LOCUS       NM_008078               5625 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus glutamic acid decarboxylase 2 (Gad2), mRNA.
ACCESSION   NM_008078
VERSION     NM_008078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5625)
  AUTHORS   Korympidou,M.M., Strauss,S., Schubert,T., Franke,K., Berens,P.,
            Euler,T. and Vlasits,A.L.
  TITLE     GABAergic amacrine cells balance biased chromatic information in
            the mouse retina
  JOURNAL   Cell Rep 43 (11), 114953 (2024)
   PUBMED   39509269
REFERENCE   2  (bases 1 to 5625)
  AUTHORS   Nemeth,D.P., Liu,X., Monet,M.C., Niu,H., Maxey,G., Schrier,M.S.,
            Smirnova,M.I., McGovern,S.J., Herd,A., DiSabato,D.J., Floyd,T.,
            Atluri,R.R., Nusstein,A.C., Oliver,B., Witcher,K.G., Juste
            Ellis,J.S., Yip,J., Crider,A.D., McKim,D.B.,
            Gajewski-Kurdziel,P.A., Godbout,J.P., Zhang,Q., Blakely,R.D.,
            Sheridan,J.F. and Quan,N.
  TITLE     Localization of brain neuronal IL-1R1 reveals specific neural
            circuitries responsive to immune signaling
  JOURNAL   J Neuroinflammation 21 (1), 303 (2024)
   PUBMED   39563437
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5625)
  AUTHORS   Min,R., Qin,Y., Kerst,S., Saiepour,M.H., van Lier,M. and
            Levelt,C.N.
  TITLE     Inhibitory maturation and ocular dominance plasticity in mouse
            visual cortex require astrocyte CB1 receptors
  JOURNAL   iScience 27 (12), 111410 (2024)
   PUBMED   39687028
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5625)
  AUTHORS   Choi,A., Kim,B., Labriola,E., Wiest,A., Wang,Y., Smith,J., Shin,H.,
            Jin,X., An,I., Hong,J., Antila,H., Thomas,S., Bhattarai,J.P.,
            Beier,K., Ma,M., Weber,F. and Chung,S.
  TITLE     Circuit mechanism underlying fragmented sleep and memory deficits
            in 16p11.2 deletion mouse model of autism
  JOURNAL   iScience 27 (12), 111285 (2024)
   PUBMED   39628570
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5625)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5625)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
REFERENCE   7  (bases 1 to 5625)
  AUTHORS   Velloso,L.A., Eizirik,D.L., Karlsson,F.A. and Kampe,O.
  TITLE     Absence of autoantibodies against glutamate decarboxylase (GAD) in
            the non-obese diabetic (NOD) mouse and low expression of the enzyme
            in mouse islets
  JOURNAL   Clin Exp Immunol 96 (1), 129-137 (1994)
   PUBMED   8149657
REFERENCE   8  (bases 1 to 5625)
  AUTHORS   Lee,D.S., Tian,J., Phan,T. and Kaufman,D.L.
  TITLE     Cloning and sequence analysis of a murine cDNA encoding glutamate
            decarboxylase (GAD65)
  JOURNAL   Biochim Biophys Acta 1216 (1), 157-160 (1993)
   PUBMED   8218409
REFERENCE   9  (bases 1 to 5625)
  AUTHORS   Jinnah,H.A., Gage,F.H. and Friedmann,T.
  TITLE     Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine
            phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan
            syndrome
  JOURNAL   Behav Neurosci 105 (6), 1004-1012 (1991)
   PUBMED   1777100
REFERENCE   10 (bases 1 to 5625)
  AUTHORS   Maxson,S.C. and Cowen,J.S.
  TITLE     Electroencephalographic correlates of the audiogenic seizure
            response of inbred mice
  JOURNAL   Physiol Behav 16 (5), 623-629 (1976)
   PUBMED   972955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ571205.1, BC018380.1 and AL928693.9.
