LOCUS       NM_008071               5568 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus GABRB3, gamma-aminobutyric acid type A receptor
            subunit beta 3 (Gabrb3), transcript variant 1, mRNA.
ACCESSION   NM_008071
VERSION     NM_008071.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5568)
  AUTHORS   Zietek,M.M., Jaszczyk,A., Stankiewicz,A.M. and Sampino,S.
  TITLE     Prenatal gene-environment interactions mediate the impact of
            advanced maternal age on mouse offspring behavior
  JOURNAL   Sci Rep 14 (1), 31733 (2024)
   PUBMED   39738558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5568)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5568)
  AUTHORS   Handforth,A., Singh,R.P., Kosoyan,H.P. and Kadam,P.A.
  TITLE     A Role for GABAA Receptor beta3 Subunits in Mediating Harmaline
            Tremor Suppression by Alcohol: Implications for Essential Tremor
            Therapy
  JOURNAL   Tremor Other Hyperkinet Mov (N Y) 14, 20 (2024)
   PUBMED   38681506
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5568)
  AUTHORS   Rankin,G., Chirila,A.M., Emanuel,A.J., Zhang,Z., Woolf,C.J.,
            Drugowitsch,J. and Ginty,D.D.
  TITLE     Nerve injury disrupts temporal processing in the spinal cord dorsal
            horn through alterations in PV+ interneurons
  JOURNAL   Cell Rep 43 (2), 113718 (2024)
   PUBMED   38294904
REFERENCE   5  (bases 1 to 5568)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5568)
  AUTHORS   Zdilar,D., Luntz-Leybman,V., Frostholm,A. and Rotter,A.
  TITLE     Differential expression of GABAA/benzodiazepine receptor beta 1,
            beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum
  JOURNAL   J Comp Neurol 326 (4), 580-594 (1992)
   PUBMED   1282920
REFERENCE   7  (bases 1 to 5568)
  AUTHORS   Leff,S.E., Brannan,C.I., Reed,M.L., Ozcelik,T., Francke,U.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Maternal imprinting of the mouse Snrpn gene and conserved linkage
            homology with the human Prader-Willi syndrome region
  JOURNAL   Nat Genet 2 (4), 259-264 (1992)
   PUBMED   1303276
REFERENCE   8  (bases 1 to 5568)
  AUTHORS   Brilliant,M.H.
  TITLE     The mouse pink-eyed dilution locus: a model for aspects of
            Prader-Willi syndrome, Angelman syndrome, and a form of
            hypomelanosis of Ito
  JOURNAL   Mamm Genome 3 (4), 187-191 (1992)
   PUBMED   1611213
  REMARK    Review article
REFERENCE   9  (bases 1 to 5568)
  AUTHORS   Wagstaff,J., Chaillet,J.R. and Lalande,M.
  TITLE     The GABAA receptor beta 3 subunit gene: characterization of a human
            cDNA from chromosome 15q11q13 and mapping to a region of conserved
            synteny on mouse chromosome 7
  JOURNAL   Genomics 11 (4), 1071-1078 (1991)
   PUBMED   1664410
REFERENCE   10 (bases 1 to 5568)
  AUTHORS   Wagstaff,J., Knoll,J.H., Fleming,J., Kirkness,E.F.,
            Martin-Gallardo,A., Greenberg,F., Graham,J.M. Jr., Menninger,J.,
            Ward,D., Venter,J.C. et al.
  TITLE     Localization of the gene encoding the GABAA receptor beta 3 subunit
            to the Angelman/Prader-Willi region of human chromosome 15
  JOURNAL   Am J Hum Genet 49 (2), 330-337 (1991)
   PUBMED   1714232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083051.1, AK147247.1 and AC158300.4.
