LOCUS       NM_017369               2791 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit
            epsilon (Gabre), mRNA.
ACCESSION   NM_017369
VERSION     NM_017369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2791)
  AUTHORS   Fang,H., Wang,Z.H., Bu,Y.J., Yuan,Z.J., Wang,G.Q., Guo,Y.,
            Cheng,X.Y. and Qiu,W.J.
  TITLE     Repeated inhalation of sevoflurane inhibits the information
            transmission of Purkinje cells and delays motor development via the
            GABAA receptor epsilon subunit in neonatal mice
  JOURNAL   Mol Med Rep 17 (1), 1083-1092 (2018)
   PUBMED   29115488
REFERENCE   3  (bases 1 to 2791)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2791)
  AUTHORS   Guo,Z., Zhao,C., Huang,M., Huang,T., Fan,M., Xie,Z., Chen,Y.,
            Zhao,X., Xia,G., Geng,J. and Cheng,L.
  TITLE     Tlx1/3 and Ptf1a control the expression of distinct sets of
            transmitter and peptide receptor genes in the developing dorsal
            spinal cord
  JOURNAL   J Neurosci 32 (25), 8509-8520 (2012)
   PUBMED   22723691
REFERENCE   5  (bases 1 to 2791)
  AUTHORS   Bollan,K.A., Baur,R., Hales,T.G., Sigel,E. and Connolly,C.N.
  TITLE     The promiscuous role of the epsilon subunit in GABAA receptor
            biogenesis
  JOURNAL   Mol Cell Neurosci 37 (3), 610-621 (2008)
   PUBMED   18206389
REFERENCE   6  (bases 1 to 2791)
  AUTHORS   Andang,M., Hjerling-Leffler,J., Moliner,A., Lundgren,T.K.,
            Castelo-Branco,G., Nanou,E., Pozas,E., Bryja,V., Halliez,S.,
            Nishimaru,H., Wilbertz,J., Arenas,E., Koltzenburg,M., Charnay,P.,
            El Manira,A., Ibanez,C.F. and Ernfors,P.
  TITLE     Histone H2AX-dependent GABA(A) receptor regulation of stem cell
            proliferation
  JOURNAL   Nature 451 (7177), 460-464 (2008)
   PUBMED   18185516
REFERENCE   7  (bases 1 to 2791)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
REFERENCE   8  (bases 1 to 2791)
  AUTHORS   Gustincich,S., Feigenspan,A., Sieghart,W. and Raviola,E.
  TITLE     Composition of the GABA(A) receptors of retinal dopaminergic
            neurons
  JOURNAL   J Neurosci 19 (18), 7812-7822 (1999)
   PUBMED   10479684
REFERENCE   9  (bases 1 to 2791)
  AUTHORS   Tobet,S.A., Henderson,R.G., Whiting,P.J. and Sieghart,W.
  TITLE     Special relationship of gamma-aminobutyric acid to the ventromedial
            nucleus of the hypothalamus during embryonic development
  JOURNAL   J Comp Neurol 405 (1), 88-98 (1999)
   PUBMED   10022198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807816.7.
            
            On Sep 7, 2006 this sequence version replaced NM_017369.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AL807816.7         41288-41363         c
            77-1527             AL807816.7         36327-37777         c
            1528-1595           AL807816.7         35871-35938         c
            1596-1816           AL807816.7         31161-31381         c
            1817-1899           AL807816.7         30385-30467         c
            1900-2037           AL807816.7         29087-29224         c
            2038-2190           AL807816.7         25056-25208         c
            2191-2390           AL807816.7         24727-24926         c
            2391-2791           AL807816.7         24074-24474         c
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.21 cM"
     gene            1..2791
                     /gene="Gabre"
                     /note="gamma-aminobutyric acid (GABA) A receptor, subunit
                     epsilon"
                     /db_xref="GeneID:14404"
                     /db_xref="MGI:MGI:1330235"
     exon            1..76
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2771
                     /gene="Gabre"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit epsilon
                     precursor"
                     /protein_id="NP_059065.2"
                     /db_xref="CCDS:CCDS30186.1"
                     /db_xref="GeneID:14404"
                     /db_xref="MGI:MGI:1330235"
                     /translation="MLPKVLLMLLNMFLALQWRVGPHVNLENKPPAQDKVVFGPQPQP
                     VPQPLTPPESPAGDTVVFGPQPQPQAESPGHDDVVFSSQPQPMPQPQPMPEPQPQPEP
                     EPEPQPQPQPQPLAGRQPLPQPLPWPMPQPQPEPEPEPEPEPEPEPEPEPEPEPEPEP
                     QPEPQPQPLAGRQPLPQPLPWPLPLPLPEPQPEPQPDPQPEPQPEPQPEPQPEPQPEP
                     QTPGQVQAGRQPRPRPQPEPQPQPEPQPEPQPEPQPQPEPEPEPQPEPEPQPEPEPQP
                     EPQPEPQPEPKPEPEPQPEPEPQPEPQPEPQPEPQPEPKPEPEPQPEPKPEPEPQPEP
                     EPEPEPEPEPQPEPEPKPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPESESELDLEP
                     EPEPHPHPHPHPHPHPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEMKSEPQSQL
