LOCUS       NM_176963               2245 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus galactose mutarotase (Galm), mRNA.
ACCESSION   NM_176963 XM_983245
VERSION     NM_176963.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Wada,Y., Kikuchi,A., Arai-Ichinoi,N., Sakamoto,O., Takezawa,Y.,
            Iwasawa,S., Niihori,T., Nyuzuki,H., Nakajima,Y., Ogawa,E.,
            Ishige,M., Hirai,H., Sasai,H., Fujiki,R., Shirota,M., Funayama,R.,
            Yamamoto,M., Ito,T., Ohara,O., Nakayama,K., Aoki,Y., Koshiba,S.,
            Fukao,T. and Kure,S.
  TITLE     Biallelic GALM pathogenic variants cause a novel type of
            galactosemia
  JOURNAL   Genet Med 21 (6), 1286-1294 (2019)
   PUBMED   30451973
  REMARK    Erratum:[Genet Med. 2020 Jul;22(7):1281. doi:
            10.1038/s41436-020-0836-z.. PMID: 32499603]
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   3  (bases 1 to 2245)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140361.2.
            
            On May 2, 2007 this sequence version replaced NM_176963.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040998.1, BC028818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AC140361.2         73191-73625         c
            436-590             AC140361.2         62929-63083         c
            591-797             AC140361.2         55910-56116         c
            798-879             AC140361.2         50926-51007         c
            880-1021            AC140361.2         19394-19535         c
            1022-1196           AC140361.2         17730-17904         c
            1197-2245           AC140361.2         16064-17112         c
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.46 cM"
     gene            1..2245
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /note="galactose mutarotase"
                     /db_xref="GeneID:319625"
                     /db_xref="MGI:MGI:2442420"
     exon            1..435
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1274
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /EC_number="5.1.3.3"
                     /note="aldose 1-epimerase"
                     /codon_start=1
                     /product="galactose mutarotase"
                     /protein_id="NP_795937.1"
                     /db_xref="CCDS:CCDS28987.1"
                     /db_xref="GeneID:319625"
                     /db_xref="MGI:MGI:2442420"
                     /translation="MVSVTRTVFGELPSGGGTVEKFQLRSDQLSVDIISWGCTITALQ
                     VKDRQGKASDVVLGFAELEGYLQKQPYFGAVVGRVANRIAKGRFTIGGKEYHLPVNRE
                     PNSLHGGFTGFDKVLWTPQVLTNGVQFFRVSPDGEEGYPGELKVWVTYTLDGGELVIN
                     YRAQASQTTPVNLTNHSYFNLAGQGSPNIYDHEVTIAADAYLPVDETLIPTGVIAPVE
                     GTAFDLRKPVELGTHLQDYHIHGFDHNFCLKESKEKKFCARVRHAASGRILEVYTTQP
                     GVQFYTGNFLDGTLKGKNGAVYPKHSGLCLETQNWPDSVNQPQFPPALLRPGEEYNHT
                     TWFKFSVA"
     exon            436..590
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..797
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..879
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1021
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1196
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..2245
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1676
                     /gene="Galm"
                     /gene_synonym="A530057M15Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggaaaagac cagcaaactc aactggaaag tttgcttctc agttacctcg gataaaggaa
       61 aaattttaaa aaggcatcgg agcattttcc ccgaccccag gagtggtcaa ctgtttaaat
      121 ccaggcaata aaggggagga gttagtctga gttcctcccc ttctcccggg aactttatct
      181 ttccaaacgt gatccaggct agagtttgaa cagcaaggag aagctgcaca ccctgaactt
      241 tcccaatggt ttcggtgacc agaaccgtgt ttggagagct gccctcgggg ggagggacag
      301 tggagaaatt ccagcttcgg tcagaccagc tgagtgtgga catcatctca tggggctgca
      361 cgatcactgc tctgcaggtc aaagacaggc aggggaaagc ctcagacgtg gtgcttggct
      421 ttgcggaatt ggaaggttac ctccagaagc agccctactt tggagcagtg gttgggaggg
      481 tagccaaccg aattgccaaa ggaagattca ctataggtgg gaaggagtac cacctgccag
      541 ttaacagaga gcccaacagt ctccatggcg gattcacggg gtttgataag gtcctctgga
      601 cccctcaggt gttgaccaat ggcgtccagt tctttcgagt cagtccagat ggtgaggaag
      661 gctaccctgg agagctgaaa gtctgggtga catataccct ggatggtggg gagcttgtaa
      721 tcaactacag agcacaggcc agccagacca ctccagttaa tctgaccaac cattcttatt
      781 tcaacctagc aggccagggc tccccaaata tatatgacca tgaagtcacc attgcagcag
      841 atgcatattt gcccgtggat gaaactctga ttccaacagg agtcattgct ccagtggaag
      901 gaactgcctt cgacctgaga aagccagtgg agcttggaac acacctgcag gattaccaca
      961 tccatggttt cgaccataat ttctgtctga aggagtcaaa agaaaagaag ttttgtgcaa
     1021 gggtgcgtca cgctgcaagt gggaggatcc tggaagtata taccacacaa ccaggcgtcc
     1081 agttttacac aggaaacttc ttggatggta ctctgaaagg caagaacggt gcggtgtatc
     1141 ccaagcactc aggtctctgc ctcgagaccc agaactggcc tgattcggtc aatcagcccc
     1201 agttccctcc ggcgctgctg aggcctggag aggaatacaa ccacactacc tggttcaagt
     1261 tctctgttgc ttaaagaaga cggaagatga gacccggtcc ccactcacct gccttgcttt
     1321 aaaagtaatc ctgcgtgtta aatcatacag atcgtagcag ccataataat caatgtgaat
     1381 actgataccc tttcccagca gctacagact atgtctaatg accagctctg ttctctgtct
     1441 agtgccatcg cctaaggtct gatcctggta gagaagtggt cctgtggact ctcctgattt
     1501 cataggttcc atctttccat cctggttcca tcttgtctat ttcctttaac gccttccttt
     1561 ctttgacaga actctgtttt cctgcctcct ctttgacctc agactacccc ctccagaagt
     1621 tttaaccagc tcttgagttc aagctgtgag aattaaagtc tccctctgtg cctctacctc
     1681 aatctgcctg aacattccta gggtcactga aggacaagca gggtcttgga ccctgctccg
     1741 tcagagcctt tcttctcaga cttaccgtag gagctagaga tggctgagca gtgaagaaca
     1801 cacactgctc ttgcagagga ccagagtcca ccctgtcagg ctctagggga gcaagccccc
     1861 tctcttctag cctctgggaa tcccacactc atgcgcaccc acacatccac aacagttaaa
     1921 aataaatctt aaatggtggg aaaaaaaaat cactttagaa gcattcgagt gagttgaact
     1981 atctttttag agatggtgtg atttaagttg taagatccaa atacccagga taatttcagt
     2041 ttttctgcct ttgagattaa ctaggagctt ggctaaggtg tagcaagacg cacaggcata
     2101 ggaggcagga gcctcacacc aacagtgccc gtagcattca actgtgcact agaagtagat
     2161 gctcccttga gatgaaatgg gtggaggctc ctcatttcct caaagatgac gtcatcgctg
     2221 atgtgcctag gctgctgatt ttggg
//