            
            On Jan 10, 2006 this sequence version replaced NM_008071.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.297899.1, AK147247.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-792               AK083051.1         13-804
            793-3349            AK147247.1         747-3303
            3350-5568           AC158300.4         111776-113994       c
FEATURES             Location/Qualifiers
     source          1..5568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 33.53 cM"
     gene            1..5568
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="GABRB3, gamma-aminobutyric acid type A receptor
                     subunit beta 3"
                     /db_xref="GeneID:14402"
                     /db_xref="MGI:MGI:95621"
     exon            1..183
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1525
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit
                     beta-3; gamma-aminobutyric acid (GABA) A receptor, subunit
                     beta 3; GABA(A) receptor subunit beta-3; cleft palate 1;
                     GABAAR subunit beta-3"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit beta-3
                     isoform a precursor"
                     /protein_id="NP_032097.1"
                     /db_xref="CCDS:CCDS21324.1"
                     /db_xref="GeneID:14402"
                     /db_xref="MGI:MGI:95621"
                     /translation="MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKL
                     LKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGI
                     PLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA
                     CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRL
                     VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARV
                     ALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGR
                     GPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSA
                     ISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDR
                     WSRIVFPFTFSLFNLVYWLYYVN"
     exon            184..275
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            276..343
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..564
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..647
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            648..785
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            786..938
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1183
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..5568
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3298..3303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="hexamer: AATAAA"
     polyA_site      3319
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="major polyA site"
     regulatory      5545..5550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="hexamer: ATTAAA"
     polyA_site      5568
                     /gene="Gabrb3"
                     /gene_synonym="A230092K12Rik; beta3; Cp1; Gabrb-3"
                     /note="major polyA site"
ORIGIN      
        1 gggccagcgc ggcggcggtg gcggcagcag cagcagcagc cccggctgcg ggtcgcgacg
       61 gcggcggggc gccccctccc ccgtgccggg gcgcggcgaa gggatgtggg gctttgcggg
      121 aggaaggctt ttcggcatct tctcggcccc ggtgctggtg gcggtggttt gctgcgctca
      181 gagcgtaaac gaccccggga acatgtcctt tgtgaaggag acggtcgaca agctgttgaa