            
            On Feb 7, 2007 this sequence version replaced NM_008078.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.35669.1,
                                           SRR1660821.37246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               BQ571205.1         109-393
            286-2385            BC018380.1         1-2100
            2386-5625           AL928693.9         64316-67555         c
FEATURES             Location/Qualifiers
     source          1..5625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.15 cM"
     gene            1..5625
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /note="glutamic acid decarboxylase 2"
                     /db_xref="GeneID:14417"
                     /db_xref="MGI:MGI:95634"
     exon            1..412
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            413..472
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            473..622
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            623..856
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            857..947
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1060
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1176
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1256
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1311
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1428
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1493
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1572
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1722
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1830
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1920
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..5625
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5602..5607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /note="hexamer: AATAAA"
     polyA_site      5623
                     /gene="Gad2"
                     /gene_synonym="6330404F12Rik; GAD(65); Gad-2; GAD65"
                     /note="major polyA site"
ORIGIN      
        1 tccctaaaaa tctcttgggc cctttccact ttccaatctc cagactgcga ggatcacggc
       61 tactcccccc atttaacctc ggcggcgcag agcacagcag cgcgtccctg cgccctgact
      121 ggaacataca aacacgcacg agcactggca tacgcagaca gcacgtttcc tgtccctgtg
      181 tgacacccac cctcgtcgcg ctgccgctcc agccctcgcg cggtgccctt ctcccgccac
      241 acgtactcgc acacgcacgc actctcgtgc agggtcgagg caaaggcagc ttgccacagc
      301 cacttggagg cgaccagcgc cagtctagca gaacccatgg cgtctcctgg ctccggcttt
      361 tggtccttcg gatctgaaga tggctctgcg gatcctgaga acccgggcac agcgagagcg
      421 tggtgccagg tggcccaaaa gttcacgggc ggcatcggaa acaagctgtg cgctctgctc
      481 tatggagact ccgggaagcc agcggagggc ggcgggagcg tgacctcgcg ggccgccacc
      541 gggaaggtcg cctgcacctg cgaccaaaaa ccctgcaact gccccaaagg ggatgtcaac
      601 tacgcgtttc tgcacgcaac agacctgctg ccagcgtgtg atggagaaag gcccactctg
      661 gcatttctac aagatgttat gaacattttg cttcagtacg tggtgaaaag tttcgataga
      721 tcaactaaag tgatcgattt ccattacccc aatgagcttc ttcaagagta taattgggaa
