LOCUS       NM_001406200            2715 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, beta 1 (Gabpb1), transcript
            variant 19, mRNA.
ACCESSION   NM_001406200 XM_006498757
VERSION     NM_001406200.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Ihashi,S., Hamanaka,M., Kaji,M., Mori,R., Nishizaki,S., Mori,M.,
            Imasato,Y., Inoue,K., Matoba,S., Ogonuki,N., Takasu,A.,
            Nakamura,M., Matsumoto,K., Anzai,M., Ogura,A., Ikawa,M. and
            Miyamoto,K.
  TITLE     Incomplete activation of Alyref and Gabpb1 leads to preimplantation
            arrest in cloned mouse embryos
  JOURNAL   Life Sci Alliance 6 (11), e202302296 (2023)
   PUBMED   37640449
  REMARK    GeneRIF: Incomplete activation of Alyref and Gabpb1 leads to
            preimplantation arrest in cloned mouse embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Ryu,D., Jo,Y.S., Lo Sasso,G., Stein,S., Zhang,H., Perino,A.,
            Lee,J.U., Zeviani,M., Romand,R., Hottiger,M.O., Schoonjans,K. and
            Auwerx,J.
  TITLE     A SIRT7-dependent acetylation switch of GABPbeta1 controls
            mitochondrial function
  JOURNAL   Cell Metab 20 (5), 856-869 (2014)
   PUBMED   25200183
  REMARK    GeneRIF: SIRT7 stabilizes and activates the GABP alpha/GABPbeta
            complex via deacetylation of GABPbeta1.
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Yu,S., Jing,X., Colgan,J.D., Zhao,D.M. and Xue,H.H.
  TITLE     Targeting tetramer-forming GABPbeta isoforms impairs self-renewal
            of hematopoietic and leukemic stem cells
  JOURNAL   Cell Stem Cell 11 (2), 207-219 (2012)
   PUBMED   22862946
  REMARK    GeneRIF: The findings identify the tetramer-forming GABPbeta1 as
            specific HSC regulators and potential therapeutic targets in
            treating LSC-based hematological malignancy.
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Batchelor,A.H., Piper,D.E., de la Brousse,F.C., McKnight,S.L. and
            Wolberger,C.
  TITLE     The structure of GABPalpha/beta: an ETS domain- ankyrin repeat
            heterodimer bound to DNA
  JOURNAL   Science 279 (5353), 1037-1041 (1998)
   PUBMED   9461436
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844555.8.
            
            On May 11, 2022 this sequence version replaced XM_006498757.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.273413.1,
                                           SRR13422600.1735122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL844555.8         104571-104717       c
            148-245             AL844555.8         92206-92303         c
            246-353             AL844555.8         87685-87792         c
            354-521             AL844555.8         82770-82937         c
            522-716             AL844555.8         81448-81642         c
            717-828             AL844555.8         79724-79835         c
            829-942             AL844555.8         79283-79396         c
            943-1128            AL844555.8         75778-75963         c
            1129-1244           AL844555.8         68444-68559         c
            1245-2715           AL844555.8         58127-59597         c
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2715
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="GA repeat binding protein, beta 1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
     exon            1..147
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..245
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1397
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform d is encoded by transcript variant 19;
                     GA-binding protein subunit beta-1; Gabp beta1; GA binding
                     protein subunit beta1; GABP subunit beta-1; GABP subunit
                     beta-2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform d"
                     /protein_id="NP_001393129.1"
                     /db_xref="GeneID:14391"
                     /db_xref="MGI:MGI:95611"
                     /translation="MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHL
                     AAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDM
                     LKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAM
                     QNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAAL
                     AEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSI
