LOCUS       NM_001290435            4943 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit theta
            (Gabrq), transcript variant 1, mRNA.
ACCESSION   NM_001290435 XM_006528174
VERSION     NM_001290435.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Mo,J., Kim,C.H., Lee,D., Sun,W., Lee,H.W. and Kim,H.
  TITLE     Early growth response 1 (Egr-1) directly regulates GABAA receptor
            alpha2, alpha4, and theta; subunits in the hippocampus
  JOURNAL   J Neurochem 133 (4), 489-500 (2015)
   PUBMED   25708312
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Guo,Z., Zhao,C., Huang,M., Huang,T., Fan,M., Xie,Z., Chen,Y.,
            Zhao,X., Xia,G., Geng,J. and Cheng,L.
  TITLE     Tlx1/3 and Ptf1a control the expression of distinct sets of
            transmitter and peptide receptor genes in the developing dorsal
            spinal cord
  JOURNAL   J Neurosci 32 (25), 8509-8520 (2012)
   PUBMED   22723691
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Li,Y.H., Liu,Y., Li,Y.D., Liu,Y.H., Li,F., Ju,Q., Xie,P.L. and
            Li,G.C.
  TITLE     GABA stimulates human hepatocellular carcinoma growth through
            overexpressed GABAA receptor theta subunit
  JOURNAL   World J Gastroenterol 18 (21), 2704-2711 (2012)
   PUBMED   22690081
  REMARK    GeneRIF: GABRQ plays important roles in hepatocellular carcinoma
            development and progression
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671908.8, AK038859.1 and AK164837.1.
            
            On Mar 13, 2014 this sequence version replaced XM_006528174.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156674.1, AK038859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL671908.8         50464-50553
            91-2570             AK038859.1         2-2481
            2571-4940           AK164837.1         963-3332
            4941-4943           AL671908.8         67886-67888
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.29 cM"
     gene            1..4943
                     /gene="Gabrq"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     theta"
                     /db_xref="GeneID:57249"
                     /db_xref="MGI:MGI:1888498"
     exon            1..427
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1856
                     /gene="Gabrq"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit theta;
                     gamma-aminobutyric acid (GABA) A receptor, subunit theta;
                     GABAAR subunit theta"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit theta
                     isoform a precursor"
                     /protein_id="NP_001277364.1"
                     /db_xref="CCDS:CCDS72390.1"
                     /db_xref="GeneID:57249"
                     /db_xref="MGI:MGI:1888498"
                     /translation="MGIRGMLRAAALLLLIRTWLAESNGPSPTPKFHFELSSSTPEVI
                     LDLFNCKNCANEAVVQKILDRVLSTYDVRLRPNFGGAPVPVSVSIYVSSIEQISEINM
                     DYTITMFLHQTWKDTRLAYYETNLNLTLDYRMHEKLWVPDCYFVNSKDAFVHDVTVEN
                     RVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDD
                     NAIHITDGLHIPQYTYLGRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTV
                     LTTILSWISFWMNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVC
                     LFFVFLSLLEYVYINYLFFSQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVE
                     DRVEDRAGPLPDSPMQAHLASQESLGSLVFTSEQAQLATSESLSLLSSASSQTQLATG
