LOCUS       NM_010250               4702 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus gamma-aminobutyric acid type A receptor subunit alpha
            1 (Gabra1), transcript variant 1, mRNA.
ACCESSION   NM_010250
VERSION     NM_010250.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4702)
  AUTHORS   da Cunha Menezes,E., de Abreu,F.F., Davis,J.B., Maurer,S.V.,
            Roshko,V.C., Richardson,A., Dowell,J., Cassella,S.N. and
            Stevens,H.E.
  TITLE     Effects of gestational hypothyroidism on mouse brain development:
            Gabaergic systems and oxidative stress
  JOURNAL   Dev Biol 515, 112-120 (2024)
   PUBMED   39048051
REFERENCE   2  (bases 1 to 4702)
  AUTHORS   Zavalin,K., Hassan,A., Zhang,Y., Khera,Z. and Lagrange,A.H.
  TITLE     Region and layer-specific expression of GABAA receptor isoforms and
            KCC2 in developing cortex
  JOURNAL   Front Cell Neurosci 18, 1390742 (2024)
   PUBMED   38894703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4702)
  AUTHORS   Jiang,Z.F., Xuan,L.N., Sun,X.W., Liu,S.B. and Yin,J.
  TITLE     Knockdown of SIK3 in the CA1 Region can Reduce Seizure
            Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1
            Expression
  JOURNAL   Mol Neurobiol 61 (3), 1404-1416 (2024)
   PUBMED   37715891
  REMARK    GeneRIF: Knockdown of SIK3 in the CA1 Region can Reduce Seizure
            Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1
            Expression.
REFERENCE   4  (bases 1 to 4702)
  AUTHORS   Li,C., McElroy,B.D., Phillips,J., McCloskey,N.S., Shi,X.,
            Unterwald,E.M. and Kirby,L.G.
  TITLE     Role of alpha1-GABAA receptors in the serotonergic dorsal raphe
            nucleus in models of opioid reward, anxiety, and depression
  JOURNAL   J Psychopharmacol 38 (2), 188-199 (2024)
   PUBMED   38293836
REFERENCE   5  (bases 1 to 4702)
  AUTHORS   Chen,H.Y., Phan,B.N., Shim,G., Hamersky,G.R., Sadowski,N.,
            O'Donnell,T.S., Sripathy,S.R., Bohlen,J.F., Pfenning,A.R. and
            Maher,B.J.
  TITLE     Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the
            density and connectivity of distinct inhibitory interneuron
            subtypes
  JOURNAL   Mol Psychiatry 28 (11), 4679-4692 (2023)
   PUBMED   37770578
REFERENCE   6  (bases 1 to 4702)
  AUTHORS   Zahniser,N.R., Buck,K.J., Curella,P., McQuilkin,S.J.,
            Wilson-Shaw,D., Miller,C.L., Klein,R.L., Heidenreich,K.A.,
            Keir,W.J., Sikela,J.M. et al.
  TITLE     GABAA receptor function and regional analysis of subunit mRNAs in
            long-sleep and short-sleep mouse brain
  JOURNAL   Brain Res Mol Brain Res 14 (3), 196-206 (1992)
   PUBMED   1359369
REFERENCE   7  (bases 1 to 4702)
  AUTHORS   Pownall,S., Kozak,C.A., Schappert,K., Sarkar,M., Hull,E.,
            Schachter,H. and Marth,J.D.
  TITLE     Molecular cloning and characterization of the mouse
            UDP-N-acetylglucosamine:alpha-3-D-mannoside
            beta-1,2-N-acetylglucosaminyltransferase I gene
  JOURNAL   Genomics 12 (4), 699-704 (1992)
   PUBMED   1533386
REFERENCE   8  (bases 1 to 4702)
  AUTHORS   Bowers,B.J. and Wehner,J.M.
  TITLE     Adrenalectomy and stress modulate GABAA receptor function in LS and
            SS mice
  JOURNAL   Brain Res 576 (1), 80-88 (1992)
   PUBMED   1325237
REFERENCE   9  (bases 1 to 4702)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   10 (bases 1 to 4702)
  AUTHORS   Wang,J.B., Kofuji,P., Fernando,J.C., Moss,S.J., Huganir,R.L. and
            Burt,D.R.
  TITLE     The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors:
            comparison in seizure-prone and -resistant mice and during
            development
  JOURNAL   J Mol Neurosci 3 (4), 177-184 (1992)
   PUBMED   1356407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034095.1, BC137733.1, AK141596.1 and BE945884.1.