                     PTSGMGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCMEIIESRVECAEIEE
                     REALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRIQTNKEAV"
     exon            246..353
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..521
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..716
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..828
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..942
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1128
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1244
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..2715
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2715
                     /gene="Gabpb1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4Tf1B;
                     GABPB; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; NRF2B1;
                     NRF2B2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggca ttttcggaaa atagcgccct gtgcagcgaa gcgctctgtg tgtggcgggg
       61 ccgcgtctgc cctgacggct ccgaggcgcc gcggtccccg cacctcctcc cgctgctccc
      121 ccgccgccgc tcccgaagct tttccagcag ccctcctacc tgctgaccag ctcccagact
      181 cttgggcatt ttcattgtct ggatgcaact gaatttctcc cagtcagaat tcattgtgtt
      241 ttcagatgtc cctggtagat ttggggaaga agcttttaga agcggcacga gccggtcaag
      301 atgatgaagt tcgcattttg atggcaaatg gagctccttt tactacagac tggttgggaa
      361 cttctccact tcatctggcc gcacagtatg ggcatttctc taccacagag gttcttctcc
      421 gagccggtgt aagtagagat gccaggacca aagtggaccg gacaccactg cacatggcgg
      481 cttctgaggg ccatgccaac atagtagaag ttttgcttaa gcatggtgct gacgtcaatg
      541 caaaggatat gttaaagatg acagctctgc attgggcaac agaacataat catcaagagg
      601 tggtggagct tttaatcaaa tatggtgctg atgtacacac gcagagtaaa ttttgtaaaa
      661 ctgcatttga tatttcaata gacaatggaa atgaagattt agcagagata ttacagattg
      721 ctatgcagaa ccaaatcaac accaacccgg agagtcctga cactgtgaca atacacgctg
      781 ccacaccaca gttcatcatt ggacccggag gggtggtgaa cctcacagat gaaacaggag
      841 tatctgctgt tcagtttgga aactcctcta cgtcagtatt agctacgtta gctgccttag
      901 ctgaagcttc tgccccattg tccaattctt cagaaactcc agtagtggcc acagaggaag
      961 tggttaccgc agaatctgtg gatggtgcaa ttcagcaagt agttagctca gggggtcagc
     1021 aagtcatcac gatagttaca gatggaatcc agctggggaa tttgcactcc ataccaacca
     1081 gtgggatggg tcagcccatc attgtgacga tgcccgatgg acagcaagta ttgacagtac
     1141 cagcaacaga cattgctgaa gaaactgtca tcagtgaaga gccaccagct aagagacagt
     1201 gtatggaaat aattgagagc cgggtggaat gtgcagaaat tgaagagaga gaagcgcttc
     1261 agaaacagct ggatgaagcc aaccgagagg cccagaaata ccgacagcag ctgcttaaga
     1321 aggagcagga ggcagaggcc tacaggcaga agctggaggc catgacacgc atccagacca
     1381 acaaagaagc cgtttagctg ccatgaacac cagtttgctt ttaccttttg tccagaaaga
     1441 atatagtctt gaactgtaca cagtaaggac acagccatgg gaataccgaa taatagaaaa
     1501 tactacagct tgataacggg acttaagcca tgagctctca attcttgtaa tataaaactt
     1561 tagaacttgt gaaatgtatt taaaactgaa ttctgtaaat agttttttgg ttgtttcttt
     1621 ttttactgtt ataaatgagt tgatgaagct tgttgctgag atccagaggc cacagcaagc
     1681 cactgttacg gggaattctt tttgatttcg gtgcagactt aatttctcag aaacagaagt
     1741 tgtaagcgtg gttgttgtct cttagaccaa atgtggaaca attatggtgg actgatgctg
     1801 gaaatactct gcaaagagat ttcgcccagg aacttttgta cagcttttaa gttgtctcag
     1861 gttctctgaa aacatttttt aggaagcaga aattttatat ttgttctatt tcagctacat
     1921 gcaagtagat ttacatgtat atgaagcaaa tatttttaaa attttgtttg tacatatcct
     1981 gcatgtttta tgattttaaa acacatccct tgcttaggta tgtctcctac aaagacgatg
     2041 aaagttacca agaaaaaaac caaggcacca ctgtcgttct gccggtcgtt gagagtgagt
     2101 aagctcacag ctggttttac tggcgaccat gacaatgttc ttggagcagc ttgcaagaga
     2161 actcgaatct gcaaaatata tgcttttctg acaattgtat tgtgaggatg tgagactgct
     2221 ctgtgccttc cttccatcat gacttccaca cgagcacttt gaggcgctgg attttaagat
     2281 aatgtttttg gcaaactcag tgcatttggg tttctgaaat atttcatgga cttactcccc
     2341 tcccctaaga aattaaatta ttcttatgga aattgctttt gtatgcagag caggaccttt
     2401 tgtactcagt gaggctatgg gtgtgtctaa cgtaactttc ggtattccct gtgaacgcgc
     2461 tccgggcctg tgctgcgact ctctcacaat attgtcaatt ctgaaatgta tggacatttg
     2521 acagactatt ccattctctt ttgtaaaatg taacttcaag ctctttatta ttttgttttg
     2581 ttctattgct ttatgaaaac gtttgcccct cccccacccc aggctcctct agcttatctg
     2641 tataaagaac cagttacctg cgagactgta ctctggcctc attttctatt ttacaattaa
     2701 ataactttcc acata
//
