LOCUS       NM_173030               6966 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 13
            (Galnt13), mRNA.
ACCESSION   NM_173030
VERSION     NM_173030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6966)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 6966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6966)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (bases 1 to 6966)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (bases 1 to 6966)
  AUTHORS   Xu,Y., Pang,W., Lu,J., Shan,A. and Zhang,Y.
  TITLE     Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to
            Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein
            Podoplanin
  JOURNAL   J Biol Chem 291 (45), 23477-23488 (2016)
   PUBMED   27629416
  REMARK    GeneRIF: This study suggests that ppGalNAc-T13 contributes to
            neuronal differentiation through glycosylating and stabilizing
            PDPN, which provides insights into the regulatory roles of
            O-glycosylation in mammalian neural development.
REFERENCE   6  (bases 1 to 6966)
  AUTHORS   Matsumoto,Y., Zhang,Q., Akita,K., Nakada,H., Hamamura,K.,
            Tokuda,N., Tsuchida,A., Matsubara,T., Hori,T., Okajima,T.,
            Furukawa,K., Urano,T. and Furukawa,K.
  TITLE     pp-GalNAc-T13 induces high metastatic potential of murine Lewis
            lung cancer by generating trimeric Tn antigen
  JOURNAL   Biochem Biophys Res Commun 419 (1), 7-13 (2012)
   PUBMED   22306014
  REMARK    GeneRIF: These data suggested that high expression of pp-GalNAc-T13
            gene generated trimeric Tn antigen on Syndecan-1, leading to the
            enhanced metastasis.
REFERENCE   7  (bases 1 to 6966)
  AUTHORS   Young,W.W. Jr., Holcomb,D.R., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Expression of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase isoforms in murine tissues
            determined by real-time PCR: a new view of a large family
  JOURNAL   Glycobiology 13 (7), 549-557 (2003)
   PUBMED   12651884
REFERENCE   8  (bases 1 to 6966)
  AUTHORS   Zhang,Y., Iwasaki,H., Wang,H., Kudo,T., Kalka,T.B., Hennet,T.,
            Kubota,T., Cheng,L., Inaba,N., Gotoh,M., Togayachi,A., Guo,J.,
            Hisatomi,H., Nakajima,K., Nishihara,S., Nakamura,M., Marth,J.D. and
            Narimatsu,H.
  TITLE     Cloning and characterization of a new human
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that
            is specifically expressed in neurons and synthesizes GalNAc
            alpha-serine/threonine antigen
  JOURNAL   J Biol Chem 278 (1), 573-584 (2003)
   PUBMED   12407114
  REMARK    GeneRIF: cloning and characterization of pp-GalNAc-T13; expressed
            in all neuroblastoma cells examined and primary cultured neurons
            but not in glioblastoma cells and primary cultured astrocytes
REFERENCE   9  (bases 1 to 6966)
  AUTHORS   Lowe,J.B. and Marth,J.D.
  TITLE     A genetic approach to Mammalian glycan function
  JOURNAL   Annu Rev Biochem 72, 643-691 (2003)
   PUBMED   12676797
  REMARK    Review article
REFERENCE   10 (bases 1 to 6966)
  AUTHORS   Hennet,T., Hagen,F.K., Tabak,L.A. and Marth,J.D.
  TITLE     T-cell-specific deletion of a polypeptide
            N-acetylgalactosaminyl-transferase gene by site-directed
            recombination
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12070-12074 (1995)
   PUBMED   8618846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038387.1, AK038492.1 and AL844895.6.