                     ESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPIKIHSRSDACDDEDSEESLSSEESHG
                     HGSSHTGRLKLQISQSA"
     exon            428..516
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            517..584
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            585..805
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            806..888
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1023
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1176
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1433
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1849
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..4943
                     /gene="Gabrq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcagcc ctgagcggtg ccagacgaag cgcaccttgc agtggcacgc cctgtggacc
       61 gctgcggggg ggcagagctg ctgcggagcc actgttcttt caggccctgg actccggaga
      121 gaccccatac tccctacttc cttcaggtct ctccttaggg tcccgattct gcggaaggac
      181 tagcgattcc gccccttttg cccggttctg actcgctccc accccaaccc tgtccccttt
      241 tccagctgtc cgctgcggtc cccaagagca ctgcagccat gggcatccga ggtatgctgc
      301 gagccgctgc gctcctgctg ctcattagga cttggctggc agagagtaac ggccccagtc
      361 ccaccccgaa attccacttc gagctctcct ccagcacgcc tgaagtcatt ctggatctct
      421 tcaactgcaa aaactgtgca aatgaagctg tggttcaaaa gattttggac agggtgctgt
      481 caacatatga tgtccgactt agaccaaatt ttggaggagc tcctgtgcct gtgtcagtat
      541 ctatctatgt gtccagtatt gaacagatct cagaaataaa tatggactat acaatcacaa
      601 tgtttttgca tcagacctgg aaggacacac gcttagctta ctatgaaacc aacctaaacc
      661 tgaccctgga ttatcggatg catgagaagc tctgggttcc tgactgctac tttgtgaata
      721 gcaaagatgc ctttgtgcat gatgtaactg tggagaatcg tgtatttcaa cttcacccag
      781 atgggacagt gcgatatggc atccgactta ccacaacagc agcctgttcc ctggatctgc
      841 aaaaattccc tatggacaaa caatcctgca agctggaggt ggagagctat ggctacactg
      901 tcgaagacat tgtgttatcc tgggaagatg ataatgccat ccacattact gatgggctgc
      961 atatccctca gtacacgtac ctggggagaa caattaccag caaggaagtg tacttctaca
     1021 caggctccta catgcgcctg atagtgaagt tccaggttca gagggaagtc cgcagttacc
     1081 ttgtgcaggt ctattggccc acggtcctca ccaccattct ctcctggata tcattttgga
     1141 tgaactatga ttcctctgca gccagggtaa ctattggact aacttcgatc cttgtcctga
     1201 ctaccatcga ctcacatatg cgggataaac tcccccatat ttcctgtatc aaagctattg
     1261 acatctacat ccttgtatgc ctattcttcg ttttcctgtc actgctggag tatgtctaca
     1321 tcaactacct tttcttcagc caagtacctc ggcgtaatca cagaagatgc aggaaaccca
     1381 ggagagttgt tgcccgatac cgctaccaag aagtggtggt agcaaatgtg caggatggcc
     1441 tgattaatgt ggaagacaga gtagaagaca gagctggtcc ccttcctgac agccccatgc
     1501 aggctcatct ggcaagccag gaaagtctag gatccttggt gttcacatca gagcaggccc
     1561 agctggctac ctcagaaagt ctcagtctac tctcttctgc ctcaagccag actcaattgg
     1621 ccactggaga aagcctgagt gatctgccct ccacctctga gcaaacagtg cctgagtgta
     1681 ccattcactt tcatggcttt cttactaatg acagtattat ccccatcaaa atccacagcc
     1741 gatctgatgc ctgtgatgat gaagactccg aagaaagcct aagctctgag gagagccatg
     1801 gccatggaag cagccacact ggaaggctca agctccagat tagccagagt gcatagtaag
     1861 tgtcaacgag ctccctgacc catcacatcg ttggatcctc acaggagccc tgtgagccag
     1921 ggaagacaaa gcaccttgtc cccagtgttc caaggaaaat gtggagcttg tgtgccatgc
     1981 ttaaagatgc ttgttctttt ccttatctgc ttaactctca actaactgcc ccttccctgt
     2041 gctcaagctg ccaagctcat ggacagcacc cggaacatct ctatatgaag aggccagctg
     2101 gtgaacatgg agcctactca gcagggctcc tgataagagt gggatgagcc tgtacaccaa
