LOCUS       NM_008073               4078 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor, subunit gamma
            2 (Gabrg2), transcript variant 1, mRNA.
ACCESSION   NM_008073
VERSION     NM_008073.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4078)
  AUTHORS   Shao,M., Botvinov,J., Banerjee,D., Girirajan,S. and Luscher,B.
  TITLE     Transcriptome signatures of the medial prefrontal cortex underlying
            GABAergic control of resilience to chronic stress exposure
  JOURNAL   Mol Psychiatry (2024) In press
   PUBMED   39550415
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4078)
  AUTHORS   Neumann,E., Cramer,T., Acuna,M.A., Scheurer,L., Beccarini,C.,
            Luscher,B., Wildner,H. and Zeilhofer,H.U.
  TITLE     gamma1 GABAA Receptors in Spinal Nociceptive Circuits
  JOURNAL   J Neurosci 44 (41), e0591242024 (2024)
   PUBMED   39137998
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4078)
  AUTHORS   Ge,Y. and Craig,A.M.
  TITLE     Haploinsufficiency of GABAA Receptor-Associated Clptm1 Enhances
            Phasic and Tonic Inhibitory Neurotransmission, Suppresses
            Excitatory Synaptic Plasticity, and Impairs Memory
  JOURNAL   J Neurosci 44 (32), e0521242024 (2024)
   PUBMED   38942471
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4078)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4078)
  AUTHORS   Poliquin,S., Nwosu,G., Randhave,K., Shen,W., Flamm,C. and Kang,J.Q.
  TITLE     Modulating Endoplasmic Reticulum Chaperones and Mutant Protein
            Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with
            Febrile Seizures Plus and Dravet Syndrome
  JOURNAL   Int J Mol Sci 25 (9), 4601 (2024)
   PUBMED   38731820
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4078)
  AUTHORS   Zahniser,N.R., Buck,K.J., Curella,P., McQuilkin,S.J.,
            Wilson-Shaw,D., Miller,C.L., Klein,R.L., Heidenreich,K.A.,
            Keir,W.J., Sikela,J.M. et al.
  TITLE     GABAA receptor function and regional analysis of subunit mRNAs in
            long-sleep and short-sleep mouse brain
  JOURNAL   Brain Res Mol Brain Res 14 (3), 196-206 (1992)
   PUBMED   1359369
REFERENCE   7  (bases 1 to 4078)
  AUTHORS   Cutting,G.R., Curristin,S., Zoghbi,H., O'Hara,B., Seldin,M.F. and
            Uhl,G.R.
  TITLE     Identification of a putative gamma-aminobutyric acid (GABA)
            receptor subunit rho2 cDNA and colocalization of the genes encoding
            rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and
            mouse chromosome 4
  JOURNAL   Genomics 12 (4), 801-806 (1992)
   PUBMED   1315307
REFERENCE   8  (bases 1 to 4078)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (bases 1 to 4078)
  AUTHORS   Wang,J.B. and Burt,D.R.
  TITLE     Differential expression of two forms of GABAA receptor gamma
            2-subunit in mice
  JOURNAL   Brain Res Bull 27 (5), 731-735 (1991)
   PUBMED   1661635
REFERENCE   10 (bases 1 to 4078)
  AUTHORS   Whiting,P., McKernan,R.M. and Iversen,L.L.
  TITLE     Another mechanism for creating diversity in gamma-aminobutyrate
            type A receptors: RNA splicing directs expression of two forms of
            gamma 2 phosphorylation site
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9966-9970 (1990)
   PUBMED   1702226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645751.12, AF233775.1 and BX284629.6.
            
            On Apr 24, 2018 this sequence version replaced NM_008073.3.
