LOCUS       NM_008075               2280 bp    mRNA    linear   ROD 20-JUN-2024
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit rho 1
            (Gabrr1), mRNA.
ACCESSION   NM_008075
VERSION     NM_008075.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2280)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2280)
  AUTHORS   Zhu,F., Feng,M., Sinha,R., Murphy,M.P., Luo,F., Kao,K.S., Szade,K.,
            Seita,J. and Weissman,I.L.
  TITLE     The GABA receptor GABRR1 is expressed on and functional in
            hematopoietic stem cells and megakaryocyte progenitors
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18416-18422 (2019)
   PUBMED   31451629
  REMARK    GeneRIF: GABRR1 is a rho subunit receptor of GABA, the major
            inhibitory neurotransmitter in the mammalian brain. The GABA
            receptor GABRR1 is expressed on and functional in hematopoietic
            stem cells and megakaryocyte progenitors.
REFERENCE   3  (bases 1 to 2280)
  AUTHORS   Dinamarca,M.C., Raveh,A., Schneider,A., Fritzius,T., Fruh,S.,
            Rem,P.D., Stawarski,M., Lalanne,T., Turecek,R., Choo,M.,
            Besseyrias,V., Bildl,W., Bentrop,D., Staufenbiel,M., Gassmann,M.,
            Fakler,B., Schwenk,J. and Bettler,B.
  TITLE     Complex formation of APP with GABAB receptors links axonal
            trafficking to amyloidogenic processing
  JOURNAL   Nat Commun 10 (1), 1331 (2019)
   PUBMED   30902970
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2280)
  AUTHORS   Travis,A.M., Heflin,S.J., Hirano,A.A., Brecha,N.C. and
            Arshavsky,V.Y.
  TITLE     Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is
            Conveyed through Wide-Field Amacrine Cells
  JOURNAL   J Neurosci 38 (3), 723-732 (2018)
   PUBMED   29217689
REFERENCE   5  (bases 1 to 2280)
  AUTHORS   Blednov,Y.A., Borghese,C.M., Ruiz,C.I., Cullins,M.A., Da Costa,A.,
            Osterndorff-Kahanek,E.A., Homanics,G.E. and Harris,R.A.
  TITLE     Mutation of the inhibitory ethanol site in GABAA rho1 receptors
            promotes tolerance to ethanol-induced motor incoordination
  JOURNAL   Neuropharmacology 123, 201-209 (2017)
   PUBMED   28623169
REFERENCE   6  (bases 1 to 2280)
  AUTHORS   Garrett-Sinha,L.A., Eberspaecher,H., Seldin,M.F. and de
            Crombrugghe,B.
  TITLE     A gene for a novel zinc-finger protein expressed in differentiated
            epithelial cells and transiently in certain mesenchymal cells
  JOURNAL   J Biol Chem 271 (49), 31384-31390 (1996)
   PUBMED   8940147
REFERENCE   7  (bases 1 to 2280)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
REFERENCE   8  (bases 1 to 2280)
  AUTHORS   Giros,B., Pohl,M., Rochelle,J.M. and Seldin,M.F.
  TITLE     Chromosomal localization of opioid peptide and receptor genes in
            the mouse
  JOURNAL   Life Sci 56 (18), PL369-PL375 (1995)
   PUBMED   7752808
REFERENCE   9  (bases 1 to 2280)
  AUTHORS   Taketo,M., Matsui,M., Rochelle,J.M., Yodoi,J. and Seldin,M.F.
  TITLE     Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene
            maps on chromosome 1
  JOURNAL   Genomics 21 (1), 251-253 (1994)
   PUBMED   8088797
REFERENCE   10 (bases 1 to 2280)
  AUTHORS   Cutting,G.R., Curristin,S., Zoghbi,H., O'Hara,B., Seldin,M.F. and
            Uhl,G.R.
  TITLE     Identification of a putative gamma-aminobutyric acid (GABA)
            receptor subunit rho2 cDNA and colocalization of the genes encoding
            rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and
            mouse chromosome 4
  JOURNAL   Genomics 12 (4), 801-806 (1992)
   PUBMED   1315307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF024620.1, BI736525.1 and AL670464.12.
