LOCUS       NM_001099641            2505 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit alpha
            6 (Gabra6), transcript variant 1, mRNA.
ACCESSION   NM_001099641
VERSION     NM_001099641.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Broersen,R., Albergaria,C., Carulli,D., Carey,M.R., Canto,C.B. and
            De Zeeuw,C.I.
  TITLE     Synaptic mechanisms for associative learning in the cerebellar
            nuclei
  JOURNAL   Nat Commun 14 (1), 7459 (2023)
   PUBMED   37985778
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Lee,J.H., Khan,M.M., Stark,A.P., Seo,S., Norton,A., Yao,Z.,
            Chen,C.H. and Regehr,W.G.
  TITLE     Cerebellar granule cell signaling is indispensable for normal motor
            performance
  JOURNAL   Cell Rep 42 (5), 112429 (2023)
   PUBMED   37141091
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Wu,C.H., Frostholm,A., De Blas,A.L. and Rotter,A.
  TITLE     Differential expression of GABAA/benzodiazepine receptor subunit
            mRNAs and ligand binding sites in mouse cerebellar neurons
            following in vivo ethanol administration: an autoradiographic
            analysis
  JOURNAL   J Neurochem 65 (3), 1229-1239 (1995)
   PUBMED   7643102
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Burrows,H.L., Seasholtz,A.F. and Camper,S.A.
  TITLE     Localization of the corticotropin-releasing hormone receptor gene
            on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (1), 55-56 (1995)
   PUBMED   7719029
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Korpi,E.R., Kleingoor,C., Kettenmann,H. and Seeburg,P.H.
  TITLE     Benzodiazepine-induced motor impairment linked to point mutation in
            cerebellar GABAA receptor
  JOURNAL   Nature 361 (6410), 356-359 (1993)
   PUBMED   7678923
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Zahniser,N.R., Buck,K.J., Curella,P., McQuilkin,S.J.,
            Wilson-Shaw,D., Miller,C.L., Klein,R.L., Heidenreich,K.A.,
            Keir,W.J., Sikela,J.M. et al.
  TITLE     GABAA receptor function and regional analysis of subunit mRNAs in
            long-sleep and short-sleep mouse brain
  JOURNAL   Brain Res Mol Brain Res 14 (3), 196-206 (1992)
   PUBMED   1359369
REFERENCE   10 (bases 1 to 2505)
  AUTHORS   Kato,K.
  TITLE     Novel GABAA receptor alpha subunit is expressed only in cerebellar
            granule cells
  JOURNAL   J Mol Biol 214 (3), 619-624 (1990)
   PUBMED   2167378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF471204.1, AK135145.1 and AI841957.1.
            
            On Mar 19, 2014 this sequence version replaced NM_001099641.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.132931.1, AK135145.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BF471204.1         1-21
            22-2486             AK135145.1         2-2466
            2487-2505           AI841957.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.03 cM"
     gene            1..2505
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 6"
                     /db_xref="GeneID:14399"
                     /db_xref="MGI:MGI:95618"
     exon            1..342
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1666
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; subunit alpha 6 gamma-aminobutyric acid
                     (GABA-A) receptor; GABA(A) receptor subunit alpha-6;
                     GABAAR subunit alpha-6; gamma-aminobutyric acid (GABA) A
                     receptor, subunit alpha 6; GABAA receptor alpha 6 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-6
                     isoform 1 precursor"
                     /protein_id="NP_001093111.1"
                     /db_xref="CCDS:CCDS48769.1"
                     /db_xref="GeneID:14399"
                     /db_xref="MGI:MGI:95618"
                     /translation="MVLLLPWLFIILWLENAQAQLEDEGNFYSENVSRILDNLLEGYD
                     NRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILS
                     LNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRL
                     VNFPMDGHACPLKFGSYAYPKTEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSE
                     TIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFG
