LOCUS       NM_010252               6397 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit gamma
            1 (Gabrg1), transcript variant 1, mRNA.
ACCESSION   NM_010252
VERSION     NM_010252.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6397)
  AUTHORS   Neumann,E., Cramer,T., Acuna,M.A., Scheurer,L., Beccarini,C.,
            Luscher,B., Wildner,H. and Zeilhofer,H.U.
  TITLE     gamma1 GABAA Receptors in Spinal Nociceptive Circuits
  JOURNAL   J Neurosci 44 (41), e0591242024 (2024)
   PUBMED   39137998
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6397)
  AUTHORS   Lowenstein,E.D., Ruffault,P.L., Misios,A., Osman,K.L., Li,H.,
            Greenberg,R.S., Thompson,R., Song,K., Dietrich,S., Li,X.,
            Vladimirov,N., Woehler,A., Brunet,J.F., Zampieri,N., Kuhn,R.,
            Liberles,S.D., Jia,S., Lewin,G.R., Rajewsky,N., Lever,T.E. and
            Birchmeier,C.
  TITLE     Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
  JOURNAL   Neuron 111 (14), 2184-2200 (2023)
   PUBMED   37192624
REFERENCE   3  (bases 1 to 6397)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6397)
  AUTHORS   Dietrich,S., Company,C., Song,K., Lowenstein,E.D., Riedel,L.,
            Birchmeier,C., Gargiulo,G. and Zampieri,N.
  TITLE     Molecular identity of proprioceptor subtypes innervating different
            muscle groups in mice
  JOURNAL   Nat Commun 13 (1), 6867 (2022)
   PUBMED   36369193
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6397)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6397)
  AUTHORS   Gustincich,S., Feigenspan,A., Sieghart,W. and Raviola,E.
  TITLE     Composition of the GABA(A) receptors of retinal dopaminergic
            neurons
  JOURNAL   J Neurosci 19 (18), 7812-7822 (1999)
   PUBMED   10479684
REFERENCE   7  (bases 1 to 6397)
  AUTHORS   Lengeling,A., Wiltshire,T., Otmani,C. and Bucan,M.
  TITLE     A sequence-ready BAC contig of the GABAA receptor gene cluster
            Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5
  JOURNAL   Genome Res 9 (8), 732-738 (1999)
   PUBMED   10447508
REFERENCE   8  (bases 1 to 6397)
  AUTHORS   Wang,J.B., Liu,Z.F., Kofuji,P. and Burt,D.R.
  TITLE     The GABA(A) receptor gamma1-subunit in seizure prone (DBA/2) and
            resistant (C57BL/6) mice
  JOURNAL   Brain Res Bull 45 (4), 421-425 (1998)
   PUBMED   9527017
REFERENCE   9  (bases 1 to 6397)
  AUTHORS   Chang,C.C., Luntz-Leybman,V., Evans,J.E., Rotter,A. and
            Frostholm,A.
  TITLE     Developmental changes in the expression of gamma-aminobutyric
            acidA/benzodiazepine receptor subunit mRNAs in the murine inferior
            olivary complex
  JOURNAL   J Comp Neurol 356 (4), 615-628 (1995)
   PUBMED   7560270
REFERENCE   10 (bases 1 to 6397)
  AUTHORS   Cutting,G.R., Curristin,S., Zoghbi,H., O'Hara,B., Seldin,M.F. and
            Uhl,G.R.
  TITLE     Identification of a putative gamma-aminobutyric acid (GABA)
            receptor subunit rho2 cDNA and colocalization of the genes encoding
            rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and
            mouse chromosome 4
  JOURNAL   Genomics 12 (4), 801-806 (1992)
   PUBMED   1315307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068252.9 and AC092716.7.
