LOCUS       NM_007836               1224 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus growth arrest and DNA-damage-inducible 45 alpha
            (Gadd45a), mRNA.
ACCESSION   NM_007836
VERSION     NM_007836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   Grinan-Ferre,C., Jarne-Ferrer,J., Bellver-Sanchis,A.,
            Ribalta-Vilella,M., Barroso,E., Salvador,J.M., Jurado-Aguilar,J.,
            Palomer,X., Vazquez-Carrera,M. and Pallas,M.
  TITLE     Deletion of Gadd45a Expression in Mice Leads to Cognitive and
            Synaptic Impairment Associated with Alzheimer's Disease Hallmarks
  JOURNAL   Int J Mol Sci 25 (5), 2595 (2024)
   PUBMED   38473843
  REMARK    GeneRIF: Deletion of Gadd45a Expression in Mice Leads to Cognitive
            and Synaptic Impairment Associated with Alzheimer's Disease
            Hallmarks.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   You,W., Liu,S., Li,J., Tu,Y. and Shan,T.
  TITLE     GADD45A regulates subcutaneous fat deposition and lipid metabolism
            by interacting with Stat1
  JOURNAL   BMC Biol 21 (1), 212 (2023)
   PUBMED   37807064
  REMARK    GeneRIF: GADD45A regulates subcutaneous fat deposition and lipid
            metabolism by interacting with Stat1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Ross,J.A., Arcos-Villacis,N., Battey,E., Boogerd,C., Orellana,C.A.,
            Marhuenda,E., Swiatlowska,P., Hodzic,D., Prin,F., Mohun,T.,
            Catibog,N., Tapia,O., Gerace,L., Iskratsch,T., Shah,A.M. and
            Stroud,M.J.
  TITLE     Lem2 is essential for cardiac development by maintaining nuclear
            integrity
  JOURNAL   Cardiovasc Res 119 (11), 2074-2088 (2023)
   PUBMED   37067297
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Broustas,C.G., Mukherjee,S., Shuryak,I., Taraboletti,A.,
            Angdisen,J., Ake,P., Fornace,A.J. and Amundson,S.A.
  TITLE     Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral
            Blood
  JOURNAL   Radiat Res 200 (3), 296-306 (2023)
   PUBMED   37421415
  REMARK    GeneRIF: Impact of GADD45A on Radiation Biodosimetry Using Mouse
            Peripheral Blood.
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Xie,M., Xie,R., Huang,P., Yap,D.Y.H. and Wu,P.
  TITLE     GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin
            Regulators in Renal Ischemia-Reperfusion Injury
  JOURNAL   Int J Mol Sci 24 (14), 11304 (2023)
   PUBMED   37511062
  REMARK    GeneRIF: GADD45A and GADD45B as Novel Biomarkers Associated with
            Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Gage,P.J. and Camper,S.A.
  TITLE     Pituitary homeobox 2, a novel member of the bicoid-related family
            of homeobox genes, is a potential regulator of anterior structure
            formation
  JOURNAL   Hum Mol Genet 6 (3), 457-464 (1997)
   PUBMED   9147650
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Zhan,Q., Lord,K.A., Alamo,I. Jr., Hollander,M.C., Carrier,F.,
            Ron,D., Kohn,K.W., Hoffman,B., Liebermann,D.A. and Fornace,A.J. Jr.
  TITLE     The gadd and MyD genes define a novel set of mammalian genes
            encoding acidic proteins that synergistically suppress cell growth
  JOURNAL   Mol Cell Biol 14 (4), 2361-2371 (1994)
   PUBMED   8139541
REFERENCE   9  (bases 1 to 1224)
  AUTHORS   Alimzhanov,M.B., Kuprash,D.V., Turetskaia,R.L., Osipovich,O.A.,
            Borodulina,O.R., Osovskaia,V.S., Chumakov,P.M. and Nedospasov,S.A.
