LOCUS       NM_001361200            4193 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 1
            (Galnt1), transcript variant 3, mRNA.
ACCESSION   NM_001361200 XM_006525650
VERSION     NM_001361200.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Tang,J., Zheng,H., Chen,L., Gao,S., Shi,X., Liu,J. and Xu,L.
  TITLE     Isoform-specific regulation of osteogenic factors by polypeptide
            N-Acetylgalactosaminyltransferases 1 and 4
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1449-1454 (2017)
   PUBMED   27965094
  REMARK    GeneRIF: the ppGalNAc-T4 was highly expressed in MC3T3-E1 cells
            during osteogenesis for the first time; ppGalNAc-T1 and -T4
            affected the expression of different osteogenic factors, suggesting
            distinct roles ppGalNAc-T isoforms play in regulating osteogenesis
            in vitro
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Xu,Y., Pang,W., Lu,J., Shan,A. and Zhang,Y.
  TITLE     Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to
            Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein
            Podoplanin
  JOURNAL   J Biol Chem 291 (45), 23477-23488 (2016)
   PUBMED   27629416
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Ten Hagen,K.G., Bedi,G.S., Tetaert,D., Kingsley,P.D., Hagen,F.K.,
            Balys,M.M., Beres,T.M., Degand,P. and Tabak,L.A.
  TITLE     Cloning and characterization of a ninth member of the
            UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family,
            ppGaNTase-T9
  JOURNAL   J Biol Chem 276 (20), 17395-17404 (2001)
   PUBMED   11278534
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Hagen,F.K., Hazes,B., Raffo,R., deSa,D. and Tabak,L.A.
  TITLE     Structure-function analysis of the
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase. Essential residues lie in a
            predicted active site cleft resembling a lactose repressor fold
  JOURNAL   J Biol Chem 274 (10), 6797-6803 (1999)
   PUBMED   10037781
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Lu,K.P. and Ramos,K.S.
  TITLE     Identification of genes differentially expressed in vascular smooth
            muscle cells following benzo[a]pyrene challenge: implications for
            chemical atherogenesis
  JOURNAL   Biochem Biophys Res Commun 253 (3), 828-833 (1998)
   PUBMED   9918813
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Hagen,F.K., Ten Hagen,K.G., Beres,T.M., Balys,M.M.,
            VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     cDNA cloning and expression of a novel
            UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 272 (21), 13843-13848 (1997)
   PUBMED   9153242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134856.3.
            
            On Mar 13, 2018 this sequence version replaced XM_006525650.2.
            
            Transcript Variant: This variant (3) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.126904.1,
                                           SRR7974084.14637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AC134856.3         81078-81470         c
            394-448             AC134856.3         54776-54830         c
            449-692             AC134856.3         48944-49187         c
            693-867             AC134856.3         41205-41379         c
            868-1034            AC134856.3         32745-32911         c
            1035-1242           AC134856.3         22897-23104         c
            1243-1413           AC134856.3         19731-19901         c
            1414-1531           AC134856.3         17864-17981         c
            1532-1712           AC134856.3         15663-15843         c
            1713-1852           AC134856.3         14628-14767         c
            1853-1951           AC134856.3         7387-7485           c
            1952-2086           AC134856.3         5193-5327           c
            2087-4193           AC134856.3         613-2719            c
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 12.9 cM"
     gene            1..4193
                     /gene="Galnt1"
