LOCUS       NM_001406206            2315 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 25, mRNA.
ACCESSION   NM_001406206
VERSION     NM_001406206.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2315)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2315)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2315)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777531.471927.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL844555.8         104571-104717       c
            148-255             AL844555.8         87685-87792         c
            256-423             AL844555.8         82770-82937         c
            424-618             AL844555.8         81448-81642         c
            619-730             AL844555.8         79724-79835         c
            731-844             AL844555.8         79283-79396         c
            845-2315            AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2315
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..147
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..876
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform h is encoded by transcript variant 25;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform h"
                     /protein_id="NP_001393135.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHL
                     AAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDM
                     LKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAM
                     QNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAAL
                     AEASAPLSNSSETPGERSASETAG"
     exon            148..255
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..423
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..618
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..730
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..844
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..2315
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2315
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccagatg tccctggtag atttggggaa gaagctttta
      181 gaagcggcac gagccggtca agatgatgaa gttcgcattt tgatggcaaa tggagctcct
      241 tttactacag actggttggg aacttctcca cttcatctgg ccgcacagta tgggcatttc
      301 tctaccacag aggttcttct ccgagccggt gtaagtagag atgccaggac caaagtggac
      361 cggacaccac tgcacatggc ggcttctgag ggccatgcca acatagtaga agttttgctt
      421 aagcatggtg ctgacgtcaa tgcaaaggat atgttaaaga tgacagctct gcattgggca
      481 acagaacata atcatcaaga ggtggtggag cttttaatca aatatggtgc tgatgtacac
      541 acgcagagta aattttgtaa aactgcattt gatatttcaa tagacaatgg aaatgaagat
      601 ttagcagaga tattacagat tgctatgcag aaccaaatca acaccaaccc ggagagtcct
      661 gacactgtga caatacacgc tgccacacca cagttcatca ttggacccgg aggggtggtg
      721 aacctcacag atgaaacagg agtatctgct gttcagtttg gaaactcctc tacgtcagta
      781 ttagctacgt tagctgcctt agctgaagct tctgccccat tgtccaattc ttcagaaact
      841 ccaggagaga gaagcgcttc agaaacagct ggatgaagcc aaccgagagg cccagaaata
      901 ccgacagcag ctgcttaaga aggagcagga ggcagaggcc tacaggcaga agctggaggc
      961 catgacacgc atccagacca acaaagaagc cgtttagctg ccatgaacac cagtttgctt
     1021 ttaccttttg tccagaaaga atatagtctt gaactgtaca cagtaaggac acagccatgg
     1081 gaataccgaa taatagaaaa tactacagct tgataacggg acttaagcca tgagctctca
     1141 attcttgtaa tataaaactt tagaacttgt gaaatgtatt taaaactgaa ttctgtaaat
     1201 agttttttgg ttgtttcttt ttttactgtt ataaatgagt tgatgaagct tgttgctgag
     1261 atccagaggc cacagcaagc cactgttacg gggaattctt tttgatttcg gtgcagactt
     1321 aatttctcag aaacagaagt tgtaagcgtg gttgttgtct cttagaccaa atgtggaaca
     1381 attatggtgg actgatgctg gaaatactct gcaaagagat ttcgcccagg aacttttgta
     1441 cagcttttaa gttgtctcag gttctctgaa aacatttttt aggaagcaga aattttatat
     1501 ttgttctatt tcagctacat gcaagtagat ttacatgtat atgaagcaaa tatttttaaa
     1561 attttgtttg tacatatcct gcatgtttta tgattttaaa acacatccct tgcttaggta
     1621 tgtctcctac aaagacgatg aaagttacca agaaaaaaac caaggcacca ctgtcgttct
     1681 gccggtcgtt gagagtgagt aagctcacag ctggttttac tggcgaccat gacaatgttc
     1741 ttggagcagc ttgcaagaga actcgaatct gcaaaatata tgcttttctg acaattgtat
     1801 tgtgaggatg tgagactgct ctgtgccttc cttccatcat gacttccaca cgagcacttt
     1861 gaggcgctgg attttaagat aatgtttttg gcaaactcag tgcatttggg tttctgaaat
     1921 atttcatgga cttactcccc tcccctaaga aattaaatta ttcttatgga aattgctttt
     1981 gtatgcagag caggaccttt tgtactcagt gaggctatgg gtgtgtctaa cgtaactttc
     2041 ggtattccct gtgaacgcgc tccgggcctg tgctgcgact ctctcacaat attgtcaatt
     2101 ctgaaatgta tggacatttg acagactatt ccattctctt ttgtaaaatg taacttcaag
     2161 ctctttatta ttttgttttg ttctattgct ttatgaaaac gtttgcccct cccccacccc
     2221 aggctcctct agcttatctg tataaagaac cagttacctg cgagactgta ctctggcctc
     2281 attttctatt ttacaattaa ataactttcc acata
//
