LOCUS       NM_183358               1734 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus growth arrest and DNA-damage-inducible, gamma
            interacting protein 1 (Gadd45gip1), mRNA.
ACCESSION   NM_183358
VERSION     NM_183358.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Regina-Ferreira,L., Valdivieso-Rivera,F., Angelim,M.K.S.C., Menezes
            Dos Reis,L., Furino,V.O., Morari,J., Maia de Sousa,L.,
            Consonni,S.R., Sponton,C.H., Moraes-Vieira,P.M. and Velloso,L.A.
  TITLE     Inhibition of Crif1 protects fatty acid-induced POMC neuron-like
            cell-line damage by increasing CPT-1 function
  JOURNAL   Am J Physiol Endocrinol Metab 326 (5), E681-E695 (2024)
   PUBMED   38597829
  REMARK    GeneRIF: Inhibition of Crif1 protects fatty acid-induced POMC
            neuron-like cell-line damage by increasing CPT-1 function.
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Lee,S., Song,S.G., Kim,G., Kim,S., Yoo,H.J., Koh,J., Kim,Y.J.,
            Tian,J., Cho,E., Choi,Y.S., Chang,S., Shin,H.M., Jung,K.C.,
            Kim,J.H., Kim,T.M., Jeon,Y.K., Kim,H.Y., Shong,M., Kim,J.H. and
            Chung,D.H.
  TITLE     CRIF1 deficiency induces FOXP3LOW inflammatory non-suppressive
            regulatory T cells, thereby promoting antitumor immunity
  JOURNAL   Sci Adv 10 (13), eadj9600 (2024)
   PUBMED   38536932
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Heo,J.Y., Park,A.H., Lee,M.J., Ryu,M.J., Kim,Y.K., Jang,Y.S.,
            Kim,S.J., Shin,S.Y., Son,H.J., Stein,T.D., Huh,Y.H., Chung,S.K.,
            Choi,S.Y., Kim,J.M., Hwang,O., Shong,M., Hyeon,S.J., Lee,J.,
            Ryu,H., Kim,D. and Kweon,G.R.
  TITLE     Crif1 deficiency in dopamine neurons triggers early-onset
            parkinsonism
  JOURNAL   Mol Psychiatry 28 (10), 4474-4484 (2023)
   PUBMED   37648779
  REMARK    GeneRIF: Crif1 deficiency in dopamine neurons triggers early-onset
            parkinsonism.
            Erratum:[Mol Psychiatry. 2023 Oct;28(10):4485. doi:
            10.1038/s41380-023-02254-1.. PMID: 37783789]
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Lee,M.J., Zhu,J., An,J.H., Lee,S.E., Kim,T.Y., Oh,E., Kang,Y.E.,
            Chung,W. and Heo,J.Y.
  TITLE     A transcriptomic analysis of cerebral microvessels reveals the
            involvement of Notch1 signaling in endothelial
            mitochondrial-dysfunction-dependent BBB disruption
  JOURNAL   Fluids Barriers CNS 19 (1), 64 (2022)
   PUBMED   36028880
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Hong,H.J., Joung,K.H., Kim,Y.K., Choi,M.J., Kang,S.G., Kim,J.T.,
            Kang,Y.E., Chang,J.Y., Moon,J.H., Jun,S., Ro,H.J., Lee,Y., Kim,H.,
            Park,J.H., Kang,B.E., Jo,Y., Choi,H., Ryu,D., Lee,C.H., Kim,H.,
            Park,K.S., Kim,H.J. and Shong,M.
  TITLE     Mitoribosome insufficiency in beta cells is associated with type 2
            diabetes-like islet failure
  JOURNAL   Exp Mol Med 54 (7), 932-945 (2022)
   PUBMED   35804190
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Kim,S.J., Kwon,M.C., Ryu,M.J., Chung,H.K., Tadi,S., Kim,Y.K.,
            Kim,J.M., Lee,S.H., Park,J.H., Kweon,G.R., Ryu,S.W., Jo,Y.S.,
            Lee,C.H., Hatakeyama,H., Goto,Y., Yim,Y.H., Chung,J., Kong,Y.Y. and
            Shong,M.