            
            On Mar 6, 2023 this sequence version replaced NM_010252.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034332.1, AK049956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC068252.9         80629-80878
            251-399             AC068252.9         106889-107037
            400-467             AC068252.9         128281-128348
            468-688             AC068252.9         140528-140748
            689-771             AC068252.9         142262-142344
            772-909             AC068252.9         144795-144932
            910-1062            AC068252.9         145724-145876
            1063-1274           AC068252.9         148512-148723
            1275-6397           AC092716.7         4823-9945
FEATURES             Location/Qualifiers
     source          1..6397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 37.43 cM"
     gene            1..6397
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     gamma 1"
                     /db_xref="GeneID:14405"
                     /db_xref="MGI:MGI:103156"
     exon            1..250
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1544
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit
                     gamma-1; GABA(A) receptor subunit gamma-1;
                     gamma-aminobutyric acid (GABA) A receptor, subunit gamma
                     1; GABAAR subunit gamma-1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-1
                     isoform 1 precursor"
                     /protein_id="NP_034382.2"
                     /db_xref="CCDS:CCDS19326.1"
                     /db_xref="GeneID:14405"
                     /db_xref="MGI:MGI:103156"
                     /translation="MGSGKAFLFSPSLLWSQTRGVRLIFLLLTLHLGNCVDKADDEDD
                     EDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPV
                     DPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHW
                     ITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEY
                     KWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQ
                     TYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMD
                     LFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRGRKLKNKTSASPGLHAGSTLIPMNS
                     ISLPQGEDDYGYQCLEGKDCTSFFCCFDDCRTGSWREGRIHIRIAKIDSYSRIFFPTA
                     FALFNLVYWVGYLYL"
     exon            251..399
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            400..467
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            468..688
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            772..909
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1062
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1274
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..6397
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="hexamer: AATAAA"
     polyA_site      3739
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="major polyA site"
     regulatory      4497..4502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="hexamer: AATAAA"
     polyA_site      4523
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
     regulatory      6377..6382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
                     /note="hexamer: AATAAA"
     polyA_site      6397
                     /gene="Gabrg1"
                     /gene_synonym="GabaA; GabaA/BZ"
ORIGIN      
        1 agttctgctg ggagtcgcat cctacctgct tcggaggtgt actgcctatc cactccttgt
       61 actcactgtg tggttgctga ggcttgaggc aaaactctgt gcttggggac tgagctagtg
      121 gaggaaggac tgtaaaagcg aacccgatgg gttctgggaa agccttcctc ttctctcctt
      181 ctctcctgtg gagtcaaact agaggagtga ggttgatatt cttgttacta accctgcatc
      241 tgggaaactg tgtcgataaa gcagatgatg aagatgatga agatttaact atgaacaaaa
      301 catgggtctt ggcaccaaaa attcatgaag gagatatcac acaaatcctc aactctttgc
