LOCUS       NM_144908               2562 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 11
            (Galnt11), transcript variant 1, mRNA.
ACCESSION   NM_144908 NM_177125
VERSION     NM_144908.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Tian,E., Rothermel,C., Michel,Z., de Castro,L.F., Lee,J., Kilts,T.,
            Kent,T., Collins,M.T. and Ten Hagen,K.G.
  TITLE     Loss of the glycosyltransferase Galnt11 affects vitamin D
            homeostasis and bone composition
  JOURNAL   J Biol Chem 300 (4), 107164 (2024)
   PUBMED   38484798
  REMARK    GeneRIF: Loss of the glycosyltransferase Galnt11 affects vitamin D
            homeostasis and bone composition.
REFERENCE   2  (bases 1 to 2562)
  AUTHORS   Bubier,J.A., He,H., Philip,V.M., Roy,T., Hernandez,C.M., Bernat,R.,
            Donohue,K.D., O'Hara,B.F. and Chesler,E.J.
  TITLE     Genetic variation regulates opioid-induced respiratory depression
            in mice
  JOURNAL   Sci Rep 10 (1), 14970 (2020)
   PUBMED   32917924
  REMARK    GeneRIF: Genetic variation regulates opioid-induced respiratory
            depression in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2562)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   4  (bases 1 to 2562)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
  REMARK    GeneRIF: Megalin in Galnt11-deficient mice displays reduced ligand
            binding and undergoes age-related loss within the kidney.
REFERENCE   5  (bases 1 to 2562)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2562)
  AUTHORS   Yoshida,C.A., Kawane,T., Moriishi,T., Purushothaman,A.,
            Miyazaki,T., Komori,H., Mori,M., Qin,X., Hashimoto,A., Sugahara,K.,
            Yamana,K., Takada,K. and Komori,T.
  TITLE     Overexpression of Galnt3 in chondrocytes resulted in dwarfism due
            to the increase of mucin-type O-glycans and reduction of
            glycosaminoglycans
  JOURNAL   J Biol Chem 289 (38), 26584-26596 (2014)
   PUBMED   25107907
REFERENCE   7  (bases 1 to 2562)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2562)
  AUTHORS   Fritz,T.A., Hurley,J.H., Trinh,L.B., Shiloach,J. and Tabak,L.A.
  TITLE     The beginnings of mucin biosynthesis: the crystal structure of
            UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1
  JOURNAL   Proc Natl Acad Sci U S A 101 (43), 15307-15312 (2004)
   PUBMED   15486088
  REMARK    GeneRIF: homology models of several ppGaNTase isoforms predict
            dramatically different surface chemistries consistent with
            isoform-selective acceptor substrate recognition
REFERENCE   9  (bases 1 to 2562)
  AUTHORS   Young,W.W. Jr., Holcomb,D.R., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Expression of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase isoforms in murine tissues
            determined by real-time PCR: a new view of a large family
  JOURNAL   Glycobiology 13 (7), 549-557 (2003)
   PUBMED   12651884
  REMARK    GeneRIF: real-time polymerase chain reaction using the Taqman
            method to determine the expression of ppGaNTase isoforms in mouse
            tissues. In contrast to the general pattern, testis, sublingual
            gland, and colon exhibited distinctive profiles of isoform
            expression
REFERENCE   10 (bases 1 to 2562)
  AUTHORS   Schwientek,T., Bennett,E.P., Flores,C., Thacker,J., Hollmann,M.,
            Reis,C.A., Behrens,J., Mandel,U., Keck,B., Schafer,M.A.,
            Haselmann,K., Zubarev,R., Roepstorff,P., Burchell,J.M.,
            Taylor-Papadimitriou,J., Hollingsworth,M.A. and Clausen,H.
  TITLE     Functional conservation of subfamilies of putative
            UDP-N-acetylgalactosamine:polypeptide
            N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis
            elegans, and mammals. One subfamily composed of l(2)35Aa is
            essential in Drosophila
  JOURNAL   J Biol Chem 277 (25), 22623-22638 (2002)
   PUBMED   11925450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127319.4 and Y12435.1.
