LOCUS       NP_001349576             474 aa            linear   ROD 11-MAR-2025
DEFINITION  gamma-aminobutyric acid receptor subunit beta-2 isoform 2 precursor
            [Mus musculus].
ACCESSION   NP_001349576
VERSION     NP_001349576.1
DBSOURCE    REFSEQ: accession NM_001362647.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Liang,D., Zhou,L., Zhou,H., Zhang,F., Fang,G., Leng,J., Wu,Y.,
            Zhang,Y., Yang,A., Liu,Y. and Chen,Y.H.
  TITLE     A GABAergic system in atrioventricular node pacemaker cells
            controls electrical conduction between the atria and ventricles
  JOURNAL   Cell Res 34 (8), 556-571 (2024)
   PUBMED   38849501
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Oh,H., Lee,S., Oh,Y., Kim,S., Kim,Y.S., Yang,Y., Choi,W., Yoo,Y.E.,
            Cho,H., Lee,S., Yang,E., Koh,W., Won,W., Kim,R., Lee,C.J., Kim,H.,
            Kang,H., Kim,J.Y., Ku,T., Paik,S.B. and Kim,E.
  TITLE     Kv7/KCNQ potassium channels in cortical hyperexcitability and
            juvenile seizure-related death in Ank2-mutant mice
  JOURNAL   Nat Commun 14 (1), 3547 (2023)
   PUBMED   37321992
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Gao,M., Zhang,H., Sun,Y., Gao,Z., Sun,C., Wei,F. and Gao,D.
  TITLE     Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms:
            GABAAR subunits, neurotransmitter metabolism disruption, and
            allopregnanolone binding
  JOURNAL   Aging (Albany NY) 14 (20), 8437-8447 (2022)
   PUBMED   36287173
  REMARK    GeneRIF: Gabrb2 knock-out mice exhibit double-directed PMDD-like
            symptoms: GABAAR subunits, neurotransmitter metabolism disruption,
            and allopregnanolone binding.
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Sente,A., Desai,R., Naydenova,K., Malinauskas,T., Jounaidi,Y.,
            Miehling,J., Zhou,X., Masiulis,S., Hardwick,S.W., Chirgadze,D.Y.,
            Miller,K.W. and Aricescu,A.R.
  TITLE     Differential assembly diversifies GABAA receptor structures and
            signalling
  JOURNAL   Nature 604 (7904), 190-194 (2022)
   PUBMED   35355020
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Wu,C.H., Frostholm,A., De Blas,A.L. and Rotter,A.
  TITLE     Differential expression of GABAA/benzodiazepine receptor subunit
            mRNAs and ligand binding sites in mouse cerebellar neurons
            following in vivo ethanol administration: an autoradiographic
            analysis
  JOURNAL   J Neurochem 65 (3), 1229-1239 (1995)
   PUBMED   7643102
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Stephenson,F.A.
  TITLE     The GABAA receptors
  JOURNAL   Biochem J 310 (Pt 1) (Pt 1), 1-9 (1995)
   PUBMED   7646429
  REMARK    Review article
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Kamatchi,G.L., Kofuji,P., Wang,J.B., Fernando,J.C., Liu,Z.,
            Mathura,J.R. Jr. and Burt,D.R.
  TITLE     GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in
            DBA/2J and C57BL/6J mice
  JOURNAL   Biochim Biophys Acta 1261 (1), 134-142 (1995)
   PUBMED   7893750
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Zdilar,D., Luntz-Leybman,V., Frostholm,A. and Rotter,A.
  TITLE     Differential expression of GABAA/benzodiazepine receptor beta 1,
            beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum
  JOURNAL   J Comp Neurol 326 (4), 580-594 (1992)
   PUBMED   1282920
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Wang,J.B. and Burt,D.R.
  TITLE     Differential expression of two forms of GABAA receptor gamma
            2-subunit in mice
  JOURNAL   Brain Res Bull 27 (5), 731-735 (1991)
   PUBMED   1661635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627444.10 and AL645964.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.227655.1,
                                           SRR1660819.165243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.08 cM"
     Protein         1..474
                     /product="gamma-aminobutyric acid receptor subunit beta-2
                     isoform 2 precursor"
                     /note="gamma-aminobutyric acid A receptor, subunit beta 2;
                     gamma-aminobutyric acid receptor subunit beta-2; GABAAR
                     subunit beta-2; gamma-aminobutyric acid receptor beta-2
                     subunit; GABA(A) receptor subunit beta-2;
                     gamma-aminobutyric acid (GABA) A receptor, subunit beta 2"
                     /calculated_mol_wt=51810
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2841
     Region          9..472
                     /region_name="LIC"
                     /note="Cation transporter family protein; TIGR00860"
                     /db_xref="CDD:273305"
     CDS             1..474
                     /gene="Gabrb2"
                     /gene_synonym="C030002O17Rik; C030021G16Rik; Gabrab2;
                     Gabrb-2"
                     /coded_by="NM_001362647.2:577..2001"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS24555.1"
                     /db_xref="GeneID:14401"
                     /db_xref="MGI:MGI:95620"
ORIGIN      
        1 mwrvrkrgyf giwsfpliia avcaqsvndp snmslvketv drllkgydir lrpdfggppv
       61 avgmnidias idmvsevnmd ytltmyfqqa wrdkrlsynv iplnltldnr vadqlwvpdt
      121 yflndkksfv hgvtvknrmi rlhpdgtvly glritttaac mmdlrrypld eqnctleies
      181 ygyttddief ywrgddnavt gvtkielpqf sivdyklitk kvvfstgsyp rlslsfklkr
      241 nigyfilqty mpsilitils wvsfwinyda saarvalgit tvltmttint hlretlpkip
      301 yvkaidmylm gcfvfvfmal leyalvnyif fgrgpqrqkk aaekaanann ekmrldvnkm
      361 dphenillst leiknemats eavmglgdpr stmlaydass iqyrkaglpr hsfgrnaler
      421 hvaqkksrlr rrasqlkiti pdltdvnaid rwsriffpvv fsffnivywl yyvn
//