  TITLE     [Cloning and characteristics of murine genes coding for the human
            GADD45 analog--a protein induced in response to DNA damage]
  JOURNAL   Dokl Akad Nauk 333 (6), 788-791 (1993)
   PUBMED   7509226
REFERENCE   10 (bases 1 to 1224)
  AUTHORS   Hollander,M.C., Alamo,I., Jackman,J., Wang,M.G., McBride,O.W. and
            Fornace,A.J. Jr.
  TITLE     Analysis of the mammalian gadd45 gene and its response to DNA
            damage
  JOURNAL   J Biol Chem 268 (32), 24385-24393 (1993)
   PUBMED   8226988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L28177.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L28177.1, AK144900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.72 cM"
     gene            1..1224
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /note="growth arrest and DNA-damage-inducible 45 alpha"
                     /db_xref="GeneID:13197"
                     /db_xref="MGI:MGI:107799"
     exon            1..207
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..661
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /note="DDIT-1; DNA-damage-inducible transcript 1; DNA
                     damage-inducible transcript 1 protein; Gadd45alpha; growth
                     arrest and DNA-damage-inducible, alpha"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 alpha"
                     /protein_id="NP_031862.1"
                     /db_xref="CCDS:CCDS20217.1"
                     /db_xref="GeneID:13197"
                     /db_xref="MGI:MGI:107799"
                     /translation="MTLEEFSAAEQKTERMDTVGDALEEVLSKARSQRTITVGVYEAA
                     KLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIRAFCCENDINILRVSNPGRLAELL
                     LLENDAGPAESGGAAQTPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVI
                     NLPER"
     exon            208..309
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /inference="alignment:Splign:2.1.0"
     exon            310..547
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1224
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /note="hexamer: AATAAA"
     polyA_site      1220
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; GADD45"
                     /note="major polyA site"
ORIGIN      
        1 cagtggcccc gaggcagcag tgcagagttc cccagcgagg ctaggcgagc agccggccgg
       61 ccggagcgga gaagggaggg tgggagcgag cgcagagccg gcgccgcgca ctgtgggggc
      121 caggagcagc ccgcgcgccg agggagggac tcgcacttgc aatatgactt tggaggaatt
      181 ctcggctgca gagcagaaga ccgaaaggat ggacacggtg ggcgatgccc tggaggaagt
      241 gctcagcaag gctcggagtc agcgcaccat tacggtcggc gtgtacgagg ctgccaagct
      301 gctcaacgta gaccccgata acgtggtact gtgcctgctg gctgctgacg aagacgacga
      361 ccgggatgtg gctctgcaga tccatttcac cctcatccgt gcgttctgct gcgagaacga
      421 catcaacatc ctgcgggtca gcaacccggg tcggctagct gagctgctgc tactggagaa
      481 cgacgcgggc ccggcggaga gcgggggcgc cgcgcagacc ccggacctgc actgtgtgct
      541 ggtgacgaac ccacattcat cacaatggaa ggatcctgcc ttaagtcaac ttatttgttt
      601 ttgccgggaa agtcgctaca tggatcagtg ggtgcccgtg attaatctcc cggaacggtg
      661 atggcatccg aatggaaata actgaaccaa attgcactga agttttgaaa tacctttgta
      721 gttactcaag cagtcactcc ccacgctgat gcaaggatta cagaaactga tgtcaagggg
      781 ccgagttcaa ctgcacgagg gctcagagat gactttgcag agggagagag aggtgagcct
      841 gaagaaggaa gctgcgagaa aagagaaatc caaggcaaaa gggacaaaaa ctacaaagca
      901 ctgcaagaaa gaaaactgct aatttaggat ggccaggtta ctttcaaata agccaaatat
      961 tgctttgttg aaactttaaa tgtatagcaa tagtttgggt attttttttc tttttttttt
     1021 ttggtcttta tgccctcaaa taaaaggaaa gtaaaagagg attaatcata ttttcaagcc
     1081 acagtttaaa tgtattttga tgagatgtta aattctcaga agttttatta taaatcttac
     1141 taagttattt tatgatgtga aaggttattt atgataaagt ttttgaagca cattatctaa
     1201 aataaactgg tatggaataa ttgt
//
