LOCUS       NM_008067               3727 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit alpha
            3 (Gabra3), transcript variant 1, mRNA.
ACCESSION   NM_008067 XM_359334
VERSION     NM_008067.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Neumann,E., Cramer,T., Acuna,M.A., Scheurer,L., Beccarini,C.,
            Luscher,B., Wildner,H. and Zeilhofer,H.U.
  TITLE     gamma1 GABAA Receptors in Spinal Nociceptive Circuits
  JOURNAL   J Neurosci 44 (41), e0591242024 (2024)
   PUBMED   39137998
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Mu,W. and Burt,D.R.
  TITLE     The mouse GABA(A) receptor alpha3 subunit gene and promoter
  JOURNAL   Brain Res Mol Brain Res 73 (1-2), 172-180 (1999)
   PUBMED   10581410
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   7  (bases 1 to 3727)
  AUTHORS   Wang,J.B., Kofuji,P., Fernando,J.C., Moss,S.J., Huganir,R.L. and
            Burt,D.R.
  TITLE     The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors:
            comparison in seizure-prone and -resistant mice and during
            development
  JOURNAL   J Mol Neurosci 3 (4), 177-184 (1992)
   PUBMED   1356407
REFERENCE   8  (bases 1 to 3727)
  AUTHORS   Faust,C.J. and Herman,G.E.
  TITLE     Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a
            region of the mouse X chromosome homologous to human Xq28
  JOURNAL   Genomics 11 (1), 154-164 (1991)
   PUBMED   1684949
REFERENCE   9  (bases 1 to 3727)
  AUTHORS   Derry,J.M. and Barnard,P.J.
  TITLE     Mapping of the glycine receptor alpha 2-subunit gene and the GABAA
            alpha 3-subunit gene on the mouse X chromosome
  JOURNAL   Genomics 10 (3), 593-597 (1991)
   PUBMED   1679744
REFERENCE   10 (bases 1 to 3727)
  AUTHORS   Herman,G.E., Faust,C.J., Darlison,M.G. and Barnard,E.A.
  TITLE     Genetic mapping of the mouse X chromosome in the region homologous
            to human Xq27-Xq28
  JOURNAL   Genomics 9 (4), 670-677 (1991)
   PUBMED   1674728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731695.11, AK039144.1, CD354278.1, AK134760.1 and BX119994.7.
            
            On Jul 2, 2009 this sequence version replaced NM_008067.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134760.1, AK039144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL731695.11        56571-56630         c
            61-1300             AK039144.1         2-1241
            1301-1909           CD354278.1         27-635
            1910-3722           AK134760.1         1819-3631
            3723-3727           BX119994.7         8099-8103           c
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.24 cM"
     gene            1..3727
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 3"
                     /db_xref="GeneID:14396"
                     /db_xref="MGI:MGI:95615"
     exon            1..240
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            241..415
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1754
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit
                     alpha-3; GABA(A) receptor subunit alpha-3;
                     gamma-aminobutyric acid (GABA) A receptor, subunit alpha
                     3; GABAAR subunit alpha-3"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-3
                     isoform 1 precursor"
                     /protein_id="NP_032093.3"
                     /db_xref="CCDS:CCDS30187.1"
                     /db_xref="GeneID:14396"
                     /db_xref="MGI:MGI:95615"
                     /translation="MIITQMWHFYVTRVVLLLLISILPGTTSQGESRRQEPGDFVKQD
                     IGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSF
                     GPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSV
                     AHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAE
                     VIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIG
                     YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAY
                     ATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKN
                     TTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIASPKATYVQDSPAETKTYN
                     SVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ"
     exon            416..537
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..605
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..826
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..909
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1053
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1206
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1418
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..3727
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3703..3708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /note="hexamer: ATTAAA"
     polyA_site      3724
