LOCUS       NM_030166               2341 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 15
            (Galnt15), mRNA.
ACCESSION   NM_030166 XM_127638
VERSION     NM_030166.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Young,W.W. Jr., Holcomb,D.R., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Expression of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase isoforms in murine tissues
            determined by real-time PCR: a new view of a large family
  JOURNAL   Glycobiology 13 (7), 549-557 (2003)
   PUBMED   12651884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC133711.1.
            
            On Jul 25, 2007 this sequence version replaced NM_030166.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133711.1, AK019470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..2341
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /note="polypeptide N-acetylgalactosaminyltransferase 15"
                     /db_xref="GeneID:78754"
                     /db_xref="MGI:MGI:1926004"
     exon            1..929
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..2307
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /EC_number="2.4.1.41"
                     /note="polypeptide N-acetylgalactosaminyltransferase-like
                     2; polypeptide N-acetylgalactosaminyltransferase-like
                     protein 2; galNAc-T-like protein 2; pp-GaNTase-like
                     protein 2; polypeptide GalNAc transferase-like protein 2;
                     protein-UDP acetylgalactosaminyltransferase-like protein
                     2; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 15"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     15"
                     /protein_id="NP_084442.1"
                     /db_xref="CCDS:CCDS36859.1"
                     /db_xref="GeneID:78754"
                     /db_xref="MGI:MGI:1926004"
                     /translation="MLPRKRPRSGRSRLQFLLLFLTLGCVLMMVILLHPPPPTLHQAV
                     TAQASKHSPDTGYRLDFGDSQEWVLEAETEGDEYSLLDGLPSFISLQEDQLLVAVASP
                     RARRSQSQGRRQGSYQFIKHRSRRWDEEALEKDWRTEEDGEESEEVLTPLGPDSDGLN
                     KPLSARLPLRRVLPEVRHPLCLQQHPTSGLPTASVILCFHDEAWPTLLRTVHSILDTA
                     PRALLQEIILVDDLSQQELLKSALSEYVARLEAVKLLRSNRRLGTIGARMLGATRATG
                     DVLVFMDAHCECHPGWLEPLLSRIADDRSRVVSPVIDVIDWKTLQYSASKLHRGTLDW
                     KLDFRWKPLGEQEQKALPSPISPVRSPVVPREVVAVDRHYFQNTGAYDPLLSLGDSEN
                     LEMSFKAWLCGGSVEILPCSRVGHIYRSQDASSRPDPEVALKNKIIIAETWLSSFKET
                     FYRHIPEAFTLSKVAKPDCTERLKLQRRLGCRTFHWFLANVYPELYPSDHRPRFSGKL
                     HNTGFGLCADCQADGDILGCPMTLAPCSNNRQQQNLEHTGRKEILFGGPQRLCFDVRG
                     GRVILQNCTEEGPAIHQQHWDFQEDGMIIHVLSGKCMEAGVQPSNKDLYLRQCDGKTS
                     QLWRFDQIHPVDER"
     exon            930..1096
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1301
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1466
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1584
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1779
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1911
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2016
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2160
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2341
                     /gene="Galnt15"
                     /gene_synonym="4631401E18Rik; Galntl2; mpp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactcgcccc agacagcttg tagaacctga ccactcatgc agagggggaa agaacatggg
       61 ctaatcacca gagcaggatg gacaagagca gggtgagaga ggagccaaca accggagacc
      121 cttctcagaa gacagctaac actcagagag gacccaggag cccaggctct ggtggctttc
      181 tgattctaga gggcagtggg tcttataaat gctacgttag catatagacg ttagcaaacg
      241 tctggtggga taagaggtgc aggtggatgg caaaaagcct tttagctgga atgaacagcc
      301 caggttcagt ttcgagcttg aaggtacctg gatagcaagg aggaagcaaa cttgatcagg
      361 acctgttgct tcgtggcgag tggctgcgac atgctcccga ggaagcgacc caggagtgga
      421 cgttccaggc ttcagttcct cctactcttc ctgactctgg gatgtgtcct gatgatggtg
      481 atcctgctgc atcctccccc gcccaccctg caccaggctg tcacagctca ggccagcaaa
      541 cacagccctg acacggggta ccgcctggac tttggagact ctcaggagtg ggtcctggag
      601 gctgagactg aaggtgatga gtacagtctc ttggatggcc tgccatcctt catctccctg
      661 caggaggatc aactgctggt ggccgtggcc tcacccagag ctaggaggag tcagagccag
      721 ggcaggagac agggcagcta ccagttcatc aaacacagga gcaggagatg ggatgaggaa
      781 gccctggaaa aggactggag gaccgaagag gatggggagg aatcagaaga ggtgctgacc
      841 ccacttggcc cggactcaga tggcctcaac aagccactca gtgcccgcct gcccctgagg
      901 agagtcctgc ccgaggtgcg acacccactg tgtctgcagc agcaccctac aagtggcctg
      961 cctacagcca gcgtcatcct ctgcttccat gatgaggcct ggcccacgct cttgagaact
     1021 gtccacagca tcctggacac agcacccagg gccctgctgc aggagatcat ccttgtagat
     1081 gacctcagcc agcaagaact gctgaagtct gctctcagtg aatatgtggc caggctggag
     1141 gctgtgaagt tgctcaggag caataggagg ctcggcacca ttggagcccg gatgctgggg
     1201 gccaccaggg ccacagggga cgtgctggtc ttcatggatg cccactgtga gtgccaccct
     1261 ggttggctgg agcccctcct cagcagaata gctgatgaca ggagccgagt ggtgtctcca
     1321 gtcatagacg tgattgactg gaagacgctt cagtactccg catccaagct gcatcgaggg
     1381 acgctggatt ggaagctgga tttccgatgg aagcccctgg gggagcagga gcagaaggcc
     1441 ctcccatccc ccatcagccc tgtcaggagc cctgtggtac cccgagaggt ggtggccgtg
     1501 gacagacatt acttccaaaa caccggagca tacgatcccc ttctgtcact gggggatagt
     1561 gaaaatctcg agatgtcttt caaggcctgg ctctgcggtg gctctgttga aatccttccc
     1621 tgctctcgag tgggacacat ctaccgaagc caagatgcca gctccaggcc tgaccccgag
     1681 gtcgccttga agaacaagat catcattgct gagacctggc tatcatcctt caaggaaacc
     1741 ttctacaggc acatcccaga ggccttcacc ctgagcaagg ttgcaaagcc agactgtaca
     1801 gagcgcctga agctgcaaag gaggctggga tgccggacgt tccactggtt tctggccaat
     1861 gtctaccctg agctgtaccc atctgatcac aggcccaggt tctctggaaa gctccacaac
     1921 actggatttg gcctctgtgc ggactgccaa gcagacggtg acatcctggg ctgccccatg
     1981 acactggctc cttgcagtaa caaccggcag caacagaacc tggagcacac cggcaggaag
     2041 gagattctct tcggcggccc acagcgcctg tgcttcgatg tcagaggagg gcgggtgatt
     2101 ctgcagaact gcacggagga aggccccgct atccatcagc agcactggga cttccaggag
     2161 gatggaatga tcatccatgt tctttctgga aaatgcatgg aagctggggt ccagccaagc
     2221 aataaggact tgtacttgcg tcaatgtgat ggtaaaacca gccagctgtg gaggttcgac
     2281 cagatccacc ctgtggatga acgatgaacg accttgacag agagcaaaga aaggctgggc
     2341 a
//
