagacgtgcc aagggggttg
      361 agcgcggggg agtttggggt gtacagcgag gaggggcccc gggtgctcta tatggaggaa
      421 ggaccccaga atggtgtgta ccaggaagac caaaactttg gtgtccactt gcgtgatcct
      481 aagcggcatg accaacatca tatgcctgct gtacgtgggc tgggtcacca actacatcgc
      541 cagcgtgtat gtgcgggggc aggagccagt gcccgacaag aagctggagg aagataaagg
      601 ggacaccctg aaaattatcg agcggctgga ccacttggag aatgtcatca aacagcatat
      661 ccaagaggct cctgccaagc ctgaggaggc agaggccgag cccttcacgg actcctccct
      721 gtttgcacac tgggggcagg agctcagccc ggaaggccgg cgtgtggccc tgaagcagtt
      781 ccagtactac ggctacaacg cctacctcag tgaccggcta cccctcgacc ggcccctgcc
      841 agacctcaga cccagtgggt gccgcaacct ctcgttcccc gacagcctac ctgaggtgag
      901 catcgtgttc atcttcgtca acgaggcgct ctcagtgctc ctgcgttcca tccactcggc
      961 catggaacgc acgccatcac acctgctcaa ggagatcatc ctggtggacg acaacagcag
     1021 caacgaggag ctcaaagaaa agctgactga atatgtggac aaggtgaacg gccagaagcc
     1081 aggcttcatc aaagttgtgc ggcacagcaa gcaggaaggc ctcatccgct ccagagtcag
     1141 cggctggagg gcagccacag cccctgtggt ggcactgttc gatgcccacg tggagttcaa
     1201 tgtgggctgg gcggaaccag tcctcacccg catcaaggaa aaccggaaac ggatcatttc
     1261 accatctttt gataacatca aatatgacaa ctttgagata gaagagtacc cgctagccgc
     1321 ccaaggcttt gactgggagc tgtggtgccg ctacctaaac ccacccaagg cctggtggaa
     1381 gctagagaac tccacagccc caatcaggag ccctgccctc attggctgtt tcattgtgga
     1441 ccggcagtac ttcgaggaga ttggcctgct ggacgaaggc atggaggtct atggagggga
     1501 gaatgtggag cttgggatca gggtatggca gtgtggcggg agtgtggagg tcctgccctg
     1561 ctctcggatt gcccacatcg agcgagctca caagccctac acagaggacc tcactgccca
     1621 cgtccgcaga aatgccctca gggtagctga agtctggatg gatgaattca aaagtcatgt
     1681 ctacatggca tggaacatac cacaagagga ctcagggatt gacatcgggg acatcaccgc
     1741 acgcaaggct ctgaggaagc agctgcagtg caagaccttc aggtggtacc tggtcagtgt
     1801 gtacccagag atgaggatgt actctgacat tatcgcctat ggagtgctgc agaattccct
     1861 gaagactgat ttgtgtcttg atcagggccc agatacagag aatgtcccca tcgtgtacat
     1921 atgccatggg atgacacccc agaatgtgta ctacacaagc agccagcaga tccacgtggg
     1981 tatcctgagc cccactgtgg atgacgatga caaccggtgt ctggtggacg tcaacagccg
     2041 gccacgtctc atcgagtgca gttacgccaa ggccaagagg atgaagctgc actggcagtt
     2101 ctcccaggga ggctccatcc agaaccgcaa gtccaagcgc tgcctggagc tgcaagagaa
     2161 cagtgacatg gagtttggtt tccagctggt gcttcagaag tgctcgggac aacactggac
     2221 tatcaccaat gtcctgagga gcctggtgtc ctgaccctcc acaggcgcca ccggccaccg
     2281 ctttgctact gtgtagcatc agctgcaatg ccgcctgctg tcacgtgggg ctgcccggag
     2341 tctgagaggg agagccaagt gggtggcctc cccccacaaa agagctttgt atttcctatt
     2401 caattttcat ggagtttata gagagacgca gagaggtggg ggagggaaca acatcctgaa
     2461 ctattttaca actgtaaata ggggacaaat ggaaaatatt tataactggc aataaaatat
     2521 tattgattaa gaaaaaaaaa aaaaa
//
