LOCUS       NM_001081421            3922 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 16
            (Galnt16), transcript variant 1, mRNA.
ACCESSION   NM_001081421 XM_987609
VERSION     NM_001081421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3922)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   2  (bases 1 to 3922)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   3  (bases 1 to 3922)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3922)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163282.3 and AC125361.4.
            
            On Mar 29, 2018 this sequence version replaced NM_001081421.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138883.1, AB175683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AC163282.3         21777-22132         c
            357-514             AC125361.4         49214-49371         c
            515-613             AC125361.4         45713-45811         c
            614-681             AC125361.4         45101-45168         c
            682-747             AC125361.4         44217-44282         c
            748-869             AC125361.4         41584-41705         c
            870-957             AC125361.4         40361-40448         c
            958-1042            AC125361.4         37936-38020         c
            1043-1146           AC125361.4         37554-37657         c
            1147-1273           AC125361.4         33085-33211         c
            1274-1366           AC125361.4         30983-31075         c
            1367-1450           AC125361.4         29186-29269         c
            1451-1592           AC125361.4         24448-24589         c
            1593-1718           AC125361.4         23527-23652         c
            1719-3922           AC125361.4         17772-19975         c
FEATURES             Location/Qualifiers
     source          1..3922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 36.79 cM"
     gene            1..3922
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /note="polypeptide N-acetylgalactosaminyltransferase 16"
                     /db_xref="GeneID:108760"
                     /db_xref="MGI:MGI:1917754"
     exon            1..356
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1856
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /EC_number="2.4.1.41"
                     /note="putative polypeptide
                     N-acetylgalactosaminyltransferase-like protein 1;
                     galNAc-T-like protein 1; pp-GaNTase-like protein 1;
                     polypeptide GalNAc transferase-like protein 1; protein-UDP
                     acetylgalactosaminyltransferase-like protein 1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 16;
                     UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 1; polypeptide
                     GalNAc transferase 16"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     16"
                     /protein_id="NP_001074890.1"
                     /db_xref="CCDS:CCDS36482.1"
                     /db_xref="GeneID:108760"
                     /db_xref="MGI:MGI:1917754"
                     /translation="MRKIRANAIAILTVAWILGTFYYLWQDNRAHAASSSGRGAQRAG
                     GRPEQLREDRTIPLIVTGTPSKGFDEKAYLSAKQLKPGEDPYRQHAFNQLESDKLSSD
                     RPIRDTRHYSCPSLSYSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPASLIQEIIL
                     VDDFSSDPEDCLLLTRIPKVKCLRNDKREGLIRSRVRGADVAGATVLTFLDSHCEVNV
                     EWLQPMLQRVMEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPLEQ
                     KMTRTDPTKPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIWGGENFELSFRVWMCGGS
                     LEIVPCSRVGHVFRKRHPYNFPEGNALTYIRNTKRTAEVWMDEYKQYYYEARPSAIGK
                     AFGSVATRIEQRKKMDCKSFRWYLENVYPELTVPVKEVLPGVIKQGVNCLESQGQNTA
                     GDLLLGMGICRGSAKSPPPAQAWLFSDHLIQQQGKCLAATSTLMSSPGSPVILQTCNP
                     KEGKQKWRRKGSFIQHSVSGLCLETKPAQLVTSKCQTDAQAQQWQLLPHT"
     exon            357..514
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            515..613
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            614..681
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            682..747
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            748..869
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            870..957
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1042
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1146
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1273
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1366
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1450
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1592
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1718
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..3922
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3894..3899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /note="hexamer: AATAAA"
     polyA_site      3918
                     /gene="Galnt16"
                     /gene_synonym="5730405L21Rik; galNAc-T16; Galntl1;
