LOCUS       NM_001406226            2294 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 45, mRNA.
ACCESSION   NM_001406226
VERSION     NM_001406226.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1495527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL844555.8         104571-104717       c
            148-245             AL844555.8         92206-92303         c
            246-353             AL844555.8         87685-87792         c
            354-521             AL844555.8         82770-82937         c
            522-707             AL844555.8         75778-75963         c
            708-823             AL844555.8         68444-68559         c
            824-2294            AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2294
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..147
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..245
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..353
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..521
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..707
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             665..976
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform w is encoded by transcript variant 45;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform w"
                     /protein_id="NP_001393155.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCMEIIE
                     SRVECAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRIQTNKEA
                     V"
     exon            708..823
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..2294
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2294
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccagcag ccctcctacc tgctgaccag ctcccagact
      181 cttgggcatt ttcattgtct ggatgcaact gaatttctcc cagtcagaat tcattgtgtt
      241 ttcagatgtc cctggtagat ttggggaaga agcttttaga agcggcacga gccggtcaag
      301 atgatgaagt tcgcattttg atggcaaatg gagctccttt tactacagac tggttgggaa
      361 cttctccact tcatctggcc gcacagtatg ggcatttctc taccacagag gttcttctcc
      421 gagccggtgt aagtagagat gccaggacca aagtggaccg gacaccactg cacatggcgg
      481 cttctgaggg ccatgccaac atagtagaag ttttgcttaa gtagtggcca cagaggaagt
      541 ggttaccgca gaatctgtgg atggtgcaat tcagcaagta gttagctcag ggggtcagca
      601 agtcatcacg atagttacag atggaatcca gctggggaat ttgcactcca taccaaccag
      661 tgggatgggt cagcccatca ttgtgacgat gcccgatgga cagcaagtat tgacagtacc
      721 agcaacagac attgctgaag aaactgtcat cagtgaagag ccaccagcta agagacagtg
      781 tatggaaata attgagagcc gggtggaatg tgcagaaatt gaagagagag aagcgcttca
      841 gaaacagctg gatgaagcca accgagaggc ccagaaatac cgacagcagc tgcttaagaa
      901 ggagcaggag gcagaggcct acaggcagaa gctggaggcc atgacacgca tccagaccaa
      961 caaagaagcc gtttagctgc catgaacacc agtttgcttt taccttttgt ccagaaagaa
     1021 tatagtcttg aactgtacac agtaaggaca cagccatggg aataccgaat aatagaaaat
     1081 actacagctt gataacggga cttaagccat gagctctcaa ttcttgtaat ataaaacttt
     1141 agaacttgtg aaatgtattt aaaactgaat tctgtaaata gttttttggt tgtttctttt
     1201 tttactgtta taaatgagtt gatgaagctt gttgctgaga tccagaggcc acagcaagcc
     1261 actgttacgg ggaattcttt ttgatttcgg tgcagactta atttctcaga aacagaagtt
     1321 gtaagcgtgg ttgttgtctc ttagaccaaa tgtggaacaa ttatggtgga ctgatgctgg
     1381 aaatactctg caaagagatt tcgcccagga acttttgtac agcttttaag ttgtctcagg
     1441 ttctctgaaa acatttttta ggaagcagaa attttatatt tgttctattt cagctacatg
     1501 caagtagatt tacatgtata tgaagcaaat atttttaaaa ttttgtttgt acatatcctg
     1561 catgttttat gattttaaaa cacatccctt gcttaggtat gtctcctaca aagacgatga
     1621 aagttaccaa gaaaaaaacc aaggcaccac tgtcgttctg ccggtcgttg agagtgagta
     1681 agctcacagc tggttttact ggcgaccatg acaatgttct tggagcagct tgcaagagaa
     1741 ctcgaatctg caaaatatat gcttttctga caattgtatt gtgaggatgt gagactgctc
     1801 tgtgccttcc ttccatcatg acttccacac gagcactttg aggcgctgga ttttaagata
     1861 atgtttttgg caaactcagt gcatttgggt ttctgaaata tttcatggac ttactcccct
     1921 cccctaagaa attaaattat tcttatggaa attgcttttg tatgcagagc aggacctttt
     1981 gtactcagtg aggctatggg tgtgtctaac gtaactttcg gtattccctg tgaacgcgct
     2041 ccgggcctgt gctgcgactc tctcacaata ttgtcaattc tgaaatgtat ggacatttga
     2101 cagactattc cattctcttt tgtaaaatgt aacttcaagc tctttattat tttgttttgt
     2161 tctattgctt tatgaaaacg tttgcccctc ccccacccca ggctcctcta gcttatctgt
     2221 ataaagaacc agttacctgc gagactgtac tctggcctca ttttctattt tacaattaaa
     2281 taactttcca cata
//
