LOCUS       NM_019749               1122 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus gamma-aminobutyric acid receptor associated protein
            (Gabarap), mRNA.
ACCESSION   NM_019749
VERSION     NM_019749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Xie,W., Zhang,C., Wang,Z., Chen,H., Gu,T., Zhou,T., Wu,Y., Xia,F.,
            Li,M., Wang,J., Jiao,R., Cui,J. and Jin,S.
  TITLE     ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic
            degradation of TBK1
  JOURNAL   Autophagy 19 (11), 2853-2868 (2023)
   PUBMED   37434364
  REMARK    GeneRIF: ATG4B antagonizes antiviral immunity by GABARAP-directed
            autophagic degradation of TBK1.
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Li,J., Liu,C., Muller,U. and Zhao,B.
  TITLE     RIPOR2-mediated autophagy dysfunction is critical for
            aminoglycoside-induced hearing loss
  JOURNAL   Dev Cell 57 (18), 2204-2220 (2022)
   PUBMED   36113482
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Reggio,A., Buonomo,V., Berkane,R., Bhaskara,R.M., Tellechea,M.,
            Peluso,I., Polishchuk,E., Di Lorenzo,G., Cirillo,C., Esposito,M.,
            Hussain,A., Huebner,A.K., Hubner,C.A., Settembre,C., Hummer,G.,
            Grumati,P. and Stolz,A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Liu,Y., Wang,D., Lei,M., Gao,J., Cui,Y., Jin,X., Yu,Q., Jiang,Y.,
            Guo,Y., Liu,Y., Cai,L. and Chen,X.
  TITLE     GABARAP suppresses EMT and breast cancer progression via the
            AKT/mTOR signaling pathway
  JOURNAL   Aging (Albany NY) 13 (4), 5858-5874 (2021)
   PUBMED   33591943
  REMARK    GeneRIF: GABARAP suppresses EMT and breast cancer progression via
            the AKT/mTOR signaling pathway.
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Ye,J., Zou,G., Zhu,R., Kong,C., Miao,C., Zhang,M., Li,J., Xiong,W.
            and Wang,C.
  TITLE     Structural basis of GABARAP-mediated GABAA receptor trafficking and
            functions on GABAergic synaptic transmission
  JOURNAL   Nat Commun 12 (1), 297 (2021)
   PUBMED   33436612
  REMARK    GeneRIF: Structural basis of GABARAP-mediated GABAA receptor
            trafficking and functions on GABAergic synaptic transmission.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Proctor,W.R., Wu,P.H., Bennett,B. and Johnson,T.E.
  TITLE     Differential effects of ethanol on gamma-aminobutyric acid-A
            receptor-mediated synaptic currents in congenic strains of inbred
            long and short-sleep mice
  JOURNAL   Alcohol Clin Exp Res 28 (9), 1277-1283 (2004)
   PUBMED   15365296
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Okazaki,N., Yan,J., Yuasa,S., Ueno,T., Kominami,E., Masuho,Y.,
            Koga,H. and Muramatsu,M.
  TITLE     Interaction of the Unc-51-like kinase and microtubule-associated
            protein light chain 3 related proteins in the brain: possible role
            of vesicular transport in axonal elongation
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 1-12 (2000)
   PUBMED   11146101
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Wang,H. and Olsen,R.W.
  TITLE     Binding of the GABA(A) receptor-associated protein (GABARAP) to
            microtubules and microfilaments suggests involvement of the
            cytoskeleton in GABARAPGABA(A) receptor interaction
  JOURNAL   J Neurochem 75 (2), 644-655 (2000)
   PUBMED   10899939
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12 and AV029091.2.
            
            On Apr 7, 2009 this sequence version replaced NM_019749.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An in-frame
            AUG is located 46 codons upstream of the annotated translation
            start site but is not being annotated as a start site since it is
            not conserved and is in a weak Kozak sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV029091.2, BC030350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AL596185.12        103015-103447
            434-1122            AV029091.2         205-893
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.95 cM"
     gene            1..1122
                     /gene="Gabarap"
                     /note="gamma-aminobutyric acid receptor associated
                     protein"
                     /db_xref="GeneID:56486"
                     /db_xref="MGI:MGI:1861742"
     exon            1..433
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..697
                     /gene="Gabarap"
                     /note="GABA-A receptor-associated protein;
                     gamma-aminobutyric acid reseptor associated protein"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein"
                     /protein_id="NP_062723.1"
                     /db_xref="CCDS:CCDS24928.1"
                     /db_xref="GeneID:56486"
                     /db_xref="MGI:MGI:1861742"
                     /translation="MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDL
                     DKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEED
                     FFLYIAYSDESVYGL"
     exon            434..512
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     exon            513..631
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1122
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gabarap"
                     /note="hexamer: AATAAA"
     polyA_site      1119
                     /gene="Gabarap"
                     /note="major polyA site"
ORIGIN      
        1 caactttgta ctgtgggaaa gggtttttca gttcactcga aacaacagca accttatctg
       61 cgatgtcata tgtgtaaccc acaagttgat tccaaagcag ttacgctgaa ggcgtaagag
      121 gaccaggcta cgggttgcgc tagcaagctg agctagtggc gtatgttagc aggcggggcc
      181 ggtccgatgg tcgggggcgg ggttgatgaa tagggaagtg gcgcaaattc gtggatcgct
      241 ccgccaagtc tgttcgtcga agccgcctcc gccgccgccc cctgtcccgg ccccccccct
      301 gggttccctc agcccagctc ggtccagccc ggttctcggg agaatgaagt tcgtgtacaa
      361 agaggagcat ccgttcgaga agcgccgctc tgagggcgag aaaatccgaa agaaataccc
      421 agaccgggtc ccggtgatag tggaaaaagc ccccaaagct cggataggag acctggacaa
      481 aaagaaatac ctggtgcctt ctgatcttac agttggtcaa ttctacttct tgatccggaa
      541 gcgaattcat ctccgtgctg aagatgcctt gtttttcttt gtcaacaatg tcattccacc
      601 caccagtgcc acgatgggtc agctgtacca ggaacaccat gaagaagact tctttctata
      661 cattgcctac agtgatgaaa gcgtctatgg tctgtgaagc tgctgtacct gaggtggggg
      721 gttccattct acgaagagag gtggcgctcc ttccttgaca tccagttcct ccttcaggct
      781 caaacaccac ctcctttctt caggacctgc acttaatgtt tgaggctgtc tctccagtcc
      841 ctctcagcag gaggggtaat ggtagataca gcctccatac atctctttct ccccttgttt
      901 accctccatt cccactctga tttagacttc ttgattgtcg atctctgtca catccgatga
      961 ttgttttggt ttctattccc tttctaactg cccatcgggc tcagaacccc aataatccct
     1021 tcctttcact atcttctttt tggggggtag gtggaaggga ttgacattgg atgggggagg
     1081 taggaggcac atcaataaaa aggaaaccac cgagctgaat tg
//
