LOCUS       NM_001406207            2678 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 26, mRNA.
ACCESSION   NM_001406207 XM_006498755
VERSION     NM_001406207.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2678)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2678)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2678)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2678)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2678)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2678)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2678)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2678)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2678)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2678)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            On May 11, 2022 this sequence version replaced XM_006498755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.881451.1,
                                           SRR7974084.5578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL844555.8         104510-104717       c
            209-316             AL844555.8         87685-87792         c
            317-484             AL844555.8         82770-82937         c
            485-679             AL844555.8         81448-81642         c
            680-791             AL844555.8         79724-79835         c
            792-905             AL844555.8         79283-79396         c
            906-1091            AL844555.8         75778-75963         c
            1092-1207           AL844555.8         68444-68559         c
            1208-2678           AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2678
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..208
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1360
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform i is encoded by transcript variant 26;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform i"
                     /protein_id="NP_001393136.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MWKLISSLMSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDW
                     LGTSPLHLAAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHG
                     ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDL
                     AEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTS
                     VLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGI
                     QLGNLHSIPTSGMGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCMEIIESR
                     VECAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRIQTNKEAV"
     exon            209..316
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..484
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..679
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..791
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..905
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1091
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1207
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2678
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2678
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccaggtc agtgcgggtc tgtgtagggc cctgttacca
      181 ccggatgtgg aagttgatct cttcgctgat gtccctggta gatttgggga agaagctttt
      241 agaagcggca cgagccggtc aagatgatga agttcgcatt ttgatggcaa atggagctcc
      301 ttttactaca gactggttgg gaacttctcc acttcatctg gccgcacagt atgggcattt
      361 ctctaccaca gaggttcttc tccgagccgg tgtaagtaga gatgccagga ccaaagtgga
      421 ccggacacca ctgcacatgg cggcttctga gggccatgcc aacatagtag aagttttgct
      481 taagcatggt gctgacgtca atgcaaagga tatgttaaag atgacagctc tgcattgggc
      541 aacagaacat aatcatcaag aggtggtgga gcttttaatc aaatatggtg ctgatgtaca
      601 cacgcagagt aaattttgta aaactgcatt tgatatttca atagacaatg gaaatgaaga
      661 tttagcagag atattacaga ttgctatgca gaaccaaatc aacaccaacc cggagagtcc
      721 tgacactgtg acaatacacg ctgccacacc acagttcatc attggacccg gaggggtggt
      781 gaacctcaca gatgaaacag gagtatctgc tgttcagttt ggaaactcct ctacgtcagt
      841 attagctacg ttagctgcct tagctgaagc ttctgcccca ttgtccaatt cttcagaaac
      901 tccagtagtg gccacagagg aagtggttac cgcagaatct gtggatggtg caattcagca
      961 agtagttagc tcagggggtc agcaagtcat cacgatagtt acagatggaa tccagctggg
     1021 gaatttgcac tccataccaa ccagtgggat gggtcagccc atcattgtga cgatgcccga
     1081 tggacagcaa gtattgacag taccagcaac agacattgct gaagaaactg tcatcagtga
     1141 agagccacca gctaagagac agtgtatgga aataattgag agccgggtgg aatgtgcaga
     1201 aattgaagag agagaagcgc ttcagaaaca gctggatgaa gccaaccgag aggcccagaa
     1261 ataccgacag cagctgctta agaaggagca ggaggcagag gcctacaggc agaagctgga
     1321 ggccatgaca cgcatccaga ccaacaaaga agccgtttag ctgccatgaa caccagtttg
     1381 cttttacctt ttgtccagaa agaatatagt cttgaactgt acacagtaag gacacagcca
     1441 tgggaatacc gaataataga aaatactaca gcttgataac gggacttaag ccatgagctc
     1501 tcaattcttg taatataaaa ctttagaact tgtgaaatgt atttaaaact gaattctgta
     1561 aatagttttt tggttgtttc tttttttact gttataaatg agttgatgaa gcttgttgct
     1621 gagatccaga ggccacagca agccactgtt acggggaatt ctttttgatt tcggtgcaga
     1681 cttaatttct cagaaacaga agttgtaagc gtggttgttg tctcttagac caaatgtgga
     1741 acaattatgg tggactgatg ctggaaatac tctgcaaaga gatttcgccc aggaactttt
     1801 gtacagcttt taagttgtct caggttctct gaaaacattt tttaggaagc agaaatttta
     1861 tatttgttct atttcagcta catgcaagta gatttacatg tatatgaagc aaatattttt
     1921 aaaattttgt ttgtacatat cctgcatgtt ttatgatttt aaaacacatc ccttgcttag
     1981 gtatgtctcc tacaaagacg atgaaagtta ccaagaaaaa aaccaaggca ccactgtcgt
     2041 tctgccggtc gttgagagtg agtaagctca cagctggttt tactggcgac catgacaatg
     2101 ttcttggagc agcttgcaag agaactcgaa tctgcaaaat atatgctttt ctgacaattg
     2161 tattgtgagg atgtgagact gctctgtgcc ttccttccat catgacttcc acacgagcac
     2221 tttgaggcgc tggattttaa gataatgttt ttggcaaact cagtgcattt gggtttctga
     2281 aatatttcat ggacttactc ccctccccta agaaattaaa ttattcttat ggaaattgct
     2341 tttgtatgca gagcaggacc ttttgtactc agtgaggcta tgggtgtgtc taacgtaact
     2401 ttcggtattc cctgtgaacg cgctccgggc ctgtgctgcg actctctcac aatattgtca
     2461 attctgaaat gtatggacat ttgacagact attccattct cttttgtaaa atgtaacttc
     2521 aagctcttta ttattttgtt ttgttctatt gctttatgaa aacgtttgcc cctcccccac
     2581 cccaggctcc tctagcttat ctgtataaag aaccagttac ctgcgagact gtactctggc
     2641 ctcattttct attttacaat taaataactt tccacata
//