  TITLE     CRIF1 is essential for the synthesis and insertion of oxidative
            phosphorylation polypeptides in the mammalian mitochondrial
            membrane
  JOURNAL   Cell Metab 16 (2), 274-283 (2012)
   PUBMED   22819524
  REMARK    GeneRIF: CRIF1 is essential for the synthesis and insertion of
            oxidative phosphorylation polypeptides in the mammalian
            mitochondrial membrane.
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Kwon,M.C., Koo,B.K., Kim,Y.Y., Lee,S.H., Kim,N.S., Kim,J.H. and
            Kong,Y.Y.
  TITLE     Essential role of CR6-interacting factor 1 (Crif1) in E74-like
            factor 3 (ELF3)-mediated intestinal development
  JOURNAL   J Biol Chem 284 (48), 33634-33641 (2009)
   PUBMED   19801644
  REMARK    GeneRIF: Results reveal that Crif1 is a novel and essential
            transcriptional coactivator of Elf3 for the terminal
            differentiation of absorptive enterocytes.
REFERENCE   8  (bases 1 to 1734)
  AUTHORS   Kwon,M.C., Koo,B.K., Moon,J.S., Kim,Y.Y., Park,K.C., Kim,N.S.,
            Kwon,M.Y., Kong,M.P., Yoon,K.J., Im,S.K., Ghim,J., Han,Y.M.,
            Jang,S.K., Shong,M. and Kong,Y.Y.
  TITLE     Crif1 is a novel transcriptional coactivator of STAT3
  JOURNAL   EMBO J 27 (4), 642-653 (2008)
   PUBMED   18200042
  REMARK    GeneRIF: Crif1 is a novel and essential transcriptional coactivator
            of STAT3 that modulates its DNA binding ability.
REFERENCE   9  (bases 1 to 1734)
  AUTHORS   Park,K.C., Song,K.H., Chung,H.K., Kim,H., Kim,D.W., Song,J.H.,
            Hwang,E.S., Jung,H.S., Park,S.H., Bae,I., Lee,I.K., Choi,H.S. and
            Shong,M.
  TITLE     CR6-interacting factor 1 interacts with orphan nuclear receptor
            Nur77 and inhibits its transactivation
  JOURNAL   Mol Endocrinol 19 (1), 12-24 (2005)
   PUBMED   15459248
REFERENCE   10 (bases 1 to 1734)
  AUTHORS   .
  TITLE     SOX9 and the switch hitting genes
  JOURNAL   Nat Genet 9 (1), 1-2 (1995)
   PUBMED   7704013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002738.1 and AK028227.1.
