LOCUS       NP_766281                576 aa            linear   ROD 02-MAY-2024
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 12 [Mus musculus].
ACCESSION   NP_766281
VERSION     NP_766281.1
DBSOURCE    REFSEQ: accession NM_172693.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 576)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 576)
  AUTHORS   Airik,M., Schuler,M., McCourt,B., Weiss,A.C., Herdman,N.,
            Ludtke,T.H., Widmeier,E., Stolz,D.B., Nejak-Bowen,K.N.,
            Yimlamai,D., Wu,Y.L., Kispert,A., Airik,R. and Hildebrandt,F.
  TITLE     Loss of Anks6 leads to YAP deficiency and liver abnormalities
  JOURNAL   Hum Mol Genet 29 (18), 3064-3080 (2020)
   PUBMED   32886109
REFERENCE   3  (residues 1 to 576)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (residues 1 to 576)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (residues 1 to 576)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 576)
  AUTHORS   Yoshida,C.A., Kawane,T., Moriishi,T., Purushothaman,A.,
            Miyazaki,T., Komori,H., Mori,M., Qin,X., Hashimoto,A., Sugahara,K.,
            Yamana,K., Takada,K. and Komori,T.
  TITLE     Overexpression of Galnt3 in chondrocytes resulted in dwarfism due
            to the increase of mucin-type O-glycans and reduction of
            glycosaminoglycans
  JOURNAL   J Biol Chem 289 (38), 26584-26596 (2014)
   PUBMED   25107907
REFERENCE   7  (residues 1 to 576)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043977.1, AK033638.1 and CK627557.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156751.1, AK033638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 25.96 cM"
     Protein         1..576
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     12"
                     /EC_number="2.4.1.41"
                     /note="polypeptide GalNAc transferase 12; protein-UDP
                     acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 12;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 12"
                     /calculated_mol_wt=66410
     Site            20..37
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGT9.1)"
     Region          38..58
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGT9.1)"
     Region          130..239
                     /region_name="Catalytic subdomain A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGT9.1)"
     Region          134..428
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(138..140,142,171,200,203,207,223..225,307..308,
                     330..331,333,358,361,366)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(223,225,358)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          299..361
                     /region_name="Catalytic subdomain B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGT9.1)"
     Region          438..574
                     /region_name="beta-trefoil_Ricin-like"
                     /note="ricin B-type lectin domain, beta-trefoil fold;
                     cl49609"
                     /db_xref="CDD:483949"
     Site            order(455..457,470,472,480..481)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467293"
     Site            order(503..504,512,514,523..524)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467293"
     Site            order(544..546,557,559,566..567)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467293"
     CDS             1..576
                     /gene="Galnt12"
                     /gene_synonym="9130206E10; A630062B03Rik; galNAc-T12;
                     mpp-GalNAc-T12; pp-GaNTase; pp-GaNTase 12"
                     /coded_by="NM_172693.4:51..1781"
                     /db_xref="CCDS:CCDS18158.1"
                     /db_xref="GeneID:230145"
                     /db_xref="MGI:MGI:2444664"
ORIGIN      
        1 mwgravrrrc prglrrgrea llallalagl gallrarsrs gtvdpgpprt plpgrhepvl
       61 prpplpadal gahgeavrlq lqgeelrlqe esvkqhqini ylsdrislhr rlperwnplc
      121 revkydydnl pktsvviafy neawstllrt vysvletspd illeevilvd dysdrehlke
      181 rlanelsqlp kvrlirasrr eglvrarllg asaargevlt fldchceche gwlepllqri
      241 hekesavvcp vidvidwntf eylgnsgepq iggfdwrlvf twhvvpqrer qsmrspidvi
      301 rsptmagglf avskryfdyl gsydtgmevw ggenlefsfr iwqcggtlet hpcshvghvf
      361 pkqapysrsk alansvraae vwmdefkely yhrnpqarle pfgdvterkk lraklqckdf
      421 kwfldtvype lhvpedrpgf fgmlqnrglr gycldynppn enhveghqvl lylchgmgqn
      481 qffeyttrke iryntrqpea citvedgkdt lvmdlcretv penqefilqe dgtlvhkhsr
      541 kcveatekvl dngfapylrd ctnsdnqrwf fkerms
//