                     /note="polypeptide N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:14423"
                     /db_xref="MGI:MGI:894693"
     exon            1..393
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..448
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..692
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..2233
                     /gene="Galnt1"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 1; pp-GaNTase 1;
                     polypeptide GalNAc transferase 1; protein-UDP
                     acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 1; ppGaNTase-T1"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001348129.1"
                     /db_xref="CCDS:CCDS29100.1"
                     /db_xref="GeneID:14423"
                     /db_xref="MGI:MGI:894693"
                     /translation="MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKQERGLPA
                     GDVLELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVR
                     LEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER
                     DFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGW
                     LEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMD
                     RRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTL
                     EIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVD
                     YGDISSRLGLRRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKE
                     NEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEY
                     DPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTLPEIF"
     exon            693..867
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1034
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1242
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1413
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1531
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1712
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1852
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1951
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2086
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..4193
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3577..3582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt1"
                     /note="hexamer: ATTAAA"
     polyA_site      3600
                     /gene="Galnt1"
                     /note="major polyA site"
     regulatory      3972..3977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt1"
                     /note="hexamer: AATAAA"
     polyA_site      3995
                     /gene="Galnt1"
                     /note="major polyA site"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt1"
                     /note="hexamer: ATTAAA"
     polyA_site      4193
                     /gene="Galnt1"
                     /note="major polyA site"
ORIGIN      
        1 agaggccgag gaggcggcgc ggcggactgc ggcccgagag gagcgcccgc gctgcggccc
       61 gcgggagcgc gccgccaccg cccgcgccgg cctgaggagc gcctgccgcc gcgcgggccg
      121 aggtgagtgc accgcaggcc ggcgggctgg tgacgccgga gcggagcgga gcggagcggg
      181 gcgaggcgca ggcccgggcg cgcccgcctc ctcggccctt tgtggccgcg cggccggggc
      241 gcggggtccg gcggcgggga ctcccggccc gcccggcgcg cggcgtctcc ctctgccggg
      301 cagccgcgca gagctgcgag ttggcgtcct agtttgacat tgagttagaa accgtttttc
      361 ttcagaagac ggaagtttgt tttattgaca gagatgattt gagacatgtg gatttgtgat
      421 atgaattcat ttggaaagcc actttggggc tatgactgtg atttctgatg aaaccaaatt
      481 ggaataattt tcatgatatt tgtatattta tatctatata tattttaaaa ttttacattt
      541 gacttaaagt gccatgagaa aatttgcata ttgcaaggtg gttctagcca cctccttggt
      601 ttgggtactc ttggatatgt tcctgctgct ttacttcagt gaatgcaaca aatgtgaaga
      661 gaagcaggag agaggacttc ctgctggtga cgttctagag ctagtgcaga aacctcatga
      721 aggtcctgga gaaatgggga aaccagtcgt cattccgaaa gaggatcaag aaaagatgaa
      781 agagatgttt aaaatcaatc agttcaactt aatggcaagt gagatgattg cactcaacag
      841 atccttacca gatgtgaggt tagaggggtg taaaacaaag gtgtatccag ataaccttcc
      901 tacaacaagt gtggtgattg ttttccacaa tgaggcatgg agcacacttc tgcgaacagt
