LOCUS       NP_058601                392 aa            linear   ROD 24-DEC-2024
DEFINITION  galactokinase [Mus musculus].
ACCESSION   NP_058601
VERSION     NP_058601.2
DBSOURCE    REFSEQ: accession NM_016905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Martinez-Garza,U., Choi,J., Scafidi,S. and Wolfgang,M.J.
  TITLE     Proteomics identifies the developmental regulation of HKDC1 in
            liver of pigs and mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (4), R389-R400 (2023)
   PUBMED   37545422
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 392)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   5  (residues 1 to 392)
  AUTHORS   Tomizawa,M., Toyama,Y., Ito,C., Toshimori,K., Iwase,K.,
            Takiguchi,M., Saisho,H. and Yokosuka,O.
  TITLE     Hepatoblast-like cells enriched from mouse embryonic stem cells in
            medium without glucose, pyruvate, arginine, and tyrosine
  JOURNAL   Cell Tissue Res 333 (1), 17-27 (2008)
   PUBMED   18478268
REFERENCE   6  (residues 1 to 392)
  AUTHORS   Martiniuk,F., Hirschhorn,R. and D'Eustachio,P.
  TITLE     Linkage of acid alpha-glucosidase (Gaa) and thymidine kinase (Tk-1)
            to esterase-3 (Es-3) on mouse chromosome 11
  JOURNAL   Mamm Genome 1 (4), 267-269 (1991)
   PUBMED   1794057
REFERENCE   7  (residues 1 to 392)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   8  (residues 1 to 392)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (residues 1 to 392)
  AUTHORS   McBreen,P., Orkwiszewski,K.G., Chern,C.J., Mellman,W.J. and
            Croce,C.M.
  TITLE     Synteny of the genes for thymidine kinase and galactokinase in the
            mouse and their assignment to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 19 (1), 7-13 (1977)
   PUBMED   196814
REFERENCE   10 (residues 1 to 392)
  AUTHORS   Mishkin,J.D., Taylor,B.A. and Mellman,W.J.
  TITLE     Glk: a locus controlling galactokinase activity in the mouse
  JOURNAL   Biochem Genet 14 (7-8), 635-640 (1976)
   PUBMED   186024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011103.1, AK045694.1 and BB771442.1.
            
            On Apr 21, 2006 this sequence version replaced NP_058601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011103.1, BC050151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     Protein         1..392
                     /product="galactokinase"
                     /EC_number="2.7.1.6"
                     /note="galactose kinase"
                     /calculated_mol_wt=42164
     Region          12..391
                     /region_name="GalK"
                     /note="Galactokinase [Carbohydrate transport and
                     metabolism]; COG0153"
                     /db_xref="CDD:439923"
     Site            37
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:Q9HHB6; propagated from
                     UniProtKB/Swiss-Prot (Q9R0N0.2)"
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51570; propagated from
                     UniProtKB/Swiss-Prot (Q9R0N0.2)"
     CDS             1..392
                     /gene="Galk1"
                     /gene_synonym="GALK; Gk; Glk; Glk1"
                     /coded_by="NM_016905.2:42..1220"
                     /db_xref="CCDS:CCDS25654.1"
                     /db_xref="GeneID:14635"
                     /db_xref="MGI:MGI:95730"
ORIGIN      
        1 maawrpprve ellaearraf meefgaepel avsapgrvnl igehtdynqg lvlpmalelv
       61 tvmvgsprtd glvsllttsk dadepqrlqf plpsaqwsle pgipqwanyv kgviqhypas
      121 plvgfsavvv ssvplgggls ssaslevaty tfiqqlcpds gaiaaraqvc qraehsfagv
      181 pcgimdqlia llgqkgyall idcrsletsl vplsdpklav litnsnvrhs lgsseypvrr
      241 rqceevaqal gkeslrevrm eeleagrelm skegfrrarh vvseirrtaq aaaamsrgdy
      301 kafgrlmves hyslrddyev scpeldqlve aalsvpgvyg srmtgggfgg ctvtlleasv
      361 aplvidhiqe qysgtatfyl sqaadgaqvl sl
//