            
            Summary: This gene encodes a gamma-aminobutyric acid (GABA)-A
            receptor subunit, which is a member of the ligand-gated ion channel
            family. GABA is the major inhibitory neurotransmitter in the adult
            central nervous system, and conversely exhibits an excitatory
            function during development. GABA-A receptors are pentameric,
            consisting of proteins from several subunit classes: alpha, beta,
            gamma, delta and rho. This gene encodes one of three gamma subunits
            in mammals, which contain the binding site for benzodiazepine
            drugs. Several mutations in this gene are associated with epileptic
            seizures, and genetic knockdown is associated with anxiety
            behavior. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as gamma
            2L).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047085.1, BC031762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AL645751.12        131781-132307
            528-2058            AF233775.1         1-1531
            2059-4078           BX284629.6         91870-93889         c
FEATURES             Location/Qualifiers
     source          1..4078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 24.8 cM"
     gene            1..4078
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="gamma-aminobutyric acid type A receptor, subunit
                     gamma 2"
                     /db_xref="GeneID:14406"
                     /db_xref="MGI:MGI:95623"
     exon            1..631
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..1952
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid (GABA) A receptor,
                     subunit gamma 2; GABAAR subunit gamma-2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-2
                     isoform 1 precursor"
                     /protein_id="NP_032099.1"
                     /db_xref="CCDS:CCDS24551.1"
                     /db_xref="GeneID:14406"
                     /db_xref="MGI:MGI:95623"
                     /translation="MSSPNTWSIGSSVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDD
                     YEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGP
                     VNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAH
                     WITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIV
                     YQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTI
                     QTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM
                     DLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPR
                     SATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDS
                     YARIFFPTAFCLFNLVYWVSYLYL"
     exon            632..783
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..851
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1072
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1155
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1293
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1446
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1652
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1676
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..4078
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2531..2536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="hexamer: AATAAA"
     polyA_site      2557
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="hexamer: AATAAA"
     polyA_site      3898
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="major polyA site"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="Gabrg2"
                     /gene_synonym="GABAA-R; Gabrg-2; gamma2"
ORIGIN      
        1 gacctcacag ttaatctgtg agagttaatc aggcaaaacc tctactgagt gatttttttt
       61 cccacacaac agaaccagac aaagagagca cagccccatc taaaaagaaa gaaaagaaag
      121 agagaaagaa agaaaaagag caagtagata aacctaaaag gaccgaccct tgggaattcc
      181 tgttagtgca ccgggcatga atgtgagcgc ctttctgctt ctctcatttg ccttcctgtg
      241 tacatctctg cgtgtaccat ccccctgcct caattctatt atcctctcag acttggaagc
      301 tgctgcctga gctgacgctt tgatggtatc tgcaagcgtt tgtactgatc tttatttctg
      361 ccccctgaat attaattttt aagctggtag caatacatct ctgagtgacg ggacctacta
      421 gaggcaggtg gggggagccg gcatcaaatc atcagcataa taataataca aaggggaggg
      481 attcttctgc aacccagagg cgagaggcga gagaaaaaaa aaaagcgatg agttcgccaa