            
            On Mar 29, 2013 this sequence version replaced NM_010250.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.254442.1, AK141596.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AK034095.1         2-322
            322-2784            BC137733.1         1-2463
            2785-4680           AK141596.1         2645-4540
            4681-4702           BE945884.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..4702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 24.97 cM"
     gene            1..4702
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 1"
                     /db_xref="GeneID:14394"
                     /db_xref="MGI:MGI:95613"
     exon            1..765
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..854
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             781..2148
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /note="gamma-aminobutyric acid receptor subunit alpha-1;
                     GABA(A) receptor subunit alpha-1; GABAA alpha 1; GABAAR
                     alpha1; gamma-aminobutyric acid (GABA) A receptor, subunit
                     alpha 1; GABAAR subunit alpha-1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_034380.1"
                     /db_xref="CCDS:CCDS24553.1"
                     /db_xref="GeneID:14394"
                     /db_xref="MGI:MGI:95613"
                     /translation="MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRI
                     LDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLK
                     FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLT
                     VRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYD
                     LLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE
                     SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN
                     YFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSA
                     TIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA
                     PTPHQ"
     exon            855..964
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1032
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1253
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1336
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1480
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1633
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1836
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..4688
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /note="hexamer: AATAAA"
     polyA_site      4688
                     /gene="Gabra1"
                     /gene_synonym="GABAA-alpha1; GABAAR-alpha1; Gabra-1"
                     /note="major polyA site"
ORIGIN      
        1 atatgtgtgg gagtgtgcga gggagagcaa gtcgaggaca gagcgctctc cacacgtgta
       61 agcctacatc tccctgcttc ctagcttgcg ttcattcata tgaatgcagt ggttaaatat
      121 ttgatcagag gtagcagagt tacaaggatc ggttgtgctt taatgagcac accttagaag
      181 agtatgctca taaatatcaa gagagaaaag atcctaagag tggcccccat ctctaaccct
      241 ttctaccctt cccttccccc atttttcagt cccccttccc ccccaaaata gaggaatgct
      301 tgcagcagat tgaagaagga tttgagccgg cagctacaga gatggggatt agggccagag
      361 tgcaagttaa attgcgctgc atataaaaaa tgggcggatt ggtgtccaga tccagtggct
      421 ggtaccacct tcctttctaa aataaaatct ctctggcatg aagtcaccgc ctatttcaca
      481 tccggtttgc gctgggacgt attactactg tcttggtaca gagaaatctt ttgttgtata
      541 gctgcagatt ggatattggg aagcaaattt gggtatgaaa tctccagtgc aggagcacgc
      601 agagtccatg atgcctcaga ccgtgtgagt gagcgcggcg cgaggacgcc ctccgcccgg
      661 cgcgcccgcg ctcgcagact cgcgcagctc cgactcaccg cgatcctctc tcccacactt
      721 ttctcccggg tctggagcga tccggtgccc agagggggcc ccgagctgtg caagcccgtg
      781 atgaagaaaa gtcggggtct ctctgactat ctttgggcct ggaccctcat tctgagcaca
      841 ctgtcgggaa gaagctatgg acagccctcc caagatgaac ttaaagacaa caccactgtc
      901 ttcacaagaa ttttggaccg actgctggac ggttatgaca atcgtctgag accaggtttg
      961 ggagagcgtg taactgaagt gaagaccgac attttcgtca ccagtttcgg accagtttca
     1021 gaccacgata tggagtatac aatagatgtg tttttccgtc aaagttggaa ggatgaaaga
     1081 ttaaaattca aaggacccat gacagtgctc cggctaaaca accttatggc cagtaaaatc
     1141 tggactccag atacattttt ccacaatgga aagaagtctg tggcccacaa catgaccatg
     1201 cctaataagc tcctgcgtat cacagaggat ggcactctgc tgtacaccat gaggttgacc
