LOCUS       NM_010253                806 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus galanin and GMAP prepropeptide (Gal), transcript
            variant 1, mRNA.
ACCESSION   NM_010253
VERSION     NM_010253.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Hevesi,Z., Bakker,J., Tretiakov,E.O., Adori,C., Raabgrund,A.,
            Barde,S.S., Caramia,M., Krausgruber,T., Ladstatter,S., Bock,C.,
            Hokfelt,T. and Harkany,T.
  TITLE     Transient expression of the neuropeptide galanin modulates
            peripheral-to-central connectivity in the somatosensory thalamus
            during whisker development in mice
  JOURNAL   Nat Commun 15 (1), 2762 (2024)
   PUBMED   38553447
  REMARK    GeneRIF: Transient expression of the neuropeptide galanin modulates
            peripheral-to-central connectivity in the somatosensory thalamus
            during whisker development in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Liu,J., Li,Y., Zhang,Y., Cheng,Q., Liu,H., He,L., Chen,L., Zhao,T.,
            Liang,P. and Luo,W.
  TITLE     Single-Cell RNA-Seq Analysis Identifies Angiotensinogen and Galanin
            as Unique Molecular Markers of Acinar Cells in Murine Salivary
            Glands
  JOURNAL   Stem Cells Dev 32 (23-24), 758-767 (2023)
   PUBMED   37823745
  REMARK    GeneRIF: Single-Cell RNA-Seq Analysis Identifies Angiotensinogen
            and Galanin as Unique Molecular Markers of Acinar Cells in Murine
            Salivary Glands.
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Guida,L.C., Charlton,P., Gilbert,D.J., Jenkins,N.A., Copeland,N.G.
            and Nicholls,R.D.
  TITLE     Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (3), 240-242 (1998)
   PUBMED   9501310
REFERENCE   6  (bases 1 to 806)
  AUTHORS   Chang,J.T., Milligan,S., Li,Y., Chew,C.E., Wiggs,J., Copeland,N.G.,
            Jenkins,N.A., Campochiaro,P.A., Hyde,D.R. and Zack,D.J.
  TITLE     Mammalian homolog of Drosophila retinal degeneration B rescues the
            mutant fly phenotype
  JOURNAL   J Neurosci 17 (15), 5881-5890 (1997)
   PUBMED   9221785
REFERENCE   7  (bases 1 to 806)
  AUTHORS   Good,D.J., Porter,F.D., Mahon,K.A., Parlow,A.F., Westphal,H. and
            Kirsch,I.R.
  TITLE     Hypogonadism and obesity in mice with a targeted deletion of the
            Nhlh2 gene
  JOURNAL   Nat Genet 15 (4), 397-401 (1997)
   PUBMED   9090387
REFERENCE   8  (bases 1 to 806)
  AUTHORS   Kofler,B., Liu,M.L., Jacoby,A.S., Shine,J. and Iismaa,T.P.
  TITLE     Molecular cloning and characterisation of the mouse preprogalanin
            gene
  JOURNAL   Gene 182 (1-2), 71-75 (1996)
   PUBMED   8982069
REFERENCE   9  (bases 1 to 806)
  AUTHORS   Xiang,M., Gan,L., Zhou,L., Klein,W.H. and Nathans,J.
  TITLE     Targeted deletion of the mouse POU domain gene Brn-3a causes
            selective loss of neurons in the brainstem and trigeminal ganglion,
            uncoordinated limb movement, and impaired suckling
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11950-11955 (1996)
   PUBMED   8876243
REFERENCE   10 (bases 1 to 806)
  AUTHORS   Lundkvist,J., Land,T., Kahl,U., Bedecs,K. and Bartfai,T.
  TITLE     cDNA sequence, ligand biding, and regulation of galanin/GMAP in
            mouse brain
  JOURNAL   Neurosci Lett 200 (2), 121-124 (1995)
   PUBMED   8614559
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL626765.22, AK133522.1 and
            BM900055.1.
            
            On Jul 22, 2016 this sequence version replaced NM_010253.3.
            
            Summary: This gene encodes a neuroendocrine peptide that is
            principally produced by a subpopulation of lactotrophs in the
            pituitary gland. The encoded protein is a precursor that is
            proteolytically processed to generate two mature peptides: galanin
            and galanin message-associated peptide (GMAP). Mice lacking the
            encoded protein fail to lactate sufficiently due to abnormalities
            in the expression of prolactin and lactotroph proliferation,
            exhibit attenuated chronic neuropathic pain and developmental
            deficits in the dorsal root ganglion neurons. This gene encodes
            distinct isoforms, some or all of which may undergo similar
            processing to generate the mature proteins. [provided by RefSeq,
            Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY729509.1, BC044055.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AL626765.22        197266-197337       c
            73-784              AK133522.1         2-713
            785-806             BM900055.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.16 cM"
     gene            1..806
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /note="galanin and GMAP prepropeptide"
                     /db_xref="GeneID:14419"
                     /db_xref="MGI:MGI:95637"
     exon            1..233
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            234..314
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            315..369
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            370..459
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            460..537
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            538..788
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      769..774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /note="hexamer: AATAAA"
     polyA_site      786
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggcg ctgagccggt gacgcggcag ctcccactgg gcataaatag cggcagcagc
       61 gcggctcctg ccacggacac gtcgagggat cctcgtgcgc ttccccatgc cgctgagctg
      121 cgccgtgcag taagcgacca tccagcccgc cactcttcac cacgcccgac ccggaccgag
      181 agagccttga tcctgcactg accagccacg cccggttctc accgctgctc aagatggcca
      241 gaggcagcgt tatcctgcta ggctggctcc tgttggttgt gaccctgtca gccactctgg
      301 gacttgggat gcctgcaaag gagaagagag gttggaccct gaacagcgct ggctaccttc
      361 tgggcccaca tgccattgac aaccacagat catttagcga caagcatggc ctcacaggca
      421 agagggagtt acaactggag gtggaggaaa ggagaccagg aagtgttgat gtgcccctgc
      481 ctgagagcaa cattgtccgc actataatgg agtttctcag tttcttgcac cttaaagagg
      541 ccggggccct cgacagcctg cctggcatcc ccttggccac ctcctcagaa gacctagaga
      601 agtcctgaga ccatgtccac tgtgcacgtg tgtcctgtgc tgtaatttaa agtcattcta
      661 ggctaagaag aatcttctgc caactcctca agccaatcgt ctgttctctg ctttgaagct
      721 gtgttatgat taagatgttt tgattggagt aattatattg tgtgacataa taaaaactag
      781 caagtatcaa aaaaaaaaaa aaaaaa
//
