LOCUS       NM_008065               5186 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus GA repeat binding protein, alpha (Gabpa), transcript
            variant 1, mRNA.
ACCESSION   NM_008065
VERSION     NM_008065.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5186)
  AUTHORS   Mooli,R.G.R., Zhu,B., Khan,S.R., Nagati,V., Michealraj,K.A.,
            Jurczak,M.J. and Ramakrishnan,S.K.
  TITLE     Epigenetically active chromatin in neonatal iWAT reveals GABPalpha
            as a potential regulator of beige adipogenesis
  JOURNAL   Front Endocrinol (Lausanne) 15, 1385811 (2024)
   PUBMED   38765953
  REMARK    GeneRIF: Epigenetically active chromatin in neonatal iWAT reveals
            GABPalpha as a potential regulator of beige adipogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5186)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   4  (bases 1 to 5186)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8.. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5186)
  AUTHORS   Ou-Yang,H., Wu,S.C., Sung,L.Y., Yang,S.H., Yang,S.H., Chong,K.Y.
            and Chen,C.M.
  TITLE     STAT3 Is an Upstream Regulator of Granzyme G in the
            Maternal-To-Zygotic Transition of Mouse Embryos
  JOURNAL   Int J Mol Sci 22 (1), 460 (2021)
   PUBMED   33466434
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5186)
  AUTHORS   Wei,J., Hodes,M.E., Wang,Y., Feng,Y., Ghetti,B. and Dlouhy,S.R.
  TITLE     Direct cDNA selection with DNA microdissected from mouse chromosome
            16: isolation of novel clones and construction of a partial
            transcription map of the C3-C4 region
  JOURNAL   Genome Res 6 (8), 678-687 (1996)
   PUBMED   8858343
REFERENCE   7  (bases 1 to 5186)
  AUTHORS   Chrast,R., Chen,H., Morris,M.A. and Antonarakis,S.E.
  TITLE     Mapping of the human transcription factor GABPA (E4TF1-60) gene to
            chromosome 21
  JOURNAL   Genomics 28 (1), 119-122 (1995)
   PUBMED   7590737
REFERENCE   8  (bases 1 to 5186)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 5186)
  AUTHORS   Brown,T.A. and McKnight,S.L.
  TITLE     Specificities of protein-protein and protein-DNA interaction of
            GABP alpha and two newly defined ets-related proteins
  JOURNAL   Genes Dev 6 (12B), 2502-2512 (1992)
   PUBMED   1340465
REFERENCE   10 (bases 1 to 5186)
  AUTHORS   LaMarco,K., Thompson,C.C., Byers,B.P., Walton,E.M. and
            McKnight,S.L.
  TITLE     Identification of Ets- and notch-related subunits in GA binding
            protein
  JOURNAL   Science 253 (5021), 789-792 (1991)
   PUBMED   1876836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164162.2.
            
            On Feb 17, 2023 this sequence version replaced NM_008065.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052448.1, AK145838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AC164162.2         38348-38966         c
            620-722             AC164162.2         34708-34810         c
            723-867             AC164162.2         32418-32562         c
            868-952             AC164162.2         29525-29609         c
            953-1198            AC164162.2         27522-27767         c
            1199-1393           AC164162.2         21237-21431         c
            1394-1447           AC164162.2         17376-17429         c
            1448-1588           AC164162.2         16717-16857         c
            1589-1781           AC164162.2         16319-16511         c
            1782-5186           AC164162.2         10112-13516         c
FEATURES             Location/Qualifiers
     source          1..5186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 46.92 cM"
     gene            1..5186
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="GA repeat binding protein, alpha"
                     /db_xref="GeneID:14390"
                     /db_xref="MGI:MGI:95610"
     exon            1..619
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            620..722
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             646..2010
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GA-binding protein alpha chain; GA-binding protein
                     alpha-subunit; GABP subunit alpha"
                     /codon_start=1
