LOCUS       NM_008655               1305 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus growth arrest and DNA-damage-inducible 45 beta
            (Gadd45b), mRNA.
ACCESSION   NM_008655
VERSION     NM_008655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Mamontova,V., Trifault,B. and Burger,K.
  TITLE     Nono induces Gadd45b to mediate DNA repair
  JOURNAL   Life Sci Alliance 7 (8), e202302555 (2024)
   PUBMED   38843934
  REMARK    GeneRIF: Nono induces Gadd45b to mediate DNA repair.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Chathuranga,W.A.G., Nikapitiya,C., Kim,J.H., Chathuranga,K.,
            Weerawardhana,A., Dodantenna,N., Kim,D.J., Poo,H., Jung,J.U.,
            Lee,C.H. and Lee,J.S.
  TITLE     Gadd45beta is critical for regulation of type I interferon
            signaling by facilitating G3BP-mediated stress granule formation
  JOURNAL   Cell Rep 42 (11), 113358 (2023)
   PUBMED   37917584
  REMARK    GeneRIF: Gadd45beta is critical for regulation of type I interferon
            signaling by facilitating G3BP-mediated stress granule formation.
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Hori,T., Yokobori,K., Moore,R., Negishi,M. and Sueyoshi,T.
  TITLE     CAR requires Gadd45beta to promote phenobarbital-induced mouse
            liver tumors in early stage
  JOURNAL   Front Oncol 13, 1217847 (2023)
   PUBMED   37746289
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Xie,M., Xie,R., Huang,P., Yap,D.Y.H. and Wu,P.
  TITLE     GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin
            Regulators in Renal Ischemia-Reperfusion Injury
  JOURNAL   Int J Mol Sci 24 (14), 11304 (2023)
   PUBMED   37511062
  REMARK    GeneRIF: GADD45A and GADD45B as Novel Biomarkers Associated with
            Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1305)
  AUTHORS   Vairapandi,M., Balliet,A.G., Hoffman,B. and Liebermann,D.A.
  TITLE     GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role
            in S and G2/M cell cycle checkpoints induced by genotoxic stress
  JOURNAL   J Cell Physiol 192 (3), 327-338 (2002)
   PUBMED   12124778
  REMARK    GeneRIF: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors
            with a role in S and G2/M cell cycle checkpoints induced by
            genotoxic stress.
REFERENCE   7  (bases 1 to 1305)
  AUTHORS   Jin,R., De Smaele,E., Zazzeroni,F., Nguyen,D.U., Papa,S., Jones,J.,
            Cox,C., Gelinas,C. and Franzoso,G.
  TITLE     Regulation of the gadd45beta promoter by NF-kappaB
  JOURNAL   DNA Cell Biol 21 (7), 491-503 (2002)
   PUBMED   12162804
  REMARK    GeneRIF: participation of NF-kappaB in the regulation of Gadd45beta
REFERENCE   8  (bases 1 to 1305)
  AUTHORS   Balliet,A.G., Hatton,K.S., Hoffman,B. and Liebermann,D.A.
  TITLE     Comparative analysis of the genetic structure and chromosomal
            location of the murine MyD118 (Gadd45beta) gene
  JOURNAL   DNA Cell Biol 20 (4), 239-247 (2001)
   PUBMED   11403721
REFERENCE   9  (bases 1 to 1305)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 1305)
  AUTHORS   Abdollahi,A., Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Sequence and expression of a cDNA encoding MyD118: a novel myeloid
            differentiation primary response gene induced by multiple cytokines
  JOURNAL   Oncogene 6 (1), 165-167 (1991)
   PUBMED   1899477
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X54149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54149.1, AK149895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1305
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /note="growth arrest and DNA-damage-inducible 45 beta"
                     /db_xref="GeneID:17873"
                     /db_xref="MGI:MGI:107776"
     exon            1..269
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..708
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /note="negative growth regulatory protein MyD118; myeloid
                     differentiation primary response protein MyD118; myeloid
                     differentiation primary response gene 118"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 beta"
                     /protein_id="NP_032681.1"
                     /db_xref="CCDS:CCDS24038.1"
                     /db_xref="GeneID:17873"
                     /db_xref="MGI:MGI:107776"
                     /translation="MTLEELVASDNAVQKMQAVTAAVEQLLVAAQRQDRLTVGVYEAA
                     KLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDIDIVRVSGMQRLAQLL
                     GEPAETLGTTEARDLHCLLVTNCHTDSWKSQGLVEVASYCEESRGNNQWVPYISLEER
                     "
     exon            270..371
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /inference="alignment:Splign:2.1.0"
     exon            372..594
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1266
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /note="hexamer: AATAAA"
     polyA_site      1266
                     /gene="Gadd45b"
                     /gene_synonym="Myd118"
                     /note="major polyA site"
ORIGIN      
        1 ggtctgcgtt catctctgtc ttcttggatt aatttcgagg gggattttgc aatcttcttt
       61 ttacccctac ttttttcttg ggaagggaag tcccaccgcc tccggaaggc ctccgacact
      121 tctggtcgca cgggaaggtt tttttgcctc ttgggttcgt atctggactt gtactttgct
      181 cttggggatc ttccgtgggg gtccgctgtg gagtgtgact gcatcatgac cctggaagag
      241 ctggtggcga gcgacaacgc ggttcagaag atgcaggcgg tgactgccgc ggtggagcag
      301 ctgctggtgg ccgcgcagcg tcaggatcgc ctcaccgtgg gggtgtacga ggcggccaaa
      361 ctgatgaatg tggaccccga cagcgtggtc ttgtgcctcc tggccataga cgaagaagag
      421 gaggatgata tcgctctgca gattcacttc accctgatcc agtcgttctg ctgcgacaat
      481 gacattgaca tcgtccgggt atcaggcatg cagaggctgg cgcagctcct gggggagccg
      541 gcggagacat tgggcacaac cgaagcccga gacctgcact gcctcctggt cacgaactgt
      601 catacagatt cctggaaaag ccaaggcttg gtggaggtgg ccagttactg tgaagagagc
      661 agaggcaata accaatgggt cccctatatc tctctagagg aacgctgaga cccactccaa
      721 acatctaaag caactgtcga gttgctgtcc cctaaaaaaa gtaaataaaa tacatatttg
      781 acagccccct catcccccag aacaatccct caaaggctac cctacccgtg ataccttctg
      841 ggaggggcgg agtcaccgag actgagatga ggagaggggc acgtgcgccc gcccgccctc
      901 tgggctgtgg agccaggagc agcaccacag gtggtcgccg aggtcggaag gagggcacct
      961 caggcaagag gagactgaga ctttagagcc aaggcctggc agtcctgcag ccagcctctg
     1021 ctcgcagccg cagacggtct ggacaccgcc gcaggggtgg ggtgaggcgt cccccaccct
     1081 gcgggacagt gaactgtgca taagtcagcg gagggcgacg accctcgccg cgggacccgg
     1141 gactcgagcc cgggacttcg cagctacagc acatctattt ttaatattgt gctgagcaag
     1201 acagatcgct tgcatatttt taaaaatttc tactacagag acattccaat aaactcgtta
     1261 agccttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
