LOCUS       NM_008072               1896 bp    mRNA    linear   ROD 26-MAR-2023
DEFINITION  Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit
            delta (Gabrd), mRNA.
ACCESSION   NM_008072
VERSION     NM_008072.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q and Mi J.
  TITLE     The delta subunit of the GABAA receptor is necessary for the
            GPT2-promoted breast cancer metastasis
  JOURNAL   Theranostics 13 (4), 1355-1369 (2023)
   PUBMED   36923530
  REMARK    GeneRIF: The delta subunit of the GABAA receptor is necessary for
            the GPT2-promoted breast cancer metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Jovasevic V and Radulovic J.
  TITLE     High ethanol preference and dissociated memory are co-occurring
            phenotypes associated with hippocampal GABAAR-delta receptor levels
  JOURNAL   Neurobiol Learn Mem 183, 107459 (2021)
   PUBMED   34015441
  REMARK    GeneRIF: High ethanol preference and dissociated memory are
            co-occurring phenotypes associated with hippocampal GABAAR-delta
            receptor levels.
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM,
            Nyitrai H, Flaquer I, El-Rifai M, Datta SR and Regehr WG.
  TITLE     Cerebellum-Specific Deletion of the GABAA Receptor delta Subunit
            Leads to Sex-Specific Disruption of Behavior
  JOURNAL   Cell Rep 33 (5), 108338 (2020)
   PUBMED   33147470
  REMARK    GeneRIF: Cerebellum-Specific Deletion of the GABAA Receptor delta
            Subunit Leads to Sex-Specific Disruption of Behavior.
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Dalby NO, Falk-Petersen CB, Leurs U, Scholze P, Krall J, Frolund B
            and Wellendorph P.
  TITLE     Silencing of spontaneous activity at alpha4beta1/3delta GABAA
            receptors in hippocampal granule cells reveals different ligand
            pharmacology
  JOURNAL   Br J Pharmacol 177 (17), 3975-3990 (2020)
   PUBMED   32484592
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Zhu M, Jia L, Li F and Jia J.
  TITLE     Identification of KIAA0513 and Other Hub Genes Associated With
            Alzheimer Disease Using Weighted Gene Coexpression Network Analysis
  JOURNAL   Front Genet 11, 981 (2020)
   PUBMED   33005179
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP,
            Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR,
            Fanselow MS, Guidotti A, Spigelman I, Li Z, DeLorey TM, Olsen RW
            and Homanics GE.
  TITLE     Attenuated sensitivity to neuroactive steroids in
            gamma-aminobutyrate type A receptor delta subunit knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12905-12910 (1999)
   PUBMED   10536021
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Penschuck S, Luscher B, Fritschy JM and Crestani F.
  TITLE     Activation of the GABA(A)-receptor delta-subunit gene promoter
            following pentylenetetrazole-induced seizures in transgenic mice
  JOURNAL   Brain Res Mol Brain Res 51 (1-2), 212-219 (1997)
   PUBMED   9427523
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Wang JB, Kofuji P and Burt DR.
  TITLE     Strain comparisons and developmental profile of the delta subunit
            of the murine GABAA receptor
  JOURNAL   Brain Res Bull 29 (1), 119-123 (1992)
   PUBMED   1324097
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   Sommer B, Poustka A, Spurr NK and Seeburg PH.
  TITLE     The murine GABAA receptor delta-subunit gene: structure and
            assignment to human chromosome 1
  JOURNAL   DNA Cell Biol 9 (8), 561-568 (1990)
   PUBMED   2176788
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Shivers BD, Killisch I, Sprengel R, Sontheimer H, Kohler M,
            Schofield PR and Seeburg PH.
  TITLE     Two novel GABAA receptor subunits exist in distinct neuronal
            subpopulations
  JOURNAL   Neuron 3 (3), 327-337 (1989)
   PUBMED   2561970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY276433.1, BC116836.1 and AI853201.1.
            
            [WARNING] On May 11, 2023 this sequence was replaced by
            NM_008072.3.