                     ITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQK
                     AERQAQTAATPPVAKSKASESLQAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKALS
                     RTPILKSTPVSPPLLLPATGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSS
                     TVE"
     exon            343..461
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            462..529
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            530..750
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            751..833
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            834..977
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1130
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1390
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..2489
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /note="hexamer: AATAAA"
     polyA_site      2489
                     /gene="Gabra6"
                     /gene_synonym="alpha6; GABA-ARalpha6; Gabra-6"
                     /note="major polyA site"
ORIGIN      
        1 ttgtcattgc tctgactctc cacttttgat ctgaaccagt cagaggaggc tgggtatctg
       61 caggacttag tctaagacca caaacaactc taatccgtga gaaaagacag aaataagaca
      121 aaaaagaagg ggaaccccta acgtttttct ggcaaaccat tcatcctttc gattgctgac
      181 tggtcacaga gtgggatgag gaatatgaag gatttggaag acttctccag gtgattgtca
      241 aaggagatct gtctgagggg aggtaaaaac aggagggtga ccgggcatcc cagtgaacca
      301 taggatggtc ttgcttctcc cctggctctt cattattcta tggctagaaa atgcccaagc
      361 tcaacttgaa gatgaaggca acttctactc tgaaaatgtc agtcggattc ttgacaactt
      421 gctggaaggc tatgacaacc gtctacggcc aggatttggg ggtgctgtaa cagaagtcaa
      481 aacagacatc tatgtgacca gctttggacc tgtgtcagat gtggagatgg agtatacaat
      541 ggatgttttc ttccgccaga cttggactga tgagagactg aaatttaaag gccctgctga
      601 gattctgagc ttaaataact tgatggtcag taagatctgg actcctgaca cttttttccg
      661 gaatgggaaa aagtcaattg ctcacaacat gaccaccccc aacaagctct tccgattaat
      721 gcagaatgga acaatcctct ataccatgag gctcaccatc aacgctgatt gccccatgag
      781 attggttaac ttccctatgg atggacacgc ttgtccactc aagtttggga gctatgctta
      841 tcctaaaact gaaatcatat atacatggaa aaaaggacca ctttactcag tagaagtccc
      901 agaagaatct tctagcctcc tccagtatga tttgattggg caaacagttt ctagtgagac
      961 aattaaatct aacactggtg aatatgtaat catgacagtc tatttccact tacaaaggaa
     1021 gatgggctat ttcatgatcc agatatacac tccgtgcatc atgacagtca ttctttctca
     1081 agtgtctttc tggattaata aggagtcagt cccagcaaga actgtctttg gaatcaccac
     1141 tgttttaacc atgaccacct taagcatcag tgctcggcac tctctaccca aagtgtccta
     1201 tgcaaccgcc atggattggt tcatagctgt atgctttgct tttgtctttt ctgctctcat
     1261 tgaattcgca gctgtcaact acttcaccaa tctccagtca cagaaggctg aaaggcaggc
     1321 acaaactgca gccacgcccc ctgtggcaaa gtcaaaagcg tctgaatccc tgcaagcaga
     1381 gattgttgtg cattctgact ccaagtacca tctgaagaag agaatcagct ctctgacttt
     1441 gcccatcgtt ccatcttctg aggccagcaa agccctcagt agaacgccca tcttaaaatc
     1501 gacgcctgtc tctcccccat tgctcttacc agccactggg ggcaccagca aaatagatca
     1561 gtattctcga attctcttcc cagtagcttt tgcaggattc aaccttgtgt actggatagt
     1621 ttacctttcc aaagatacaa tggaagtgag cagtactgtt gagtagtttg taaccagaaa
     1681 aatctggata ctgtagtttg tcattttcca ttttcctcac tgacagaaca caaattattg
     1741 aggttagtag acatagtctc atttcagata cgacttgaaa attgaatgtc tgcatttcat
     1801 aatatggaat aggtatgtat gggctaaaaa caatagtggt actcttcaaa attaaattta
     1861 aaataaaatt tagaaggcta ctgaaaatac aaattttctg taaataatat taataatagt
     1921 aataataata ataatgtgaa taaggtagat tcaaaatgag tttgccaacc tttgtcttca
     1981 tattcaatat cttaattgtc actgtgaata atattttcca catagcagat aaattcagac
     2041 atactgaccc ttctaaagct tgccttaaat ttatttattt tgtcttaatt tctactctaa
     2101 atatttattg gtatgtttat acagcatgct ggtggccttt acaattttac aagaactttc
     2161 agtggcattg gactgcttat atttagttta gacatttctt tttaaccttg ctgtgttctt
     2221 ttacctcaat aaaatgtggc attatataaa aataaataat acatagttta taaattatgt
     2281 atgcatatgt acatagcttt agttatgctg caatactgtt gctatttccc actaaattca
     2341 catttaaaaa gaagatgctt gctaacacca ggaggttcta gcaaggtcac ttggtggact
     2401 atactatgac tgtatattct gattatggct accatcatat gctacacttt cctaaatata
     2461 atgctaaata aaaccacaac aggcctgcaa aaaaaaaaaa aaaaa
//
