LOCUS       NM_181584               2129 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus growth factor receptor bound protein 2-associated
            protein 3 (Gab3), mRNA.
ACCESSION   NM_181584 NM_153073 XM_975532
VERSION     NM_181584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Sliz,A., Locker,K.C.S., Lampe,K., Godarova,A., Plas,D.R.,
            Janssen,E.M., Jones,H., Herr,A.B. and Hoebe,K.
  TITLE     Gab3 is required for IL-2- and IL-15-induced NK cell expansion and
            limits trophoblast invasion during pregnancy
  JOURNAL   Sci Immunol 4 (38) (2019)
   PUBMED   31375526
  REMARK    GeneRIF: The Gab3 is a key component required for cytokine-mediated
            NK cell priming and expansion that is essential for antitumor
            responses and limits trophoblast cell invasion during pregnancy.
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Wang,Z., Vaughan,T.Y., Zhu,W., Chen,Y., Fu,G., Medrzycki,M.,
            Nishio,H., Bunting,S.T., Hankey-Giblin,P.A., Nusrat,A.,
            Parkos,C.A., Wang,D., Wen,R. and Bunting,K.D.
  TITLE     Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage
            and CD8+ T-Cell Activation
  JOURNAL   Front Immunol 10, 486 (2019)
   PUBMED   30936879
  REMARK    GeneRIF: Gab2 and Gab3 Redundantly Suppress Colitis by Modulating
            Macrophage and CD8(+) T-Cell Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Seiffert,M., Custodio,J.M., Wolf,I., Harkey,M., Liu,Y.,
            Blattman,J.N., Greenberg,P.D. and Rohrschneider,L.R.
  TITLE     Gab3-deficient mice exhibit normal development and hematopoiesis
            and are immunocompetent
  JOURNAL   Mol Cell Biol 23 (7), 2415-2424 (2003)
   PUBMED   12640125
  REMARK    GeneRIF: Gab3-deficient mice exhibit normal development and
            hematopoiesis and are immunocompetent
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Bourgin,C., Bourette,R.P., Arnaud,S., Liu,Y., Rohrschneider,L.R.
            and Mouchiroud,G.
  TITLE     Induced expression and association of the Mona/Gads adapter and
            Gab3 scaffolding protein during monocyte/macrophage differentiation
  JOURNAL   Mol Cell Biol 22 (11), 3744-3756 (2002)
   PUBMED   11997510
  REMARK    GeneRIF: Induced expression and association of the Mona/Gads
            adapter and Gab3 scaffolding protein during monocyte/macrophage
            differentiation. (Gab3 scaffolding protein)
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Wolf,I., Jenkins,B.J., Liu,Y., Seiffert,M., Custodio,J.M., Young,P.
            and Rohrschneider,L.R.
  TITLE     Gab3, a new DOS/Gab family member, facilitates macrophage
            differentiation
  JOURNAL   Mol Cell Biol 22 (1), 231-244 (2002)
   PUBMED   11739737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031227.1, BB634123.1 and BX640116.1.
            
            On or before Nov 1, 2008 this sequence version replaced
            NM_153073.2, NM_181584.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031227.1, AY057988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AK031227.1         2-72
            72-74               BB634123.1         67-69
            75-2124             AK031227.1         73-2122
            2125-2129           BX640116.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.12 cM"
     gene            1..2129
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /note="growth factor receptor bound protein 2-associated
                     protein 3"
                     /db_xref="GeneID:210710"
                     /db_xref="MGI:MGI:2387324"
     exon            1..238
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1954
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /note="GRB2-associated binder 3"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 3"
                     /protein_id="NP_853615.1"
                     /db_xref="CCDS:CCDS30235.1"
                     /db_xref="GeneID:210710"
                     /db_xref="MGI:MGI:2387324"
                     /translation="MSTGDTVCMGWLIKSPPERKLQRYAWRKRWFVLRRGRMSGNPDV