                     /product="GA-binding protein alpha chain isoform 1"
                     /protein_id="NP_032091.2"
                     /db_xref="CCDS:CCDS28284.1"
                     /db_xref="GeneID:14390"
                     /db_xref="MGI:MGI:95610"
                     /translation="MTKREAEELIEIEIDGTEKAECTEESIVEQTYTPAECVSQAIDI
                     NEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPDRSLFDQGVKTDGTVQLSVQVISYQ
                     GMEPKLNILEIVKTAETVEVVIDPDAHHAEAEAHLVEEAQVITLDGTKHITTISDETS
                     EQVTRWAAALEGYRKEQERLGIPYDPIHWSTDQVLHWVVWVMKEFSMTDIDLTTLNIS
                     GRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASV
                     PPATPTTIKVINSSAKAAKVQRSPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKD
                     ARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQG
                     KRFVYKFVCDLKTLIGYSAAELNRLVIECEQKKLARMQLHGIAQPVTAVALAATSLQA
                     DKEI"
     exon            723..867
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            868..952
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1198
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1393
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1447
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1588
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1781
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..5186
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="hexamer: AATAAA"
     polyA_site      3001
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="major polyA site"
     regulatory      5143..5148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="hexamer: AGTAAA"
     regulatory      5167..5172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="hexamer: AATAAA"
     polyA_site      5182
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
     polyA_site      5186
                     /gene="Gabpa"
                     /gene_synonym="GABPalpha"
                     /note="major polyA site"
ORIGIN      
        1 agtcgttcga cgctcaccgg acaggaagcg cctcgaaggg agtctgcgac cggacgcctc
       61 taggtgagac agaagccaaa caggaggagg aagtggaggg taagtgcttc cgggtccctc
      121 agctaagact ccgccatctt tcctacactt taacttcacc cccttttccc tcttggagac
      181 actgcactgt acgcatgcgt attctggcct gtcccctagt tcaagctccc ttcggagtca
      241 gcgtcccgat ccttggggtt ggggaggtgg atgtagggtg ggggtacaaa ggagcgcgta
      301 aaaaccaaaa ccaaaacaaa acaaaaaacc aaagcggctg gggggcgttt gtgcctcgtg
      361 agccccgtcg tcgcgggcgt ttcgggccgc gcagcctgct gggagttgta gttccaggcc
      421 cgggggtgcc tgggaggcgg gagaggggct ggggttcctt agcgccgatt ccacgggaag
      481 ggccccggga ccttaccctg ctactcgcgg gagcggcgcg gctcgcccgg agaggcgctg
      541 tacctggagc ccgcgccgcc gccgttccca gccggctgtg gaagcgcggg ctagggccac
      601 gggacgaatt ccggagctgg actgaacttt tgaacgtctt caaccatgac taagagagaa
      661 gcagaagagc tgatagaaat tgagatcgac gggactgaga aagcagagtg cacagaagaa
      721 agcattgtgg aacaaaccta taccccagct gaatgtgtaa gccaggccat agacatcaat
      781 gaaccaatag gcaatttaaa gaaactacta gaaccaagac tgcagtgttc tttggatgct
      841 catgaaattt gcctgcaaga tattcagctg gatccagacc gaagcttgtt tgatcaagga
      901 gtgaaaacag atgggactgt acagcttagt gtacaggtaa tttcttacca aggaatggag
      961 ccaaagttga acattcttga aattgttaag actgcggaaa cggtcgaggt ggtcatcgat
     1021 ccagatgccc accacgcgga agcagaagcg catctcgttg aagaagctca agtgataact
     1081 cttgacggca ccaagcacat tacgaccatt tcagacgaga cctcggagca ggtgacgaga
     1141 tgggctgctg cactggaagg ctacagaaaa gagcaggagc gccttggcat cccctatgat
     1201 cctatacact ggtccacgga ccaagtcctg cattgggtgg tttgggtaat gaaggagttc
     1261 agcatgactg atatagacct caccacactc aacatttcgg gaagagaatt atgtagtctc
     1321 aaccaagaag atttttttca gcgggtccct cggggagaaa ttctttggag tcatctggag
     1381 cttcttcgaa aatatgtttt ggccagccaa gagcaacaga tgaatgagat agttaccatt
     1441 gaccagcctg tgcagattat tccagcctca gtgcctcccg ctacaccgac tacgattaaa
     1501 gttataaaca gcagtgcaaa agcagctaaa gtgcaacggt ccccaaggat ttcaggagaa
     1561 gacagaagtt caccggggaa cagaacagga aacaatggtc agatccaact atggcagttt
     1621 ttgctagaac ttcttactga caaggatgct cgagactgta tttcttgggt tggtgatgaa
     1681 ggtgaattta agctaaatca gcctgagttg gttgcgcaaa aatggggaca acgtaagaac
     1741 aagcctacca tgaactatga gaaacttagc cgtgcattac ggtattatta tgatggggac
