LOCUS       NM_011817               1081 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus growth arrest and DNA-damage-inducible 45 gamma
            (Gadd45g), mRNA.
ACCESSION   NM_011817
VERSION     NM_011817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Zhang,P., You,N., Ding,Y., Zhu,W., Wang,N., Xie,Y., Huang,W.,
            Ren,Q., Qin,T., Fu,R., Zhang,L., Xiao,Z., Cheng,T. and Ma,X.
  TITLE     Gadd45g insufficiency drives the pathogenesis of myeloproliferative
            neoplasms
  JOURNAL   Nat Commun 15 (1), 2989 (2024)
   PUBMED   38582902
  REMARK    GeneRIF: Gadd45g insufficiency drives the pathogenesis of
            myeloproliferative neoplasms.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Katano,W., Mori,S., Sasaki,S., Tajika,Y., Tomita,K., Takeuchi,J.K.
            and Koshiba-Takeuchi,K.
  TITLE     Sall1 and Sall4 cooperatively interact with Myocd and SRF to
            promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38014633
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Lu,B., Yu,H., Chow,C., Li,B., Zheng,W., Davis,R.J. and Flavell,R.A.
  TITLE     GADD45gamma mediates the activation of the p38 and JNK MAP kinase
            pathways and cytokine production in effector TH1 cells
  JOURNAL   Immunity 14 (5), 583-590 (2001)
   PUBMED   11371360
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Hoffmeyer,A., Piekorz,R., Moriggl,R. and Ihle,J.N.
  TITLE     Gadd45gamma is dispensable for normal mouse development and T-cell
            proliferation
  JOURNAL   Mol Cell Biol 21 (9), 3137-3143 (2001)
   PUBMED   11287618
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Azam,N., Vairapandi,M., Zhang,W., Hoffman,B. and Liebermann,D.A.
  TITLE     Interaction of CR6 (GADD45gamma) with proliferating cell nuclear
            antigen impedes negative growth control
  JOURNAL   J Biol Chem 276 (4), 2766-2774 (2001)
   PUBMED   11022036
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Zhang,W., Bae,I., Krishnaraju,K., Azam,N., Fan,W., Smith,K.,
            Hoffman,B. and Liebermann,D.A.
  TITLE     CR6: A third member in the MyD118 and Gadd45 gene family which
            functions in negative growth control
  JOURNAL   Oncogene 18 (35), 4899-4907 (1999)
   PUBMED   10490824
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Nakayama,K., Hara,T., Hibi,M., Hirano,T. and Miyajima,A.
  TITLE     A novel oncostatin M-inducible gene OIG37 forms a gene family with
            MyD118 and GADD45 and negatively regulates cell growth
  JOURNAL   J Biol Chem 274 (35), 24766-24772 (1999)
   PUBMED   10455148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126247.3.
            
            On Jul 22, 2009 this sequence version replaced NM_011817.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001989.1, AF055638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC126247.3         102793-102950
            159-260             AC126247.3         103470-103571
            261-474             AC126247.3         103674-103887
            475-1081            AC126247.3         103987-104593
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.36 cM"
     gene            1..1081
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /note="growth arrest and DNA-damage-inducible 45 gamma"
                     /db_xref="GeneID:23882"
                     /db_xref="MGI:MGI:1346325"
     exon            1..158
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..585
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /note="cytokine-responsive protein CR6; growth arrest and
                     DNA-damage-inducible, gamma"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 gamma"
                     /protein_id="NP_035947.2"
                     /db_xref="CCDS:CCDS26515.1"
                     /db_xref="GeneID:23882"
                     /db_xref="MGI:MGI:1346325"
                     /translation="MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVY
                     ESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLA
                     AIVGADEEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE"
     exon            159..260
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            261..474
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1081
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1062..1067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /note="hexamer: AATAAA"
     polyA_site      1081
                     /gene="Gadd45g"
                     /gene_synonym="CR6; DDIT2; OIG37"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcactcg ctggtggtgg gcgcgcatcg gactctggga atctttacct gcgctcgggt
       61 tccctccgca ctcttttgga taacttgctg ttcgtggatc gcacaatgac tctggaagaa
      121 gtccgtggcc aggatacagt tccggaaagc acagccagga tgcagggcgc cgggaaagca
      181 ctgcacgaac ttctgctgtc ggcgcagcgc cagggctgtc tgaccgctgg cgtctacgag
      241 tccgccaaag tcctgaatgt ggaccctgac aatgtgacct tttgcgtgct ggctgccgat
      301 gaagaagatg agggcgacat agcgctgcag atccatttca cgttgattca ggcgttctgc
      361 tgtgagaacg acattgatat cgtgcgcgtg ggagacgtgc agaggctggc ggcgatcgtg
      421 ggcgccgacg aagagggggg cgcgccggga gacctgcatt gcatcctcat ttcgaatcct
      481 aatgaggaca catggaagga ccctgccttg gagaagctca gtttgttctg cgaggagagc
      541 cgcagcttca acgactgggt gcccagcatc acccttcccg agtgacagcc tggcagggac
      601 cttggtctga tcgacttggt gacactctag cgcgctgctg gctctggagt ggccctccga
      661 gggcgctcga gtgcgcgtgg agactggcag gcgatgttgc ctggagagcg aggagcgcgg
      721 cctcccaaga agggggtctg gcggcagcgg ggacaccttg ttccgagccc aggactctgc
      781 cagtgtccgg agaggctgct agcacaggaa ggcctaggcg aggacgttgg ccccagggcc
      841 gggaagaacc gaccagcgag gcaggtgtga ctcagcaagc agccttccag tgaaaggagg
      901 ggaaagaaag gcaggcgacc gcctggactt ggtacagcgg caggagcggc cactgcagga
      961 gcgagctgga cttagccgac tgcactgctc tttcaaaaaa cggatcccgg gcaatgcttt
     1021 cattttctaa aggacgctat cgtggaagct ttgaatatca caataaactt attgaaacaa
     1081 a
//