            
            On Nov 20, 2007 this sequence version replaced NM_008072.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.272427.1, BC116832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BY276433.1         45-109
            66-1713             BC116836.1         1-1648
            1714-1896           AI853201.1         1-183               c
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..1896
                     /gene="Gabrd"
                     /note="gamma-aminobutyric acid (GABA) A receptor, subunit
                     delta"
                     /db_xref="GeneID:14403"
                     /db_xref="MGI:MGI:95622"
     exon            1..175
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1457
                     /gene="Gabrd"
                     /note="gamma-aminobutyric acid receptor subunit delta;
                     GABA(A) receptor subunit delta"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit delta
                     precursor"
                     /protein_id="NP_032098.2"
                     /db_xref="CCDS:CCDS19028.1"
                     /db_xref="GeneID:14403"
                     /db_xref="MGI:MGI:95622"
                     /translation="MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNL
                     DGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSY
                     NHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITS
                     TVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITS
                     YRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAV
                     PARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFN
                     ADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYR
                     SVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM"
     exon            176..288
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            289..356
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            357..577
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            578..660
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            661..798
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            799..954
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1166
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1879
                     /gene="Gabrd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctccttcgc gctcccgccc ttctggtgcc gccgcgcggc cgcaggcaaa gcaactttgc
       61 ttgcgctggg gctagctgga cctgtcccgc gcacagcccg caaggccatg gacgttctgg
      121 gctggctgct gctgccgctc ctgctgctct gcacgcagcc gcaccatggc gccagggcaa
      181 tgaatgacat tggggactac gtgggctcca acctggaaat atcctggctc cccaacctgg
      241 atggcttaat ggagggctat gcccgaaact tccgaccagg cattggaggt gctcctgtga
      301 atgtggcgct tgccctagag gtggccagca ttgaccatat ctcagaggca aacatggaat
      361 acaccatgac tgtgttcctg catcagagct ggcgggacag caggctgtcc tacaaccata
      421 ccaacgagac cttaggcctg gacagccgct ttgtggacaa gctatggctc cctgacacct
      481 tcatcgtgaa tgccaaatct gcctggttcc atgatgtgac tgtggaaaac aagcttatcc
      541 gcctacagcc tgatggggtg attttataca gcatccgcat cacctccaca gtggcctgtg
      601 acatggacct cgccaagtac ccactggatg agcaggagtg catgctggac ctagagagct
      661 atggctactc ttctgaggac attgtctatt attggtcaga aaaccaggag cagatccatg
      721 ggctggacag gctgcagctg gcccagttca ctatcaccag ttaccgcttc accacggagc
      781 tgatgaactt caaatcggct ggccagttcc cacggctcag cttacacttc cagcttcgga
      841 ggaaccgggg cgtctacatc atccagtctt acatgccctc tgtcctcctg gttgccatgt
      901 cctgggtctc cttctggatt agccaggcag ccgtgcctgc cagagtatct ctaggcatca
      961 ccactgtgct gacaatgacc acgctcatgg tcagtgcccg ctcctccctg ccacgggctt
     1021 cagctatcaa agctctggat gtgtattttt ggatctgcta cgtctttgtg tttgctgccc
     1081 tggtggagta tgcatttgcc cacttcaatg ccgactacag gaagaaacgg aaagccaagg
     1141 tcaaggtcac caagccaagg gcagagatgg atgtgaggaa cgccatcgtc cttttctccc
     1201 tctcagctgc tggggtcagt caggagttgg ctatctcccg tcgtcaaggc cgggtccctg
     1261 ggaacctcat gggttcctat aggtctgtgg aagtggaggc aaagaaggag ggggggtccc
     1321 gcccaggggg cccaggagga atccgttcca gactcaaacc catcgatgca gacaccatcg
     1381 acatctatgc ccgcgccgtc ttcccggcag cttttgcagc ggtcaacatc atctactggg
     1441 cggcgtacac catgtgacgg cagtgtgtgc accaggtgat ggctgtacac ataccacgtg
     1501 aggtggttgc cacaaactcc tggaggccct ctccatgggt cccaaaatgg gacagagagg
     1561 aggctcggct tcttgggctt tacctcaact ttgctctaaa gacgagcctg cacttcttgt
     1621 agatggaaca ggatgggctt tgcatagagg gtcatagctg gcctgaccct gaagttgagc
     1681 ctagtgctgc tgggcccttg ggagctgtga agttttagac ccacatcagg atggtcctga
     1741 tttctaggcc ttttctctgt gggatcagga tcagagagaa aaacagtggg ggtggatgac
     1801 cactctcacg gtgacctgga ggagaagggc attgcgaggc ctctttggtc ccagcatgaa
     1861 ataaagcctt gacctggcca aaaaaaaaaa aaaaaa
//
