LOCUS       NM_172693               2269 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 12
            (Galnt12), transcript variant 1, mRNA.
ACCESSION   NM_172693
VERSION     NM_172693.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Airik,M., Schuler,M., McCourt,B., Weiss,A.C., Herdman,N.,
            Ludtke,T.H., Widmeier,E., Stolz,D.B., Nejak-Bowen,K.N.,
            Yimlamai,D., Wu,Y.L., Kispert,A., Airik,R. and Hildebrandt,F.
  TITLE     Loss of Anks6 leads to YAP deficiency and liver abnormalities
  JOURNAL   Hum Mol Genet 29 (18), 3064-3080 (2020)
   PUBMED   32886109
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Yoshida,C.A., Kawane,T., Moriishi,T., Purushothaman,A.,
            Miyazaki,T., Komori,H., Mori,M., Qin,X., Hashimoto,A., Sugahara,K.,
            Yamana,K., Takada,K. and Komori,T.
  TITLE     Overexpression of Galnt3 in chondrocytes resulted in dwarfism due
            to the increase of mucin-type O-glycans and reduction of
            glycosaminoglycans
  JOURNAL   J Biol Chem 289 (38), 26584-26596 (2014)
   PUBMED   25107907
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043977.1, AK033638.1 and CK627557.1.
            
            On May 5, 2018 this sequence version replaced NM_172693.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156751.1, AK033638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK043977.1         1-30
            31-2246             AK033638.1         2-2217
            2247-2269           CK627557.1         581-603
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 25.96 cM"
     gene            1..2269
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /note="polypeptide N-acetylgalactosaminyltransferase 12"
                     /db_xref="GeneID:230145"
                     /db_xref="MGI:MGI:2444664"
     exon            1..406
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1781
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /EC_number="2.4.1.41"
                     /note="polypeptide GalNAc transferase 12; protein-UDP
                     acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 12;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 12"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     12"
                     /protein_id="NP_766281.1"
                     /db_xref="CCDS:CCDS18158.1"
                     /db_xref="GeneID:230145"
                     /db_xref="MGI:MGI:2444664"
                     /translation="MWGRAVRRRCPRGLRRGREALLALLALAGLGALLRARSRSGTVD
                     PGPPRTPLPGRHEPVLPRPPLPADALGAHGEAVRLQLQGEELRLQEESVKQHQINIYL
                     SDRISLHRRLPERWNPLCREVKYDYDNLPKTSVVIAFYNEAWSTLLRTVYSVLETSPD
                     ILLEEVILVDDYSDREHLKERLANELSQLPKVRLIRASRREGLVRARLLGASAARGEV
                     LTFLDCHCECHEGWLEPLLQRIHEKESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDW
                     RLVFTWHVVPQRERQSMRSPIDVIRSPTMAGGLFAVSKRYFDYLGSYDTGMEVWGGEN
                     LEFSFRIWQCGGTLETHPCSHVGHVFPKQAPYSRSKALANSVRAAEVWMDEFKELYYH
                     RNPQARLEPFGDVTERKKLRAKLQCKDFKWFLDTVYPELHVPEDRPGFFGMLQNRGLR
                     GYCLDYNPPNENHVEGHQVLLYLCHGMGQNQFFEYTTRKEIRYNTRQPEACITVEDGK
                     DTLVMDLCRETVPENQEFILQEDGTLVHKHSRKCVEATEKVLDNGFAPYLRDCTNSDN
                     QRWFFKERMS"
     exon            407..576
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            577..766