      961 ccatagtgtc attaatcgct cgccaagaca tatgatagaa gagattgttc ttgtagatga
     1021 tgccagtgaa agagactttt tgaaaagacc tctagagagt tatgtgaaaa aactgaaagt
     1081 gccggttcat gtaattcgaa tggagcagcg ctctgggttg atcagagcta gattgaaagg
     1141 agctgctgtg tccagaggcc aagtgatcac cttcttagat gctcactgtg aatgcaccgc
     1201 agggtggctg gagcctctgt tggcccggat caaacatgac aggaggacag tggtgtgtcc
     1261 tatcatcgac gtgatcagtg atgacacttt cgagtacatg gcgggctctg acatgaccta
     1321 tggtggcttc aactggaagc tcaattttcg ttggtatcct gttccccagc gagaaatgga
     1381 cagaaggaaa ggtgacagga ctcttcctgt cagaacacct acaatggctg gaggcctttt
     1441 ttcaatagac agagattact ttcaggaaat tggaacatac gatgctggaa tggatatttg
     1501 gggaggagaa aacctagaaa tttcatttag gatttggcag tgtggaggaa ctttggaaat
     1561 agtgacatgc tcccatgttg gtcatgtgtt tcggaaagct acaccttaca catttccagg
     1621 agggacaggg cagattatca ataagaataa caggcggctt gcagaagtat ggatggatga
     1681 attcaagaat ttcttctata taatttctcc aggtgttaca aaggtagatt atggagatat
     1741 atcatcaaga cttggcctaa gacgtaaact acaatgcaaa cctttctctt ggtacctaga
     1801 aaatatttac cctgattctc aaattcctcg tcactatttc tcattgggag agatacgaaa
     1861 tgtggaaaca aatcagtgtc tagataacat ggctagaaaa gagaatgaaa aggttggaat
     1921 ctttaattgt catggtatgg gaggtaatca ggttttctcc tacactgcca acaaagaaat
     1981 tagaacagac gacctttgtt tggacgtttc caaacttaat ggcccagtca ccatgctcaa
     2041 atgccaccac ctaaaaggca accagctctg ggagtatgac ccagtgaaat taaccctgca
     2101 gcatgtgaac agcaatcagt gcctggataa agccacagag gaggacagcc aggtgcccag
     2161 cattagagac tgcactggaa gccggtccca gcagtggctt cttcgaaacg tcacccttcc
     2221 agaaatattc tgagaccaaa tttacaacaa caaagaaaga aggaaggatt gactgggcta
     2281 cctcagcata cattctgcca cattcttcag tagcaaaaaa ggaaagtgct tccctcttct
     2341 gtgggatgtt aaggtttctc agccattaaa actcagactc ctagcttttc acttgctgtg
     2401 aaccggcctt cctgtcccag gacgtgcgac tgcaaagtag cgagactgtg cacactgatg
     2461 tttacaaggc tggaagagtc ttcatcaaga gcagcggcaa agccttcaga tcccaaacag
     2521 gcgcacgagc gctctcggga tagatgcact ttctacagcg tgggtgcacg tcagccgttt
     2581 ctgctgaatg tgccttgtga agaagagttt tcctgattag aatcagtagc tggaatatta
     2641 aatattgata gaaaagtaag tggaaaagag ctggaaccag gttcagaatc atgaaaacat
     2701 ttttacaaca ataaaaatta tgtcaaacag ggtttaaagg aaattaaaaa gaattatgag
     2761 aagtacaatt tgttatagta tagtatgaga tttctatata gattttatac ctcagtgggg
     2821 aaaaactgat tccagtgatg ttgatgttgt tttcatctgt gatagtcatg gatgcttcta
     2881 ttttcctcgg ggtgctcaga gtgagatagt gggtggggtg agctctctga acatagtttg
     2941 aatttctttt tacaatattc ttatttggtt tgtgggctgt tggaattgta agtttaattg
     3001 ccattcttta aaaaaaaaaa aatggagatt tactctgcct ggtctcagtt ggaaagtttt
     3061 cgatctctct ctgttgttct tgggtcaact ggcgtacaga ctctgcctcg ccctgcctcc
     3121 ctccctccac acagtttctt aacatgctgt ccacttaact ctgctgagct gattgtgctt
     3181 catgcccaag actcacgcta ctgcactgca ggtttgtctc cacagcaata acctctgacc
     3241 cctgcgagtc acttcacaga gtgctgttta tctggagatt gggagatcag acatttaatg
     3301 ggttttttga aacccttgcc actccactta gccgtgtgct tccctgtcgg acgcacactc
     3361 aggttcctcc tcagttgtaa tgttgatttg ctgctttttc acaaaataaa aatggactga
     3421 aagtgtttaa ttggcatttt ttaatgagtt agccaaagaa gtgcaactgt gattccacat
     3481 cacagtcctg cgtttcctcc ctaaattcta ttttgttatt tggttttctt tactctggtt
     3541 tttagtaaca ggatcacgta ttaaaatttg ctgttaatta aagtttacct tttgatttta
     3601 cagaaatctc attgtgacat ttttttccat agcagcccat tggccaaaat gcataattct
     3661 gcttcctgtc tgtcaggtga tacttgatgg tattcctctt tttttgatta tcaaagactt
     3721 gcttcaggaa gtgctgtttc ttgtgcgtaa gaatgttcct gaagtcacac tcgtcagtga
     3781 caccatctgt catcattcat ccagtcgtca gcatcgaata tatggatgct tagggtaagg
     3841 ctgtcctcca ggatgcagag actccccatg caatctgaat gaaaccggtg ttggctggaa
     3901 tactttttct cttctgtgag ctatgttaat tctgtctcca atgggcccaa tgtttgaaaa
     3961 gtcagatgtc taataaatta ttttcatgct cagaatttca gatttttgta ccctaacaac
     4021 atggttttat tccttattgt aaaagtttaa cagcgttgtg atttaaaaat gtgtctcact
     4081 tttttaagtg gggggatgtg agtgacttaa ttcatgggta cttttagaac ctattagata
     4141 atcttattgc ctttattttt ctaattaaaa tattcctaaa tactttgaaa ata
//
