LOCUS       NP_001393136             391 aa            linear   ROD 13-FEB-2025
DEFINITION  GA-binding protein subunit beta-1 isoform i [Mus musculus].
ACCESSION   NP_001393136 XP_006498818
VERSION     NP_001393136.1
DBSOURCE    REFSEQ: accession NM_001406207.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 391)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 391)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (residues 1 to 391)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (residues 1 to 391)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (residues 1 to 391)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (residues 1 to 391)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (residues 1 to 391)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (residues 1 to 391)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (residues 1 to 391)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (residues 1 to 391)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            On May 11, 2022 this sequence version replaced XP_006498818.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.881451.1,
                                           SRR7974084.5578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     Protein         1..391
                     /product="GA-binding protein subunit beta-1 isoform i"
                     /EC_number="3.2.1.3"
                     /note="GA-binding protein subunit beta-1; Gabp beta1; GA
                     binding protein subunit beta1; GABP subunit beta-1; GABP
                     subunit beta-2"
                     /calculated_mol_wt=42186
     Region          <18..187
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          18..43
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          46..76
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(47,51..52,55..57,59..60,64,67,76,78,80,84..85,
                     88..90,92..93,97,100,109,111,113,117..118,121..123,
                     125..126,130,133)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          78..109
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          111..141
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <324..>378
                     /region_name="Oberon_cc"
                     /note="Coiled-coil region of Oberon; pfam16312"
                     /db_xref="CDD:465089"
     CDS             1..391
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /coded_by="NM_001406207.1:185..1360"
                     /note="isoform i is encoded by transcript variant 26"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
ORIGIN      
        1 mwklisslms lvdlgkklle aaragqddev rilmangapf ttdwlgtspl hlaaqyghfs
       61 ttevllragv srdartkvdr tplhmaaseg hanivevllk hgadvnakdm lkmtalhwat
      121 ehnhqevvel likygadvht qskfcktafd isidngnedl aeilqiamqn qintnpespd
      181 tvtihaatpq fiigpggvvn ltdetgvsav qfgnsstsvl atlaalaeas aplsnssetp
      241 vvateevvta esvdgaiqqv vssggqqvit ivtdgiqlgn lhsiptsgmg qpiivtmpdg
      301 qqvltvpatd iaeetvisee ppakrqcmei iesrvecaei eerealqkql deanreaqky
      361 rqqllkkeqe aeayrqklea mtriqtnkea v
//
