LOCUS       NM_026693                996 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GABA type A receptor associated protein like 2
            (Gabarapl2), mRNA.
ACCESSION   NM_026693
VERSION     NM_026693.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 996)
  AUTHORS   Gonzalez-Rodriguez,P., Cheray,M., Fullgrabe,J., Salli,M.,
            Engskog-Vlachos,P., Keane,L., Cunha,V., Lupa,A., Li,W., Ma,Q.,
            Dreij,K., Rosenfeld,M.G. and Joseph,B.
  TITLE     The DNA methyltransferase DNMT3A contributes to autophagy long-term
            memory
  JOURNAL   Autophagy 17 (5), 1259-1277 (2021)
   PUBMED   32876528
REFERENCE   3  (bases 1 to 996)
  AUTHORS   Sakaguchi,N., Sasai,M., Bando,H., Lee,Y., Pradipta,A., Ma,J.S. and
            Yamamoto,M.
  TITLE     Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent
            Excess Inflammation and Lethal Endotoxic Shock
  JOURNAL   Front Immunol 11, 561948 (2020)
   PUBMED   33042141
  REMARK    GeneRIF: Role of Gate-16 and Gabarap in Prevention of
            Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic
            Shock.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 996)
  AUTHORS   Mayeuf-Louchart,A., Lancel,S., Sebti,Y., Pourcet,B., Loyens,A.,
            Delhaye,S., Duhem,C., Beauchamp,J., Ferri,L., Thorel,Q.,
            Boulinguiez,A., Zecchin,M., Dubois-Chevalier,J., Eeckhoute,J.,
            Vaughn,L.T., Roach,P.J., Dani,C., Pederson,B.A., Vincent,S.D.,
            Staels,B. and Duez,H.
  TITLE     Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown
            Adipocyte Differentiation
  JOURNAL   Cell Rep 29 (6), 1410-1418 (2019)
   PUBMED   31693883
REFERENCE   5  (bases 1 to 996)
  AUTHORS   Sasai,M., Sakaguchi,N., Ma,J.S., Nakamura,S., Kawabata,T.,
            Bando,H., Lee,Y., Saitoh,T., Akira,S., Iwasaki,A., Standley,D.M.,
            Yoshimori,T. and Yamamoto,M.
  TITLE     Essential role for GABARAP autophagy proteins in
            interferon-inducible GTPase-mediated host defense
  JOURNAL   Nat Immunol 18 (8), 899-910 (2017)
   PUBMED   28604719
  REMARK    GeneRIF: Cells that lacked GABARAPs and mice that lacked Gate-16
            alone were defective in the IFN-gamma-induced clearance of vacuolar
            pathogens such as Toxoplasma. Gate-16 specifically associated with
            the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate
            uniform distribution of interferon-inducible GTPases. GABARAPs are
            uniquely required for antimicrobial host defense through cytosolic
            distribution of IFN-inducible GTPases.
REFERENCE   6  (bases 1 to 996)
  AUTHORS   Marino,G., Fernandez,A.F., Cabrera,S., Lundberg,Y.W.,
            Cabanillas,R., Rodriguez,F., Salvador-Montoliu,N., Vega,J.A.,
            Germana,A., Fueyo,A., Freije,J.M. and Lopez-Otin,C.
  TITLE     Autophagy is essential for mouse sense of balance
  JOURNAL   J Clin Invest 120 (7), 2331-2344 (2010)
   PUBMED   20577052
REFERENCE   7  (bases 1 to 996)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   8  (bases 1 to 996)
  AUTHORS   Xin,Y., Yu,L., Chen,Z., Zheng,L., Fu,Q., Jiang,J., Zhang,P.,
            Gong,R. and Zhao,S.
  TITLE     Cloning, expression patterns, and chromosome localization of three
            human and two mouse homologues of GABA(A) receptor-associated
            protein
  JOURNAL   Genomics 74 (3), 408-413 (2001)
   PUBMED   11414770
REFERENCE   9  (bases 1 to 996)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
REFERENCE   10 (bases 1 to 996)
  AUTHORS   Sagiv,Y., Legesse-Miller,A., Porat,A. and Elazar,Z.
  TITLE     GATE-16, a membrane transport modulator, interacts with NSF and the
            Golgi v-SNARE GOS-28
  JOURNAL   EMBO J 19 (7), 1494-1504 (2000)
   PUBMED   10747018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134873.1, BC081436.1 and AI845404.1.
            
            On Nov 30, 2011 this sequence version replaced NM_026693.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190644.1, AK134873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK134873.1         2-16
            16-645              BC081436.1         1-630
            646-996             AI845404.1         1-351               c
FEATURES             Location/Qualifiers
     source          1..996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 58.19 cM"
     gene            1..996
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /note="GABA type A receptor associated protein like 2"
                     /db_xref="GeneID:93739"
                     /db_xref="MGI:MGI:1890602"
     exon            1..150
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..470
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /note="GABA(A) receptor-associated protein like 2;
                     golgi-associated ATPase enhancer of 16 kDa; ganglioside
                     expression factor 2; gamma-aminobutyric acid (GABA) A
                     receptor-associated protein-like 2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein-like 2"
                     /protein_id="NP_080969.2"
                     /db_xref="CCDS:CCDS40480.1"
                     /db_xref="GeneID:93739"
                     /db_xref="MGI:MGI:1890602"
                     /translation="MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDI
                     DKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDED
                     GFLYVAYSGENTFGF"
     exon            151..206
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..379
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..980
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /note="hexamer: AATAAA"
     polyA_site      980
                     /gene="Gabarapl2"
                     /gene_synonym="0610012F20Rik; 2900019O08Rik; GATE-16;
                     Gef2"
                     /note="major polyA site"
ORIGIN      
        1 agccggaagt cccgcctgtg gagtagtcgt cgctgccgcc gccgcctccg ttgttgttgt
       61 ggtcgcttcg ccgaagtccg cggctcgaag agccggctcc gtcgcttccc gtcgccatga
      121 agtggatgtt taaggaggac cactctctgg aacacagatg cgtggaatcc gcgaagatca
      181 gagcgaagta ccccgaccga gttccggtga tcgtggaaaa agtctcgggc tctcagattg
      241 ttgacataga caagaggaag tacttggtcc cctcggacat cactgtggct cagttcatgt
      301 ggatcatcag gaaaaggatc cagcttccct ccgagaaggc catcttcctg tttgtggaca
      361 agacagtccc acagtccagc ctaactatgg gacagcttta cgagaaggaa aaagatgaag
      421 atggattctt gtatgtggcc tacagcggag agaacacttt tggcttctga ggcccttgct
      481 gggctaggtg cgcccttcct gcttgtgtct cttgtaaata actggctgtt ctcagttact
      541 ctgccagagc ctccacacag acctactagt gcatttgtaa ctggatttat ttcttaatat
      601 attggaaggt tttgtttcct tagattagta aattatcata cagagtttta ttttcagttt
      661 tctttttgtg cactgtcctc atggctattt gctccaggga acctgtcctc tgggaatcat
      721 atttaatgaa gatatttccg taatgaaggg aggtaggtgt ggtggtaaag ggaaaaggag
      781 gggctgatgc atagttctgg attatgttga aagtgttaga tggctaagta ttaaaagcac
      841 ccagattaaa tccttagcaa tcagaacact tgcttcacta gattttgcca actgcaaatc
      901 atgttggact gagctaatct attcttcttt ctgagactat taaggtaaat aattaacaat
      961 aaagcctcct tataaaggca aaaaaaaaaa aaaaaa
//
