LOCUS       NM_001362162            2734 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit alpha
            5 (Gabra5), transcript variant 3, mRNA.
ACCESSION   NM_001362162 XM_006540558
VERSION     NM_001362162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Zietek,M.M., Jaszczyk,A., Stankiewicz,A.M. and Sampino,S.
  TITLE     Prenatal gene-environment interactions mediate the impact of
            advanced maternal age on mouse offspring behavior
  JOURNAL   Sci Rep 14 (1), 31733 (2024)
   PUBMED   39738558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Syding,L.A., Kubik-Zahorodna,A., Reguera,D.P., Nickl,P.,
            Hruskova,B., Kralikova,M., Kopkanova,J., Novosadova,V.,
            Kasparek,P., Prochazka,J., Rozman,J., Turecek,R. and Sedlacek,R.
  TITLE     Ablation of Gabra5 Influences Corticosterone Levels and
            Anxiety-like Behavior in Mice
  JOURNAL   Genes (Basel) 14 (2), 285 (2023)
   PUBMED   36833213
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Chang,C.C., Luntz-Leybman,V., Evans,J.E., Rotter,A. and
            Frostholm,A.
  TITLE     Developmental changes in the expression of gamma-aminobutyric
            acidA/benzodiazepine receptor subunit mRNAs in the murine inferior
            olivary complex
  JOURNAL   J Comp Neurol 356 (4), 615-628 (1995)
   PUBMED   7560270
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Greger,V., Knoll,J.H., Woolf,E., Glatt,K., Tyndale,R.F.,
            DeLorey,T.M., Olsen,R.W., Tobin,A.J., Sikela,J.M., Nakatsu,Y. et
            al.
  TITLE     The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3)
            is tightly linked to the alpha 5 subunit gene (GABRA5) on human
            chromosome 15q11-q13 and is transcribed in the same orientation
  JOURNAL   Genomics 26 (2), 258-264 (1995)
   PUBMED   7601451
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Brilliant,M.H., Ching,A., Nakatsu,Y. and Eicher,E.M.
  TITLE     The original pink-eyed dilution mutation (p) arose in Asiatic mice:
            implications for the H4 minor histocompatibility antigen, Myod1
            regulation and the origin of inbred strains
  JOURNAL   Genetics 138 (1), 203-211 (1994)
   PUBMED   8001787
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Glatt,K.A., Sinnett,D. and Lalande,M.
  TITLE     Dinucleotide repeat polymorphism at the GABAA receptor alpha 5
            (GABRA5) locus at chromosome 15q11-q13
  JOURNAL   Hum Mol Genet 1 (5), 348 (1992)
   PUBMED   1338907
REFERENCE   10 (bases 1 to 2734)
  AUTHORS   Khrestchatisky,M., MacLennan,A.J., Chiang,M.Y., Xu,W.T.,
            Jackson,M.B., Brecha,N., Sternini,C., Olsen,R.W. and Tobin,A.J.
  TITLE     A novel alpha subunit in rat brain GABAA receptors
  JOURNAL   Neuron 3 (6), 745-753 (1989)
   PUBMED   2561977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160553.7 and AC102129.9.
            
            On Apr 6, 2018 this sequence version replaced XM_006540558.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.196339.1,
                                           SRR10662773.92529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC160553.7         34888-35157
            271-330             AC160553.7         36340-36399
            331-490             AC160553.7         36759-36918
            491-612             AC160553.7         54036-54157
            613-680             AC160553.7         55703-55770
            681-901             AC160553.7         55875-56095
            902-984             AC160553.7         91870-91952
            985-1128            AC102129.9         21811-21954
            1129-1281           AC102129.9         25325-25477
            1282-1493           AC102129.9         29900-30111
            1494-2734           AC102129.9         34788-36028
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 33.52 cM"
     gene            1..2734
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 5"
                     /db_xref="GeneID:110886"
                     /db_xref="MGI:MGI:95617"
     exon            1..270
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            271..330
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            331..490
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1796
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /note="gamma-aminobutyric acid receptor subunit alpha-5;
                     ligand-gated ion channel subunit; GABA(A) receptor subunit
                     alpha-5; gamma-aminobutyric acid (GABA) A receptor,
                     subunit alpha 5; GABAAR subunit alpha-5"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     precursor"
                     /protein_id="NP_001349091.1"
                     /db_xref="CCDS:CCDS21322.1"
                     /db_xref="GeneID:110886"
                     /db_xref="MGI:MGI:95617"
