LOCUS       NM_019439               4456 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus gamma-aminobutyric acid type B receptor subunit 1
            (Gabbr1), transcript variant 1, mRNA.
ACCESSION   NM_019439 XM_001001239
VERSION     NM_019439.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Gobbo,D., Rieder,P., Fang,L.P., Buttigieg,E., Schablowski,M.,
            Damo,E., Bosche,N., Dallorto,E., May,P., Bai,X., Kirchhoff,F. and
            Scheller,A.
  TITLE     Genetic Downregulation of GABAB Receptors from Oligodendrocyte
            Precursor Cells Protects Against Demyelination in the Mouse Spinal
            Cord
  JOURNAL   Cells 13 (23), 2014 (2024)
   PUBMED   39682762
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Gao,S., Shen,R., Li,J., Jiang,Y., Sun,H., Wu,X., Li,X., Miao,C.,
            He,M., Wang,J. and Chen,W.
  TITLE     N-acetyltransferase 10 mediates cognitive dysfunction through the
            acetylation of GABABR1 mRNA in sepsis-associated encephalopathy
  JOURNAL   Proc Natl Acad Sci U S A 121 (36), e2410564121 (2024)
   PUBMED   39190359
  REMARK    GeneRIF: N-acetyltransferase 10 mediates cognitive dysfunction
            through the acetylation of GABABR1 mRNA in sepsis-associated
            encephalopathy.
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Chen,H.Y., Phan,B.N., Shim,G., Hamersky,G.R., Sadowski,N.,
            O'Donnell,T.S., Sripathy,S.R., Bohlen,J.F., Pfenning,A.R. and
            Maher,B.J.
  TITLE     Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the
            density and connectivity of distinct inhibitory interneuron
            subtypes
  JOURNAL   Mol Psychiatry 28 (11), 4679-4692 (2023)
   PUBMED   37770578
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Wang,X., Zhao,Z., Guo,J., Mei,D., Duan,Y., Zhang,Y. and Gou,L.
  TITLE     GABAB1 receptor knockdown in prefrontal cortex induces behavioral
            aberrations associated with autism spectrum disorder in mice
  JOURNAL   Brain Res Bull 202, 110755 (2023)
   PUBMED   37678443
  REMARK    GeneRIF: GABAB1 receptor knockdown in prefrontal cortex induces
            behavioral aberrations associated with autism spectrum disorder in
            mice.
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Cheng,Y.T., Luna-Figueroa,E., Woo,J., Chen,H.C., Lee,Z.F.,
            Harmanci,A.S. and Deneen,B.
  TITLE     Inhibitory input directs astrocyte morphogenesis through glial
            GABABR
  JOURNAL   Nature 617 (7960), 369-376 (2023)
   PUBMED   37100909
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Calon,F., Lavertu,N., Lemieux,A.M., Morissette,M., Goulet,M.,
            Grondin,R., Blanchet,P.J., Bedard,P.J. and Di Paolo,T.
  TITLE     Effect of MPTP-induced denervation on basal ganglia GABA(B)
            receptors: correlation with dopamine concentrations and dopamine
            transporter
  JOURNAL   Synapse 40 (3), 225-234 (2001)
   PUBMED   11304760
  REMARK    GeneRIF: MPTP-induced denervation is associated with a decrease of
            GABA(B) receptors restricted to the substantia nigra pars compacta
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Lamp,K., Humeny,A., Nikolic,Z., Imai,K., Adamski,J., Schiebel,K.
            and Becker,C.M.
  TITLE     The murine GABA(B) receptor 1: cDNA cloning, tissue distribution,
            structure of the Gabbr1 gene, and mapping to chromosome 17
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 116-121 (2001)
   PUBMED   11306808
REFERENCE   8  (bases 1 to 4456)
  AUTHORS   Sullivan,R., Chateauneuf,A., Coulombe,N., Kolakowski,L.F. Jr.,
            Johnson,M.P., Hebert,T.E., Ethier,N., Belley,M., Metters,K.,
            Abramovitz,M., O'Neill,G.P. and Ng,G.Y.