            
            On Sep 7, 2007 this sequence version replaced NM_008075.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF024620.1, SRR7345562.4376589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AF024620.1         1-41
            42-138              BI736525.1         77-173
            139-373             AF024620.1         139-373
            374-772             BI736525.1         408-806
            773-1337            AF024620.1         773-1337
            1338-2226           AL670464.12        85713-86601         c
            2227-2280           AF024620.1         2227-2280
FEATURES             Location/Qualifiers
     source          1..2280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 14.68 cM"
     gene            1..2280
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /note="gamma-aminobutyric acid type A receptor subunit rho
                     1"
                     /db_xref="GeneID:14408"
                     /db_xref="MGI:MGI:95625"
     exon            1..220
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1541
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /note="gamma-aminobutyric acid receptor subunit rho-1;
                     GABA(A) receptor subunit rho-1; gamma-aminobutyric acid
                     (GABA) C receptor, subunit rho 1; GABA(C) receptor;
                     gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1;
                     GABAAR subunit rho-1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit rho-1
                     precursor"
                     /protein_id="NP_032101.3"
                     /db_xref="CCDS:CCDS18021.2"
                     /db_xref="GeneID:14408"
                     /db_xref="MGI:MGI:95625"
                     /translation="MLAVQNMKFGIFLLWWGWVLAAESTAHWPGREVHEPSRKGSRPQ
                     RQRRGAHDDAHKQGSPILRRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGV
                     DVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSSNNLSMTFDGRLVKKIWVPDMF
                     FVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIE
                     SYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINF
                     TLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNA
                     SMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISCTCGLPQ
                     PRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKGQRGSYVSMR
                     INTHAIDKYSRIIFPAAYILFNLIYWSIFS"
     exon            221..274
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            275..381
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            382..449
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            450..673
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            674..756
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            757..897
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1050
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1247
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..2251
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /note="hexamer: AATAAA"
     polyA_site      2251
                     /gene="Gabrr1"
                     /gene_synonym="GABA-C"
                     /note="major polyA site"
ORIGIN      
        1 aacaaacaca gcaatgatgc cttaagagag ggcgggcggc aactcctcac cggctccttc
       61 tcacggcttc ttgggagaac cgtttgattt gggaatctat gttggctgtc cagaatatga
      121 aatttggcat attccttttg tggtggggat gggttctggc tgctgagagc acagcgcact
      181 ggccaggaag agaagttcat gagccatcta ggaaaggcag cagacctcag agacagagac
      241 gaggagcaca cgacgatgcc cacaagcaag gcagcccaat cctgagacga agctctgaca
      301 taaccaagtc tcctctcacc aagtctgagc agctgctgag gatagacgac catgatttca
      361 gcatgaggcc tggttttgga ggcccagcca ttcctgtggg cgtggatgtg caggtggaga
      421 gcctggacag catctcagag gttgacatgg acttcaccat gacgctatat ttgaggcact
      481 actggaagga cgagagactg tctttcccca gctccaacaa cctcagcatg acctttgatg
      541 gccgacttgt aaagaagatc tgggttcccg acatgttctt tgtgcactcc aaacgctcct
      601 tcatccacga caccaccaca gacaacgtca tgctgcgcgt ccagccagac ggcaaagtgc
      661 tctacagcct cagagttaca gtgaccgcga tgtgcaacat ggacttcagc aggtttcccc
      721 tggacacaca gacctgctct ctggaaatcg aaagctacgc ttatacggaa gacgacctaa
      781 tgctgtactg gaaaaaaggc aatgactcct taaagacaga tgagaggatc tccctctctc
      841 agttcctcat tcaagaattc cacaccacca caaaactagc cttctacagc agtacaggct
      901 ggtacaaccg tctgtacatc aacttcactc tgcgtcgtca catcttcttc ttcttgctcc
      961 aaacctactt tcctgccacc ctcatggtca tgctgtcctg ggtgtctttc tggatcgacc
     1021 gcagagctgt gcctgctaga gtccccttag gcatcaccac ggtgctgacc atgtccacca
     1081 tcatcacggg cgtgaatgcc tccatgcccc gagtgtccta catcaaagct gtggacatct
     1141 acctctgggt cagctttgtg ttcgtcttcc tctccgtgct ggagtacgca gctgtcaact
     1201 acctgaccac agtgcaggag cggaaggaac ggaagcttcg ggagaagatc tcctgcacct
     1261 gtgggctgcc ccagcctcga ggggtgatgc tggacagcag ctacagtgat ggagaggtga
     1321 acgacctggg cggctacatg cctgagaacg gagagaaacc cgaccggatg atggtgcagc
     1381 tgactctggc ctctgagagg ggctctccac agaggaaggg ccagagaggc agctatgtga
     1441 gcatgaggat caacactcac gccattgata aatactcaag gatcattttc ccagccgctt
     1501 acattttatt caatctgata tactggtcaa ttttctctta gatgcctgta attgtgtatg
     1561 tctcagcatg tcctacagaa gttgctgtga aatgaaaatt agggcttaaa gccatcccac
     1621 tgggttttca ctgtcccctt ttcagctatt caaagctgca ctgacaagac acctctgttt
     1681 gcacttatta aatatcagtt ctctacacaa cattatacta ggtgttgcag gaagttgcca
     1741 tgatagtacc tgacattagc tgctcccaga tccaggaaaa gcacagagga catatggaca
     1801 tgtcgcaatc aggagcccct gactctgttc acattgaggg gtttcttcat cagtggactg
     1861 tgttctttag actaggtagc tctgggaagt acctaaataa aatgcgtttg cattgagccc
     1921 acaggcccat aaaccccttc tgatgaaagg ccaggcttca gggtctctgc acctgctcgc
     1981 atccccggta cttaatgaaa ggcagtggtg ctcacaggat ctcctttttt ttcaagctgt
     2041 gcatttgttt ccttataaga aacactcttt aaattgctga gatttcccta gcagagaaac
     2101 tctggagata tggatacatg tatcatttcg tctgttttgt ggaggtgact aagctggaga
     2161 actctcttcc tttccctgtc ctctagtcac tgttgcctgc ctctccacca cggagcaggt
     2221 gctttcttca aaataaagtc ttttctcagt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