      541 atacatggag cattggaagc tcagtctact ctcctgtatt ttcacagaaa atgacgctgt
      601 ggattctgct cctgctatcg ctctacccag gcttcacaag ccaaaagtca gatgatgact
      661 atgaagatta cgcttctaat aaaacatggg tgttgactcc aaaagttcca gagggtgatg
      721 tcactgtcat cttaaacaac ctgctggaag ggtatgacaa caaacttcga cctgacatcg
      781 gagtgaaacc aacattaatt catacagata tgtatgtgaa cagcattggt ccagtgaatg
      841 ctatcaatat ggaatataca attgatattt tttttgccca aacctggtat gacagacgtt
      901 tgaaatttaa cagtaccatt aaagttctcc ggttgaatag caatatggtg gggaaaatct
      961 ggattccaga cactttcttc aggaactcca aaaaggctga tgctcactgg atcaccactc
     1021 ccaacaggat gctgagaatt tggaatgatg gtcgagttct ctacacctta aggctaacaa
     1081 ttgatgctga gtgccagttg caattacaca acttcccaat ggatgaacac tcctgccccc
     1141 tggagttctc cagttatgga tatcctcgtg aagaaattgt ttatcaatgg aagcgcagtt
     1201 ctgttgaagt gggtgacaca agatcatgga ggctgtatca attttccttt gttggattga
     1261 ggaatacaac tgaagtagtg aagacaactt ctggtgacta tgtggtgatg tctgtgtact
     1321 tcgatctgag cagaagaatg ggctacttca ccatccagac ttacattccc tgcacactca
     1381 tcgtggtcct gtcctgggtg tccttctgga tcaataagga tgctgttcct gccagaacat
     1441 ctttaggaat cactactgtc ctgaccatga caactttaag caccatagcc agaaaatctc
     1501 tgcccaaggt ctcctatgtc acagcaatgg atctctttgt atctgtttgc ttcatctttg
     1561 tgttttctgc tttggtggag tatggcaccc tgcattattt tgtcagcaac cggaagccaa
     1621 gcaaggataa agacaaaaag aagaaaaacc ctcttcttcg gatgttttcc ttcaaggccc
     1681 ctaccattga tattcgtccc agatcagcaa ccattcaaat gaacaatgcc acacaccttc
     1741 aagagaggga tgaagaatat ggctatgagt gtttggatgg caaggactgt gccagtttct
     1801 tctgctgttt tgaagattgc cgaacaggag cctggagaca tgggaggata catattcgca
     1861 ttgccaaaat ggactcctat gctcggatct tcttccctac cgccttttgc ttgttcaatc
     1921 ttgtttactg ggtctcctat ctttatctgt aaagaggtat gggttttatt gataggggtg
     1981 ttattcgctg aatcttatgg agacaaaatg cactttctaa gtccaacgat ataatcccct
     2041 atgtggtcac cgaatgtgtt tctctgtctc aacgtagtaa tacatataat gtcatactat
     2101 ccatgcccaa tccgtggtta ttgtaatttg aatttcagcg tgcactgtcc ttcaaacctg
     2161 caaggcaaag taaagttaga acaagagctg ttacactgag caagatacct ttgagcaaca
     2221 gcaatgaaaa cagtggaagc tgggagggtt taaagtggca ttatcagtct ttgactcata
     2281 tatagtttag tacaaaaggt ataaagctgt gtactatgtt cacttgggat caagttgtgg
     2341 taaactggaa aaaattagaa tacctcccgt atctgtgaag aatcacaata gaaaagccta
     2401 gattagaatt ctattatacc tttattccaa ggtagaaagc aaatttcctt catatcatat
     2461 gtacagtgat gtaaatattt cagtaatgta gaatgcttca ggtttaatgc atgcatctct
     2521 ttagagccaa aataaatgaa ctcatgttat catcatatag cattgtcttt ttttttattt
     2581 ctttgggcta taaaataata tattaatata attataaaaa tttgggcttg aaattgaagg
     2641 gggctcacaa ccttctccct catgcatgaa aattcaggtt ttaaaattat gtttgtctgt
     2701 acgacattaa aacaccttaa gtaccattta ggctgactga catttgacag ctctaaatat
     2761 gcccaacttt atcactagaa tataaagtaa ctgtatgtgc ttgctaatgt tttaccttac
     2821 tttgacgatg tgcgttctca acagaacttg ctctctattt caatatctgc ttctagtgac
     2881 tgtgaacgcc ttgtaggcag agttcttgtt gtttcttctt ttacttctca acatcttgca
     2941 ctgtgcctgg catatagtca gtgctcaata aatatggctg ggagcaatgc atactcttgt
     3001 ctggtgaata acttcttctg acccagaaca agtggtttat gttttttttc acattactgt
     3061 tgacatctga tacttcctta tctgtagaaa tacccgagaa tctaaagaac tgtagcttat
     3121 atgttcatct tcaaaaattt gttttaggca aagtgtatct attttaaaat aatatctatt
     3181 tcctatacca aagtagcaat tgttgaatta agcatagagt tcttgattat cccatttttt
     3241 aaaagaaaga attgattatg tctggtgaaa attctgcttg tgaacctatg aaagtatgag
     3301 caatattcat acctgactgg tatacagtat gcttggaaac aatgtactga aggttaaatt
     3361 aaaagcagga acaatattaa gtgacttgca tggaggacat ggagcctctg actgtgggct
     3421 cattttgctc catagtaatt aaatggagtg attggctgac ttcagtcatg atgagttgga
     3481 ccttaatgtg actattctga attcttgttt ttctaaaata tgaccctatg gtcagttctt
     3541 ctttaaggaa aatattgatt caaatcaatg ttaaatcata aagtaacact atagataata
     3601 ggaagacaat taaaggaagc atctctgtta atagaaaacc acacgaagtc gttataattc
     3661 atctggatga atcttgaaaa cattcagctg ctggttttac aaacctttat tataccagtg
     3721 ttttagtatc taacctcaaa cagatgtaaa taagtgatta atttctcatt ttaaaatgtc
     3781 aaaataatca atattgactc tttgggagag ttgctggaaa atttaatttg tgagaaacaa
     3841 ggtattattg tcaatttgga atgtgttttg caattgggac atggaaataa aaattaaagc
     3901 tagcatacca acatgtgtat aacactgtca atatggatat atattacaca tcatctaagt
     3961 ctcaatcatc agctgctccc tgtctatgta tttgcaaacc ttttcacaca caaaaaaatg
     4021 cctagcatat ggacttttac aataaaaaat gctgcattct aatctatggt ggcacctc
//
