LOCUS       NM_001356493            1446 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus galactose-4-epimerase, UDP (Gale), mRNA.
ACCESSION   NM_001356493 XM_006539217
VERSION     NM_001356493.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Zhu,Y., Zhao,S., Deng,Y., Gordillo,R., Ghaben,A.L., Shao,M.,
            Zhang,F., Xu,P., Li,Y., Cao,H., Zagnitko,O., Scott,D.A.,
            Gupta,R.K., Xing,C., Zhang,B.B., Lin,H.V. and Scherer,P.E.
  TITLE     Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating
            Tff3 Expression
  JOURNAL   Diabetes 66 (11), 2789-2799 (2017)
   PUBMED   28877911
  REMARK    GeneRIF: These studies reveal a new link between hepatic GALE
            activity and whole-body glucose homeostasis via regulation of
            hepatic Tff3 expression.
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Deng,Y., Wang,Z.V., Tao,C., Gao,N., Holland,W.L., Ferdous,A.,
            Repa,J.J., Liang,G., Ye,J., Lehrman,M.A., Hill,J.A., Horton,J.D.
            and Scherer,P.E.
  TITLE     The Xbp1s/GalE axis links ER stress to postprandial hepatic
            metabolism
  JOURNAL   J Clin Invest 123 (1), 455-468 (2013)
   PUBMED   23257357
  REMARK    GeneRIF: results provide evidence that the Xbp1s/GalE pathway
            functions as a novel regulatory nexus connecting the UPR to the
            characteristic postprandial metabolic changes in hepatocytes.
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Yager,C., Ning,C., Reynolds,R., Leslie,N. and Segal,S.
  TITLE     Galactitol and galactonate accumulation in heart and skeletal
            muscle of mice with deficiency of galactose-1-phosphate
            uridyltransferase
  JOURNAL   Mol Genet Metab 81 (2), 105-111 (2004)
   PUBMED   14741191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672076.10, BB854114.1, BG077710.2, CO429161.1, AW544394.1 and
            AI847878.1.
            
            On Oct 4, 2017 this sequence version replaced XM_006539217.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146184.1, SRR7652917.684025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL672076.10        142836-142860
            26-488              BB854114.1         1-463
            489-656             BG077710.2         447-614
            657-982             CO429161.1         227-552
            983-1429            AW544394.1         1-447               c
            1430-1446           AI847878.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.29 cM"
     gene            1..1446
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /note="galactose-4-epimerase, UDP"
                     /db_xref="GeneID:74246"
                     /db_xref="MGI:MGI:1921496"
     exon            1..64
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            65..187
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1113
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /EC_number="5.1.3.2"
                     /EC_number="5.1.3.7"
                     /note="galactowaldenase; UDP-galactose 4-epimerase;
                     UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase;
                     UDP-galactosamine 4-epimerase; UDP-N-acetylglucosamine
                     4-epimerase"
                     /codon_start=1
                     /product="UDP-glucose 4-epimerase"
                     /protein_id="NP_001343422.1"
                     /db_xref="CCDS:CCDS18796.1"
                     /db_xref="GeneID:74246"
                     /db_xref="MGI:MGI:1921496"
                     /translation="MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSM
                     PESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLD
                     YYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK
                     FFIEEMIRDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGR
                     REALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSV
                     LQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWR
                     WQKQNPSGFGAQA"
     exon            188..303
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..417
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..594
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..708
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..775
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            776..861
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..939
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1054
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1432
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1430
                     /gene="Gale"
                     /gene_synonym="2310002A12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttaaaggggc cgcggcgctg gtcgcgggag gcggtgcctg gagtcagcgc tggagcttcc
       61 gcaggcgcca tggaaaaggt gctggtcaca ggtggggctg gctacatcgg cagccacacg
      121 gtattggagc tgctggaggc aggctactca cctgtggtca ttgacaactt ccataacgcc
      181 attcgtggag aagactccat gcctgagagc ctgcgccggg tccaggagtt gacaggccgc
      241 tctgtggagt ttgaggagat ggacatcttg gaccaggcag ccctacagca cctctttaag
      301 aagcacagct ttaaggccgt catccacttt gctggcctca aggctgtggg cgagtcagtg
      361 cagaagcctc tggactacta tagagttaac ttaacaggga ccatccagct tctagagatc
      421 atgagggccc acggagtgaa gaacctggtg ttcagcagct cagccaccgt gtacgggaac
      481 ccccagtacc tgcctctgga tgaggcccac cccacggggg gctgtaccaa cccctacggc
      541 aagtccaagt tcttcatcga ggagatgatc cgggacctgt gccgggcaga cacggcctgg
      601 aacgccgtgc tgcttcggta cttcaatccc ataggcgccc acgcctctgg gcgcatcggt
      661 gaagatcctc agggtattcc caacaacctc atgccctacg tctcccaggt ggcaatcggg
      721 cgacgagagg ccctgaatgt ctttggtgat gactatgcta cagaggacgg gacaggtgtg
      781 agggattaca ttcacgtggt ggacctggcg aagggccata tagcagcctt gaagaagctg
      841 aaggagcaat gtggttgccg gacctacaac ctgggcacgg gcacaggcta ctctgtcctg
      901 cagatggtcc aagccatgga gaaagcctca gggaagaaga tcccgtacaa ggtggtggca
      961 cggcgggaag gtgatgtggc ggcctgttat gccaacccca gcctggccca tgaggagctg
     1021 ggctggacag cagccctggg gctggacagg atgtgtgaag atctgtggcg ctggcagaag
     1081 cagaaccctt cgggctttgg ggcgcaggcc tgaggacctc gttaccatgg accagaaaag
     1141 agcagctgcc tgctttccag tctccacagg accctgtacc ctcacactct ggggccaccc
     1201 tacctcaaat gccagctgtc tgctcagccc tccaggcagg agacctctgg ttccactgac
     1261 cagaaagaag tccaggtctt tccagcctgt ctcccccccg agttcagcag ctcatgtgat
     1321 ccccagagcc ttggggatgg ggaggccagg gggtctggga ccatagcctc ccccaggcac
     1381 tgatgattaa gctttccaaa gtatttaaaa taaagatgtt ttcttatcga gaaaaaaaaa
     1441 aaaaaa
//