  TITLE     Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B))
            receptors with truncated receptors and metabotropic glutamate
            receptor 4 supports the GABA(B) heterodimer as the functional
            receptor
  JOURNAL   J Pharmacol Exp Ther 293 (2), 460-467 (2000)
   PUBMED   10773016
REFERENCE   9  (bases 1 to 4456)
  AUTHORS   Ng,G.Y., Clark,J., Coulombe,N., Ethier,N., Hebert,T.E.,
            Sullivan,R., Kargman,S., Chateauneuf,A., Tsukamoto,N., McDonald,T.,
            Whiting,P., Mezey,E., Johnson,M.P., Liu,Q., Kolakowski,L.F. Jr.,
            Evans,J.F., Bonner,T.I. and O'Neill,G.P.
  TITLE     Identification of a GABAB receptor subunit, gb2, required for
            functional GABAB receptor activity
  JOURNAL   J Biol Chem 274 (12), 7607-7610 (1999)
   PUBMED   10075644
REFERENCE   10 (bases 1 to 4456)
  AUTHORS   Kuner,R., Kohr,G., Grunewald,S., Eisenhardt,G., Bach,A. and
            Kornau,H.C.
  TITLE     Role of heteromer formation in GABAB receptor function
  JOURNAL   Science 283 (5398), 74-77 (1999)
   PUBMED   9872744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116130.15 and CR974567.10.
            
            On Nov 14, 2022 this sequence version replaced NM_019439.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054735.1, AF008649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC116130.15        108215-108508       c
            295-376             AC116130.15        107728-107809       c
            377-580             AC116130.15        106847-107050       c
            581-766             AC116130.15        105898-106083       c
            767-787             AC116130.15        104707-104727       c
            788-948             AC116130.15        103345-103505       c
            949-1083            AC116130.15        100239-100373       c
            1084-1254           AC116130.15        99597-99767         c
            1255-1356           AC116130.15        98557-98658         c
            1357-1422           AC116130.15        98143-98208         c
            1423-1614           AC116130.15        97525-97716         c
            1615-1857           AC116130.15        91728-91970         c
            1858-1921           AC116130.15        91111-91174         c
            1922-1965           AC116130.15        89801-89844         c
            1966-1999           CR974567.10        1-34
            2000-2150           CR974567.10        2511-2661
            2151-2283           CR974567.10        3073-3205
            2284-2400           CR974567.10        4409-4525
            2401-2508           CR974567.10        4610-4717
            2509-2602           CR974567.10        5278-5371
            2603-2730           CR974567.10        5951-6078
            2731-2859           CR974567.10        7150-7278
            2860-3003           CR974567.10        7441-7584
            3004-4456           CR974567.10        8150-9602
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..4456
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /note="gamma-aminobutyric acid type B receptor subunit 1"
                     /db_xref="GeneID:54393"
                     /db_xref="MGI:MGI:1860139"
     exon            1..294
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..3177
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GABA-BR1b receptor; bM573K1.1.1
                     (gamma-aminobutyric acid (GABA) B receptor, 1a); gb1;
                     GABA-B-R1; GABA-B receptor 1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid type B receptor subunit
                     1 isoform 1 precursor"
                     /protein_id="NP_062312.3"
                     /db_xref="CCDS:CCDS37616.1"
                     /db_xref="GeneID:54393"
                     /db_xref="MGI:MGI:1860139"
                     /translation="MLLLLLVPLFLRPLGAGGAQTPNVTSEGCQIIHPPWEGGIRYRG
                     LTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKS
                     YLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNR
                     TPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSK
                     CDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNR
                     QRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGI
                     EITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLI
                     GWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLT
                     KRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQI
                     YRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDK
                     WIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNS
                     QPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFT
                     KIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDILTLAIWQIVDPLHRTIETF
                     AKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKI
                     NDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKM
                     RRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQ
                     LQSRQQIRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK"
     exon            295..376
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..580
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..766
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..787
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..948
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1083
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1254
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1356
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1422
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1614
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1857
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1921
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1999
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2150
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2283
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2400
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2508
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2602
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2730
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2859
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3003
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..4456
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /note="hexamer: AATACA"
     polyA_site      3300
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /note="hexamer: AATAAA"
     polyA_site      4456
                     /gene="Gabbr1"
                     /gene_synonym="bM573K1.1; GABAB1; GABAbR1"
                     /note="major polyA site"
ORIGIN      
        1 gcaccctcct tcctccctcc gcccgagagc ttccccggtc cccggcgccg cctccttccc
       61 tcccggcacc gtgctctcgc ggccgccgtc gccccgggga aggagagacg ggggtggggt
      121 ttgcgggtag cgatcgcgaa ggggagagac cccggccggg ctggagcctg gattcctgtg
      181 gaagaagaac agggggaggg gaagctggag gaccgggagg gagaacgggg agccgcggcc
      241 gggcctgggc ccttgaggcc cggggagagc cgcggagcgg gaccggccgc cgagatgctg
      301 ctgctgctgc tggtgcctct cttcctccgc cccctgggcg ctggcggggc tcagaccccc
      361 aacgtcacct cggaaggttg ccagattata catccgccct gggaaggtgg catcaggtac
      421 cgtggcttga ctcgcgacca ggtgaaggcc atcaatttcc tgcctgtgga ctatgagatt
      481 gaatatgtgt gccggggcga acgcgaggtg gtggggccca aggtgcgcaa gtgcctggcc
      541 aacggctcct ggacggatat ggacacaccc agtcgctgtg tccgaatctg ctccaagtct
      601 tatttgaccc tggaaaatgg gaaggttttc ctgacgggtg gggacctccc agctctggat
      661 ggagcccggg tggatttccg atgtgacccc gacttccatc tggtgggcag ctcccggagc
      721 atctgtagtc agggccagtg gagcaccccc aagccccact gccaggtgaa tcgaacgcca
      781 cactcagaac ggcgtgcagt atacatcggg gcgctgtttc ccatgagcgg gggctggccg
      841 gggggccagg cctgccagcc tgcggtggag atggcgctgg aggacgttaa cagccgcaga
      901 gacatcctgc cggactacga gctcaagctt atccaccacg acagcaagtg cgacccaggg
      961 caagccacca agtacttgta tgaactactc tacaacgacc ccatcaagat catcctcatg
     1021 cccggctgca gctctgtgtc cacactggta gccgaggctg cccggatgtg gaaccttatt
     1081 gtgctctcat atggctccag ctcaccagcc ttgtcaaacc gacagcggtt tccaacgttc
     1141 tttcggacac atccatccgc cacactccac aatcccaccc gggtgaaact cttcgaaaag
