LOCUS       NM_016905               1506 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus galactokinase 1 (Galk1), mRNA.
ACCESSION   NM_016905
VERSION     NM_016905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Martinez-Garza,U., Choi,J., Scafidi,S. and Wolfgang,M.J.
  TITLE     Proteomics identifies the developmental regulation of HKDC1 in
            liver of pigs and mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (4), R389-R400 (2023)
   PUBMED   37545422
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Tomizawa,M., Toyama,Y., Ito,C., Toshimori,K., Iwase,K.,
            Takiguchi,M., Saisho,H. and Yokosuka,O.
  TITLE     Hepatoblast-like cells enriched from mouse embryonic stem cells in
            medium without glucose, pyruvate, arginine, and tyrosine
  JOURNAL   Cell Tissue Res 333 (1), 17-27 (2008)
   PUBMED   18478268
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Martiniuk,F., Hirschhorn,R. and D'Eustachio,P.
  TITLE     Linkage of acid alpha-glucosidase (Gaa) and thymidine kinase (Tk-1)
            to esterase-3 (Es-3) on mouse chromosome 11
  JOURNAL   Mamm Genome 1 (4), 267-269 (1991)
   PUBMED   1794057
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   8  (bases 1 to 1506)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (bases 1 to 1506)
  AUTHORS   McBreen,P., Orkwiszewski,K.G., Chern,C.J., Mellman,W.J. and
            Croce,C.M.
  TITLE     Synteny of the genes for thymidine kinase and galactokinase in the
            mouse and their assignment to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 19 (1), 7-13 (1977)
   PUBMED   196814
REFERENCE   10 (bases 1 to 1506)
  AUTHORS   Mishkin,J.D., Taylor,B.A. and Mellman,W.J.
  TITLE     Glk: a locus controlling galactokinase activity in the mouse
  JOURNAL   Biochem Genet 14 (7-8), 635-640 (1976)
   PUBMED   186024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011103.1, AK045694.1 and BB771442.1.
            
            On Apr 21, 2006 this sequence version replaced NM_016905.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011103.1, BC050151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AK011103.1         2-98
            98-1346             AK045694.1         72-1320
            1347-1386           AK011103.1         1348-1387
            1387-1506           BB771442.1         408-527
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..1506
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /note="galactokinase 1"
                     /db_xref="GeneID:14635"
                     /db_xref="MGI:MGI:95730"
     exon            1..206
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1220
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /EC_number="2.7.1.6"
                     /note="galactose kinase"
                     /codon_start=1
                     /product="galactokinase"
                     /protein_id="NP_058601.2"
                     /db_xref="CCDS:CCDS25654.1"
                     /db_xref="GeneID:14635"
                     /db_xref="MGI:MGI:95730"
                     /translation="MAAWRPPRVEELLAEARRAFMEEFGAEPELAVSAPGRVNLIGEH
                     TDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTTSKDADEPQRLQFPLPSAQWSLEPG
                     IPQWANYVKGVIQHYPASPLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCPDS
                     GAIAARAQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKL
                     AVLITNSNVRHSLGSSEYPVRRRQCEEVAQALGKESLREVRMEELEAGRELMSKEGFR
                     RARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPELDQLVEAALS
                     VPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGTATFYLSQAADGAQVLSL
                     "
     exon            207..396
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..516
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..652
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..834
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..985
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1148
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1506
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /note="hexamer: AATAAA"
     polyA_site      1339
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /note="major polyA site"
     polyA_site      1398
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
ORIGIN      
        1 agcatcccgc ggggcggtgc gcccagctgc agacgagcgt catggctgct tggagaccgc
       61 cccgggtcga ggagctgctg gccgaggccc gccgggcctt catggaggag tttggagccg
      121 agccggagct ggcagtgtcg gcgccgggcc gcgtcaacct catcggggag cacacggact
      181 acaaccaggg cctggtgctg cccatggcac tggagctcgt gaccgtgatg gttggcagcc
      241 cccggacaga tgggcttgtt tctcttctca ccacttccaa agatgcagac gagccccaaa
      301 gactgcagtt cccactgccc tcagcccagt ggtccttgga gcctggaatc ccacagtggg
      361 ccaattatgt caagggagtg attcaacatt acccagcttc cccgctcgtt ggcttcagtg
      421 cagtggtggt cagctcagtg cccctggggg gtgggctttc cagctcagcg tctctggaag
      481 tggccacgta caccttcatc cagcagctct gcccagactc gggggcaata gctgcccggg
      541 cccaggtgtg tcaacgggct gagcacagct tcgcaggggt gccctgtggc atcatggacc
      601 aactcatcgc gctgctgggg cagaaaggct atgcactact cattgactgc aggtccctgg
      661 aaacaagcct ggtgccactg tcagacccca agctggccgt gctcatcacc aactccaatg
      721 tccgccattc cctgggctcc agcgagtacc cggttcgtcg gcgacagtgt gaagaagtgg
      781 cccaggccct gggcaaggag agccttcgag aggtgcggat ggaggagctt gaggcgggca
      841 gggagctaat gagcaaggag ggcttccggc gggcccggca tgtggtaagc gagatccgga
      901 gaacagccca ggcagcagct gctatgagcc gaggagacta caaggccttt gggcgtctca
      961 tggtggagag tcactactca ctcagggatg actatgaggt cagctgccct gagctggatc
     1021 aattggttga ggccgcgctc tctgtgcctg gggtttatgg cagtcgcatg acaggtggtg
     1081 gctttggtgg ctgcaccgtc acattgctgg aggcctctgt tgcccctctt gtcatagatc
     1141 atatacagga gcagtacagt gggacagcca ccttctacct ctctcaagct gccgatggag
     1201 cccaggtgct gagcttgtga ggtgtccctg agaccgatgg acgcacaggc atgaggcgga
     1261 ggcagcaggt gtgtgccgca gctctgcctc gggcatcctc cttctctatc tgggtgctta
     1321 ataaacgtgt gcctcttaat ggcggtagcc acctgcctcc agaggtgggt aacatgctct
     1381 gggggcaaag aatggggatt atgggagtca gtgttcctac tgcaggcctg tgaagaacgg
     1441 acagagtggc taagcagtag caaaaccttt tattaagtgc agaacaaaag gctggggact
     1501 tgtgcc
//