                     EPQPSGKKLPAKEPELTVDCMTERPGGKLTRASRILNTILSNYDHKLRPGIGEKPTVV
                     TVEVIVNSLGPISTPDMEYSIDIIFHQTWYDERLRYNDTFETLILHGNVVSQLWIPDT
                     FFRNSKRTQEYDITIPNQMALIHKDGKVLYSVRMTIDARCSLHMLNFPMDSHSCPLSF
                     SSFSYDDSEMIYKWENFKLEINAKNTWKLLEFDFTGVNNKTEIISTPFGDFMVMTFFF
                     NVSRRFGFIVFQNYVPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTLSCK
                     NFPRVSYLTALDFYIAICFVLCFCTLLEFAVLNFLTYNNIKRQASLKVYQLPTNSRAN
                     ARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRS
                     YVCFRVLRKYFCMAPGCEGGSWQRGRICIHVYRLDNYSRVLFPITFFFFNVLYWLICL
                     NL"
     exon            77..1527
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1595
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1816
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1899
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2037
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2190
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2390
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2791
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgtgccagg caccgccgag atgttgccta aagttctcct gatgcttctc aacatgttcc
       61 tggcccttca gtggagggtt ggacctcatg ttaatctgga gaataaaccc cctgcccaag
      121 ataaggtagt ctttggccct cagcctcagc ctgtgccaca gcctctaact ccgcctgaat
      181 ctcctgctgg agatactgta gtcttcggcc ctcagcccca gccccaggct gaatcccctg
      241 gccatgatga tgtagtcttt agttcccagc cccagccgat gcctcagcct cagccgatgc
      301 ctgagcccca gcctcagccg gagccggagc ctgagccgca gccgcagcca caaccacagc
      361 cgttggctgg gcgccagcct ctgccccagc ccctgccttg gcccatgcct cagccccagc
      421 cggagccaga gcctgagcca gagcctgagc ctgagcctga gcctgagcct gagcctgagc
      481 ctgagcctga gcctgagccc caaccagaac ctcagcctca gcctctggct ggccgtcagc
      541 ctcttcccca acctctgcct tggcccctgc cactgccttt gcccgagccc caacctgagc
      601 ctcagcctga tccccaaccc gaacctcagc ctgaacccca acctgagccc caacccgagc
      661 cccaacctga gccccagacc ccaggccagg tccaggctgg gcgccaaccc cgacccagac
      721 ctcagcctga gccccagccc cagcctgagc ctcagcctga gccacagcct gagccacagc
      781 cacagcctga gcctgagccc gagccccagc cggagcctga gccccagcct gagcctgagc
      841 ctcagccgga gccccagccg gagccccagc cagaacccaa gccggagcct gagccccagc
      901 ctgagcctga gcctcagccc gagccccagc ctgagcccca gcctgagccc cagccagaac
      961 ccaagccgga gcctgagccc cagccagaac ccaagccgga gcctgagccc cagcctgagc
     1021 ctgagcctga gcctgagcct gagcctgagc ctcagcccga gcccgagccc aagccggagc
     1081 cccagccgga gcctgagcct gagcctgagc ctgagccgga gccggagccg gagcctgagc
     1141 cggagcctga gcctgagccg gagccggagt cggagtcgga gctggacctg gagccggaac
     1201 cggagcccca tccccatccc catccccatc cccatcccca tccggagccc gagcccgagc
     1261 ccgagccgga gcccgagcca gagccagagc cagagccaga gccagagcca gagccagagc
     1321 cagagccaga gccagagcca gagatgaaat cagagcccca gtcccagctg gagcctcaac
     1381 ctagtggaaa gaagcttcca gcaaaagaac cagaactcac tgttgattgc atgactgaac
     1441 gcccaggtgg gaaactgaca agagcttctc gaatccttaa caccatcctg agcaactatg
     1501 accataaact gcgccctggc attggagaga agcctactgt ggtcactgtt gaagtcattg
     1561 tcaacagcct cgggcctatt tccaccccag acatggaata ttccattgac atcatcttcc
     1621 accagacctg gtatgatgag cgtcttcgtt acaatgacac atttgaaacc cttattctgc
     1681 atggcaacgt ggtgagccag ttgtggatcc cggatacctt ttttaggaat tctaagagga
     1741 cccaagagta tgatatcacc atacctaacc agatggctct catccacaag gatggaaagg
     1801 tgttgtactc agttaggatg accattgatg caagatgctc actccacatg ctcaattttc
     1861 caatggattc tcactcttgc cctctgtctt tctctagctt ttcctatgat gacagtgaaa
     1921 tgatctacaa atgggagaat ttcaagctcg aaatcaatgc gaagaacact tggaagctat
     1981 tggaatttga ttttacaggc gtgaacaaca aaactgaaat catctctacc ccatttggtg
     2041 acttcatggt catgacattc ttcttcaatg taagcaggcg gtttggcttc attgtctttc
     2101 aaaattatgt tccttcttct gtcaccacaa tgctctcctg ggtctccttc tggatcaaga
     2161 tagaagctgc tgctgccagg gcctctgtag gggtcagttc tgtgctcacc atggccacgc
     2221 tgggtacctt gtcctgtaag aatttccctc gtgtctccta tctcacggct ttggacttct
     2281 atattgcaat ttgtttcgtc ttgtgcttct gcactctgct agagtttgct gtgctcaact
     2341 tcctgaccta caataatatt aaacgacagg cttctctaaa ggtctaccaa cttccaacca
     2401 atagccgtgc taatgcacgt actcgtgctc gtgcacgcac ccgcgctcgt gctcgtgccc
     2461 gtgcacgaca gcagcaggaa gtgtttgtgt gtgagattgt cacctatgag gaaaatgctg
     2521 aagaggggta tcaatggtct ccaagatcaa gaagacctca gtgtccctgg aggcggtgtg
     2581 gcagaagcta tgtgtgcttc agggttctca ggaagtattt ctgcatggct cctggttgtg
     2641 agggaggcag ctggcagcgg ggccgcatct gcatccatgt ttatcgtctg gataactatt
     2701 cgcgggtgct ttttcccatt acattcttct tctttaatgt gctctactgg ctgatttgcc
     2761 ttaacctgta ggctccagcc agtagctcat g
//
