LOCUS       NM_020488               2258 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit theta
            (Gabrq), transcript variant 2, mRNA.
ACCESSION   NM_020488
VERSION     NM_020488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Mo,J., Kim,C.H., Lee,D., Sun,W., Lee,H.W. and Kim,H.
  TITLE     Early growth response 1 (Egr-1) directly regulates GABAA receptor
            alpha2, alpha4, and theta; subunits in the hippocampus
  JOURNAL   J Neurochem 133 (4), 489-500 (2015)
   PUBMED   25708312
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Guo,Z., Zhao,C., Huang,M., Huang,T., Fan,M., Xie,Z., Chen,Y.,
            Zhao,X., Xia,G., Geng,J. and Cheng,L.
  TITLE     Tlx1/3 and Ptf1a control the expression of distinct sets of
            transmitter and peptide receptor genes in the developing dorsal
            spinal cord
  JOURNAL   J Neurosci 32 (25), 8509-8520 (2012)
   PUBMED   22723691
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Li,Y.H., Liu,Y., Li,Y.D., Liu,Y.H., Li,F., Ju,Q., Xie,P.L. and
            Li,G.C.
  TITLE     GABA stimulates human hepatocellular carcinoma growth through
            overexpressed GABAA receptor theta subunit
  JOURNAL   World J Gastroenterol 18 (21), 2704-2711 (2012)
   PUBMED   22690081
  REMARK    GeneRIF: GABRQ plays important roles in hepatocellular carcinoma
            development and progression
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671908.8 and AF189260.1.
            
            On Mar 13, 2014 this sequence version replaced NM_020488.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (b)
            has a distinct C-terminus and is longer than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189260.1, BC119074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL671908.8         50464-50721
            259-2258            AF189260.1         1-2000
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.29 cM"
     gene            1..2258
                     /gene="Gabrq"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     theta"
                     /db_xref="GeneID:57249"
                     /db_xref="MGI:MGI:1888498"
     exon            1..427
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2195
                     /gene="Gabrq"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; gamma-aminobutyric acid receptor subunit theta;
                     gamma-aminobutyric acid (GABA) A receptor, subunit theta;
                     GABAAR subunit theta"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit theta
                     isoform b precursor"
                     /protein_id="NP_065234.1"
                     /db_xref="CCDS:CCDS30188.1"
                     /db_xref="GeneID:57249"
                     /db_xref="MGI:MGI:1888498"
                     /translation="MGIRGMLRAAALLLLIRTWLAESNGPSPTPKFHFELSSSTPEVI
                     LDLFNCKNCANEAVVQKILDRVLSTYDVRLRPNFGGAPVPVSVSIYVSSIEQISEINM
                     DYTITMFLHQTWKDTRLAYYETNLNLTLDYRMHEKLWVPDCYFVNSKDAFVHDVTVEN
                     RVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDD
                     NAIHITDGLHIPQYTYLGRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTV
                     LTTILSWISFWMNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVC
                     LFFVFLSLLEYVYINYLFFSQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVE
                     DRVEDRAGPLPDSPMQAHLASQESLGSLVFTSEQAQLATSESLSLLSSASSQTQLATG
                     ESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPIKIHSRSDACDDEDSEESLSSEESHG