      781 ttggcagacc aaccgcaaaa tctggaggaa attttgacgc attgccaaac aactctaaaa
      841 tatgcaatta aaacagggca tccccgatat tttaatcagc tgtctactgg attggatatg
      901 gttggattag cagcagactg gttgacatca acagcaaaca ctaacatgtt cacctatgag
      961 atcgcccctg tatttgtgct gctagaatat gttacactaa agaaaatgag agaaatcatt
     1021 ggctggcccg ggggctctgg cgatggaatc ttttctcctg gtggcgccat ctccaacatg
     1081 tatgccatgc tcattgcccg ctataagatg tttccagaag tcaaggagaa ggggatggca
     1141 gcagtgccca ggctcatcgc gttcacatca gagcatagtc acttttctct caagaaggga
     1201 gctgcagcct tagggattgg aacagacagt gtgattctga ttaaatgtga cgagagaggg
     1261 aaaatgattc catctgatct tgaaagaaga atccttgaag tcaaacagaa aggatttgtt
     1321 cctttcctgg tgagtgccac agctggaacc accgtgtatg gggcttttga tcctctcttg
     1381 gctgtagctg acatctgcaa aaagtataag atctggatgc acgtggatgc tgcttggggt
     1441 ggagggttac tgatgtcccg gaaacacaag tggaagctga gtggagtaga gagggccaac
     1501 tctgtgacat ggaatcctca caagatgatg ggtgtcccct tgcagtgttc agctctcctg
     1561 gttagagagg agggactgat gcagagctgc aaccagatgc atgcttccta cctctttcag
     1621 caagataagc actatgacct gtcctatgac acaggagaca aggccttgca gtgtggacgc
     1681 catgtggatg tctttaaatt atggctcatg tggagagcaa aggggactac tgggtttgag
     1741 gcacacattg ataagtgttt ggagctagca gagtatttat acactatcat aaaaaaccga
     1801 gaaggctatg aaatggtgtt tgatgggaag cctcaacaca caaatgtctg cttctggttt
     1861 gtacctccta gtttgcgcac tctggaagac aatgaagaga gaatgagccg cctctcaaag
     1921 gtggcgccag tgattaaagc cagaatgatg gagtatggga ccacaatggt cagctaccaa
     1981 cccttagggg acaaggtcaa cttcttccgc atggtcatct caaaccctgc agcaactcac
     2041 caagacattg acttccttat tgaagaaatc gaacgcctcg gacaagattt gtaatcacct
     2101 cactcatcaa actgtttcag ttctctaggt agacagctaa gttgtcacaa actgtgtaaa
     2161 tgtatttgta gtttgttcca gaataattct atttctatat cgtggtgtca cagtagagta
     2221 cagtttaaaa aaatcaaaac cagtggggtg gtggtggcgc atgcctttaa tcccagcact
     2281 tgggaggcag aggcaggcag atttctaagt tcaaggccag cctggtctac aaagtgagtt
     2341 ccaggacagc cagggctaca cagagaaacc ctgtctcgaa aaaaaccaaa aaacaaagaa
     2401 atcaaaacca acaggaaaca tcactccttt ttaaaatcct ttcttaagtt tagaatacct
     2461 ctctaataat tagtgacaaa aggctgtgtt ctaatcagta agagaaagta taaaattgtt
     2521 ataaatactt cccttttaat atagtatgtt aatccaacct tattttcact tcagagcagt
     2581 agtaataaat agtgccaaat cacccttgaa tcataaaagg ttctctgggg tacagtgaaa
     2641 aggacaaagt aaatataaaa tgtatgtgga caagaaaaac tcttgccttt ttcatagtat
     2701 taggaaaaga atttctaatt tacctagagc aacatttcaa atgtatttaa atacatataa
     2761 ttttacaaaa gaaaaatata tattaaaaga aatcctattt tgtaacatat agattttatt
     2821 ttatatgggt tatacagact gcagaggcag atatgaaaca taagccagag ttatttcttt
     2881 acttttttct atctttcttc tcatggaggc acaataaaac actttagcaa gatagtttta
     2941 acatagaacc cacaaaattc ttttaaaatg taataactta ctttagaata cattgtggct
     3001 tatcatatcc ctaaagctag tatttcaaag caaacacaca caaaaatgaa acttctaaaa
     3061 acaattgaac agatcaacaa ttaagattct cttcctgttt agatgttgca ctagttgacc
     3121 tcgcagaccc tgtctagaag ccaggcaagc ccagcttgga cccagatcca ggcaagctcg
     3181 tccactctgc ttcccggcgg cctgctttca accaaaggtt gatattagtt cttgaagtgt