      241 aggctacgac attcgcctga gacccgactt cgggggtccc ccagtctgcg tggggatgaa
      301 catcgacatc gccagcatcg acatggtttc tgaagtcaac atggattata ccttaactat
      361 gtatttccaa caatactgga gagataaaag gctcgcctat tctgggatcc ctctcaacct
      421 cacgcttgac aatcgagtgg ctgaccagct ctgggtgccc gacacatatt tcttaaatga
      481 caaaaagtca tttgtccacg gagtgacagt gaaaaaccgc atgatccgcc tccaccctga
      541 tgggacagtg ctgtatgggc tcaggatcac tacgacagca gcgtgcatga tggacctcag
      601 aagataccca ctggatgagc aaaactgcac tttggaaatt gaaagctatg gctacactac
      661 ggatgacatt gaattttact ggcgtggcgg ggacaaggct gtcactggcg tggaaaggat
      721 cgagctccca cagttctcca ttgtagagca ccgtctggtc tccaggaatg ttgtcttcgc
      781 cacaggtgcc tatcctcgac tttcattgag ttttcggttg aagagaaata tcgggtactt
      841 cattcttcag acgtatatgc cctcaatcct gatcacaatc ctctcgtggg tgtccttctg
      901 gatcaattac gatgcatctg ctgctcgagt tgcccttggg attaccaccg tgctcaccat
      961 gacaaccatc aacactcacc ttcgggagac tctacccaaa attccctatg tcaaagccat
     1021 cgacatgtac ctgatgggct gctttgtctt tgtattcctg gcacttctgg agtacgcctt
     1081 tgtcaactac attttctttg gaagaggtcc ccaaaggcag aagaagcttg cggagaagac
     1141 agccaaggcc aagaatgatc gttctaagag tgaaataaac cgggtggatg ctcacgggaa
     1201 tatcctatta gcaccgatgg atgttcacaa tgaaatgaat gaggttgcag gcagcgttgg
     1261 tgacaccagg aattcagcaa tatcctttga caactcagga atccagtata ggaaacagag
     1321 catgcccaag gaagggcatg ggcggtacat gggagacaga agcatcccgc acaagaagac
     1381 ccacctacgg aggaggtctt cacagctcaa aatcaaaatc cctgatctaa ccgatgtgaa
     1441 tgccatagac agatggtccc gcatcgtgtt tccattcacc ttttctctct tcaatttagt
     1501 ttactggctg tactatgtta actgagtgac tgtacttgat ttttcaaaga cttcatttaa
     1561 cactgagtga aatattaccc tgcctgtcaa gtttttatac cagtacacat acaaacacac
     1621 acacacatac gcacacacac acacacggac acacacacaa ttgtgtatat atatgtgaac
     1681 tttctcagca tatatataaa atacacgtgt atatgagaat gtatgtgtat atgttcaagg
     1741 acacagataa gagtatctgt gtacataaaa caaatacgca tacataccat acattttgca
     1801 actatggaca atttaacaca ggatgcatat taaagaaact catagctttt tctttctttt
     1861 tttaattgaa agggacaagt atctaaatat tatgcctcaa gaatgagggc gtgaaacaca
     1921 gtcatcccaa agtgtgtctt ttattatcat aagttagata ttttcgctta aaaatccaaa
     1981 aggaattctt agttaatctt tgggaactcc cacagccgta gttgtacacc tcataccctc
     2041 tcagtttgca accgaggctt gttggcttct ctgtgatggg cttgtttcat caggtgtgtt
     2101 tttctgtagt gggttagcat atgagatgag tcactggcag tgcacttacc tgactcttac
     2161 tggtaggtag ctcctacgct ggtgtctgaa tagtcatctt gaaaaactca ctgggaataa
     2221 acggtgtccc gttttaagta ctccaccatc ccatatacat gggagatttc tgttaacatt
     2281 aagtgggtcc agcttaactg tcatgtggga acacagtggc acattttgat aatgacattc
     2341 aatcgctaga agtgtgctcc acatctcatc cagatttcta ggtctgctat ttaactggaa
     2401 gcatagacgt ctcaggttct ttgttactct aaggtaaaac catctagagt ggtttccccc
     2461 ttgcagttat gttaccattc ttataacatt gtatgttaat ataaatatat ttgcataata
     2521 tgcataccta catatattac caagattttg tttcttctgc ttgctatcat ggcagcatgc
     2581 aacgtcatat ttttcattct gtgatgtaac tattttctgt tatctagaag ttaggattga
     2641 atctaaaatg tttctactgt tcacttttgg aaacttaaaa atcttcacag cctttattta
     2701 tgtactgaca tatctcataa gcacacccag ctcctcctag actgactaga attctgcagg
     2761 aacacttcca gtctacacac cacacaacaa cccatgaccg tttctgaggc aaggagagca
     2821 acctgacaca aatagtctct tttggttcct tctgatccac agcctcatca ggatttggac