                     /translation="MDNGMLSRFIMTQTLLVFCISMTLSSHFGFSQMPTSSVQDETND
                     NITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQ
                     SWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGT
                     LLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAED
                     GSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQ
                     VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSA
                     LIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKE
                     QPPAGTANAPTVSIKASEEKTAESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYL
                     NREPVIKGATSPK"
     exon            491..612
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            613..680
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..901
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..984
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1128
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1281
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1493
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2734
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1995
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2731
                     /gene="Gabra5"
                     /gene_synonym="A230018I05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggtga gagcgagcgc gagtccgccg ggggcgctgg gggaatctgc agcggggcaa
       61 cgcgcggcct caggcgcggc gcggaacaga gccgcaaggc ggcagcggga gcgcagggct
      121 ccggggctcc tcggcgccga gcgccgggca agttcgctcc ggcagtatgg ggcggtgaca
      181 ccgcaccagc cagccgcgca gggacagcgg gcggcggcga agcaggatgc gccctcgccg
      241 acggctcgcc agccggggcc cgcgcgtagg caccttgcag aacaagaagc agcttgctgg
      301 ctttgaacgt gtggcaaata tttcagaaag cgtcaagatc aagttggagg caagaacagt
      361 ttttcttcca aattcatctg cttcgactat tattcttact gggaatggac aatggaatgc
      421 tctctagatt tatcatgacc caaaccctcc ttgtcttctg tatttccatg accttatcca
      481 gtcactttgg cttttcgcaa atgccaacta gttctgtaca agacgagacc aatgacaaca
      541 tcacaatatt caccaggatc ttggacggac tcttggatgg ctatgacaac agactgcggc
      601 ctgggctggg agagcgaatc acgcaggtgc gaacagacat ctatgttacc agctttggcc
      661 cagtgtctga cacggaaatg gaatatacca tcgatgtgtt tttccggcaa agctggaaag
      721 atgaaaggct gcggtttaag ggccccatgc aacgcctccc tctcaacaac cttcttgcca
      781 gcaaaatctg gactccagac acgttcttcc acaacggcaa gaagtccatt gcacacaaca
      841 tgacgacacc caacaagctg ctgaggctgg aggatgatgg cacacttctc tacaccatgc
      901 gtctgacaat ctctgctgag tgcccaatgc agcttgagga ctttccaatg gatgcccatg
      961 cctgtcccct gaaatttggc agttatgctt accctaattc tgaagttgtc tatgtttgga
     1021 ccaatggctc caccaagtct gtggtggtgg cagaagatgg ctccaggctc aaccagtacc
     1081 acctcatggg gcagacagta ggcactgaga acatcagcac cagcacaggt gaatatacga
     1141 tcatgactgc tcacttccac ctgaagagga agataggcta ctttgtcatc cagacctacc
     1201 ttccctgcat catgactgtc atcttatccc aggtgtcctt ttggctaaat cgagaatctg
     1261 tcccagctag gacagttttt ggagtgacca cagtgctgac catgacaaca ctcagcatca
     1321 gtgcccggaa ttcgctgccc aaagtggcct atgccacagc catggactgg ttcattgctg
     1381 tctgctatgc atttgtcttc tctgctctga ttgaatttgc cacagtcaac tactttacaa
     1441 agagaggatg ggcctgggat ggcaagaaag ccctggaagc agctaaaata aagaaaaaag
     1501 aacgcgaact catactaaat aagtcaacaa atgcttttac aactggaaag ctgacccatc
     1561 ctccaaacat cccaaaagag cagcctccag ctgggaccgc gaatgcaccc acagtctcca
     1621 tcaaagcttc tgaagagaag actgcggaga gtaaaaagac atacaacagc atcagcaaga
     1681 tcgacaaaat gtcccggatt gtgttcccca tcttgtttgg cactttcaac ttagtttact
     1741 gggcaacata tttgaataga gagcccgtga taaaaggggc cacctctcca aagtaaacta
     1801 ggaaacccca ctcccacaga aatgaaactg cggagagagc ccgagctcac agagactctc
     1861 tgggcgctgt ctttcaggaa attttgcatg tttaataata tgtacaaata atattgcctt
     1921 gatgtttcta cgtgtaactt caaatgtttc aaggatgtac ccttaataaa ccaagcaaat
     1981 ggccttctag aacaacgatg ggaggcaatg actgactctc agatgctcag cgccctaaca
     2041 tcaatagttt acaaacgaga gaagtatatt tttaactgtt ctgagtatat gacattttta
     2101 tacttcgaat gccatttcat acggtttttc ccagccaaca gaacatttta gggaacccct
     2161 gtgatgacca cttcacaggt gaaaaaaagc aaagttcctg gggtacacgc tgttaatgaa
     2221 gagcaaactg tggacattta agtccagtac gaattgcctt taacaattct tcttgttctg
     2281 aaattagaaa actactgcat gaactgacat taagaaatag aataagcaaa catttatgca
     2341 gacaaattta atgacaagca catagtgtct tagattagca gatcaaatac ttcccccaag
     2401 gaaaagaaat caactaattc aaagttaatt ttggttttgg tggaaaataa atatatttct
     2461 taccctatcc caacacctca acaaccttaa taatgactaa gaaaaaaacc aatcttaaac
     2521 ccttaaagca acgaggcctt ggtctttgga ggcagaaccc tttgaacatt gtttctggac
     2581 gccggctcct cttgctgccg attcagcgct gagaaattgt aactgagtta ttttctgttt
     2641 tattgccctg tacatatttc atgattggat tatcgctctg ttagcttttg tatatgaatc
     2701 ttaaatgttc attaaaaaaa tgtaaaaatc acct
//