            
            On Nov 20, 2009 this sequence version replaced NM_183358.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028227.1, AK009723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-715               AK002738.1         7-721
            716-1734            AK028227.1         717-1735
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.19 cM"
     gene            1..1734
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /note="growth arrest and DNA-damage-inducible, gamma
                     interacting protein 1"
                     /db_xref="GeneID:102060"
                     /db_xref="MGI:MGI:1914947"
     exon            1..359
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..678
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /note="papillomavirus L2 interacting nuclear protein 1;
                     growth arrest and DNA damage-inducible
                     proteins-interacting protein 1; 39S ribosomal protein L59,
                     mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL64"
                     /protein_id="NP_899202.3"
                     /db_xref="CCDS:CCDS22478.1"
                     /db_xref="GeneID:102060"
                     /db_xref="MGI:MGI:1914947"
                     /translation="MAALAMRSGYLLRLSVALGPRSRSYRAPPPPRRRPGPHSPDPEN
                     LLTPRWQLTPRYVAKQFGRHGAISGVPPASLWPTPEQLRELEAEEQEWYPSLATMQES
                     LRLQQQALEARRQAREQRIAECMAKMPQMIENWRKQKRERWEKIQADKERRARLQAEA
                     QERLGYHVDPRSARFQELLQDLDKQQRKRLKEERQRQKKEARIAAMASAEAQDSAVSG
                     EPSS"
     exon            360..1734
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /note="hexamer: AATAAA"
     polyA_site      716
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /note="major polyA site"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
                     /note="hexamer: AATATA"
     polyA_site      1724
                     /gene="Gadd45gip1"
                     /gene_synonym="2310040G17Rik; Crif1; MRP-L59; Plinp1"
ORIGIN      
        1 acagccaaga tggcggcgct cgcaatgcgg agtggctatc tcctgcggct ctctgtggct
       61 ctgggtccca ggtcccgcag ctaccgtgcg cccccgcccc cgcgccgccg tcccgggccc
      121 cactcgccag acccggagaa cctgctgacc ccgcgatggc agctaacgcc ccgctatgtg
      181 gccaagcagt tcggacgaca tggcgccatc tccggggtgc ccccggcctc cctgtggccc
      241 accccagagc agctgcgcga gttggaggcc gaggagcaag aatggtaccc gagcttagcg
      301 accatgcaag agtcgctgcg cttgcagcag caggccttgg aggcaaggcg ccaagccagg
      361 gagcagcgta tcgcagagtg catggccaag atgccacaaa tgattgaaaa ctggcgaaag
      421 cagaagcgag aacgctggga gaaaattcag gctgacaagg agcggagggc ccggttacag
      481 gctgaggccc aggaacgcct gggctaccac gtggacccaa ggagtgctcg cttccaggaa
      541 ctattacagg acctagacaa gcagcaacga aagcgcctaa aggaagaaag acaacgacag
      601 aagaaggagg cacgaattgc tgctatggcc tctgctgaag cccaggactc agcagtgtct
      661 ggtgaaccca gctcctgaaa gctcccttcc caataaagcc agctgctgac aacccatatt
      721 ctacacattc tccctcaagt tgtgacttcc tgggtcgccc ggctcattcc ccaacacctg
      781 ggcgggagaa tccctccacc tggctgtgtt cacacctgga cactaggcca tgccatgaac
      841 tggggctttg gggagagaga aaggggaatg gatgggcaaa taatgaagga gcagatggca
      901 ggagaggagg aggcttctgt ttaccaacat taatctccag taattagcca attaccaggg
      961 ggagtacagc caaacagact gcatgataga aggagcagca gtccttctag ggttgagctg
     1021 aggcaggggc ccaagtttcc agagggagga gatgctgggg cccgtctgta aggctcctag
     1081 gctcctcccc gtttctcagc atgcccactt cacctgtgcc cccggctagc tcagactcac
     1141 aaacagctgt gagaagctcc agtaggcatg aaccattatt agggctcatt tttaaaactt
     1201 tattcacgtc aaaaccttta tcagagatgt ggttctgtcc tggggaaggg gtggccttgg
     1261 ccttcagaac tgatgataac cccttttcca ggctggaggc caaggccaga ctggggagaa
     1321 ggcctttggc ttctaacata gacttactcc agatggaaag atctgggcca ctccaataga
     1381 ggatcaaagc ttagggctcc agcttcccct catcatggtg gaggaaggag ggttgtcctt
     1441 ggggatgctt cagggatggg gaagcaggca ggcgcccctc catctggctg cagggagctg
     1501 ggacagaggc caagaggggc ccatctgtcg cctcatggtc ttgccaacaa cttttgagta
     1561 ggctgggctg ttaagaggac ggggacagct gtctggccca ggtcttctcg gactgatatg
     1621 ggaatggggg ccacttcagg agggtgggaa gctgggctgg gttttttttt gttgttgttt
     1681 ttttaatggt ttttgatatt cttcctctta aacatgaata tatatatgtt atat
//