     1801 atgatttgta aagttcaagg caagagattt gtgtacaaat ttgtttgtga cttgaagact
     1861 cttattggat acagtgcagc agaactgaac cgtctggtca tagagtgtga acagaagaaa
     1921 ctggcacgga tgcagctgca tgggattgcc cagccagtca cggcagtagc actggcagcc
     1981 acctctctac aggcagacaa agagatttga gacctaggac ctcctgggga gtcttaaggt
     2041 ttttcttaaa tatttagagc aagctttgct ctaaccttta ttactgaatt tgaatcgtat
     2101 ttctagagtg tacaatctga tgcatgattt tttttataaa tatttcatac tcttgtgaat
     2161 ttggatcttt ttacgttgaa catatatttt agaatatgtt aaaggatcac cacgatgcct
     2221 gcaatgtgag agcaggttca tcggggtagt ttgctaacag tcaggaaagc taaactggtc
     2281 agtattaatg tctagcccta ccaaaaaata gccagtagcg tctgaagatg aaaggaggga
     2341 agcatttcca ggaaacagcc tggtgtagcc actgcgggcg tggagctgtt tcctctccgc
     2401 tgctttacac agagcctgaa aaaggacatt ctcagctaaa gcatgtgtgc ctgtttcatc
     2461 taatcaagca gagctaagca gtcctatcaa atacaattac attggtaatt actaaactat
     2521 caggttatta atttataatt tacaagaaga gaggaagtta actggcagaa gaaagtgttg
     2581 aatgagaccc agatttaaag ctggcttaac tcaaaccact attaatggtt ttctgtatag
     2641 attattcatt atgtcaagcc aaggtcttaa attattttga gagaggcatt taattctaat
     2701 aaaccagcta ttgcaaaaat tccaaaatga tatcattctt tctctcagat tttaaaaagt
     2761 atacctcaga aagaaaaaat tggtttagtt ttgacttcct atttttttaa aaattaatct
     2821 gtagtaccag attattatgc aagaccgttt atatattccc ttctgtgttt ctgataaaat
     2881 gaagacttta gatcaggcga catgtttaac gtttgacgta agttccttgt gagtagttat
     2941 gaaagggttt gactgggctc tgtaggcgat cttctttaaa taaagtttcc cacttgtttc
     3001 attttttttc ttttgaatat tgcatatatg actcttaaaa aatactgtac acatgactag
     3061 ctaaccattt ctgcatatat gaagacagat attcaagggg agattaatat ttctaacatt
     3121 tttaaataaa tcttatatga aatgccttac tgcttgctaa cactaagaag aaatgcctaa
     3181 aaaatttttt tcttcattta ttttaaagta ttatccataa atcatgatat gagagattag
     3241 catatagttt tcataacaga aaggaattcc tcagaacagg ataaaggcta ctttatatac
     3301 acctctctca tttgtttttc tttcagttca tttcccaaat tggctttaga agagtttgag
     3361 gagagaaagt gcagcctgat gatgcagcca ggaccgagtg ttagggagaa gacagagggt
     3421 ttcttacctc ctatatcatg acttccagtg ctgggctgtc agacttcaac aagggttgct
     3481 agtttcttta tattaagtcc tttaagatta tacagtaaat agttaaaaag agtaaaatcc
     3541 tattttttta tatttgctct ttgtttttat aaacaacagt aggcaggcaa attattagta
     3601 cagtttggtc accatgaatt gaaagagtag agtataagaa taatctttag gccctgactt
     3661 tcgacagcaa ataggcctgg gagccgtaag tcactgcttg agaacagggc attgccgcag
     3721 tacatcagag cttgagaagc tcagacttac agtgtgttgg agacattatg ttaaagcttt
     3781 agccaagagg acagactttg tgtatcattc ggaggaatgt gttttaagga aaggaacatt
     3841 tatatttgtt ctaggtccct acaatcaaac atttccaaat ccttaacaaa acaaaacaaa
     3901 acacacaaaa cgtgttgtat agctttgctt cctttggaag ctggtgggtt agttgtgatt
     3961 tgagcacagt tctcagatct taggtggttg ttctctaccc ctcctgcatc ctccatgctc
     4021 cccccacacg gaaggagacc caagctttct cactctggct ccactgagag ttcaaagatg
     4081 tgttgttctt attgaggccc cagtttgcta tcatctatta aaataactca tgttataaaa
     4141 gaatgttaat tcatggtaat ccttgctcag ttttgtcgtg catttttcat agagcctaag
     4201 atacagttga acaaaaagaa cagaaaacgg tctgaccatc ttttgtacct tataagttga
     4261 agaataatga aatgttcctg ttgctagaaa agcgagtttt ccatgtgatg tttacattga
     4321 cgtcatttta tatctgtgct agcctgaagt ctgagctagc ctgaggtctg tgctagcctg
     4381 aggtctgagt tagcctgagg tctgagctag cctgaggtct gagctagcct gtagtctgtg
     4441 ctagcctgaa gtctgagcta gcctgaggtc tgagctagcc tgtagtctgt gctagcctga
     4501 agtctgagct agcctgaggt ctgtgctagc ctgaggtctg agctagcctg aggtctgagc
     4561 gttggtgctg gcattggaag gtgcagccag ttaggcagaa gtgctggctg tgactgagct
     4621 cctcatgatg agttagccaa ctgcattcat tttagtgttg atccatgtaa ataaagtagg
     4681 aaaaattatt cagtttttct ccccagataa acagtaatgc tggagtatgg ttatttcttt
     4741 taaagagtgt acctccaagt atttttggca agttctgtca ttttctgcat ttgccattta
     4801 tgctactgcc ttttataaag aactagtgta tccttgaaat agcacaaaaa tgttttaaaa
     4861 tttataattg caaaacaaac ctgtgactga cttaatgtct tcagatctaa aggctataaa
     4921 aaaaatgttg atattcaata tttcacttac tcccaagaaa aaatactctt gagtcttttg
     4981 tagaagggag gagaattttt gcatacattt ttactcttta aataaagaca cttatactat
     5041 cataataaca attatgtatt tctttgtttt tttgtaattt tacataaaac agttattttc
     5101 tatttttact cagataaata tttgtgcata aaatgtaaaa atagtaaatg agaaaaatta
     5161 ttatacaata aattcttatg ttgaaa
//