     1261 gtgagagctg aatgcccaat gcacttggaa gacttcccta tggatgccca tgcctgccca
     1321 ctaaaattcg gaagctatgc ttatacaaga gcagaagttg tctatgagtg gaccagagag
     1381 ccagcccgtt cagtggttgt agcagaagat gggtcacgtt taaaccagta tgaccttctt
     1441 ggacaaacag ttgactctgg aattgttcag tccagtactg gagaatatgt ggttatgacg
     1501 actcacttcc acttgaagag aaaaattggc tactttgtta ttcaaacata tctgccgtgc
     1561 ataatgacag ttattctctc ccaagtctcc ttctggctca acagagagtc agtaccagca
     1621 agaactgtct ttggagtgac gactgttctg actatgacaa ccttgagtat cagtgccaga
     1681 aattccctcc cgaaggtggc ttatgcaaca gctatggact ggtttattgc agtatgctat
     1741 gcctttgttt tctcagctct gattgagttt gccacagtaa actatttcac caagagaggg
     1801 tatgcgtggg atggcaaaag cgtggttcca gaaaagccaa agaaagtaaa ggatcctctc
     1861 attaagaaaa acaacacata tgctcctaca gcaaccagct atacccctaa cttagccagg
     1921 ggtgaccccg gcttggcaac tattgctaaa agtgcgacca tagaaccgaa agaagtcaag
     1981 cctgagacaa aaccaccaga acccaagaaa acctttaaca gcgtcagcaa aatcgaccga
     2041 ctgtcaagaa tagcctttcc gctgctattt ggaatcttta acttagtcta ttgggccacg
     2101 tatttaaaca gagagcctca gctaaaagcc cccacacccc atcaataggt tcttttagtc
     2161 gtattctgtt gttcagtcct ctgcaccgag aattgctttc tgttctcaac gcagtgattc
     2221 ctatctgctt tactgcctct gtcctaaaga atttgaaggt ttccttattt ccatatttca
     2281 tacaagaaca agagacccct gtctgacagt ccagagcaga gcagagtatt cagctcaggg
     2341 acaggattct gagaggaagc cagggagcaa aagcatgtca gacggagata gacaagagga
     2401 agagagaggg taagaaggtc caaagatagg agaaaaagta gaaaaaacca gagcttaact
     2461 gtaaccacag agtcatttgt agatatatat ttccaaatat tctaaaaaaa tatatacgtc
     2521 aaaaatattt ttgtgtgaaa gtgtttaaaa gggcaaataa caaatgttta atgaacttta
     2581 aacctatgtc tttattgcac aaatgatata gtgtgcttat gtttttattc gtcaatgttg
     2641 aagctgatat atagatttaa tgttttgttt gtcaaattaa aaattcccta ggctttctct
     2701 ttttaaattt cactatgtaa tattttgttg ttaaatgcta ttttagaatg taagaaagcc
     2761 taacaaatag ggcaaggtgg ggctatcact gtagcattct gaatccagtg tgggggaaac
     2821 cctttcaatg ggctacactg ctgtcatctg aacttttacc agtagactct atagagatca
     2881 gccagcctaa cacagatgtt tacttgatag aatctgaaat aaataaaaga atggaataat
     2941 ttaaaaacta tcctttttac tcttattccc agatagccca ttcacccaag aattctctat
     3001 tcttatgatg aagatgcttt cagaggggca aatctatttt gcaagctcta gaattgttga
     3061 atgtattctt ttatataact acatcaaaag ctttagattg aaatttatga ctagccaaca
     3121 aaaaatagaa tatataaatt atatatgtaa atattcagca tgagattgta catttaattt
     3181 ttttttaagt tatgttcttt aaatatcatg agggatctcc acttttagct gttagatgtt
     3241 gttaaatgct atggaaatac atttagagcc tgcatttaag aacagaacag cctgtaggag
     3301 acagatgcca cttaaaacat attgagtatg aaattcaatt ataccgagaa ctctcataac
     3361 ttcactgctg ccctgtgttc aatagtagat cagttgctat ctgctcgaat tatgtcatac
     3421 catattttcc tattttaggc tattgtgata aagagaaaaa atagggaaga gtagttggag
     3481 ctagaaaacc aactgtatat tatttctcta tttgctgata ccaactattt caataagtgc
     3541 tgtaccatat gtagcatcta atataaaata catgaaagaa tgtacaggaa ctagctttta
     3601 ttgagtaata ttattacagt tcatttatac tgcagcaata tatttgtagg tatactatgt
     3661 aagggcttta aataaaagag gtccattaat attccttata aaaaattcta gcctttcatt
     3721 attgcccaga tgttttagaa gtaaatattt atgaagaagg tatttttgaa gtctcctttt
     3781 gtctgataga ttttcacaga tatttaacat tagttcagaa tccacggatc atggtctaat
     3841 cacatttata agaccatgat ataagccttt tagcataatg gccaaataag acaattagaa
     3901 tccatacctg agttttgagc aatgttattc tcaaaaagct gctatccaat gatgttggaa
     3961 aacacactgc ctgtgtttcc ctaaaacgac aaatctctgg tttcatctta aatgtgcttc
     4021 attgtttgat ttggtcctgc ctaaatttca tgagctatgc caaaaaaaaa aaaaaaaaat
     4081 ggctgaacaa aggacatttc atgtatagat atgtatagaa aataaaataa attatggctc
     4141 taacatccgt gttgccgttt atcttgttat tttccggcgt taacctaaca tgtttagtgc
     4201 gagtatttta tcttccagac tcctcatgcc taggtttggg tctgtatttt gctcattaga
     4261 tgtgaatatc tcttattagt ctgcttatgc tttgcaatga tcgtattgcc atcatttctt
     4321 agttgttagt acatgtgagt agtactctat tatgtaaatt gattgcaaac ttatcaaaga
     4381 gaaattattc tatgtagctt tacaacagtg ctttgctaaa ccatgtacta gtagttaagt
     4441 cttccttgag aaaaataaag atacactctt ataaagaaca gttcctgctg actcccagga
     4501 attttttttt aagatgacac tgaatgttga tgcaccttag tgcagtgaag tggcaataaa
     4561 acccaaactg agtcaagatt gctcatggca gctgcatgtc tcgctttcca gagtttagca
     4621 aaacctttta atctcatgtc tcactgtatt ctattataat aataaagctt acattattca
     4681 ataataaaaa aaaaaaaaaa aa
//