            
            On Oct 17, 2017 this sequence version replaced NM_144908.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021504.1, AK088014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC127319.4         101841-102000       c
            161-198             AC127319.4         77381-77418         c
            199-2025            Y12435.1           1-1827
            2026-2562           AC127319.4         58954-59490         c
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 12.35 cM"
     gene            1..2562
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /note="polypeptide N-acetylgalactosaminyltransferase 11"
                     /db_xref="GeneID:231050"
                     /db_xref="MGI:MGI:2444392"
     exon            1..160
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            161..493
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2025
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T11; pp-GaNTase 11; polypeptide GalNAc
                     transferase 11; protein-UDP
                     acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 11;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 11"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     11"
                     /protein_id="NP_659157.1"
                     /db_xref="CCDS:CCDS19133.1"
                     /db_xref="GeneID:231050"
                     /db_xref="MGI:MGI:2444392"
                     /translation="MGSITVRYFCYGCLFTSATWTVLLFIYFNFSEVTQPLRNVPIKG
                     SGPHGPFPKKFYPRFTRGPGRVLDPQFKANRIDRLMNNHIEDPDKGLSKSSSELGMIF
                     NERDQELRDLGYQKHAFNMLISNRLGYHRDVPDTRNAECRRKSYPTDLPTASIVICFY
                     NEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDFDDLKGELDEYIQRYLPAKVKVIR
                     NMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTVVCPVIDI
                     ISADTLAYSSSPVVRGGFNWGLHFKWDLVPVSELGGPDGATAPIRSPTMAGGLFAMNR
                     QYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFILPCSRVGHIFRKRRPYGSPEGQ
                     DTMTHNSLRLAHVWLDEYKEQYFSLRPDLKNKSFGNISERVELRKKLGCQSFKWYLDN
                     IYPEMQIPGPNAKPQQPVLINRGPKRPRVLQRGRLYHLQTNKCLVAQGRSSQKGGLVL
                     LKTCDYGDPTQVWIYNEDHELILNNLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGK
                     NNRLYQVSVGQCLRVMDLMDQKGYVGMAICDGSSSQQWRLEG"
     exon            494..617
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..784
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..910
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1160
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1278
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1431
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1650
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1755
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1893
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2562
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2531..2536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="Galnt11"
                     /gene_synonym="A430075I06Rik; E430002F06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggtgac gcgtgccgtg acgcgagggc tccgcaaggc tgcgtgtcgt gggccgcgtc
       61 gcgcgccgcg gctcgtgcgg ctcggcccgg gctgtggcgg gagcggagat gccgcagccc
      121 gtgccctgga gcgccgctat cccggcctgc gggtgtcgcg gaaactgaaa atggcctttg
      181 agctatgcta ggtctataat gggaagcatc acagttcgat atttttgtta tgggtgcctt
      241 tttacatctg ctacctggac agttctgctt ttcatttatt ttaacttcag tgaagtgact
      301 cagcccctta ggaatgtgcc catcaagggg tctgggcccc acgggccatt tcccaaaaaa
      361 ttctacccac gtttcactcg aggtccaggt cgggtattag atccacagtt caaagcaaac
      421 agaatcgacc gtttgatgaa taatcacatt gaagatccag ataaaggcct ctcaaaatct
      481 tcctctgaac taggtatgat tttcaatgaa cgtgatcagg aattgagaga cctgggctac
      541 cagaagcacg cctttaatat gctcattagt aaccgcttgg gataccacag agacgtgccg
      601 gacaccagga atgcagagtg taggaggaag tcctacccga ctgacctgcc aactgctagc
      661 attgtcatct gtttctacaa tgaagccttt tctgccttac tgcggactgt gcacagtgtt
      721 gtggaccgca caccggccca ccttcttcat gagatcatcc ttgtggatga cagcagtgac
      781 tttgatgatt taaaaggaga actggatgag tacatccaaa gatacctgcc tgcaaaagtc
      841 aaggtcataa gaaatatgaa gcgcgaggga ttgatccgag gacgaatgat cggagcagcc
      901 cacgctacag gagaagtcct ggtgttcctg gacagccact gtgaagtgaa tgtgatgtgg
      961 ttacagcccc tgctggccat tatccttgag gacccacaca cagtggtgtg ccccgtgatt
     1021 gacatcatca gtgcagacac actcgcttac agctcatccc cagtagttcg gggaggtttc
     1081 aactgggggc tgcacttcaa gtgggatcta gttcccgtat ctgagctggg aggccctgac
     1141 ggcgccacgg ccccaataag gtcacctaca atggctggag gcttgtttgc catgaacaga
     1201 cagtatttca atgatcttgg acagtatgac agtggcatgg atatctgggg aggagaaaat
     1261 ctggaaatct catttcggat ctggatgtgt ggcggcaagc tcttcatcct cccttgctca
     1321 agagtaggac acattttccg aaaaaggcga ccgtacggat ctccggaagg ccaggacacc
     1381 atgacacaca actccctgag actggcacat gtctggctgg atgagtacaa ggagcaatat
     1441 ttttccttaa gacctgattt gaagaacaaa agcttcggga atatcagtga gcgtgttgaa
     1501 ttgaggaaga aactgggctg tcagtcattc aagtggtatt tggataatat ttaccctgag
     1561 atgcagatac ctggcccgaa tgccaaacct cagcagcccg ttctcatcaa cagaggaccc
     1621 aagcgcccca gagtcctgca gcgtggaagg ctctaccact tgcagaccaa caaatgcctg
     1681 gtggcccagg gccgctccag ccagaaagga ggcctagtgc tgcttaagac ctgtgactac
     1741 ggagacccaa ctcaggtctg gatttataat gaagaccatg aattgatttt aaacaacctc
     1801 ctttgccttg acatgtcaga aactcgctca tcggatccac cccgactcat gaagtgccat
     1861 gggtcaggag gatcccagca gtggaccttt gggaagaaca accggctgta ccaagtgtcc
     1921 gttgggcagt gcctgagagt tatggacctg atggatcaga agggctacgt tggcatggcg
     1981 atctgcgatg gctcctcctc tcaacagtgg cgtctagaag gttaaaggtg ggccctggct
     2041 ggacacaaca taattcacct ggttttgtca tgcctgccat aaatcaaggt gctttaaggt
     2101 tgctgactgc agcagacaag aaccttggtg gagggcgacc atctcaggag cgccactggg
     2161 atttgggttt acttccgagc tgctgttaag ggattcttgt ttatccaggg aaaacagaaa
     2221 ataattctaa agagttgggt ctacagagta taaacccagg aagtaggcat ttgtattcat
     2281 atttatgttt ttcgcattct cccttggaga tggaattgtt tctgtccaat caggaacttg
     2341 tcacaatttc ctttcataga ggacttcata agagattttt ttctatttct atcatgccta
     2401 atgttccaaa tagattttaa aaactggttg agtgcatatt acttttagct tcagaagata
     2461 tcatgtatat ttaagaggca tttaactatt ataaattatt ttgatgactt aatattgtct
     2521 gtctacatta aataaaggat ctttttgatc atttaactag ga
//
