LOCUS       NM_001406227            2196 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 46, mRNA.
ACCESSION   NM_001406227
VERSION     NM_001406227.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.816627.1,
                                           SRR17784645.1270893.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL844555.8         104571-104717       c
            148-255             AL844555.8         87685-87792         c
            256-423             AL844555.8         82770-82937         c
            424-609             AL844555.8         75778-75963         c
            610-725             AL844555.8         68444-68559         c
            726-2196            AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2196
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..147
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..255
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..423
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..609
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..878
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform w is encoded by transcript variant 46;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform w"
                     /protein_id="NP_001393156.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCMEIIE
                     SRVECAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRIQTNKEA
                     V"
     exon            610..725
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2196
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2196
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccagatg tccctggtag atttggggaa gaagctttta
      181 gaagcggcac gagccggtca agatgatgaa gttcgcattt tgatggcaaa tggagctcct
      241 tttactacag actggttggg aacttctcca cttcatctgg ccgcacagta tgggcatttc
      301 tctaccacag aggttcttct ccgagccggt gtaagtagag atgccaggac caaagtggac
      361 cggacaccac tgcacatggc ggcttctgag ggccatgcca acatagtaga agttttgctt
      421 aagtagtggc cacagaggaa gtggttaccg cagaatctgt ggatggtgca attcagcaag
      481 tagttagctc agggggtcag caagtcatca cgatagttac agatggaatc cagctgggga
      541 atttgcactc cataccaacc agtgggatgg gtcagcccat cattgtgacg atgcccgatg
      601 gacagcaagt attgacagta ccagcaacag acattgctga agaaactgtc atcagtgaag
      661 agccaccagc taagagacag tgtatggaaa taattgagag ccgggtggaa tgtgcagaaa
      721 ttgaagagag agaagcgctt cagaaacagc tggatgaagc caaccgagag gcccagaaat
      781 accgacagca gctgcttaag aaggagcagg aggcagaggc ctacaggcag aagctggagg
      841 ccatgacacg catccagacc aacaaagaag ccgtttagct gccatgaaca ccagtttgct
      901 tttacctttt gtccagaaag aatatagtct tgaactgtac acagtaagga cacagccatg
      961 ggaataccga ataatagaaa atactacagc ttgataacgg gacttaagcc atgagctctc
     1021 aattcttgta atataaaact ttagaacttg tgaaatgtat ttaaaactga attctgtaaa
     1081 tagttttttg gttgtttctt tttttactgt tataaatgag ttgatgaagc ttgttgctga
     1141 gatccagagg ccacagcaag ccactgttac ggggaattct ttttgatttc ggtgcagact
     1201 taatttctca gaaacagaag ttgtaagcgt ggttgttgtc tcttagacca aatgtggaac
     1261 aattatggtg gactgatgct ggaaatactc tgcaaagaga tttcgcccag gaacttttgt
     1321 acagctttta agttgtctca ggttctctga aaacattttt taggaagcag aaattttata
     1381 tttgttctat ttcagctaca tgcaagtaga tttacatgta tatgaagcaa atatttttaa
     1441 aattttgttt gtacatatcc tgcatgtttt atgattttaa aacacatccc ttgcttaggt
     1501 atgtctccta caaagacgat gaaagttacc aagaaaaaaa ccaaggcacc actgtcgttc
     1561 tgccggtcgt tgagagtgag taagctcaca gctggtttta ctggcgacca tgacaatgtt
     1621 cttggagcag cttgcaagag aactcgaatc tgcaaaatat atgcttttct gacaattgta
     1681 ttgtgaggat gtgagactgc tctgtgcctt ccttccatca tgacttccac acgagcactt
     1741 tgaggcgctg gattttaaga taatgttttt ggcaaactca gtgcatttgg gtttctgaaa
     1801 tatttcatgg acttactccc ctcccctaag aaattaaatt attcttatgg aaattgcttt
     1861 tgtatgcaga gcaggacctt ttgtactcag tgaggctatg ggtgtgtcta acgtaacttt
     1921 cggtattccc tgtgaacgcg ctccgggcct gtgctgcgac tctctcacaa tattgtcaat
     1981 tctgaaatgt atggacattt gacagactat tccattctct tttgtaaaat gtaacttcaa
     2041 gctctttatt attttgtttt gttctattgc tttatgaaaa cgtttgcccc tcccccaccc
     2101 caggctcctc tagcttatct gtataaagaa ccagttacct gcgagactgt actctggcct
     2161 cattttctat tttacaatta aataactttc cacata
//
