LOCUS       NM_001406221            2501 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 40, mRNA.
ACCESSION   NM_001406221 XM_030247529
VERSION     NM_001406221.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2501)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2501)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2501)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2501)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            On May 11, 2022 this sequence version replaced XM_030247529.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.646315.1,
                                           SRR13422598.230264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL844555.8         104571-104717       c
            148-255             AL844555.8         87685-87792         c
            256-423             AL844555.8         82770-82937         c
            424-618             AL844555.8         81448-81642         c
            619-730             AL844555.8         79724-79835         c
            731-844             AL844555.8         79283-79396         c
            845-1030            AL844555.8         75778-75963         c
            1031-2501           AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2501
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..147
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1062
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform s is encoded by transcript variant 40;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform s"
                     /protein_id="NP_001393150.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHL
                     AAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDM
                     LKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAM
                     QNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAAL
                     AEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSI
                     PTSGMGQPIIVTMPDGQQGERSASETAG"
     exon            148..255
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..423
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..618
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..730
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..844
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1030
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..2501
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2501
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccagatg tccctggtag atttggggaa gaagctttta
      181 gaagcggcac gagccggtca agatgatgaa gttcgcattt tgatggcaaa tggagctcct
      241 tttactacag actggttggg aacttctcca cttcatctgg ccgcacagta tgggcatttc
      301 tctaccacag aggttcttct ccgagccggt gtaagtagag atgccaggac caaagtggac
      361 cggacaccac tgcacatggc ggcttctgag ggccatgcca acatagtaga agttttgctt
      421 aagcatggtg ctgacgtcaa tgcaaaggat atgttaaaga tgacagctct gcattgggca
      481 acagaacata atcatcaaga ggtggtggag cttttaatca aatatggtgc tgatgtacac
      541 acgcagagta aattttgtaa aactgcattt gatatttcaa tagacaatgg aaatgaagat
      601 ttagcagaga tattacagat tgctatgcag aaccaaatca acaccaaccc ggagagtcct
      661 gacactgtga caatacacgc tgccacacca cagttcatca ttggacccgg aggggtggtg
      721 aacctcacag atgaaacagg agtatctgct gttcagtttg gaaactcctc tacgtcagta
      781 ttagctacgt tagctgcctt agctgaagct tctgccccat tgtccaattc ttcagaaact
      841 ccagtagtgg ccacagagga agtggttacc gcagaatctg tggatggtgc aattcagcaa
      901 gtagttagct cagggggtca gcaagtcatc acgatagtta cagatggaat ccagctgggg
      961 aatttgcact ccataccaac cagtgggatg ggtcagccca tcattgtgac gatgcccgat
     1021 ggacagcaag gagagagaag cgcttcagaa acagctggat gaagccaacc gagaggccca
     1081 gaaataccga cagcagctgc ttaagaagga gcaggaggca gaggcctaca ggcagaagct
     1141 ggaggccatg acacgcatcc agaccaacaa agaagccgtt tagctgccat gaacaccagt
     1201 ttgcttttac cttttgtcca gaaagaatat agtcttgaac tgtacacagt aaggacacag
     1261 ccatgggaat accgaataat agaaaatact acagcttgat aacgggactt aagccatgag
     1321 ctctcaattc ttgtaatata aaactttaga acttgtgaaa tgtatttaaa actgaattct
     1381 gtaaatagtt ttttggttgt ttcttttttt actgttataa atgagttgat gaagcttgtt
     1441 gctgagatcc agaggccaca gcaagccact gttacgggga attctttttg atttcggtgc
     1501 agacttaatt tctcagaaac agaagttgta agcgtggttg ttgtctctta gaccaaatgt
     1561 ggaacaatta tggtggactg atgctggaaa tactctgcaa agagatttcg cccaggaact
     1621 tttgtacagc ttttaagttg tctcaggttc tctgaaaaca ttttttagga agcagaaatt
     1681 ttatatttgt tctatttcag ctacatgcaa gtagatttac atgtatatga agcaaatatt
     1741 tttaaaattt tgtttgtaca tatcctgcat gttttatgat tttaaaacac atcccttgct
     1801 taggtatgtc tcctacaaag acgatgaaag ttaccaagaa aaaaaccaag gcaccactgt
     1861 cgttctgccg gtcgttgaga gtgagtaagc tcacagctgg ttttactggc gaccatgaca
     1921 atgttcttgg agcagcttgc aagagaactc gaatctgcaa aatatatgct tttctgacaa
     1981 ttgtattgtg aggatgtgag actgctctgt gccttccttc catcatgact tccacacgag
     2041 cactttgagg cgctggattt taagataatg tttttggcaa actcagtgca tttgggtttc
     2101 tgaaatattt catggactta ctcccctccc ctaagaaatt aaattattct tatggaaatt
     2161 gcttttgtat gcagagcagg accttttgta ctcagtgagg ctatgggtgt gtctaacgta
     2221 actttcggta ttccctgtga acgcgctccg ggcctgtgct gcgactctct cacaatattg
     2281 tcaattctga aatgtatgga catttgacag actattccat tctcttttgt aaaatgtaac
     2341 ttcaagctct ttattatttt gttttgttct attgctttat gaaaacgttt gcccctcccc
     2401 caccccaggc tcctctagct tatctgtata aagaaccagt tacctgcgag actgtactct
     2461 ggcctcattt tctattttac aattaaataa ctttccacat a
//
