LOCUS       NP_001277931             458 aa            linear   ROD 30-APR-2024
DEFINITION  N-acetylgalactosamine kinase isoform a [Mus musculus].
ACCESSION   NP_001277931 XP_006500215
VERSION     NP_001277931.1
DBSOURCE    REFSEQ: accession NM_001291002.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 458)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 458)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   3  (residues 1 to 458)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU698705.1, BC079843.1 and AK082521.1.
            
            On Mar 21, 2014 this sequence version replaced XP_006500215.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079843.1, AK154762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     Protein         1..458
                     /product="N-acetylgalactosamine kinase isoform a"
                     /EC_number="2.7.1.157"
                     /note="N-acetylgalactosamine kinase; galNAc kinase"
                     /calculated_mol_wt=50372
     Region          18..456
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     Site            43
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:Q9HHB6; propagated from
                     UniProtKB/Swiss-Prot (Q68FH4.1)"
     CDS             1..458
                     /gene="Galk2"
                     /gene_synonym="2810017M24Rik; Gk2"
                     /coded_by="NM_001291002.1:111..1487"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS71134.1"
                     /db_xref="GeneID:69976"
                     /db_xref="MGI:MGI:1917226"
ORIGIN      
        1 maaedpatrr vqvaehprll klkemfnskf gstpkfyvra pgrvniigeh idycgysvip
       61 maveqdmlia vepvkthtlq lantdplypd fsttannici dktkplwhny flcgfkgiqe
      121 hfglsklpgm nclvdgnipp ssglssssal vccaglvtlt vlglrlskve laeicakser
      181 yigtegggmd qsisflaeeg takliefspl ratnvklpsg avfvianscm emnkaatshf
      241 nvrvmecrla akvlakhkgl qwdnvlrlee vqsklgisle emllvtedal hpepysreei
      301 crclgisler lrtqiltpnt qdeltfklyq rakhvyseaa rvlqfkqvce dapdnavqll
      361 gelmnqshrs crdmyecscp eldqlvdicr kfgakgsrlt gagwggctvs lvpadmlssf
      421 lasvheayyq gntsrlaqek hslfatkpgg galvfrev
//