            
            On Oct 1, 2005 this sequence version replaced NM_173030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045417.1, SRR7345562.4346820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1907              AK038387.1         2-1908
            1908-2544           AK038387.1         2017-2653
            2545-2768           AK038492.1         361-584
            2769-6966           AL844895.6         114645-118842
FEATURES             Location/Qualifiers
     source          1..6966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 30.77 cM"
     gene            1..6966
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /note="polypeptide N-acetylgalactosaminyltransferase 13"
                     /db_xref="GeneID:271786"
                     /db_xref="MGI:MGI:2139447"
     exon            1..343
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            344..414
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            415..654
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            655..823
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            824..990
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1198
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1369
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1487
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1668
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1808
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1907
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2042
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..6966
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /note="hexamer: ATTAAA"
     polyA_site      2431
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /note="major polyA site"
     regulatory      5760..5765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /note="hexamer: ATTAAA"
     polyA_site      5787
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
     regulatory      6517..6522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
                     /note="hexamer: ATTAAA"
     polyA_site      6522
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
     polyA_site      6540
                     /gene="Galnt13"
                     /gene_synonym="A230002A12; A230020F20"
ORIGIN      
        1 aggcggtggc ggctctgccg aggtgacaat gtgctaggag ccccgctccg tgtctcctgc
       61 gcctccttgg cctgggcgcc tcctggcagc gctctcggag cctcgcggcc gcttgccgcg
      121 ctatgaggga gcatctccgg ggctggccga ggcccgggcc gcctcgctct gctcgccgag
      181 aagtgtgaag agaggcgcgg gcgggagccg gggctgcgcg cggcggcggc tccaggtgag
      241 cgcggctctc ggcgcagccg gccactggtc gggctggatc caggcagcat cccgtgcgcg
      301 gaccgccgag ctctctccgc gggatcgaca gccaccgtag cagacatatt ttttaggagt
      361 tttttgaaga tggatatttt caaatcattt tgaaacagtc aaacaccata tacatgggat
      421 gcatcttgct tttgtcctgg agatcacctc tgtggcttgg atatatctca ggaacacccg
      481 tcttcagtct ccgtattgat tagtaatcaa gcatgaggag atttgtctac tgcaaggtgg
      541 ttctggccac ttctctgatg tgggtgcttg ttgatgtctt cttactcctg tacttcagcg
      601 agtgtaacaa gtgtgatgac aagaaggaga gatccctgct gcctgcgctg agggctgtta
      661 tttcaagaaa ccaagaaggt ccaggagaaa tgggaaaggc tgtgcttatt ccaaaagatg
      721 accaagagaa aatgaaagag ttgtttaaaa tcaatcagtt taacctcatg gccagtgact
      781 tgatcgcact taaccgaagt ctgccggatg tgagattaga aggatgcaag actaaagtct
      841 accctgatga acttccaaac acaagtgtag tcattgtgtt ccataatgaa gcttggagca
      901 ctctacttag aactgtctat agtgtcataa atcgctcccc acactacctg ctctctgagg
      961 tcatcttggt tgatgatgcc agtgaaagag attttctcaa gttgacatta gagaactacg
     1021 tgaaaacttt agaagtgcca gtgaagatta tcaggatgga agagcgctct gggttaatac