     2881 tttttaaagc tcgtagaaac aagacaaggt gcaccggttt catagatgca accttaactt
     2941 agtatttaga tgagctcttt ctaaagaaaa acaaagatga tatatttttt gtaaactatt
     3001 tctatcacag gcatccataa accgactgca gttatgtaaa cgggtgtcac agcgaagcat
     3061 ttggaagaca ggataaaaaa cgacaagcag taaagaactg ctaaattaat aacccccaaa
     3121 tcccacacac gcggcacctt caagtctggc gccatcgttt ttccacatag gcaggcagca
     3181 ccaccaccct ccccaggagg catgtggaca gtcaccatgg actgacacta cttgattttt
     3241 cggtggccat tgcaatctct aatatgtggg agtctgactg ttcaaaacct aatattaaat
     3301 aaaacctaaa tccacaaaat ccgtgtgagg gacagttact gatttttata ccctttgcct
     3361 cccccattct tatctgctaa gtcttcttta catcactgct cctttgtttt attttctatc
     3421 tggagatgag cctgtgaatt ttgccatttg gcttttctct ggagtttttt tccccccatg
     3481 ggtaacagtg ggaggagaca aaaagttaga tttaaaaaaa aattctgtaa gtggccttat
     3541 cattgtaaca tgttaaaaga atacaaatgt ttgcaaagac cttatccctt tcaataattc
     3601 aggtatctct ctctgtatcc tgtaactcaa ggtgtaagtg ccacaggtag acaaggaact
     3661 ccaaaatgca agcagtgtgg cagaaacagt cactggctga taatttatta tactcagaac
     3721 tgtgacttgt ttttctgggg aagtgactca gagctttttt gatgcatagt tgagataccc
     3781 acatatcaag gcagagaccc cgcagggctc agaagagcag cagtgcactc ccggggaatc
     3841 tctggataaa aatttgcatg gtatagtcat aatagctttt gagcttttta tatgcatttg
     3901 gcaccaagac tgggatccac aactttatag acactgtaat gaagttacca tagtagctag
     3961 actctaagta atatttgtaa ttacacacac atacatacat acatacatac atacatacac
     4021 atacacacac atacacaaat acatacatgt attctgtaaa aaaaaaatcc tttctaagat
     4081 ccttgggtat gtgtttgctt tattccattt cagaagaaaa atatttttct tctaataact
     4141 tatgttatgg cttctctatt ttttaaagct aggagaagtg ttgagaagag aagtctggct
     4201 gtgttagcag aagagtgggt tctgatccct atctaggaaa gtagcctcta gtaactttac
     4261 agcagccatt tgagtcagta agtgagggta cagagggatt ccaccaggac ctctgaatgg
     4321 aggtggctgt tacccatgtc cagagctctt aagaacagaa aattttagct tctcaccaat
     4381 tcaataaacc tttagttttc tcaatagtac tgtctttcca aaacgaaatg cttcgcagag
     4441 ggcccatggt gttgacgcct tgatgacagc cctttattag tcatttccag atatgtctgt
     4501 gacaattcag tagcccttct ctatcagtcc cagcagaaaa aagactcacc agagtggaat
     4561 tatctttaat tgaatgaaag tcactcctgc tcaccaatcc cgggacagtt gagtggttgt
     4621 gttgccaatg ccgtgacacc ctcactgccc ctgaatctca aatgaactaa agagtatatc
     4681 ataataatgt tcccactagg ctttaagtga catgtccatc tgcagtattg tgtgttttga
     4741 tgccaacacg gggacatctt cagttgttcc catcaaaagc agttctcttg ttttgaaaca
     4801 cggagttgac aatttcacca atgagatcat ctcagagggg tcaggcacat tgtagctgta
     4861 ggtgtttgaa ccacggaaac acattctgaa aagatgtgtc cattgttgaa tctccttgct
     4921 taaaagcata agcctactat aattcatatt ttaaccctcc acctaaaaat aaaaagagtt
     4981 catatttctg gccattttct gtaagccaac tgaaccaatg gtaaaatatt ttgttacttt
     5041 tggaatgaac tctgacttca tgtcagtgtg aactttccat cacagtaaca ttgactcttt
     5101 gggcaaagaa ctgccctggt ggagtaaatt tcccaggaca ctggtgagtg taccttggac
     5161 tgattacctc ttctactgca ttgaaaggtg ccatgttttc ctgaatgact aaatccccct
     5221 caccttgtaa gtgacctccc agagtggctc atgcaccata gctctcctag ggacggccca
     5281 caaacatgtc attcgtgact catttttcta cttcccaagt cagtagatgt gttcaaggta
     5341 agtacaggat tgttctcgta ggaataggcg gttgctgtcc tgattggtat tcccgtcgat
     5401 ttcatttcat tgtaaagatt aaacttaaac ccggttttgc ttaagcacat tgatgtaatt
     5461 ttttggtatt atttgacatg aaaaaaaaaa cagcaaaatt gagtgacaga tacaatatga
     5521 aacttgttga atgaattcaa atttattaaa aaaggactaa ctgataaa
//