                     HGSSHTGRLKLQISQRCVQEASWDLDKIEILQDDISITSSWLGLDEQCKGDADSIWSL
                     TDEELMACDQEKDSSSESEENCSPSPGCSFNEGFSFQLFKPNRVPKVDRWSRFLFPLS
                     FGLFNVVYWLYHVY"
     exon            428..516
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            517..584
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            585..805
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            806..888
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1023
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1176
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1433
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2258
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcagcc ctgagcggtg ccagacgaag cgcaccttgc agtggcacgc cctgtggacc
       61 gctgcggggg ggcagagctg ctgcggagcc actgttcttt caggccctgg actccggaga
      121 gaccccatac tccctacttc cttcaggtct ctccttaggg tcccgattct gcggaaggac
      181 tagcgattcc gccccttttg cccggttctg actcgctccc accccaaccc tgtccccttt
      241 tccagctgtc cgctgcggtc cccaagagca ctgcagccat gggcatccga ggtatgctgc
      301 gagccgctgc gctcctgctg ctcattagga cttggctggc agagagtaac ggccccagtc
      361 ccaccccgaa attccacttc gagctctcct ccagcacgcc tgaagtcatt ctggatctct
      421 tcaactgcaa aaactgtgca aatgaagctg tggttcaaaa gattttggac agggtgctgt
      481 caacatatga tgtccgactt agaccaaatt ttggaggagc tcctgtgcct gtgtcagtat
      541 ctatctatgt gtccagtatt gaacagatct cagaaataaa tatggactat acaatcacaa
      601 tgtttttgca tcagacctgg aaggacacac gcttagctta ctatgaaacc aacctaaacc
      661 tgaccctgga ttatcggatg catgagaagc tctgggttcc tgactgctac tttgtgaata
      721 gcaaagatgc ctttgtgcat gatgtaactg tggagaatcg tgtatttcaa cttcacccag
      781 atgggacagt gcgatatggc atccgactta ccacaacagc agcctgttcc ctggatctgc
      841 aaaaattccc tatggacaaa caatcctgca agctggaggt ggagagctat ggctacactg
      901 tcgaagacat tgtgttatcc tgggaagatg ataatgccat ccacattact gatgggctgc
      961 atatccctca gtacacgtac ctggggagaa caattaccag caaggaagtg tacttctaca
     1021 caggctccta catgcgcctg atagtgaagt tccaggttca gagggaagtc cgcagttacc
     1081 ttgtgcaggt ctattggccc acggtcctca ccaccattct ctcctggata tcattttgga
     1141 tgaactatga ttcctctgca gccagggtaa ctattggact aacttcgatc cttgtcctga
     1201 ctaccatcga ctcacatatg cgggataaac tcccccatat ttcctgtatc aaagctattg
     1261 acatctacat ccttgtatgc ctattcttcg ttttcctgtc actgctggag tatgtctaca
     1321 tcaactacct tttcttcagc caagtacctc ggcgtaatca cagaagatgc aggaaaccca
     1381 ggagagttgt tgcccgatac cgctaccaag aagtggtggt agcaaatgtg caggatggcc
     1441 tgattaatgt ggaagacaga gtagaagaca gagctggtcc ccttcctgac agccccatgc
     1501 aggctcatct ggcaagccag gaaagtctag gatccttggt gttcacatca gagcaggccc
     1561 agctggctac ctcagaaagt ctcagtctac tctcttctgc ctcaagccag actcaattgg
     1621 ccactggaga aagcctgagt gatctgccct ccacctctga gcaaacagtg cctgagtgta
     1681 ccattcactt tcatggcttt cttactaatg acagtattat ccccatcaaa atccacagcc
     1741 gatctgatgc ctgtgatgat gaagactccg aagaaagcct aagctctgag gagagccatg
     1801 gccatggaag cagccacact ggaaggctca agctccagat tagccagagg tgtgtgcaag
     1861 aagcaagttg ggaccttgat aaaattgaga tcttacagga tgacatcagt atcacgagca
     1921 gctggcttgg ccttgatgaa caatgcaagg gggatgctga cagtatctgg agccttactg
     1981 atgaggagct catggcctgt gaccaagaga aggacagtag ctcagagtct gaggagaatt
     2041 gctccccaag ccctgggtgc tccttcaatg aagggttctc ttttcagctc tttaaaccta
     2101 accgggtccc caaggttgat agatggtccc gtttcctctt tcctctttcc tttgggctgt
     2161 tcaatgtggt ttactggtta taccatgtct attagtttct catacaccac agccgcggag
     2221 atactatgat atgtttcctt tatggtttct tcgggttt
//