     1081 gcgcccgtct ccgaggagca gcagcttcaa aaggacaggt cataactttt ctggatgcac
     1141 actgcgagtg caccttagga tggctggagc ccttgctggc gagaataaag gaagacagga
     1201 aaacagttgt gtgcccgatc attgatgtta ttagtgatga tacgtttgag tacatggctg
     1261 ggtcagacat gacttatggt ggtttcaact ggaagctaaa tttccgatgg tatcctgtcc
     1321 ctcaaagaga aatggatagg agaaaaggag acaggacatt acctgtcagg acccctacta
     1381 tggctggtgg cctattttct attgacagaa actactttga agagatagga acttacgatg
     1441 caggaatgga tatctggggt ggagagaatc ttgaaatgtc ttttaggatc tggcaatgtg
     1501 gaggttcttt ggagattgtg acttgctctc atgtcggtca tgtttttcga aaggcaactc
     1561 catacacatt ccctggtggc actggccatg tcattaacaa gaacaacaga agactggcag
     1621 aagtgtggat ggatgaattc aaagatttct tctatatcat atccccaggt gttgtcaaag
     1681 tggattatgg agatgtgtca gtcagaaaaa cactgaggga aaatctgaag tgtaagcctt
     1741 tttcttggta cctggaaaac atctatccgg actcccagat cccaagacgt tattactcac
     1801 ttggtgagat acgaaatgtt gagaccaatc aatgcttaga taacatgggc cgcaaagaaa
     1861 atgaaaaagt gggtatcttc aactgtcacg gcatgggagg taaccaggtg ttttcttata
     1921 ctgctgacaa agaaatccga actgacgact tgtgcctgga tgtatccaga ctcagtggcc
     1981 ctgtaatcat gctaaaatgc caccacatga gaggaaatca gctgtgggaa tatgacgctg
     2041 agagactcac tttgagacat gctaacagta accaatgtct tgatgaacct tctgaagaag
     2101 acaaaatggt gcctaccatg caggactgca gtggcagcag atcccaacaa tggctgctga
     2161 ggaacatgac cttggggaca tgaagatatt ttttttccca agatgtgaaa gtctctacat
     2221 gtttgtttgt ccattatttt agtttggtga aagtattaac ttttctgaat taaaagttta
     2281 aaaaatactt ttagtaatat aaaacacaat tgtttataat tcatttttag gaatgtttat
     2341 ttccctacta aaatttgtat ctgattaaag aagcacataa aatataaata ataagaaact
     2401 gttattaaac atttgaactg tttgggaaaa acacaccttg tatttacttt taaaatgtct
     2461 tcaataacct cttgtcacag ggttatttgg aattggttta ttttgtgttg taataataat
     2521 taaaagagag atcatgtaaa gccttataca atatcataat tataaaatat taatgtagct
     2581 ttataaaaca ctctttttta caaaagcttc atgggaccct ggttgaattt ctatgccaac
     2641 aattagaatc catatgaaat cattcctgaa cattgaattc atcaaacaaa atataaggta
     2701 gtaggaaaat aattaagcta gttattgaat ttgtaaaata aaaatcatca tacaaaataa
     2761 agaaaagaat ttttaaaacc tatttataat aataaattta aatcaaatga tgtaaggagt
     2821 acatgaggta ttgaggaaaa caagagctat ataaactaca agagttgctg tgaaagaatc
     2881 ttcattctga acacaagctg aagacggtct tgctctgagg tgtgatatca ggacctgaat
     2941 ccccagtttc tccctgtctc catacagaga gtttttgtcc atcagctgta tctttgccct
     3001 tcactccaga gggtgagatt tgtcacagcc tacagaactg taggtgaaga gtgacctttt
     3061 agatttaatt tctaaagtac tatccctttt agttcagtca gtgcggtcat tggcactttg
     3121 cattctataa aaagaatggc actcaaaatc tattgctatg ctataaaatc caacattggt
     3181 cactggaaaa attggagtta ttaaaaatta tattaattaa actactagac atgattttgc
     3241 ataaactatg gctgtcataa ttaggacaat ttcgtgtgtc atttccacat aaaacccctt
     3301 tgttcacagt gcatggacta attatatgaa aaaggaaaac ctaccaattc atgggacagt
     3361 aataattgtt atatgtttgc taccatttta ggtggccaca tagttgttgt acatgtatgt
     3421 tttggttgta tatctagcag ctggaggaac tctatggggg tgaagctaga agattcttca
     3481 ggaacagaaa gtccatactt ttgacctttt attttaaagg atcttctata aaaagagtta
     3541 atgagcttgc tacacttgct ttctttctct ctcctctctc tccatttttc actgattctc
     3601 tcctctgtct attgtcactg tctttctctg tttctattac tgtctctctt ttacacaaac
     3661 acaaacacac acatgcatat gtgtacacac atacacatat actcacacac acacacacac
     3721 aaacacacac acacacacct gagttgggct attatatttt tcatactgca caagtctacc
     3781 catttcagtg gtctttctca tcagaacaaa tgcatgtttc accttctgga cgctcaagtc
     3841 aaaactatga aactgggata agggcttgct cactcagtag gtgtttgccc ctcaaccaag
     3901 aggaactgat gctgattcca agctaaataa ccactagatg tgggaggatg tacttgtaac
     3961 tctaatactg gggaggtaaa aaaaaagaga atttcttgaa tttcctcacc agccaggttg