     2161 ctttccagga agcaccagct tattgatgga ggtcatgagg gagctttccc aagcactcaa
     2221 cctatatccc cccttcctct ataggcagcc tctccttcag ccctatactc ctctgcccac
     2281 ccgccttctt aagtatactc ctgtacttct atatttatat gtttctgcgt atctctgagg
     2341 atgactatgt atgtattcag gtaggtatat gtgctatcca tacaaccatc tgagaagctg
     2401 tactagtgcc aatctacact gtgtggataa atagtatgta tgcatctcta tgagagtgtc
     2461 acttgtagtg tcacttatag taacagagct gaatgcattc tgcatacatt catagaatgt
     2521 gcatgtctat atacctgtgt ttgtcaaagt tagttagtgt aaaaggatat acataaaaaa
     2581 aaaaaaacac atgtattccc tttaggaggt tcttgtagaa acagcatgac tctagtgacc
     2641 tgttttagca gagtggggac agtcttagtt agctggactg attaactctt tcttttcagt
     2701 tcttgagagc caggtggacc tattggtaaa gtacatttgt agctaatcct tggacaggct
     2761 tggctgcttg aacaggccca caaatctacc ttgtgtttgg agtttgaaca ttccttactt
     2821 taacttgatt ccgggaaaga ctcagagaag taaaaatgga caggagaact aagtactgaa
     2881 tagatgatct cagtattgtc tcttgtccat gcataggcac aattctagcc ttttatgcat
     2941 acacacccag acacatatac ctactccatt acatgtgcat acatatattt catgagcacc
     3001 cacgcactgg gttatattta caagcatgtc cagatatata cacacacaaa taaacacaca
     3061 cacacacata cttttaaaac aactcaaaac aaggatattt ttaccaaaat atctaagatt
     3121 gtttatttgg ggggcggggg gagaacccag cataaaacgg tccagattaa agggagagca
     3181 aaagctctcc tctggaatct gagcattcgt tagatgtgca cttggatctg gagacctata
     3241 taatcttgta gtgttgaaca catcactgga ctaaagttac taagagggat tagagtagtg
     3301 ggaccaacga taaagtagag aagaggcaga gaggccagtt gtaaatatcc atgtagctag
     3361 atatagcata ccctaaaaag actattttgc cctaatgtgc tgcaatgaga gcagttaaac
     3421 tgcaattcat actatgtgag gttacatgta ccatggagat ctggtaatga cagcttttca
     3481 ggaacttgaa tcatctgggt tgtttttgtt tttttgtttt ttgtttttgt tgttgttgtt
     3541 gttgttgttg ttgttgttgt tatttttcat ggctatggtc tttcttactt gaaagttgcc
     3601 agatctctcc ttgtattctc tgtgtggtct gttgtttatc ttcattaagc cctgtatcct
     3661 gctgccctca gccccttttc agccatacag gcacaccctc tctattggct gcctatgtct
     3721 cctcccaaac ttcctccaac accaagtagt tgttgaagtg cagagcatct gagcagtgct
     3781 cctgaggttc agtcagtcca acagcttgga aagaaggaag agccttacta agtctgagat
     3841 ggagcaaccc cactttacta ctctattctg tcttgtctta ccctctcctg tccccctaga
     3901 attcctgtct gagaaagacc ccagctttct gtctttccaa tgcatcattt tattgtagaa
     3961 atatgtgata taattcctgc ccagcttgat ttgcactgtg gggtgtctct gcagagtttg
     4021 gccattgtag tcttacaatt tgtatcatcc ttattcatag caaggctgca aactcttgac
     4081 atacctaaac caagttttgc tgagattgtg accattccta atgaggattc cttactctgt
     4141 atatacagca gcaatgcttt caagctatta agtactgaaa gccctcacta agcactccac
     4201 ctgcatgcta ccctgtggta gtaagcagga actttctagc tactccacag cccagcattc
     4261 aaagtaatta tcccttgtcc tactgaaagt gcagtgtgtt tgtgtttctg tttgtgtttg
     4321 ttgtatggtg tcctgagatt aatatgaatc tacattttca gtgttgggtt ttcagaggag
     4381 ggaaggaatg atgttaaaat atctctctgg tattcttcaa taataaaata tgccagctgg
     4441 tcaaggtcat ctgtgtagaa ctctgggtca gaattttcac ccactatcat gctagactat
     4501 atccctgaga tcagtattca ttagtaaagg caacttacca gaattctgca cagtaataga
     4561 agccaacttc agataatacc agaggagtct ttcagtggct attaagttag taacattctg
     4621 ggagcatatg aactatggta aagtcacata catacagatc ttcagtagtg gtgtagggcc
     4681 aagacaataa aaagtaagaa aatagaatga ccaacagcca ggtaacccgg gtgagctgac
     4741 ctgcaagggc cacagaagca gagccttact agataagtgg gtgcccatgt tgagctcatt
     4801 aattgacatt gttgtgagaa agagaccttg accagtccgg acttcaagaa agtgaaacat
     4861 gaaagagcat aaaatcatgc ttctgaaaaa tatactttaa aaacatgtaa atagcaaaag
     4921 gcaaaataaa gatctataat agc
//