      361 ttcaaggtta tgataacaaa cttcgtccag atataggcgt gagacccaca gtgattgaaa
      421 cagatgttta tgtaaacagc attggacctg tggatcccat aaacatggag tatacaatag
      481 acataatttt tgcccaaacc tggtttgaca gccgtttaaa gttcaatagc accatgaaag
      541 tacttatgct caacagcaac atggtgggga aaatttggat tcccgacact ttcttcagga
      601 actcaagaaa atcggatgca cactggataa caacgcctaa tcgcctgctg cggatttgga
      661 gtgatggaag ggttctctat actcttcgat taacaattaa tgcagagtgc taccttcaac
      721 ttcataattt tcctatggat gaacattcct gtccactgga attttcaagc tatggatacc
      781 ctaaaaatga aattgagtac aagtggaaaa agccctctgt ggaagtagct gatcctaagt
      841 actggagatt atatcagttt gcatttgtag ggttacgaaa ttctactgaa atctctcaca
      901 caatctctgg agattatatt atcatgacta ttttttttga cctgagcaga cggatgggct
      961 atttcacgat tcagacatac attccgtgta ttctaacagt ggttctttcc tgggtgtctt
     1021 tttggatcaa taaagatgca gtacctgcta gaacatccct gggtatcact acggttttga
     1081 ctatgacaac cctcagtaca attgctagaa aatctttacc taaggtttct tacgtgacag
     1141 caatggatct ctttgtctct gtgtgtttca tttttgtgtt tgcagcactc atggaatacg
     1201 gaaccttgca ttattttact agcaacaata aaggaaaaac caccagaggc aggaagctga
     1261 aaaacaagac ttcggcttcc ccaggtctcc atgctggatc cactctcatt cccatgaaca
     1321 gcatttcttt gccacaaggg gaagatgatt atggctacca gtgtttggag ggcaaagact
     1381 gtactagctt tttctgttgc ttcgatgact gcagaactgg gtcctggagg gaagggcgga
     1441 tacacatacg cattgcaaaa attgactcct actccagaat ctttttccca acagcttttg
     1501 ccttgttcaa tctggtttac tgggttgggt atctatactt ataagttcag ccaataaatt
     1561 aaaaataatc ataaaagtct ggcttagtcc aatataatca gttgtatttc ataacatgaa
     1621 gtttaaatta aagtgaaagt ctactagtta aaatatgaat aagatggtta tgtgactagg
     1681 gctttcataa atgaataaga cagaattatt caggttaatc tatctaaata aacatgtaat
     1741 tgattgtcca atatagcaca gttatatcat aaacttatat ttttacttta atttttttat
     1801 gtttattgta taaatctaat attggactta atacttatgt gagaaatatt ttgaatatga
     1861 gataatttta acacatattt tatttaaata taccttttgc ttataatgaa atactactgt
     1921 caaatattaa aatattcttt gcctagattg ctcattagct tgattttatt ttttgctttg
     1981 tatttgctct gtttaggata tggtttcttt aaaacaaagc catgattttc ttggatttgt
     2041 tcaaagatat gttattccca agaagaaaat aatgtattga ttacttttta aataattttt
     2101 gtgaactgac agtttgtata catttatata tttaaacact gtcatgtctt atgtttgaag
     2161 tacaaaggaa ttaaaccaag ctacttggaa actacagttt tcaaaatgga caacttttat
     2221 tagttatcca atcaattttc tgctcaatgt taagcagaag tcaaccttca cttattttga
     2281 ggatttttaa atttggagag gaaacactaa agtcattttt tgtttttttg taatgcaagt
     2341 tcaaaaaact caaagttata ttctgccttg taggatttat gaggtataaa gaggttaaca
     2401 caaaaatgtt catatgtact aacaatgaaa tcaaatggga aatgttttgt ttttccttta
     2461 agtgctacaa aagggattca caagttcaaa gaatcattga gtaaaagagc ttgatttaac
     2521 agggcttaac gagccatctg gcaaaataaa ctctaggttg tctcaaaata cagacttaaa
     2581 tatatgctat tgatatttta tagagtagat atatttgaaa accatcaaaa ttatgtatct
     2641 acccagctga tttttacaac tatattataa tcgccatgtt ctctctttta ggcgtgtgaa
     2701 atttctcaaa actcatttta caagtggact ttgtatgaga caactgtaat gaacttgagt
     2761 agggacatca cgaaatccat acagagagga aaggactcta gagactctca ctttagggaa
     2821 agctgacagt gttgccaatg ctacatctgt gagaggaggc ttccacttgg aaataagcaa
     2881 tagaaatatt cactgtaggt ctggcaagat ggctcagcac acaagagcat tttatgctct
     2941 tgctgaggac acaggctgag ttattatcct ccacaggata atttactaag gtctgtaatc
     3001 aggaatctaa agcccttttc tggcctttgt tgatactgca tgcacgtggt tcatacaagc
     3061 agagaaacac tcacataaaa taaaaataat aaatcagaga aaggcatgtc catttttgac
     3121 agcagttgtc acaatgagag gtcttatcat caaaagtgtg ttgattttga ggaggagctg
     3181 tcatgtgggt gttagacaca catactttta attcatgaat tggtgcacct ggtgtagcag
     3241 tcactaggtg aaaccttgat tgtattatac tgtgagaatt atagttgtcc agataactat
     3301 aactttccac cttactcaga aacacacaga atttgaagga caataaaata ttgagttttt