                     LEYYRNKHSNKPIRVIDLSECTVWKHAGPGFIRKEFQKNFVFIVKTTSRTFYLVAKTE
                     EEMQVWVHSISQVCNFSHLEDGADSMESLSHMPSSFQPSPASSLHTVHVANSALLKDD
                     RNTNSVVTEETRRESEFLFLPDYLILSNCETGRLHHASLPTRCDSWSNSNHSLAQTSF
                     DDVFLDGLQPFISNNLVHPLHHGKVSQDFPSIRPQASLIWNREINGPSRNLMSSSPLL
                     ESSLNPTVHVEEKQVSLPSGVKELNIMSNTPPPRPPKPSYLSEQRQDQPLLTGHSSNK
                     KPGYTMVPRRISLSGLDHVGSWKGDVQSQSLRHRDKRLSLNLPCKFSPIYPTASPSAE
                     DSYVPMSPKGTASELRPHCSQDDYIPMSSSMLPELPADLEPPPVNRNLKPQRKSRPPP
                     LDSRNLSTIQEHTSLTRTYTVPCNRTSFLSPQRNGINCARLFSTPSEEEEEEEEEEEE
                     EEEEEKYIQMEEYGTVSSLSRSALSWTKKFSLDYLALDFNSTSPAPVQKKLLLSEEQR
                     VDYVQVDEQKTQALRSTKQEWTDERQSKV"
     exon            239..542
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..759
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1238
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1294
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1502
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1584
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1720
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1837
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2129
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2047
                     /gene="Gab3"
                     /gene_synonym="5930433H21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcccagctg gaggaagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc
       61 agcagcagca gcagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagcagc
      121 agcagcagca gcagcagaag cggctgcggc ggcggcggcg gccaggatga gcactggtga
      181 cactgtgtgc atgggctggc tcatcaagtc gcctcccgag aggaagctgc agcgctatgc
      241 ttggcgcaaa cgctggtttg tcctcaggcg gggccgcatg agtggcaatc ctgatgtctt
      301 agaatactac cgcaacaagc actccaacaa gcccatccgt gtgatagacc tcagtgaatg
      361 cactgtgtgg aaacatgcag gccctggttt cattaggaag gaatttcaga aaaattttgt
      421 gtttattgtc aagaccactt cccgtacatt ctacctagta gccaagactg aggaagaaat
      481 gcaggtgtgg gtacacagca tcagtcaagt ttgcaatttc agtcatctgg aagatggtgc
      541 agattccatg gagagtctct ctcacatgcc ctcctccttc cagccatctc ctgccagttc
      601 acttcatact gtccatgttg ccaactctgc cttactaaaa gatgaccgaa acactaatag
      661 tgtagtcact gaggaaacca gacgtgagtc agagtttctg ttccttcctg attatctgat
      721 cctgtccaac tgtgagactg gaagactaca ccatgccagt cttcccacca gatgtgatag
      781 ctggtcaaat tcaaaccact cattggcaca gacttcattt gatgatgttt ttcttgatgg
      841 tctacagcca tttatctcta ataatttggt ccatcccttg caccatggga aagtatctca
      901 ggattttcct tccatacggc cccaggcttc tttaatctgg aatagagaaa tcaatggccc
      961 atctaggaac ctcatgtctt cttcaccatt gttggaatct tccttaaacc ccacagttca
     1021 tgtagaagaa aagcaagttt ccttacccag tggggtaaaa gaactaaaca ttatgtctaa
     1081 cactccacct cctcgtcccc ctaagccaag ttatctctct gaacaacgcc aagatcagcc
     1141 cttgttgact gggcacagca gtaacaagaa gccagggtat actatggtac caagaagaat
     1201 ctctctctct gggttagacc atgtggggtc ctggaaaggt gatgtacaaa gccaatcctt
     1261 aagacacaga gataagcggc tcagtttaaa tctgccatgt aagttttcac cgatatatcc
     1321 cacagcttca cccagtgctg aagacagcta tgtgcccatg agccctaaag gcactgcttc
     1381 tgaacttaga ccccattgca gccaggatga ctacattcca atgagctcaa gcatgctgcc
     1441 tgagttacct gcagacttgg agccaccccc agtgaacaga aatctcaagc cccagagaaa
     1501 atcacggcca cctcccttgg actcgagaaa cctttccacc atccaggaac acacatctct
     1561 aaccaggact tacactgtgc cttgcaatcg aaccagtttt ctctctccac aaagaaatgg
     1621 tattaattgt gcaagacttt tttccactcc ttctgaagaa gaagaagaag aagaagaaga
     1681 agaagaagaa gaagaagaag aagaaaagta catccaaatg gaggaatacg gaacagtcag
     1741 ttccctgagc agaagtgctc tttcttggac aaagaaattc agcttggatt atttggccct
     1801 ggacttcaat tcaacatcac cagcccctgt acagaagaaa cttctccttt cagaagagca
     1861 gagagtagac tatgttcaag tggatgaaca aaagacacaa gctcttcgga gcaccaagca
     1921 ggaatggact gatgagaggc aatccaaagt gtgagaagtg tgggcttggg tgtgatttta
     1981 gcctttattt ctaagttctc tctaaaaagt tctccaaaaa gttttctaag aaagttcttt
     2041 tctaaaaggt tcttcctctt ctctttgtcc tcagcactta tacatctttc agaatacatg
     2101 atcatgtgtt aaaacgtttc tcacaaaaa
//