     4021 tcctcatgga caagctccca atcaaatgag agactttgtc cccaaaatca agtgataatg
     4081 tctttcaaac ttttcaagcc tgttctaact gtagcttaca gacttcatga aactgcctga
     4141 tgtcaaagtt aactaggatc ttggtccaac acaaaattta aacttgtttt aaattttcat
     4201 tttggatatt cacactgttt tgataccaag tgtttatttt tgtagataac aacattattg
     4261 caatgtaaaa ctttggacaa attgagtcta accatcttaa aagtaacttg atgctatctt
     4321 tgacatataa cagcaaacca acaatttggg gccacaacca ttgtgggttg ctccttctga
     4381 ctaaatcata agaaatatgc atatattata attctctatt catgccaagt cttacccaat
     4441 gctacacttg tttacttaat acaagagtca catagatact attatgtatg aatttgtgta
     4501 ttttcctgaa cataatcttc ccattaatcc tcaaatcatt tcatagccat tgtgtctcta
     4561 tacccagaac aaaacactca acaaacatat acacatacct tggacagatg gagagggaga
     4621 gagagagaga gagagagaaa gagagagaga gagagagaga gagagagaga gagagagaga
     4681 gagagacctc tgcctttttt ttatctctta ctgtcttgca tttcattaca ttgttctggc
     4741 tgccaaacaa gtctgtttta ctgttggttc tatcagtccc aagatatcat tcacttattt
     4801 ctttaggtct ctatacaaac atgacctctt cagtacaaca aatgcttgtc ctgcctgtag
     4861 tctctcattc ctatctctct gagcaaatct aagattattc ttttgcttat ttcaatttct
     4921 tccagtctca tacaccaaca cacacttggc catataatca catttattta tgtttttttt
     4981 tttttttttt ctgtttcaga gccagggcca catctttgtt aagtaagcac acggccactg
     5041 atccactaat ccttttaaag gcagagtcta cattattttt gtccactggc tgtgctcacc
     5101 ttctcatgct atctctttgc ttattgtaac tacacttctt gaactaataa acttaagaat
     5161 ctgttaaagt tgttaagcaa cacagtatca catgtttcca tgttaaaaat gtaaagtgtc
     5221 cagtagtgac tttatagaga ctttcagagc tttgtttcca aatattaaat ttccttctaa
     5281 tattattgat attaaagtac aaattctatg ttgtcctttg tgttaaaatc accagctttg
     5341 tggaaatgaa atatggcatt tattaaaata ctgttataag atataagttg cttcacaact
     5401 aaaaataaac atagtttcag tgttttggtt gtattagatt gaccacagaa gggctaagat
     5461 tttgagtttt agaaagaaga taagtacatt ctttaaaatc acatttattt tcatggtttg
     5521 ataatgacta tacaaagctt attttcaatg taaaaatcta ttaacaaaaa atattataga
     5581 aaccttaaaa cattaaagat gttatattat taatttctat gtttatagat aataaaactg
     5641 agctatgaac atatactata gttttctcat agatcataga gttataaaac tatgtgccca
     5701 ggactcataa tactactgcc aaaatgttat aaggtcacaa taatgaaaga aatgccttta
     5761 ttaaaaactc tcttattatt aacttgattc tttagaattg tttaagttat tgttttttca
     5821 tactttaatt aaacttgttc aataaactaa gaccacaggt aatagaagaa aacctgcagc
     5881 agaacaatag aataccgtac atcagtggca agtagtttga ggaaagcacc atcaagcctt
     5941 cagcagtaat ttattgaact ctggtttttt gtttgtttgc tttgatttga tttcatattt
     6001 tcttgcaatt cccttcaagt ttcaagtaaa gctgacctac agcttgcacg gagtattaga
     6061 ccatctgtcc ctatgaacac tgggtgagtt ctttgtttga agctttgtgg acttcagaga
     6121 aaccagcaaa tatctctagg cttcccagtg tcactttact ataaacataa catgtaaatt
     6181 tcatttttct ctagtgctta gaaacagcat aataaatttt aaaaaattaa aggagaggaa
     6241 tgtaaactgc tacaataaaa taacataact ggttttcaat gttttttttt taatttagtg
     6301 ggaggttata aatacagtag aattgcttca gcaaacttca gaacattgcc ttgctccaac
     6361 atagattgct actccattta agaagtgatc aagcataatc attgccattg cgtttgcatt
     6421 ttatctgttg attcaaactg tagtttcaag gggacaaaat acaatgcatt cttaaattct
     6481 taaattctat aatgatttga ggaaatatga aaaaaaatta aagacttcac caaatgtgaa
     6541 tcattgtctg agaggtgtta ttttgtacaa ctaagatccc cctgtcttga ctaaaagctc
     6601 agtatagctg ggcagcagaa attcaactgt gcaaaggcaa cttgtgtttc aggaattagc
     6661 tatttcccac cgttatgtca gatatcgagt ggaaacactc agctcttctg tatagcatag
     6721 gaatatcagg ttttactgca cctattcaga gtgttatcaa gtatgacata ctatataaag
     6781 ctaaaggtgt tgggtaagct ctaaaaattt gcttaaacct cgttggtata gatttgttcc
     6841 ccctaatttt tgtcttaagg tgtttaatac attctaaagc aaatttccat tgactctgca
     6901 ttcaaaaatc cccatgagaa agtagtgatg caatacagtc ttttgtcaat aaatgtgttt
     6961 aagatg
//