     3361 taacaaatgg aggttcaaat aaaattttga ctatgtgtat attaattttt agatattcca
     3421 tgcatttatg ttgaaaatat taaatattgg taagatgtta atgaaataat catcatttaa
     3481 gggataaaag aagtatggac aatccgttag ggcgtaacat gcttcactat atttttgtgg
     3541 ctacttccat atttgtattg atggcttgct cattgttaaa ggtgttaggg agtttagagg
     3601 ttttcaattg tatctaagca tgcctatttg ttaaaatact ttaaaatgct tgatatgatt
     3661 atttttttca ttgctgtttt attacctagg atttaaatgt tgacaatatt tacaagtgaa
     3721 aataaaattg ttaaaaatat catgttctct acatatattc catatatata tatatatatc
     3781 atcaaataag caatttgctt caaagccagt ggtattttat ttaaatataa ttattagaag
     3841 aacagatgtg caaatctaat tatcttctaa acctagaaac aaaaagatta tattttcatt
     3901 tagatcttaa gaaattctct agagcttaga gcttatcttc aagggagtaa aacccaatac
     3961 ttgtttttat catatttcaa atttaaaatc aactatgtac tattcagata aatatatcct
     4021 ttttttctag atgagttgaa ataatttatt agattcattt tcctgtacac aaattgattt
     4081 gaatactaac ataaaccaaa aatatagtca ctaggaatga caagaaattg tcaaatagga
     4141 agatgtaaga gcacatgaga aggcgttaat ttatgtggac cccgttccga tttacaagac
     4201 caggatttaa actgagaagc agaaggtgca tagcagcatt ttattcttgt agacaaaaca
     4261 gcatagtaac ctttatgtgc ccttgaactg catcctaagt agttttctct ataagctcca
     4321 ttttatccca gaacattatt ttgaacagtt atgtcgccct cacccatctg aatgcaacac
     4381 aagaagattc cagctttaca tttgctaaca aagctgggcc atttggaatg acattagtaa
     4441 ctaagttgtg ttttctgtca ttttaaagtg gcaatgtgca taccatccta caataaaata
     4501 aacaactgca atcaggaaca caatgccaac tgagtctgcc cttcatctgg caggattctg
     4561 aagagctgaa tttgtgtgtg tgtatgtgtg tgtgtgagaa tatagtttga agaaaatggt
     4621 tccaatttcc agtttaacaa atgctagaca tcttaatgtc tattgtgaca cttcaacccc
     4681 aaaacaagta ccaccgtgag ataactataa ctggggcttc ctacttgaga aaatgtggca
     4741 aggataaaaa taagcacaga cctttgagaa gtgtgtatca aggtatagac atacatacag
     4801 gttacataaa tctagatata aatgcctatt tctaatttgt tgtttattaa attaatggtt
     4861 gttaatttaa attgtattga ccccacttaa tgctatgttc acacataatc aaagtaggtc
     4921 atacttagtc aaaatatatt tacattagct acgtttactg agagggaaac cttggtgtaa
     4981 aggactgtcc attcttcagc tgatgctgaa ccattggcaa gaatgcagcc ttcaatcaaa
     5041 aagaaccatc cactttctca ctgatcaaag ctatcaggat atgggaacac attgaaagga
     5101 aaaatttccc ttacttactc aaacatactt gcatttccag ttgatggctt ttaaaaaatt
     5161 attcattata cattcaaatg actctgtagt ttggacatca aaagttggct attttggtta
     5221 gttgaagaat tttccccttt gtccactgaa attttagata ttctaatagc tattctatta
     5281 aaaaaatctt gagtagaggg atttaactca agtaagatta atttaacata tttttagatt
     5341 aactaaattt catattagtg aacattgcct ttaaatattt gagtagaaaa tggccattac
     5401 tgaaatttca gtgggtttat gctatgagcg agcatgggta ttggggtcat taattaatga
     5461 aggactctct aggactgaaa ttggagaaca ctttgttgac gaagttacca gtgatgacta
     5521 gatagcatgg gacacaagag aaaaagacta gatattaaaa cataaataat tagcaaaatt
     5581 aacaaagaga tatagtgtgt ttaggggcct gcatatgcac atcttatgtt tagtatttgt
     5641 gtgtttttga atagatagta aggcaaattc tgtcctatag tttgcttact gctatattta
     5701 atcctatttt aatctatatg atctatctca ttatggatga aggattatat cccaaaatac
     5761 aaatggtagg tgaactacca aataattatt actttataat atatcattat tattaaaaaa
     5821 tatgtgtttg taatcacaat tttgaggatg gggacagaaa caagaaggac cctgaacttc
     5881 attgacacta ttgatactat gttcagttca gtgaacttca ggttggatgt gaaatctttt
     5941 gtcaaatgat gaggtgaaaa ccaatttagg aaacgcctga tttagacata tggcttccac
     6001 acatacatta acaagcacat aatcacatat acgcatggat acatgcatac atcacctaca
     6061 catatacaat tccgtcagaa aaacagacaa acacatacac aatttactgt acataaacca
     6121 ttagtagact tgataaaacc atattgtttt acatatagac aaccgcttgt cataagaaat
     6181 aaattaaatt ttttaatagg cagtgaaatt tacaaggact cgttgtgcct gtgaataaga
     6241 aaaattgtga taactggaaa acaggactat gcagattgta aagaagaatt tacttcaaag
     6301 aaagtagttc gtgtcttgat aagtcactgt aataactgtt atttgcatcc attaagtgtg
     6361 cacagccaca tcgcataata aagtttcagg ctcatga
//