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            767..952
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1070
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1247
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1379
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1493
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1640
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2247
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2074
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /note="major polyA site"
ORIGIN      
        1 gatccgggtc cagcctcggc ccgaggccgc ggggtgcagc tagcgggtgc atgtgggggc
       61 gtgcggtgag gaggcgctgc ccgcgggggc tgcggcgcgg ccgggaggcg ttgctggcac
      121 tgctggccct ggcagggctg ggcgcgctgc tgcgggctcg aagcaggtcg gggacggtgg
      181 acccgggacc cccgcggact cctctccccg ggcgtcacga gccagtgctg cccaggccgc
      241 cgctgcccgc cgatgctctg ggagcgcatg gggaggcggt gcggctgcag ctgcagggcg
      301 aggagctgcg gctgcaggag gagagcgtga agcagcacca gatcaacatc tatctgagcg
      361 accgtatctc gctgcaccgc cgactgcccg agcgctggaa ccctctgtgc agagaggtga
      421 aatacgatta tgataacctg cccaagactt ctgttgtcat agcattttat aatgaagcct
      481 ggtccacact ccttcggaca gtttacagtg ttcttgagac ctcccctgac atcctgctgg
      541 aggaggtcat tctggtagat gactacagcg acagagagca cctaaaggaa cgcttggcca
      601 acgagctgtc acagctcccc aaggtgcgcc tgatccgtgc tagcaggaga gagggcctag
      661 tgcgagcccg gctactggga gcctctgcgg ccaggggcga agtgctgacc ttcctagact
      721 gtcactgtga atgtcatgag gggtggctgg agcctctgct gcagaggatc cacgagaagg
      781 agtccgcagt cgtgtgccct gttatcgatg tgattgactg gaacaccttt gagtacctgg
      841 gcaactcggg agagccgcag attggcggct ttgactggcg gctggtattc acgtggcacg
      901 tggttcccca gcgggagcgg cagtcgatgc ggtcgccgat cgatgttatc aggtctccaa
      961 ctatggctgg gggcctgttt gctgtgagta agagatattt tgattatctg gggtcttacg
     1021 atacaggaat ggaagtctgg ggaggagaaa accttgagtt ctcctttagg atctggcagt
     1081 gtggtggcac tctggaaacg cacccgtgct cccatgtggg ccacgtcttc cctaagcaag
     1141 ctccctattc ccgtagcaag gccctggcca acagtgtccg agctgcagaa gtgtggatgg
     1201 atgaatttaa agaactctac taccaccgca atccccaggc ccgcctggaa ccctttgggg
     1261 acgtgacaga gaggaagaag cttcgggcta agctccagtg taaagacttc aagtggttct
     1321 tagatacagt gtacccagaa ttgcacgtgc cagaggacag gcctggcttc tttgggatgc
     1381 tccagaacag aggcctaaga gggtactgcc ttgactacaa tcctcccaat gaaaaccatg
     1441 ttgaaggcca ccaggtcctt ctgtacctct gccatgggat gggtcagaac cagtttttcg
     1501 agtatacgac ccggaaagaa atacgctata acacccgcca gcccgaagcc tgcatcaccg
     1561 tggaggacgg gaaggatacc cttgtcatgg atctctgccg agagaccgtc ccagagaacc
     1621 aggagttcat cctacaggag gatggcactt tagttcacaa gcacagcagg aaatgtgtgg
     1681 aggccacaga gaaggtgtta gacaacggct ttgcaccata cttacgggac tgtaccaact
     1741 cagataacca gaggtggttc ttcaaggagc gcatgtcgta gtgcatcgcc ttgccaagga
     1801 aggagccctc cacggctgtg gactgtgtgc ccaatgagat ggacagcgta cacggttgtc
     1861 attcgtgaat gtgctgggtg tcacaagagt gtgaataagc tttgtacaga ttttgaaaac
     1921 tttaaaaatg tctcctggca tcctgctttc tgagggcaat cctaagatgt tgcctttggt
     1981 atttggaaag gatattttcc tatcaagatg tgcattttac aatggtgcct tttattctca
     2041 ttagcaaaaa aggtaaatac tttattttga tacatacaaa gcttcctggg tgtttgtagc
     2101 acattttaca caaactgtta atacctcaaa tgttgagtta gagttctctc agggggatga
     2161 ggtggacact agaaatactg ttgatttctt caggtgtgag tggggtgaga tagtctagat
     2221 tcatacaata aagaatgctt ttgcttaaaa aaaaaaaaaa aaaaaaaaa
//
