LOCUS       NM_001395760            1892 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Mus musculus glutamate decarboxylase-like 1 (Gadl1), transcript
            variant 1, mRNA.
ACCESSION   NM_001395760 XM_036155340
VERSION     NM_001395760.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Raasakka,A., Mahootchi,E., Winge,I., Luan,W., Kursula,P. and
            Haavik,J.
  TITLE     Structure of the mouse acidic amino acid decarboxylase GADL1
  JOURNAL   Acta Crystallogr F Struct Biol Commun 74 (Pt 1), 65-73 (2018)
   PUBMED   29372909
  REMARK    GeneRIF: The crystal structure of GADL1 is described, together with
            a solution model based on small-angle X-ray scattering data. While
            the overall fold and the conformation of the bound PLP are similar
            to those in other PLP-dependent decarboxylases, GADL1 adopts a more
            loose conformation in solution, which might have functional
            relevance in ligand binding and catalysis.
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Liu,P., Ge,X., Ding,H., Jiang,H., Christensen,B.M. and Li,J.
  TITLE     Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine
            biosynthesis
  JOURNAL   J Biol Chem 287 (49), 40898-40906 (2012)
   PUBMED   23038267
  REMARK    GeneRIF: analysis of the role of glutamate decarboxylase-like
            protein 1 (GADL1) in taurine biosynthesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167467.1, AC133169.3 and AC131777.2.
            
            On Aug 9, 2021 this sequence version replaced XM_036155340.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164132,
                              SAMN01766828 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC167467.1         196238-196363
            127-299             AC133169.3         27739-27911
            300-426             AC133169.3         31871-31997
            427-517             AC133169.3         34769-34859
            518-624             AC133169.3         39256-39362
            625-740             AC133169.3         40095-40210
            741-820             AC133169.3         45169-45248
            821-875             AC133169.3         45380-45434
            876-992             AC133169.3         50954-51070
            993-1057            AC133169.3         56202-56266
            1058-1139           AC133169.3         56839-56920
            1140-1339           AC133169.3         97096-97295
            1340-1391           AC133169.3         112377-112428
            1392-1481           AC133169.3         121338-121427
            1482-1892           AC131777.2         1681-2091
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 68.25 cM"
     gene            1..1892
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /note="glutamate decarboxylase-like 1"
                     /db_xref="GeneID:73748"
                     /db_xref="MGI:MGI:1920998"
     exon            1..126
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1655
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutamate decarboxylase-like protein 1; aspartate
                     1-decarboxylase; cysteine sulfinic acid decarboxylase;
                     acidic amino acid decarboxylase GADL1"
                     /codon_start=1
                     /product="acidic amino acid decarboxylase GADL1 isoform 1"
                     /protein_id="NP_001382689.1"
                     /db_xref="GeneID:73748"
                     /db_xref="MGI:MGI:1920998"
                     /translation="MSHARDDHQGASQGDSGQKEMTPGKKIPIFVDGVVLNGPQTDVK
                     AGEKFVEEACRLIMEEVVLKATDVNEKVCEWQPPEQLRQLLDLEMRDTGESQDKLLKL
                     CQDVIHFSVKTNHPRFFNQLYAGLDYYSLAARIITEALNPSIYTYEVSPVFLLVEEAV
                     LKKMIECVGWKEGDGIFNPGGSVSNMCAMNLARYRHCPDIKEKGLSGLPRLILFTSAE
                     CHYSMKKAASFLGIGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCATSGT
                     TVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHK
                     MLMAGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAF
                     KFWMTWKALGTSGLEERVNRAFALSRYLVDEIKKREGFKLLMEPEYTNVCFWYIPPSL
                     REMEEGPEFWRKLSLVAPAIKEKMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDM
                     DFLLDEIDSLGRDM"
     exon            127..299
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            300..426
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            427..517
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            518..624
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            625..740
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            741..820
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            821..875
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            876..992
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1057
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1139
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1339
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1391
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1481
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1892
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="Gadl1"
                     /gene_synonym="1110027M19Rik; ADC; CSADC"
                     /note="major polyA site"
ORIGIN      
        1 gtcctggtct ctagtgtctc tgcctgcacc tgtgtgatcc agaacggcgc cccgctgcag
       61 ccccagcaga gaagccagga gccgagatga gccacgcccg cgacgaccac cagggtgcca
      121 gccaaggaga cagtggccag aaggagatga cccctggtaa gaagatcccc atctttgtgg
      181 atggggttgt acttaatgga cctcaaacag atgtgaaagc tggagaaaaa tttgttgaag
      241 aagcctgtag gctcataatg gaagaggtgg ttttgaaagc tacggacgtc aatgaaaagg
      301 tatgtgagtg gcagccccct gagcagctga ggcagctcct tgacctggag atgagggaca
      361 caggcgagtc acaggacaag ctgctgaaac tctgccaaga cgtcatccac ttcagcgtca
      421 aaaccaacca tccaagattt ttcaaccagc tctatgctgg ccttgattac tactccttgg
      481 cggcccggat tataacagag gcgctgaatc caagcattta tacgtatgag gtgtccccag
      541 tgtttctgtt agtggaagag gcggttctga agaaaatgat tgaatgtgtt ggctggaaag
      601 aaggggatgg aatatttaac ccaggtggct cagtgtccaa tatgtgtgca atgaatttag
      661 ctagatacag acattgccct gatatcaaag agaaaggcct gtctggtttg ccaagattaa
      721 tccttttcac atcggcagag tgccattact ccatgaagaa agcggcctcc ttccttggga
      781 ttggcactca gaacgtgtac tttgtagaaa cagatggaag aggaaaaatg ataccggagg
      841 atctggaaaa acaaatttgg caagcgagac aagagggggc ggtgccattt cttgtctgcg
      901 ccacctctgg taccaccgtg ctgggcgcat ttgaccccct ggatgagatt gctgaggtct
      961 gcgagaggca tggcctctgg ctccatgtgg atgcctcttg gggcggctca gctttggtgt
     1021 caagaaagca ccgccggctc ctgcatggca tccacagggc tgactcagtg gcctggaacc
     1081 cacacaagat gctgatggcg ggaatccagt gctctgctct acttgtcaag gacaaatctg
     1141 atcttcttaa gaagtgctac tctgccaaag caacgtacct gttccagcag gataaattct
     1201 atgatgtcag ctatgacacc ggagacaagt ccattcagtg cagcaggagg cctgatgcat
     1261 tcaagttctg gatgacctgg aaggctctgg gcacatcagg actcgaggag agagtaaatc
     1321 gtgcctttgc tctatctcgg tacctggtag acgaaatcaa gaaaagagaa ggcttcaagc
     1381 tgctgatgga gcctgaatat accaatgttt gcttttggta cattccaccg agtctcagag
     1441 agatggagga aggaccagag ttctggagaa agcttagctt ggtggcccca gccatcaagg
     1501 agaaaatgat gaagaaggga agtctgatgt tgggctacca gccccaccgg gggaaggtca
     1561 acttcttccg ccaggtggtc atcagccctc aagtgagccg ggaagacatg gacttcctgc
     1621 tggatgagat agacagcctg gggagagata tgtagccatg gctttcttac ccccaatggc
     1681 accactcctg tcctggggag ggtcacagat ccagtgcgtc tgaagacaca ctaggtagat
     1741 gacaatcctg gttcgattag gaaacatgtc cactcccccc ctcccccgaa aaccaaaatg
     1801 ctaagcaaat agtcctaagg gctctttggc tgcctgctgc tgctgtttgt atcatggaga
     1861 aagtagatgt aataaaaaat tattccctca aa
//