                     /gene="Gabra3"
                     /gene_synonym="Gabra-3"
                     /note="major polyA site"
ORIGIN      
        1 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
       61 gagaggagaa gagaggaaga acgtgagcgc gcgctagcta gctagctagc aaagcagaga
      121 gacagactga gatagggact aggagaaata tctagagaaa gaaaagaagc caggctctat
      181 cagggcttag cctccaactt gtttctcctc tctgcttcgg ggaagtgact gtgacactcg
      241 atctcacagg tctcttcaag ttgctgtcta agaagatgat aatcacacaa atgtggcact
      301 tttatgtgac cagagttgta cttcttctcc tgattagtat tctccctgga accactagcc
      361 aaggggaatc aagacgacaa gaacctgggg actttgtgaa acaagatatt ggaggactct
      421 ctcccaagca tgccccagat attcctgacg atagtacaga taatatcact atcttcacta
      481 gaatcttgga tcggcttttg gatggctatg ataaccggct tcgacctgga cttggagatg
      541 cagtgactga agtgaagaca gacatctatg tgaccagttt tggccctgtg tcagacactg
      601 atatggaata tactattgat gtatttttta gacagacatg gcatgatgaa agactgaaat
      661 ttgatggacc aatgaagatc cttccactga acaatcttct ggctagtaag atatggactc
      721 ctgatacctt cttccacaat ggtaaaaaat cagtggctca caatatgacc acacccaaca
      781 agctgctcag actggtagat aatgggaccc tcctctatac aatgaggtta acaatacacg
      841 ctgaatgccc catgcatttg gaagatttcc ccatggatgt gcatgcctgc ccactgaagt
      901 ttggaagcta tgcctatacc aaagctgaag taatttattc ttggactctt gggaagaaca
      961 aatctgtgga agtagcacag gatggctcac gcctgaatca gtatgacttg cttggccatg
     1021 ttgttgggac agagataatc cggtctagta caggagaata tgtcgtcatg acaacccact
     1081 ttcatctgaa gagaaaaatt ggctactttg tcatccagac ctacttgcca tgtatcatga
     1141 ctgtcattct gtcacaagtg tctttctggc ttaatagaga atctgtccct gcccgcacag
     1201 tctttggtgt caccactgtt ctcaccatga ccaccttgag tatcagtgcc agaaactctt
     1261 tacctaaagt ggcatacgcg acggccatgg actggttcat agccgtctgt tatgcctttg
     1321 tattttctgc actgattgaa tttgctactg tcaactactt caccaagcgg agttgggctt
     1381 gggaaggcaa gaaggtacca gaggccctgg agatgaagaa gaaaacacca gcagctccaa
     1441 caaagaaaaa caccaccttc aacatagtgg gtaccaccta tcctatcaat ctggccaagg
     1501 atactgagtt ctccaccatc tccaagtctg ctgctgctcc cagtgcttct tcaactccaa
     1561 cagcgattgc ttcacccaag gctacttatg tgcaagacag tcctgctgag accaagacct
     1621 acaacagtgt cagcaaggtt gacaaaattt cccgcatcat cttccctgtg ctctttgcca
     1681 tattcaatct tgtctattgg gctacatatg tgaaccggga atcagctatc aagggcatga
     1741 tccgcaaaca gtagataata gtggcagcac agcaaccaga gcactgtata ccccaggaag
     1801 catccaaacc cgaaacccca gggctcccct catgtttcag gattcttttt aaccctgttc
     1861 caaactgagt gtaatcactt tctcaattcg tattcatgag cctcaatgaa aatgtaaaac
     1921 agaaaaatga cttgtccttt gaacattgct tggattgagc caaacactgc catttgtcca
     1981 gtttctcatc ttagtatgcc agtctacccc agctgaccgc actgcatgtg tttaatttca
     2041 ctctgcccac tggagaaagg acaggagact ctacttctag tggaaacctt ggcggtgtga
     2101 ggtctagggt gttgagatcc aggagcactg ttgactgggg cttcattgga tggttctgac
     2161 tcactacaga gtcggctggg ctatctcata taatcttact tacctgatac ccattagtgc
     2221 ttactaggca tatggcctac ctggtagaat gggaagaagt ctatggaaac ttctgaagta
     2281 accaatagtt tcttgccttg gaggtcagtg ggggacaatt gatgcttacc tctgtcaaac
     2341 atatgtatat gagagacaga gaaagagaca gagagacaga aagacagaga gagagagaga
     2401 aaactagttg ggtcattcca acgttagagc agtgggctct attgtagttt aagtcagccc
     2461 ctcaggaaag tagtgcctga atatatgtct ccttcaagaa agtcccattg cttcaataat
     2521 attgagccct ttatagccag ttgagtattg cttattttgg attcatggct gcctacaaaa
     2581 tcttccagga aaaaaatgaa cagacatttt tgagttaaat taaaatggta catgtacaaa
     2641 caaaatgatc tagatcaaat gactacacaa gaattgttca aagatgggga atataagaaa
     2701 ctcactttcc tgccaaagca attagtcaaa ttgtagatgg aatatgatgg tggtggctaa
     2761 aggctaaatc tgcctcagaa gaaagggcca caaacagatt gtatatatgg tgtcctcttt
     2821 caggcccagt cactttgttc cccattatgt caaggactcc ttacctgatt tggatgccag
     2881 ttgtaatgag gtgtgaattg tagagtcata gaaatacctg tacttatttt ttgagtcagt
     2941 taaatcatga attttattac caattttata atgtattaga gggcatttga tctcatgtgt
     3001 tcttaaatgt gaacaaaatg aacagaggca atttttataa ggtagtctca gaagtttgaa
     3061 taatttgcct ttacctctta caaatgtctt taataaagaa atattccaca ctcatttcca
     3121 atgtgaagga atagctgaga agctagggcc attttgacct tagaaccagc acagccatgg
     3181 agggccctct ggattatgga gacaatttgg acactacaaa ggtcttttaa aaggtaacaa
     3241 tatattaccc aagaagatca cttctagtag taatggctca aaggagtgag attgtttagt
     3301 ataacagcct cagccacttt ggatctgaat agctcaacta gtccagcata tccttaaggt
     3361 caaaggtaaa agccacaaat agcaccacaa gcagattctt cctgcccact cactgagcaa
     3421 ggctcctaag gggtgtatca ttagctgctg gttgtctttt catccatctt tccattattc
     3481 cctgcttcct gccattgttg ggataatgca tgccagtccc attattctta agactgtgtc
     3541 tgtaggtaaa cttatgacta gaagagtgta gtcttgtgga tgtgtgggga tggggggtgg
     3601 gatggggggc tgtcttaagg aatttagaat ggaagcctga tctttgcctc tctgtagaaa
     3661 ttgtgtttta aaatgctttg gtgcaatgtt tagcggctgt tcattaaact ctttatgaat
     3721 tgaactt
//