                     mpp-GalNAc-T16"
                     /note="major polyA site"
ORIGIN      
        1 ttcctatcac accccccccc cctccccaac caccaccacc acctctctct tttttctgct
       61 ctgcaggact gagcagcccg gcgcaagcga caacaaacgg ctggggcagc aagctcccct
      121 gctcgggctc cgagagcacg ccggcctcgg gccccacgcg gagcgcccgt ccgcccacca
      181 tgaggaagat ccgcgccaat gccatcgcca tcctgaccgt agcctggatc ctgggcactt
      241 tctactactt atggcaggac aaccgagccc atgcagcatc ctccagcggc cgcggcgcgc
      301 agagggccgg cgggagacca gagcagctcc gcgaggaccg caccattccg ctcattgtga
      361 caggaacacc ctcaaagggc tttgatgaga aggcgtacct gtcagccaag cagctgaagc
      421 ctggagagga cccatacaga caacatgcct tcaaccaact ggagagtgac aaactgagct
      481 cagaccgacc catcagggac acccgccatt acagttgccc atccttgtcc tattcttcgg
      541 acctgccggc caccagtgtc atcatcacct tccacaacga ggctcgctcc acactcctgc
      601 gcacagtgaa gagcgtcctg aaccgaactc ctgccagctt gatccaggag atcattttag
      661 tggatgactt cagttcggat cctgaagact gtttgcttct gaccaggatc cccaaggtca
      721 agtgccttcg caatgacaaa cgggaaggac tgatccggtc ccgggttcgt ggggcagatg
      781 tggcaggagc cacagttctc acttttctgg atagtcactg tgaggtgaat gtggagtggc
      841 tgcagccaat gctgcagcgg gtgatggagg accacacccg tgtggtgagc cccatcatcg
      901 acgtcatcag cttggacaat tttgcctacc ttgcagcatc tgcagatctt cgaggagggt
      961 ttgactggag tctgcatttc aagtgggagc agatcccgct ggagcagaag atgacccgga
     1021 ctgaccccac taaacccatc aggacacctg ttatagctgg aggaatcttc gtgattgaca
     1081 agtcctggtt taaccatctg ggaaagtatg atgcccagat ggacatctgg ggaggagaga
     1141 attttgaact ctccttcagg gtatggatgt gtggtggcag cttggagatt gtgccctgca
     1201 gccgagtggg ccatgtcttc aggaagcggc atccctacaa cttccccgag ggcaatgccc
     1261 tcacctatat caggaataca aagcgaacgg cagaggtgtg gatggacgag tacaaacagt
     1321 attattatga ggcccggccc tcagccatcg ggaaggcctt tggcagtgtg gccacgcgga
     1381 tcgagcagag gaagaagatg gactgtaagt ccttccgctg gtacctggag aacgtctatc
     1441 ccgagctcac tgtccccgtg aaggaagtgc tccctggtgt cattaagcaa ggagttaact
     1501 gcttagaatc ccaaggccag aacacagctg gtgacctcct gcttggaatg gggatatgca
     1561 gagggtcagc caagagccca ccaccagccc aggcatggtt atttagcgat caccttatcc
     1621 agcagcaggg gaaatgcctg gctgccacct ccaccttaat gtcttcccct ggatccccag
     1681 tcatactgca aacgtgtaac cctaaagaag gcaagcagaa atggagaagg aaaggatctt
     1741 tcatccagca ttcagtcagc ggcctctgcc tggagacaaa gcctgcccag ctggtgacca
     1801 gcaaatgtca gacagatgcc caggcccagc aatggcagct gctgccacac acatgatggt
     1861 agcccccagc ctcctgtacc ttctgcatga gacttgggga ctggaagggg ttagggtggg
     1921 ggagtgtcaa gcgggctgtt tcccatctcc tcacatttcg accggatcat cagtacacac
     1981 ccctaccacg catttctcca aagctagttc aggcagggtg caggggcatg cttcatgccc
     2041 tctgtgccac ccaagtcttg ccctgggaga ggagatggtt agtatgcagc tgtcctgggc
     2101 agagacttgg cagctgctcc tggccctttg tcttctccct tggccctttt tgggctccag
     2161 acagtgatgt gtgggccttc cccttgttgc ctaagaggga cgaggaccaa aacctaccaa
     2221 aggggccagt tgggtcacgg ggctagccta aagtcaacac aagaggacag gtggcatcgt
     2281 gtgtgaagag gctgaaagca aggcagctag agaagaggaa gggttgagaa gctccggcca
     2341 ctgggtgagc gagggaggga tgcagcctgg gagcagagga tggagattca cagaagaacg
     2401 tggatagaga agcagccaac tgtgaagtgc cagaaaacca aggtctcttt tcaggacatc
     2461 atcaccctgt tgctgctttg ccagccccag gtcccaagcc caacatatgt ctgcagcccc
     2521 taggtgacca cagtcttagc aagaaactgg agagggatct ggggtataat ttattaagta
     2581 gaataatttc cacttccgct tagccatatg tcacgccaag acctcacact tgggcgtgtc
     2641 cccactaact ggtcatacac cctgaaatac ccttatcttt gctaactgtt ttggactcct
     2701 actttttcag gttctttgcc tctgtaaaca ttgcattgtg gggcaaggtg gctagtcaga
     2761 attggacccc tttcctggag tataaccatt cctagtcagt agagactgag tcacccaggt
     2821 caaaacaccg cgctaaatcc cttcaccaaa ggccagtggt tgtagtgggt ttcgaagctg
     2881 gctagtggct cctgtctgtg tacagaataa cctgctctct cctctcccga tactgagaac
     2941 acggagacta taggttggta tcatcctgga atcccgtcct tttcctcacc attggcttac
     3001 acaatggctc ttgggtaaaa gagcccaaaa ttcttggggt ctctatccca aagcaagtct
     3061 gcctaagaag gccagtccta tcccaggagc acccagtctt tcataaacca ggcagccaga
     3121 tattcacagg gaatcaacac acttgagaag gttgagaaat ctctagtaaa ttgcatgtgt
     3181 atgtacatgt gcaattacat aggtgggggt tgagcctgga ttttccctgc ttcgtggttt
     3241 ttcaaagcct ctgatccttt gcgctggatt agcactacca gctagctatc tggggctctg
     3301 ccccgaatct ccctctctgc tgggcccagc ctgtacatca ccaggtgtta gaaaccaagt
     3361 cctgggtttg tagtgcccac tctggcgggt actccagcag tttccctgca cctctggctc
     3421 tcaccagcat cctctcagct gttctgtgcc aaatacgtct gcacccctgg gttcagccca
     3481 ggggcccctc acctcggtga ctaagcttcg cccaccttgt tacgatgtct tatatatata
     3541 cacactgcta tttacagacc tggccttgga tcctgtgacc ctctgggaag agtcctgcca
     3601 aagtccagga cagcattggg gctaaggcag aggcttttct ctagaggctt gggccctgtc
     3661 ccaacgtgga ctttggggct aggaacctgg gcttctctct gtgaatgtaa ggacagctac
     3721 tcagagagcc ttgatggggg cctctcccca tttcctgtgg tcagacccgg ctcagcactt
     3781 ggcagctgtc ccgtgcgggg actcagtcca actctgtgtt tgcttttctt cttggccaaa
     3841 gcatgtgcca ctaagctgtc ctggaggaca ttgtctttat gaaacacacc tggaataaaa
     3901 ccacttctta catgtccaca ta
//