     3241 cttttcaaac catattcttt tattagatca tctggattaa ttaggaaaaa gggtgaaaat
     3301 aaaaccaaat cagccctagc aaagaggggt acagcacact ccttaagtgt gataagcaca
     3361 gaatattaaa cccagtcatg ggagtcgaga cctctgtatg acaagaatgg cttcctccca
     3421 gatgccattt tgctactgtc tggggaaagg gtcgtttgca tcccagatgc tctcttcttc
     3481 aaattccttc tccatcccac actttaaagt ctctcctgct agactccctg cccccagacc
     3541 cctagtaatg aattactatc ccatgtggct cttttccttt cctgaaatga gttcctcatg
     3601 caagcaattt caaggtagcc taagaacttc ttttatctgc ctcccatcaa gacccacagt
     3661 gactagaatg tgcagagatc gctaaaattc aaatcaagag tttgaaaata cgtttctttc
     3721 cctgtaaact ggatggagaa tgatcaacag ctcccatgat aactttaagt cacagatgaa
     3781 cagatctaag tgctggtaga actatggact tttacatgca aaaggcaagt accagtctgg
     3841 aagcattctc ccactccata tggatgggca ttttggtact cagaaagata caggaacaga
     3901 agaaagaagg ccctgtccct aactaccaca aatctttaca acttagccca gaccttattt
     3961 gactagacat actgatcctc agtatgactg tagctttggg cccttgctgt ctagacagcc
     4021 aaaaagaaaa caacctgtac accagagtgt catgaagtag gtcagcactc cctaatggac
     4081 aggcataact ttcctttcta gaacctggct gctgagagta aatatgcagc tgcccatcca
     4141 tcttgtgcct caggcccaca gatctcactt cccgggcaga gactcactta tcaaaccgag
     4201 tgtcccgctt agagaaggca gaagggccta ctgtctgata gatggaaagc ttagcccttg
     4261 ggggacagac ttagtagctc aagctggctt ctagtttgat gagatgacag aatttaaaaa
     4321 gttgtgtcca tgcacttttt gctagtgaat tggatctcca atccccttct tctccagatt
     4381 cttcctcaaa atttctagga gccttgctcg ggcatgcaaa tcttctcatc ctgtatccta
     4441 gaaaaggagg tacatgcatg cccagtactt taatagatcc tctacagcag ctctgccatc
     4501 cactcaggag agtgctaagg aaaatgggat gaaagagtaa taatggagta ataatggagg
     4561 gagactatat tgaacgttgg tccaaatccc cagtgccaat ggtctctatc tgtgattttt
     4621 ttttcttttt aaacattggt ttcagtttta atcagaattg atatgctaat ttttatttat
     4681 atagcaatat ttcatttatt atttaaaata cttgaaaaaa gtgcagtatg tgtttatcta
     4741 agacttctaa gtggtataga cttcatgttc tgtcacagga tttgaagaaa gaaaatcgtg
     4801 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgagtgttgc cgttagtaca
     4861 ttgttagtac tgtcttgtca cctcagattg aggttgtgca ctttatattg aattgtgtgg
     4921 tgttgcaaaa caacatgtgt tgctgtaaaa acttgcacaa tgtattacca gtgtgtcttc
     4981 ttctatgtgg tagttgtatt gaactttgaa ctttgaaatt atgagaacta catttgcatc
     5041 cattcctgtc cttgcctctc ttctaccctc accctttcac ccagtcccaa gctgtgtgcc
     5101 ctctccattg gctcttagag aaaacataac ctcaactaag tcccacccta agaaatctct
     5161 ttgacaactg tgtgatggca cacaaaatgc ttcatctctg aggccagaga aaccaattat
     5221 ggagcgtcac aggctgctga cagtgcaggt attgactcta cagggtcttg gagaaggtgc
     5281 tgctcctcag aacatggaca aaggatgcac aggtgtaaat atagtaacag gacaaagaag
     5341 caaaaacatc aaaccaggta tcatcttgca cgtgcttttc tgttttcaag tgctaaatgc
     5401 aaacactgtg tattaattag ttgtgtatgc aaagatcttg ttgccaaatg gtgtttctga
     5461 ataatgtcaa catttcccca gcaccactac attaactaaa gacagaaaaa ataaaataaa
     5521 aacaaatgtg gcaacctatg ctaccaaata taaacttgtg tatgatcaaa gtattttacc
     5581 tgtgttttct ctctaaaccc aaataaatgt gtaaatgtag acata
//