     1201 tggggctgga agaagattgc caccatccag cagactaccg aggtcttcac ctcaacactg
     1261 gatgacctgg aggagcgagt gaaagaggct gggattgaga tcacttttcg acagagtttc
     1321 ttctcagatc cagctgtgcc tgttaaaaac ctgaagcgtc aagatgctcg aatcatcgtg
     1381 ggacttttct atgagaccga agcccggaaa gttttttgtg aggtctataa ggaacggctc
     1441 tttgggaaga agtatgtctg gtttctcatc gggtggtatg ctgacaactg gttcaaaacc
     1501 tatgacccgt caatcaattg tacagtagaa gagatgactg aggcggtgga gggccatatc
     1561 accacggaga ttgtcatgct gaaccctgcc aacacccgaa gcatttccaa catgacatca
     1621 caggaatttg tggagaaact aaccaagcgg ctgaaaagac accctgagga gactggaggc
     1681 ttccaggagg caccactggc ctatgatgct atctgggcct tggctttggc cttgaacaag
     1741 acctctggag gaggtggccg ttcaggagtg cgcctggagg actttaacta caacaaccag
     1801 accattacag accaaatcta ccgggccatg aactcctcct cctttgaggg tgtttctggc
     1861 cacgtggtct ttgatgccag cggctcccgg atggcatgga cgcttatcga gcagctacag
     1921 ggcggcagct acaagaagat cggctactac gacagcacca aggatgatct ttcctggtcc
     1981 aaaacagaca agtggatcgg agggtctccc ccagccgacc agaccttggt catcaagaca
     2041 ttccgtttcc tgtcacagaa actctttatc tccgtctcag ttctctccag cctgggcatt
     2101 gttcttgctg ttgtctgtct gtcctttaac atctacaact cccacgttcg ttatatccag
     2161 aactcccagc ccaacctgaa caatctgact gctgtgggct gctcactggc actagctgct
     2221 gtcttccccc ttgggctgga tggttaccac atagggagaa gccagttccc atttgtctgc
     2281 caggcccgcc tttggctctt gggcttaggc tttagtctgg gctatggctc tatgttcacc
     2341 aagatctggt gggtccacac agtcttcaca aagaaggagg agaagaagga atggaggaag
     2401 accctagagc cttggaaact gtacgccact gtaggcctgc tggtgggcat ggatatcctg
     2461 actcttgcca tctggcagat tgtggacccc ttgcaccgaa ccattgagac ttttgccaag
     2521 gaggaaccaa aggaagacat tgatgtctcc attctgcccc agctggagca ctgcagctcc
     2581 aagaagatga atacatggct cggcattttc tatggttaca aagggctgct gctgctgctg
     2641 ggaatctttc ttgcttatga gaccaaaagt gtgtccactg aaaagatcaa tgaccacagg
     2701 gccgtgggca tggctatcta caatgttgcg gtcctgtgtc tcattaccgc tcctgtcacc
     2761 atgatccttt ccagccagca ggacgcagcc ttcgcctttg cctctctggc cattgtgttc
     2821 tcttcctaca ttactctggt tgtgctcttt gtgcctaaga tgcgcaggtt gatcactcga
     2881 ggtgaatggc agtctgaagc acaggacaca atgaaaacag gatcatccac caacaacaat
     2941 gaggaagaga agtcccgact gttggagaag gaaaaccgtg aattggaaaa gatcatcgcc
     3001 gagaaagagg agcgtgtctc tgaactgcgc catcagctcc agtctcggca gcagatccgc
     3061 tcccggcgcc accccccaac acccccagac ccctctgggg gccttcccag gggaccctca
     3121 gagccccctg accggcttag ctgtgatggg agtcgagtac atttgcttta caagtgaggg
     3181 tgtatcgaga aggatgaggc cagcagggga gggaagggtg tggggagtgg gtggggaact
     3241 gggaagaggg tggagaacaa gctccaatcc ccctcttaga aatacatgtc attctgtgca
     3301 tctggggtta tctgggtctt cagtactctg ggaaacagat ggttttcttt ctttccatat
     3361 aattttatat caccacttca cagttttgtt tgaaccctgc ttggagctat tcactcatga
     3421 ctccagaggg gcatctcgtt tgtctcccat aggctgtctt gtatagttgt tactacagca
     3481 actcctgtca tttcagcagc aggggtcttc ctacattatc agggctttct ctccatttct
     3541 cagcattaga atctccttcc atcatccttc tcctccatgt ccctgtgtct tcctctcctt
     3601 aaatgttgct tcttccaggg gactcaccac acacacacac acacacacac acacacacac
     3661 acacacacac accatatcct ctcctctcct aggcagctgg atgtgtttct gtgcaaatat
     3721 gttcttttct gaatgctgct atcacttgtg tttgcatatg ctgcacctgt gagtgcacag
     3781 tggttgtggg tgtgtgcagt ggtgtgcttg ggtaggcgtg catgatgtgt tgagcacacc
     3841 aagctgtctt cctcatgtgc atatgtcatg gttgtctatg ttttacttgt gtgcctcctt
     3901 gcattgtgta ttttttcttt gcattttaat atcactatgt agtgtgtgtg tgtgttgccc
     3961 tgactcgtgt cagggcaggc ttcctgtctc agccttctga gtattgggat tacagttgtc
     4021 tgcctagctg atgtcctgtc ttctttcagc agaggcatgt gcacccaaca tgcacatgat
     4081 taagcaggct cttccccagt acgtgttttc tgagccatgc ataccctctc cttggcctta
     4141 ggtttactct caagtgttcc ctctattctc atgcgtccca ctttgggtct gtacaatcat
     4201 ctctcagaac tactgcatct tggttttctt ttctttgttg tcattattat tatttttcag
     4261 aactaagggg aaaagaaatg gggacaggtt ggaggctgtt tccagtggat agtgggtgca
     4321 catttgatca aatgaaggca tggacagatg gactgaccgg gcgggaggca gcatcccttt
     4381 cacactgtgg tgtctcttgg gggaaggatc tccctgaatc tcaataaagc agttaacagt
     4441 gtgactcagc acctca
//
